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Abstract

Amaranthus caudatus belongs to the family Amaranthaceae, are spread throughout the world growing under a wide range of climatic conditions. It has been widely used in Mexican traditional medicine for the treatment of different central nervous system disorders. Nevertheless, the available scientific information about this species is scarce and there are no reports related to its possible effect on the CNS. In this work, the effects of ethanolic seed extract of Amaranthus caudatus were evaluated in mice using behavioral tests sensitive to clinically effective antidepressant compounds. The extract (100 and 200mg/kg), administered intraperitoneally, was able to decrease the immobility time of mice dose dependently when subjected to both tail suspension and forced swim tests and the effects are comparable to that of standard drugs fluoxetine (20mg/kg). Preliminary phytochemical analysis showed the presence of phenolic compounds, steroids, alkaloids, flavonoids, saponins and amino acids in ethanolic extract of A. caudatus. It is concluded that A. caudatus possess antidepressant activity may be due to the presence of polyphenolic compounds and flavonoids. However further study is needed to understand mechanism of action and to identify active component responsible for antidepressant activity.

Keywords

Amaranthus caudatus, Antidepressant activity, Tail suspension test, Forced swimming test

Reference

 
  1. The World Health Report.  Mental health: New understanding new hope. WHO, Geneva, 2001. 
  2. Reynolds EH.  Brain and mind:  A challenge for WHO.  Lancet 2003; 361:1924?1925.
  3. Caspi A, Sugden K, Moffitt TE, Taylor A, Craig IW, Harrington H. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003;301(5631): 386-9.
  4. Guze SB, Robins E. Suicide and primary affective disorders. Br J Psychiatry. 1970;117:437 8.
  5. Cryan JF, Mombereau C, Vassout A. The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev. 2005; 29(4-5):571-625.
  6. Yu ZF, Kong LD and Chen Y. Antidepressant activity of aqueous extracts of Curcuma longa in mice:  Ethnopharmocol 2002; 83: 161.
  7. Rastrelli L, Pizza C, Saturnino P, Schettino O, Dini A. Isolation and characterization of Amaranthin, a lactin present in seeds of Amaranthus caudatus that recognizes the T-antigen. J Agric Food Chem. 1995;43:904-9.
  8. Yineger H, Kelbessa E, Bekele T, Lulekal E. Plants used in Traditional Management of Human Ailments at Bale Mountains National Park, Southeastern Ethiopia. Journal of Medicinal Plants Research. 2008;2:132-53.
  9. Vanila D, Ghanthikumar S, Manickam VS. Ethnomedicinal uses of plants in the plains area of the Tirunelveli-District. Tamilnadu, India, Ethnobotonical leaflets. 2008;12:1198-205.
  10. Khare CP. Indian Medicinal Plants, an Illustrated Dictionary. New Delhi: Springer; 2007. p. 41.
  11. Kabiri N, Asgary S, Madani H, Mahzouni P. Effect of Amaranthus caudatus extract and lovastatin on atherosclerosis in hypercholesterolemic rabbits. J Medicinal Plants Res. 2010;4(5):355-61.
  12. Ashok Kumar BS, Lakshman K, Arun Kumar PA, Viswanth GL, Veerapur VP, Thipeswamy BS. Hepatoprotective activity of methanol extract of Amaranthus caudatus Linn. against paracetamol- induced hepatic injury in rats. J Chin Integr Med. 2010;9(2):194-200.
  13. Ashok Kumar BS, Lakshman K, Jayaveera KN, Ranganayakulu D, Manoj B. Comparative in vitro anthelmintic activity of three plants belongs to Amaranthaceae. Arch Biol Sci. 2010; 62(1):185-9.
  14. Jayaveera KN, Sheshadri Shekar D, Narayan Swamy VB, Velmurgan C. In vitro ?-Amylase inhibition and anti- oxidant activities of methanolic extract of Amaranthus caudatus. Oman Medical Journal, 2011;26(3):166-70.
  15. Bruni R, Medici A, Guerrini A, Scalia S, Poli F, Muzzoli M, et al. Wild Amaranthus caudatus seed oil a nutraceutical resource from Ecuadorian flora. J Agri Food Chem. 2001; 49(11):5455-60.
  16. Broekaert WF, Marien W, Terras FRG, Debolle MFC, Proost P, Vandamme J. Antimicrobial peptides from Amaranthus caudatus seed with sequence homologue to the cystein/glycine-rich domain of chitin-binding proteins. Biochem. 1992;31:4308-14.
  17. Kokate CK. Preliminary phytochemical screening. In: Khandelwal KR, editor. Practical Pharmacognosy. 1st ed. New Delhi: Vallabh Prakashan; 1986. p. 111.
  18. OECD: Guidelines for testing chemicals. Guidelines 423, acute oral toxicity. Acute Toxic Class Methods Paris. 2000.
  19. Porsolt RD, Bertin A, Jalfre M. Behavioral despair in mice: a primary screening test for antidepressants. Arch Int Pharma- codyn Ther. 1977;229:327–36.
  20. Steru L, Chermat R, Thierry B, Simon P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl.). 1985;85: 367–70

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Rimsha Parveen
Corresponding author

Department of Pharmacology, Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India-462022

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Dilip Kumar Tiwari
Co-author

Department of Pharmacology, Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India-462022

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Abhishek Sharma
Co-author

Department of Pharmacology, Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India-462022

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Mehta Parulben D
Co-author

Department of Pharmacology, Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India-462022

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Priyanka Namdeo
Co-author

Department of Pharmacology, Lakshmi Narain College of Pharmacy, Raisen Road, Bhopal, Madhya Pradesh, India-462022

Rimsha Parveen*, Dilip Kumar Tiwari, Abhishek Sharma, Mehta Parulben D, Priyanka Namdeo, Phytochemical Analysis and Antidepressant activity of Ethanolic Extract of Amaranthus caudatus, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 8, 32-37. https://doi.org/10.5281/zenodo.8228362

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