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Abstract

The demand for herbal preparations is rising on the global market, and plants have been identified as having potent antimicrobial, antioxidant, and anti-inflammatory properties. The purpose of this study is to create and formulate a herbal anti-aging cream and to assess its physicochemical qualities, with a focus on safety and efficacy. Papaya (Carica papaya) seeds were used as natural ingredients in the creation of the oil-in-water (O/W) herbal anti-aging lotion. Beeswax and methyl paraben were also added in various concentrations. Soxhlet extraction was used to extract the seeds after they had been dried. Its anti-inflammatory and antioxidant properties have been used to treat skin disorders like rashes, dry skin, and ageing skin. Utilizing several evaluation techniques, the product's quality was evaluated. The formulation was assessed based on a variety of factors, including pH, spreadability, and stability, among others. Good spreadability, good consistency, homogeneity, appearance, pH, no signs of phase separation, and ease of removal were all displayed by the formulation. During irritancy trials, the formulation exhibits no redness, edoema, inflammation, or irritation. The skin can be safely used with these formulas. According to these research, the base of the cream and the composition of the extracts are more stable and safe, which may result in a synergistic effect. Conclusion: Antioxidant-rich herbal creams can be utilised to provide a barrier for the skin, keeping it safe and preventing ageing.

Keywords

Anti-aging, antioxidant, cosmetic, and carica papaya herbal cream

Reference

  1. Kaur IP, Kapila M, Agarwal R. Role of novel delivery Systems in developing topical antioxidants as therapeutics To combat photo aging, Int J of Pharm Sci, 2007; 6:271-288.
  2. Watson, Ogden S, Cotterell LF, Bowden JJ, Bastrilles JY, Long SP et al. A cosmetic ‘anti-ageing’ product improves Photo aged skin, a double-blind, randomized controlled Trial British. J Dermatol, 2009; 161:419-426.
  3. Saraf S, Kaur CD. Phytoconstituents as photo protective novel cosmetic formulations, Pharmacogn. Rev., 2010; 4(7):1-11.
  4. Hema Sharma Datta, Rangesh Paramesh, Trends in aging and skin care: Ayurvedic concepts, Journal of Ayurveda and Integrative Medicine, 2010; 1(2):110-113.
  5. Herrling T, Jung K, Fuchs J. The important role of melanin as protector against free radicals in skin. SOFW J Cosmet, 2007; 9: 26-32.
  6. Ganceviciene R, Liakou AI, Theodoridis A, Makrantonaki E, Zouboulis CC. Skin anti-aging strategies. Dermatoendocrinol, 2012; 4: 308-19.
  7. Khare N, Khare PP, Yadav G. Recent advances in anti-aging-a review. Global J Pharmacol, 2015; 9: 267-71.
  8. Anila L, Vijayalakshmi NR Antioxidant action of flavonoids from Mangifera indica and Emblica officinalis in hypercholesterolemic rats. Food Chem., 2003; 83:569–574.
  9. Mishra AK, Mishra A, Chattopadhyay P. Herbal Cosmeceuticals for Photoprotection from Ultraviolet B Radiation, A Review, T.J.P.R., 2011; 10(3):351-360.
  10. Ashish Aswal, Mohini Kalra and Abhiram Rout: Preparation and evaluation of polyherbal cosmetic cream. Der Pharmacia Lettre, 201,5(1):83-88.
  11. U.S. National Plant Germplasm System. Carica papaya L. https://npgsweb.ars-grin.gov/gringlobal/taxonomydetail.aspx?9147
  12. Lim T (2012) Edible medicinal and non-medicinal plants. Vol. 1. Fruits. New York, Dordrecht, Netherlands: Springer, pp 693-714. 
  13. United States Department of Agriculture Agricultural Research Service National Nutrient Database for Standard Reference Legacy Release https://ndb.nal.usda.gov/ndb/foods/show/09226?fgcd=&manu=&format=&count=&max=25&offset=&sort=default&order=asc&qlookup=Papayas,+raw&ds=&qt=&qp=&qa=&qn=&q=&ing=
  14. Asghar N, Naqvi SA, Hussain Z et al (2016) Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents. Chem Cent J 10:5. doi: 10.1186/s13065-016-0149-0.
  15. Vuong, QV, Hirun S, Roach PD et al (2013) Effect of extraction conditions on total phenolic compounds and antioxidant activities of Carica papaya leaf aqueous extracts. J. Herb. Med 3:104–111. Doi: 10.1016/j.hermed.2013.04.004.
  16. Santana LF, Inada AC, Espirito Santo BLS et al (2019) Nutraceutical Potential of Carica papaya in Metabolic Syndrome. Nutrients 11:1608.doi: 10.3390/nu11071608.
  17. Nguyen TT, Shaw PN, Parat MO, Hewavitharana AK (2013) Anticancer activity of Carica papaya: a review. Mol Nutr Food Res 57(1):153-164.doi: 10.1002/mnfr.201200388.
  18. Samaram S, Mirhosseini H, Tan CP et al (2013) Ultrasound-assisted extraction and solvent extraction of papaya seed oil: yield, fatty acid composition and triacylglycerol profile. Molecules 18(10):12474-12487.doi:10.3390/molecules181012474
