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  • Natural Product Research for Drug Development: Methods, Limitations, and Potential Applications

  • Department of Chemistry , The Islamia university of Bahawalpur, Pakistan, The faculty of chemical and biological sciences

Abstract

The multifaceted strategy used in contemporary exploration on the development of new medicines from medicinal shops combines botanical, phytochemical, biochemical combinatorial chemistry, and bioassay- guided separation ways. Natural coffers continue to offer an volition to pharmacological leads in the fight against multitudinous deadly conditions as diabetes, cardiovascular complaint, cancer, etc. There’s a huge global demand for medicinals that are both safe and effective moment. Scientists are now turning again to natural coffers as a possible source of drugs for the treatment and operation of similar habitual and deadly conditions as a result of this. Still, there are also significant obstacles and constraints in this area, similar as the scale- up and commercialization of active substances, which only allow one out of every a thousand lead motes to be turned into a drug. Medicine development requires a rigorous, scientific approach as a abecedarian component from natural resource. This mini review provides an overview of the styles involved in natural product exploration starting from crude factory excerpt to bioactive pharmacological lead. Also, it also discusses the limitations of working concerning the bioactivity of medicinal shops.

Keywords

Multifaceted strategy, Bioassay- guided separation, Pharmacological leads , Cardiovascular diseases, limitations

Reference

  1. Grover, J. K.; Yadav, S.; Vats, V. Medicinal Plants of India with Anti-Diabetic Potential. J. Ethnopharmacol., 2002, 81, 81-100.
  2. Scartezzini, P.; Speroni, E. Review on Some Plants of Indian Traditional Medicine with Antioxidant Activity. Ethnopharmacology, 2000, 71, 23-43.
  3. Sharma,     S.B.;    Nasir, A.; Prabhu, K.M.; Murthy, P.S.

Antihyperglycemic Effect of the Fruit- Pulp of Eugenia Jambolana in Experimental Diabetes Mellitus. J. Ethnopharmacol., 2006, 104, 367- 373.

  1. Gupta, S.; Sharma, S.B.; Prabhu, K.M. Ameliorative Effect of Cassia Auriculata L. Leaf Extract on Glycemic Control and Atherogenic Lipid Status in Alloxan-Induced Diabetic Rabbits. Indian J. Exp. Biol., 2009, 47, 974-980.
  2. Harinantenaina, L.; Tanaka, M.; Takaoka, S.; Oda, M.; Mogami, O.; Uchida, M.; Asakawa, Y. Momordica Charantia Constituents and Antidiabetic Screening of the Isolated Major Compounds. Chem. Pharm. Bull. (Tokyo), 2006, 54, 1017-1021.
  3. Sugihara, Y.; Nojima, H.; Matsuda, H.; Murakami, T.; Yoshikawa, M.; Kimura, I. Antihyperglycemic Effects of Gymnemic Acid IV, a Compound Derived from Gymnema Sylvestre Leaves in Streptozotocin-Diabetic Mice. J. Asian Nat. Prod. Res., 2000, 2, 321-327.
  4. Sharma, S. B.; Rajpoot, R.; Nasir, A.; Prabhu, K. M.; Murthy, P. S. Ameliorative Effect of Active Principle Isolated from Seeds of Eugenia Jambolana on Carbohydrate Metabolism in Experimental Diabetes. Evid. Based. Complement. Alternat. Med., 2009, doi:10.1093/ecamnep233.
  5. Hemalatha, T.; Pulavendran, S.; Balachandran, C.; Manohar, B. M.; Puvanakrishnan, R. Arjunolic Acid: A Novel Phytomedicine with Multifunctional Therapeutic Applications. Indian J. Exp. Biol., 2010, 48, 238-247.
  6. Langcake, P. The Production of Resveratrol by Vitis Vinifera and Other Members of the Vitaceae as a Response to Infection or Injury. Physiologial Plant Pathology, 1976, 9, 77-86.
  7. Dixon, R.A.; Ferreira, D. Genistein. Phytochemistry, 2002, 60, 205211.
  8. Rao, K.V. Taxol and Related Taxanes. I. Taxanes of Taxus Brevifolia Bark. Pharm. Res. 1993, 10, 521-524.
  9. Noble,       R.L.     The      Discovery        of the   Vinca   Alkaloids--

Chemotherapeutic Agents against Cancer. Biochem. Cell Biol., 1990, 68, 1344-1351.

