View Article

  • Bell's Palsy: New Emerging Disease
  • 1,3Department Of Quality Assurance Vidya Bharti College of Pharmacy, Amravati, Maharashtra
    2Department Of Pharmaceutical Chemistry Vidya Bharti College of Pharmacy, Amravati, Maharashtra
     

Abstract

Bell's palsy, also known as "unexplained facial paralysis", is a medical condition that causes paralysis or complete paralysis of the facial muscles, which is characteristic on the one hand and occurs immediately and can occur within 48 hours on the other. It is caused by facial nerve insufficiency due to injury or inflammation of the seventh cranial nerve or facial nerve or its branch (only in the bone canal). Both sexes are equally affected and although there is no age- related immunity, the incidence increases with age. It is more likely to occur in diabetic patients, people with high blood pressure, pregnant women, obese people and people with upper respiratory tract diseases. It is generally considered idiopathic and is diagnosed by exclusion of other causes. Bell's Palsy can cause physical and mental problems and harm the patient and their relatives. Therefore, early diagnosis and rapid determination of the cause are the main roles of correct treatment. However, the exact cause of Bell's palsy is unknown, which prevents its treatment. However, determining the effective and relevant factors is important for the clinical approach and requires a comprehensive examination and a complete history. Although most patients recover in less than three weeks without treatment. However, there is always a risk of residual hemiparesis, which may require medical intervention after treatment or rehabilitation. The aim of this review is to provide a better understanding of Bell's palsy by focusing on anatomy, etiology, clinical features, diagnosis, treatment evaluation results and treatment preferences.

Keywords

electromyography, nerve excitability test, acyclovir, corticosteroids, lower motor neuron palsy, facial nerve

