View Article

  • A RETROSPECTIVE STUDY ON EVALUATION OF ANTIBIOTIC UTILIZATION IN RENAL IMPAIRMENT IN A TERTIARY CARE HOSPITAL IN DAKSHINA KANNADA DISTRICT

  • 1Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, INDIA.

Abstract

Renal impairment is the inability of the kidneys to perform their excretory functions, which results in the retention of nitrogenous waste products in the blood. Infectious disease is recognized as an important complication among patients with renal impairment, contributing to excess morbidity and health care costs. Epidemiological research revealed that individuals with end-stage renal disease are more prone to develop infectious complications, which include urinary tract infection, pneumonia, and sepsis. These infections can be managed with the appropriate antibiotics. The objective of the study was to evaluate the utilization patterns of antibiotic in patients with renal impairment. A retrospective study was conducted by screening the medical records of 100 patients who fulfilled the inclusion criteria. Antibiotic utilization was analysed using Microsoft Excel. The mean age of the study participant 59.8 years with 67% male and 33?male. Majority of the patients were diagnosed with CKD (56%). Commonly utilized antibiotics were Inj. Meropenem (21.42%), Inj. Ceftriaxone (12.5%), T. Amoxicillin + Clavulanic acid (9.82%), Inj. Pipracillin + Tazobactam (9.82%).The rational use of antibiotics is critical for optimising clinical outcomes. The most commonly prescribed parenteral antibiotic was Injection Meropenem, while the most commonly prescribed oral antibiotic was Tablet Amoxicillin + Clavulanic acid.

Keywords

Renal impairment, Infections, Antibiotics

Reference

  1. Luo X, Jiang L, Du B, Wen Y, Wang M, Xi X, et al. A comparison of different diagnostic criteria of acute kidney injury in critically ill patients. Critical Care. 2014; 18(4): 1-8.
  2. Levey AS, de Jong PE, Coresh J, El Nahas M, Astor BC, Matsushita K, et al. The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report. Kidney International. 2011; 80(1): 17–28.
  3. Shrestha N, Gautam S, Mishra SR, Virani SS, Dhungana RR. Burden of chronic kidney disease in the general population and high-risk groups in South Asia. PLoS One. 2021; 16(10): 1-19.
  4. Griffin BR, You Z, Holmen J, SooHoo M, Gist KM, Colbert JF, Chonchol M, Faubel S, Jovanovich A. Incident infection following acute kidney injury with recovery to baseline creatinine: A propensity score matched analysis. PLoS One. 2019; 14(6): 1-13.

 

  1. MacRae C, Mercer SW, Guthrie B, Henderson D. Comorbidity in chronic kidney disease: a large cross-sectional study of prevalence in Scottish primary care. British Journal of General Practice. 2021; 71(704): 243–9.
  2. Shankar M, Narasimhappa S, Madhura. Urinary tract infection in chronic kidney disease population: A clinical observational study. Cureus. 2021; 13(1): 1-9.
  3. Chou CY, Wang SM, Liang CC, Chang CT, Liu JH, Wang I-Kuan, et al. Risk of Pneumonia Among Patients With Chronic Kidney Disease in Outpatient and Inpatient Settings: a nationwide population-based study. Medicine. 2014; 93(27): 1-4.
  4. Bou Chebl R, Tamim H, Abou Dagher G, Sadat M, Ghamdi G, Itani A, et al. Sepsis in end-stage renal disease patients: are they at an increased risk of mortality? Annals of Medicine. 2021; 53(1): 1737–43.
  5. Hui K, Nalder M, Buising K, Pefanis A, Ooi KY, Pedagogos E, et al. Patterns of use and appropriateness of antibiotics prescribed to patients receiving haemodialysis: an observational study. BMC Nephrology. 2017; 18(1): 1-9.
  6. Kourkouta L, Tsaloglidou A, Koukourikos K, Iliadis C, Plati P., Dimitriadou A., History of Antibiotics. Sumerianz Journal of Medical and Healthcare. 2018; 1(2): 51-54.
  7. Fraser SD, Roderick PJ, May CR, McIntyre N, McIntyre C, Fluck RJ, et al. The burden of comorbidity in people with chronic kidney disease stage 3: a cohort study. BMC Nephrology. 2015; 16(1): 1-11.
  8. Bábí?ková J, Klinkhammer BM, Buhl EM, Djudjaj S, Hoss M, Heymann F, et al. Regardless of etiology, progressive renal disease causes ultrastructural and functional alterations of peritubular capillaries. Kidney International. 2017; 91(1):70–85.
  9. Hsu CY, Fang H, Kang Wei Chou, Chen CL, Lee PT, Chung HM. The Clinical Impact of Bacteremia in Complicated Acute Pyelonephritis. The American Journal of the Medical Sciences. 2006; 332(4):175–80.
  10. Dalrymple LS, Mu Y, Nguyen DV, Romano PS, Chertow GM, Grimes B, et al. Risk factors for infection-related hospitalization in in-center hemodialysis. Clinical Journal of  American Society of  Nephrology. 2015; 10(12): 2170–80.
  11. Saeed Abdulrahman I, Al-Mueilo SH, Bokhary HA, Ladipo GOA, Al-Rubaish A. A prospective study of hemodialysis access-related bacterial infections. Journal of Infection and Chemotherapy. 2002; 8(3): 242–6.
  12. Kumar A, Ellis P, Arabi Y, Roberts D, Light B, Parrillo JE, et al. Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock. Chest. 2009; 136(5): 1237–48.
  13. Al Himali N, Al Suleimani YM, Al-Zakwani I, Abdelrahman AM. Antibiotics utilization patterns and dosage appropriateness among patients receiving hemodialysis. Saudi Pharmaceutical Journal. 2022; 30(7): 971–8

