Associate Professor Department of Oral and Maxillofacial Pathology and Oral Microbiology Index Institute of Dental Sciences, Indore, Madhya Pradesh,India-452016
miRNAs play an important function in development, differentiation, survival, proliferation, and cell metabolism. Various miRNAs are repeatedly transformed in pathological processes like cancers. Irregular expression of miRNA was seen broadly in cancer cells, which activates apoptosis. During the development and progression of tumors, miRNAs function as tumor suppressors or oncogenes. This review summarizes the various aspects of miRNA for the development of anticancer drugs. The role of various miRNA-based therapeutics in selected cancers and the activity of miRNA in the diagnosis of cancer is also discussed. This review scrutinizes the existing documentation in the literature related to the miRNAs and their role in cancer. English language articles were searched in various databases such as Pubmed, Science Direct, Scopus, Web of Sciences, and Google scholar. The keywords used for searching are "miRNAs", "miRNAs in cancer", "miRNAs and anticancer therapeutics", "miRNAs in diagnostics", and "miRNA and oncogenesis".
2010;21(7):728-37
DP. The microRNAs of Caenorhabditis elegans. Genes Dev. 2003;17(8):991-1008
Hmanshu Singh, miRNA And Cancer : From Anticancer Drug Development To Cancer Diagnosis And Therapy-A Review Article, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 367-386. https://doi.org/10.5281/zenodo.10529217