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Abstract

The abstract discusses the significance of preformulation studies, which analyze the physicochemical characteristics of potential new drug candidates and their impact on drug performance and dosage form development. These studies provide essential information for designing formulations and may indicate the need for molecular modifications. Before creating pharmaceutical formulations, it's crucial to consider the inherent chemical and physical properties of each drug, which serve as the foundation for combining them with other ingredients in dosage form production. The primary objective of preformulation studies is to create elegant, stable, effective, and safe dosage forms. This is achieved by establishing kinetic rate profiles, assessing compatibility with other components, and determining the physicochemical parameters of the new drug substances. Several properties play vital roles in preformulation studies, including drug solubility, partition coefficient, dissolution rate, polymorphic forms, and stability. Polymorphism, which includes crystal and amorphous forms, can lead to variations in the chemical, physical, and therapeutic characteristics of the drug molecule. This article provides insights into these properties and techniques for evaluating preformulation parameters of drugs.

Keywords

Bulk characteristics, crystallization, flow properties, pKa, Hygroscopicity

Reference

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Tushar B. Aher
Corresponding author

Department of bachelor’s in pharmacy, Shivajirao Pawar College of Pharmacy, Pachegaon, Ahmednagar-413725

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Prof. Poonam P. Khade
Co-author

Department of bachelor’s in pharmacy, Shivajirao Pawar College of Pharmacy, Pachegaon, Ahmednagar-413725

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Dr. Megha T. Salve
Co-author

Department of bachelor’s in pharmacy, Shivajirao Pawar College of Pharmacy, Pachegaon, Ahmednagar-413725

Tushar B. Aher, Prof. Poonam P. Khade, Dr. Megha T. Salve, Pharmaceutical Formulation and Development: A Comprehensive Review, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 346-355. https://doi.org/10.5281/zenodo.10144551

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