Photo
K. Anjali
Corresponding author

Department of Pharmacy Practice, Srinivas College of Pharmacy

Viresh K. Chandur, K. Anjali*, Ashitha Ephrem, Ramakrishna Shabaraya A., A Retrospective Study On Evaluation Of Antibiotic Utilization In Renal Impairment In A Tertiary Care Hospital In Dakshina Kannada District, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 214-220. https://doi.org/10.5281/zenodo.10092365

More related articles
A Review on Potential Health Importance of Nutrace...
Snehal Mate, Vikram Saruk, Ramdas Darade, Sakshi Kadam, Shivani S...
Stroke and Quality of Life: A Mini Review of India...
Dr. Satish Karoli, Omkar Shedbale, Suraj Angadi, ...
Atovaquone: A Comprehensive Review of Its Antimicr...
Tejaswini Gedam, Dr. Nilesh Chachda , Gaurav Meshram , ...
A Review of Pharmacological Activity of Nagdantyadi Ghrita ...
Tushar G. Hone, Dr. Shivshankar D. Mhaske, Prof. Shatrughna U. Nagrik , Mr. Vaibhav P. Jamdhade, Pro...
Formulation And Development of Oral Fast Dissolving Tablets Using a Model Drug ...
Megha Pandey, Dr. Shilpa Gawande, Dr. A. V. Chandewar, ...
Purification Of 2-Methoxy Naphthalene by UV And IR Spectroscopic Methods...
Ankita Thaikar , Rani Madnakaari, Kiran Patil, Priyanka Kankanwadi, ...
Related Articles
Prognostic Biomarkers For Triple Negative Breast Cancer: A Narrative Review...
Prudence A Rodrigues, Preethi nivedhaa A, Sneha B, Ranjith kumar P, ...
Review on Shankhpushpi (Convolvulus Pluricaulis Choisy) as a CNS Stimulant...
Sase Suraj Arjun , Najiya Salim Shaikh , Sagar Nikita Sanjay , ...
Clinical Review on Mucormycosis...
Devshatwar Radhika, Sonkamble Sumed, Jamadar Amrata, Kamshette Arati, Akuch Sandhya, Survase Mohini,...
Formulation and Evaluation of Moringa oleifera Extract Gel...
Adinath Ware, Harshdeep Patil, Yogeshwar Chaudhari, ...
A Review on Potential Health Importance of Nutraceuticals...
Snehal Mate, Vikram Saruk, Ramdas Darade, Sakshi Kadam, Shivani Sangale, Dikshita Valvi, ...
More related articles
A Review on Potential Health Importance of Nutraceuticals...
Snehal Mate, Vikram Saruk, Ramdas Darade, Sakshi Kadam, Shivani Sangale, Dikshita Valvi, ...
Atovaquone: A Comprehensive Review of Its Antimicrobial Efficacy and Mechanism o...
Tejaswini Gedam, Dr. Nilesh Chachda , Gaurav Meshram , ...
A Review on Potential Health Importance of Nutraceuticals...
Snehal Mate, Vikram Saruk, Ramdas Darade, Sakshi Kadam, Shivani Sangale, Dikshita Valvi, ...
Atovaquone: A Comprehensive Review of Its Antimicrobial Efficacy and Mechanism o...
Tejaswini Gedam, Dr. Nilesh Chachda , Gaurav Meshram , ...