  19. Facciola S (1998) Cornucopia II – A Source Book of Edible Plants. Kampong Publications, pp 73.
  20. Yon RM (1994) Papaya: Fruit Development, Postharvest Physiology, Handling and Marketing in ASEAN; ASEAN food Handling Bureau:Kuala Lumpur, Malaysia.
  21. Lee WK, Lee MH, Su NW (2011) Characteristics of papaya seed oil obtained by extrusion-expelling processes. J. Sci. Food Agric 91:2348–2354.doi: 10.1002/jsfa.4466.
  22. Veronezi CM, Jorge N (2018) Effect of Carica papaya and Cucumis melo seed oils on the soybean oil stability. Food Sci Biotechnol 27(4):1031–1040. Doi: 10.1007/s10068-018-0325-1.
  23. Gunstone FD (2000) Composition and properties of edible oils. In Edible Oil Processing. W. Hamm and R.J. Hamilton, eds., Sheffield Academic Press, Sheffield, UK 1–33.
  24. Wabo Poné J, Ngankam Ntemah JD, Bilong Bilong CF et al (2011) Comparative study of the ovicidal and larvicidal activities of aqueous and ethanolic extracts of pawpaw seeds Carica papaya [Caricaceae] on Heligmosomoides bakeri. Asian Pac J Trop Med 4(6):447–450.doi:10.1016/S1995-7645(11)60123-5.
  25. Puangsri T, Abdulkarim SM, Ghazali HM (2005) Properties of Carica papaya L. [Papaya] seed oil following extraction using solvent and aqueous enzymatic methods. J. Food Lipids 12:62–67. doi: 10.1111/j.1745-4522.2005.00006.x.
  26. Porte A, Silva EF, Almeida VDS et al (2011) Propriedades funcionais tecnolo´gicas das farinhas de sementes de mama˜o [Carica papaya] e de abo´boras [Cucurbita sp]. Rev. Bras. Prod. Agro 13:91–96.
  27. Silva AC, Jorge N (2014) Bioactive compounds of the lipid fractions of agro-industrial waste. Food Res. Int 66:493–500.doi:10.1016/j.foodres.2014.10.025.
  28. Asghar N, Naqvi SA, Hussain Z et al. (2016) Compositional difference in antioxidant and antibacterial activity of all parts of the Carica papaya using different solvents. Chem Cent J 10:5. Doi: 10.1186/s13065-016-0149-0.
  29. Indian Materia Medica by K M Nadkarni, 1st Edn by A. K. Nadkarni, Popular Prakashan Pvt. Ltd, Bombay,1954, pp.273-277.
  30. Marotta F, Weksler M, Naito Y, Yoshida C, Yoshioka M and Marandola P, Nutraceutical supplementation,effect of a fermented papaya preparation on redox status and DNA damage in healthy elderly individuals and relationship with GSTM1 genotype, a randomized, placebo-controlled, cross-over study, Ann N Y Acad Sci, 2006, 1067(1): 400-407
  31. Indian Medicinal Plants by KR Kirtikar and BD Basu, Reprint, 2nd Edn, International Book Distributors,Dehra Dun, Vol. II, 1998, pp.1097-1099.
  32. Arya Vaidya Sala, Carica papaya, In: Indian Medicinal Plants & Compendium of 500 species, 1st Edn, Vol I, Orient Longman Pvt Ltd, Hyderabad, 2005, pp. 383-384.
  33. Pal Arti, Soni Manish*, Patidar Kalpana, Mandsaur Institute of pharmacy, Mandsaur 458001. (M.P), Formulation and Evaluation of Poly Herbal Cream, International Journal of Pharmaceutical & Biological Archives, 2014; 5(4): 67–71.
  34. Surya Prabha. Matangi, Santhosh Aruna. Mamidi, Gulshan. MD, S.T.V. Raghavamma, Rama Rao Nadendla. Formulation and Evaluation of Anti-Aging Poly Herbal Cream, Int. J. Pharm. Sci. Rev. Res., 2014, 24(2):133-136.
  35. K Uddandu Saheb, Aduri Prakash Reddy, K Rajitha, B Sravani, B Vanitha. Formulation and evaluation of cream from naturally containing plant extract. World J Pharm Sci 2018; 7:851-61.
  36. Mahendran Sekar, Pavitra sivalinggam and afzan mahmad: formulation and evaluation of novel anti-aging cream containing rambutan fruits extract: ijspr (2017), vol.8, issue 3.
  37. Surya Prabha. Matangi, Santhosh Aruna. Mamidi, Gulshan. MD, S.T.V. Raghavamma, Rama Rao Nadendla. Formulation and Evaluation of Anti-Aging Poly Herbal Cream, Int. J. Pharm. Sci. Rev. Res., 2014, 24(2):133-136

Photo
Ojasvita Anil Khole
Corresponding author

Pres’s, College of Pharmacy (for women), Chincholi, Tal: Sinnar, Dist: Nashik (422103), Maharashtra, India.

Photo
Kamal Bahiram
Co-author

Pres’s, College of Pharmacy (for women), Chincholi, Tal: Sinnar, Dist: Nashik (422103), Maharashtra, India.

Photo
Vaishnavi godase
Co-author

Pres’s, College of Pharmacy (for women), Chincholi, Tal: Sinnar, Dist: Nashik (422103), Maharashtra, India.

Photo
Punam Sanap
Co-author

Pres’s, College of Pharmacy (for women), Chincholi, Tal: Sinnar, Dist: Nashik (422103), Maharashtra, India.

Photo
Pradnya Gaikwad
Co-author

Pres’s, College of Pharmacy (for women), Chincholi, Tal: Sinnar, Dist: Nashik (422103), Maharashtra, India.

Ojasvita Anil Khole*, Kamal Bahiram, Pradnya Gaikwad, Punam Sanap, Vaishnavi Godase, Formulation and Evaluation of Anti-aging Cream, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 6, 78-85. https://doi.org/10.5281/zenodo.8036882

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