Reference

  1. Efficacy of laser acupuncture for patients with chronic Bell's palsy: a study protocol for a randomized, double-blind, sham-controlled pilot trial. Ton G, Lee LW, Ng HP, et al. Medicine (Baltimore) 2019;98:0.
  2. Bell's palsy: a manifestation of prediabetes? Bosco D, Plastino M, Bosco F, et al. Acta Neurol Scand. 2011;123:68–72.
  3. LMN facial palsy in pregnancy: an opportunity to predict preeclampsia-report and review. Aditya V. Case Rep Obstet Gynecol. 2014;2014:626871.
  4. Increased risk of Bell palsy in patients with migraine: a nationwide cohort study. Peng KP, Chen YT, Fuh JL, Tang CH, Wang SJ. Neurology. 2015;84:116–124.
  5. Radiation exposure and Bell’s palsy: a hypothetical association. Khateri M, Cheraghi S, Ghadimi A, Abdollahi
  6. says RK. Bell’s Palsy Recovery. [Aug; 2021]. 2009. 
  7. The history of facial palsy and spasm: Hippocrates to Razi. Sajadi MM, Sajadi MR, Tabatabaie SM. Neurology. 2011;77:174–178.
  8. The neurologist's dilemma: a comprehensive clinical review of Bell's palsy, with emphasis on current management trends. Zandian A, Osiro S, Hudson R, Ali IM, Matusz P, Tubbs SR, Loukas M. Med Sci Monit. 2014;20:83–90.
  9. Gaillard F. Facial nerve. [ Jul; 2022 ]. 2022. 
  10. The etiology of Bell's palsy: a review. Zhang W, Xu L, Luo T, Wu F, Zhao B, Li X. J Neurol. 2020;267:1896–1905.
  11. Histopathological changes in the temporal bone in Bell's palsy. Michaels L. Acta Otolaryngol Suppl. 1990;470:114–117.
  12. Bell's palsy: aetiology, clinical features and multidisciplinary care. Eviston TJ, Croxson GR, Kennedy PG, Hadlock T, Krishnan AV. J Neurol Neurosurg Psychiatry. 2015;86:1356–1361.
  13. Global and regional estimates of prevalent and incident herpes simplex virus Type 1 infections in 2012. Looker KJ, Magaret AS, May MT, Turner KM, Vickerman P, Gottlieb SL, Newman LM. PLoS One. 2015;10:0.
  14. Bell’s palsy - Symptoms and causes. [ Jul; 2022]. 
  15. A comparison of herpes simplex virus type 1 and varicella-zoster virus latency and reactivation. Kennedy PG, Rovnak J, Badani H, Cohrs RJ. J Gen Virol. 2015;96:1581–1602.
  16. Facial palsy, a disorder belonging to influential neurological dynasty: review of literature. Newadkar UR, Chaudhari L, Khalekar YK. N Am J Med Sci. 2016;8:263–267.
  17. Bell's palsy-tertiary ischemia: an etiological factor in residual facial palsy. Grewal DS. Indian J Otolaryngol Head Neck Surg. 2018;70:374–379.
  18. A meta-analysis uncovers the first sequence variant conferring risk of Bell's palsy. Skuladottir AT, Bjornsdottir G, Thorleifsson G, et al. Sci Rep. 2021;11:4188.
  19. Everything about Bell’s Palsy. [ Jul; 2022 ]. 2018
  20. Bell palsy: Clinical examination and management. Patel DK, Levin KH. Cleve Clin J Med. 2015;82:419–426.
  21. Neuro-ophthalmological approach to facial nerve palsy. Portelinha J, Passarinho MP, Costa JM. Saudi J Ophthalmol. 2015;29:39–47.
  22. sorensenclinic.com: Jesper Sorensen MD PhD. House Brackmann. Plastic and Reconstructive Surgeon. [ Jul; 2022 ]. 
  23. Surgical interventions for the early management of Bell's palsy. McAllister K, Walker D, Donnan PT, Swan I. Cochrane Database Syst Rev. 2013:0.
  24. Etiology, diagnosis, and management of facial palsy: 2000 patients at a facial nerve center. Hohman MH, Hadlock TA. Laryngoscope. 2014;124:0–93.
  25. The diagnosis and treatment of idiopathic facial paresis (Bell's palsy) Heckmann JG, Urban PP, Pitz S, Guntinas-Lichius O, Gágyor I. Dtsch Arztebl Int. 2019;116:692–702.
  26. Normal and pathological findings for the facial nerve on magnetic resonance imaging. Al-Noury K, Lotfy A. Clin Radiol. 2011;66:701–707.
  27. Management of Bell's palsy. Somasundara D, Sullivan F. Aust Prescr. 2017;40:94–97.
  28. ENT features. [ Oct; 2022 ]. 
  29. Corticosteroids for Bell's palsy (idiopathic facial paralysis) Salinas RA, Alvarez G, Daly F, Ferreira J. Cochrane Database Syst Rev. 2010:0.
  30. Bell’s Palsy: Symptoms, Diagnosis & Treatment. [ Aug; 2021 ]. 
  31. Bell's palsy: treatment guidelines. Murthy JM, Saxena AB. Ann Indian Acad Neurol. 2011;14:0–2.
  32. Danette C Taylor. Bell Palsy Treatment & Management: Approach Considerations, Pharmacologic Therapy, Local Treatment. Published Online First: 14 June. [ Jul; 2022 ]. 2021. 
  33. Scleral contact lenses as an alternative to tarsorrhaphy for the long-term management of combined exposure and neurotrophic keratopathy. Weyns M, Koppen C, Tassignon MJ. Cornea. 2013;32:359–361.
  34. Facial nerve outcomes after middle fossa decompression for Bell's palsy. Cannon RB, Gurgel RK, Warren FM, Shelton C. Otol Neurotol. 2015;36:513–518.
  35. Laser acupuncture for treating musculoskeletal pain: a systematic review with meta-analysis. Law D, McDonough S, Bleakley C, Baxter GD, Tumilty S. J Acupunct Meridian Stud. 2015;8:2–16.