  1. Richardson, P.M.; Harborne, J.B. In Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis, 2nd ed; Vol. 42, Routledge, Chapman & Hall, New York, Brittonia, 1990, 115.
  2. Shoeb, M.; Celik, S.; Jaspars, M.; Kumarasamy, Y.; MacManus, S. M.; Nahar, L.; Thoo-Lin, P. K.; Sarker, S. D. Isolation, Structure Elucidation and Bioactivity of Schischkiniin, a Unique Indole Alkaloid from the Seeds of Centaurea Schischkinii. Tetrahedron 2005, 61, 9001-9006.
  3. Latif, Z.; Sarker, S. D. Isolation of Natural Products by Preparative High Performance Liquid Chromatography (prep-HPLC). In Methods in Biotechnology, Natural Products Isolation, 2nd Ed. Sarker, S.D.; Latif, Z.; Gray, A.1., Eds. Humana Press Inc.: Totowa (New Jersey}, 2005, 20, 213-232.
  4. Starmans, D.A.J.; Nijhuis, H.H. Extraction of Secondary Metabolites from Plant Material: A Review. Trends Food Sci. Technol. 1996, 7, 191-197.
  5. Balunas, M. J.; Kinghorn, A. D. Drug Discovery from Medicinal Plants. In Life Sciences, 2005, 78, 431-441.
  6. Itokawa, H.; Morris-Natschke, S. L.; Akiyama, T.; Lee, K.-H. Plant-Derived Natural Product Research Aimed at New Drug Discovery. J. Nat. Med., 2008, 62, 263-280.
  7. Weller, M.G. A Unifying Review of Bioassay-Guided Fractionation, Effect-Directed Analysis and Related Techniques.

Sensors, 2012, 12, 9181-9209.

  1. Dias, D. A.; Urban, S.; Roessner, U. A Historical Overview of Natural Products in Drug Discovery. Metabolites, 2012, 2, 303-336.
  2. Marston, A.; Hostettmann, K. Modern Separation Methods. Natural Product Reports, 1991, 8, 391.
  3. Latif, Z. Isolation by Preparative High-Performance liquid Chromatography. In Methods in Biotechnology, Natural Products Isolation, 2nd ed. Sarker, S.D.; Latif, Z.; Gray, A.1., Eds. Humana Press Inc.: Totowa (New Jersey}, 2005, 20, 213-232.
  4. L. Huber & S. A. George. Diode Array Detection in HPLC. J. Liq. Chromatogr. 1994, 17, 4057-4058.
  5. Niessen, W. M. State-of-the-Art in Liquid Chromatography–mass Spectrometry. J. Chromatogr. A, 1999, 856, 179-197.
  6. Spraul, M.; Hofmann, M.; Dvortsak, P.; Nicholson, J. K.; Wilson, I. D. High-Performance Liquid Chromatography Coupled to HighField Proton Nuclear Magnetic Resonance Spectroscopy: Application to the Urinary Metabolites of Ibuprofen. Anal. Chem. 1993, 65, 327-330.
  7. Wolfender, J.-L.; Rodriguez, S.; Hostettmann, K. Liquid Chromatography Coupled to Mass Spectrometry and Nuclear Magnetic Resonance Spectroscopy for the Screening of Plant Constituents. J. Chromatogr. A, 1998, 794, 299-316

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Maryam javaid
Corresponding author

Department of Chemistry , The Islamia university of Bahawalpur, Pakistan, The faculty of chemical and biological sciences

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Kainat Javeed
Co-author

Department of Chemistry , The Islamia university of Bahawalpur, Pakistan, The faculty of chemical and biological sciences

Maryam javaid, Kainat Javeed, Natural Product Research for Drug Development: Methods, Limitations, and Potential Applications, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 356-364. https://doi.org/10.5281/zenodo.10149044

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