Late Bhagirathi Yashwantrao Pathrikar College of Pharmacy
Microsponge technology has been developed for topical drug products in order to promote controlled release of the drug's active ingredient into the skin, thereby reducing systemic exposure and minimizing local cutaneous reactions to active drugs. Microsponge is made up of macroporous beads that are normally 10-25 micron in diameter and loaded with an active agent. When applied to the skin, the microsponge releases its active ingredients on a timer as well as in response to other signals. Microsponge drug delivery technology holds great promise for achieving the goal of controlled and site-specific drug delivery, and thus has sparked the curiosity of many investigators. This article provides a comprehensive overview of the Microsponges delivery system, including principles and preparation methods. Particle size and distribution, surface morphology, porosity, and density are all covered using appropriate approaches for characterization of microsponges. These microsponges are used in sunscreens, creams, ointments, as well as over-the-counter skin care preparations for topical application. Microsponge drug delivery can provide greater efficacy for topically active agents while also improving safety, product stability, and aesthetic properties in an efficient and novel way. They are mostly used topically, but have recently been used for oral administration.
Akshata V. Raut , Nakul Kathar , Ganjanan Sanap, Microsponges: The Drug Delivery System, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 328-341. https://doi.org/10.5281/zenodo.10523750
10.5281/zenodo.10523750
