Department of Pharmaceutics, LBYP College of Pharmacy, Pathri, Ch.Sambhajinagar. Maharashtra, India
Lipid nanocarriers represent an alternative to polymeric nanoparticles, liposomes, and emulsions. Nanostructured Lipid Nanocarriers (NLCs), considered as the second-generation lipid carriers, aim to address the limitations of Solid Lipid Nanoparticles. They are employed across diverse therapeutic approaches and were initially designed for delivering lipophilic drugs, but their effectiveness with hydrophilic drugs is now well-established. The biocompatibility of lipids underpins their emergence as a promising avenue for drug delivery, exhibiting superior traits compared to other lipid formulations. This article delves into NLCs, covering their structures, preparation methods, characterization, stability, and advantages over first-generation lipid nanoparticles. The review predominantly highlights the manifold therapeutic applications of NLCs and their specificity concerning various physiological contexts. Given their biologically benign, non-immunogenic, and harmonious traits, NLCs are poised to become extensively explored systems among lipid nanocarriers.
Pranali Subhashrao Jadhav*,Pranali Hatwar, Gajanan Sanap, Review On Lipid Based Carrier As A Drug Delivery System, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 179-191. https://doi.org/10.5281/zenodo.10352354