1School Of Pharmaceutical Sciences, MVN University, Palwal Haryana
2Department of Pharmacy, Himachal Institute of Pharmacy, Paonta Sahib, Himachal Pradesh
The ability to deliver extremely effective dosages to precise target areas within the human body has become the holy grail of medication delivery research. Drugs with established efficacy in in vitro research usually face a major obstacle in in vivo testing due to a lack of an effective delivery mechanism. Furthermore, many therapeutic conditions necessitate the delivery of entrepreneurs, which may be beneficial at the desired delivery location but are otherwise systemically hazardous. Magnetically responsive microspheres containing Cytarabine were prepared using the CSE technique and chitosan and Eudragit l-100 polymers, and they were assessed with regard to particle duration assessment via SEM, entrapment overall performance, magnetite content material fabric, and in vitro magnetic responsiveness in a 7000 Oe magnetic subject, in vitro drug release tests, in vivo drug targeted investigations, and stability experiments were conducted. Spherical particles with an average diameter of 3-12 m and an incorporation overall performance of 56.37% were achieved. The existence of magnetite in prepared Cytarabine magnetic microspheres is confirmed by X-ray diffractometry results. Using chemical analysis, it was determined that the average proportion of Fe2O3 within the microspheres was between 40.53% and 53.48%. For F-1-F-9, the cumulative percent drug release after 24 hours was 80.60%, 78.22%, 76.41%, 74.35%, 73.25%, 71.23%, 64.21%, 61.56%, and 58.45%, respectively. The results of in vitro magnetic responsiveness and in vivo focused on confirmed that the retention of microspheres in the presence of magnetic subject became significantly greater than those in the absence of magnetic subject become significantly greater than those without the magnetic subject. Stability investigations revealed that the samples maintained at 4 degrees Celsius had the highest drug content material fibre and the closest in vitro release to the initial records. Overall, this research reveals that magnetic microspheres may be kept at their target site in vivo, using magnetic subject software, and are capable of freeing their drug content material fibre for an extended period of time. This could lead to them being directed to a suitable depot for administering chemotherapeutic agent(s) in vivo.
Rajeshwar Verma, Ramandeep Singh, Formulation And Evaluation Of Magnetic Microspheres Of Cytarabine Using Eudragit L-100 And Chitosan As Polymers, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 180-206. https://doi.org/10.5281/zenodo.10443939
10.5281/zenodo.10443939