Photo
Mrunal D. Thakare
Corresponding author

Department Of Quality Assurance Vidya Bharti College of Pharmacy,Amravati,Maharashtra

Photo
Madhuri D Game
Co-author

Department Of Pharmaceutical Chemistry Vidya Bharti College of Pharmacy,Amravati,Maharashtra

Photo
Aditi G. Asole
Co-author

Department Of Quality Assurance Vidya Bharti College of Pharmacy,Amravati,Maharashtra

Mrunal D. Thakare, M. D. Game, Aditi G. Asole, Bell's Palsy: New Emerging Disease, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 590-596. https://doi.org/10.5281/zenodo.10688837

More related articles
A Review of Dapagliflozin Effect On Disease Condit...
P. Shaheera, G. Anjani Tejaswi, A. Navyasree, M. Bala Tripur Sund...
An Update On Proton Pump Inhibitors As A Treatment...
Vikash Kumar, Sanjeev Kumar Chauhan , ...
Breathless: A Comprehensive Study Of Pathophysiolo...
Hema Arya, Shelesh Kumar Bansal, Tanuj Bhardwaj , Kanishk, Shivam...
Analytical Profiling of Eliglustat for Gaucher Disease: Method Development and V...
Abhishek Lawsare, Abhishek Lawsare, Vaishnavi Umretkar, Shyam Rangari, Milind Umekar, ...
Emerging Trends In Pharmaceutical Analysis: Techniques And Applications...
Rohit S. Kshirsagar, Rameshwar P. Tathe, Prashant S. Malpure, Rishikesh S. Bacchav, ...
Review on 'Polycystic kidney disease pathophysiology and prognosis'...
Seema Kashyap, Eshu Sahu, Bignesh Pradhan, Dali Kanwar, Chhabi Lal, ...
Related Articles
The Phytochemical And Pharmacological Review Article Of Fig Tree (Ficus Carica)...
Shaikh Mohammadsaad A., Patel Munavvar Y., Shaikh Umed K., Shaikh Rayyan J., Quazi Majaz , Aejaz Ahm...
An Updated Review On Herbal Drugs Used In Alzheimer’s Disease ...
Pranav Manik Sonawane , Saurabh Arjun Khairnar , Pranav Bhausaheb Sanap , ...
Herbal Mouthwash For The Management Of Oral Diseases...
Suryakant H. Bokhare, Aishwarya S. Maske, Ravi S. Mohite, Adinath P. Magar, Vishal V. Mane, ...
Shaping Health Horizons: The Dynamic Impact Of Innovative Public Health Awarenes...
Nilima N. Khakal, Udayanraj M. Bhosale, Suraj B. Kumbhar, Vikram R. Shinde, N. H. Aloorkar, Dipak D....
A Review of Dapagliflozin Effect On Disease Conditions Like Diabetes Mellitus, H...
P. Shaheera, G. Anjani Tejaswi, A. Navyasree, M. Bala Tripur Sundari, P. Seetharamaiah, ...
More related articles
A Review of Dapagliflozin Effect On Disease Conditions Like Diabetes Mellitus, H...
P. Shaheera, G. Anjani Tejaswi, A. Navyasree, M. Bala Tripur Sundari, P. Seetharamaiah, ...
Breathless: A Comprehensive Study Of Pathophysiology, Diagnosis, And Treatment O...
Hema Arya, Shelesh Kumar Bansal, Tanuj Bhardwaj , Kanishk, Shivam, ...
A Review of Dapagliflozin Effect On Disease Conditions Like Diabetes Mellitus, H...
P. Shaheera, G. Anjani Tejaswi, A. Navyasree, M. Bala Tripur Sundari, P. Seetharamaiah, ...
Breathless: A Comprehensive Study Of Pathophysiology, Diagnosis, And Treatment O...
Hema Arya, Shelesh Kumar Bansal, Tanuj Bhardwaj , Kanishk, Shivam, ...