Shraddha Institute of Pharmacy, Washim Maharashtra, India
The present research focuses on the formulation and evaluation of an Ayurvedic solid dosage form Vati, using Triphala (a classical combination of Haritaki, Bibhitaki, and Amla) and jaggery (Gud). Triphala is known for its rejuvenating, digestive, and antioxidant properties, while jaggery acts as a natural binder and sweetener with additional nutritional benefits. The study involves standardizing raw materials, preparing the Vati by traditional methods, and evaluating its physicochemical properties such as hardness, friability, weight variation, and disintegration time. The formulation exhibited acceptable results across all evaluation parameters, indicating good stability, uniformity, and patient compliance. This study supports the integration of traditional Ayurvedic knowledge with modern pharmaceutical evaluation techniques for enhancing therapeutic efficacy and standardization of herbal dosage forms.
Vati (solid dosage form tablet) is an important drug delivery system in Ayurveda. Acharya Sharagandhar, in 13th century A. D. was first person who explained in detail about Bhaishajya Kalpana (Bhashaijya means medicine; Kalpana means dosage form) in Sharangadhara Samhita. He explained various Kalpana and in one of the chapters he explained about Vati. Ayurveda, the ancient system of medicine, uses various formulations to deliver therapeutic benefits and Vati Kalpana (tablet or pill form) is one of the most important solid dosage forms. It is prepared by grinding herbal or herbo-mineral ingredients into a fine powder, mixing them with binding agents like honey, jaggery or medicinal decoctions and shaping them into tablets. Vati is widely preferred due to its ease of administration, longer shelf life and accurate dosage. Unlike liquid formulations, Vati is convenient for storage and transport, making it a popular choice in Ayurvedic treatment. The preparation process ensures that the medicinal properties of the ingredients are retained while enhancing their stability and bioavailability. [4,5]
With growing interest in traditional medicine, scientific standardization and quality control of Vati formulations have become crucial. Research continues to validate their efficacy, ensuring they meet modern safety and therapeutic standards while preserving the essence of Ayurveda. It is fact that the success of treatment depends mostly upon the quality of drugs, for that medical research work gives emphasis to drug research. Similarly in Ayurveda Pharmacy also several Acharyas has been added or modified the different formulations or preparations according to their own experiences from time to time without violating the basic principles, to find out the most potent drug to prepared different formulations of herbal, Herbo-mineral compounds in various form. To keep the medicine potent for long time, to prepared the medicine for easy administration and also quick action is taken into consideration. [9,11] In the Ayurvedic field of practice through several types of Kalpanas are being used presently, Vati Kalpana plays an important role in pharmaceutics of Ayurveda, owing to many advantages like easy administration, palatability, convenient form for dispensing and transportation. In Ayurvedic pharmaceutics, Vati Kalpana is one of the most admired and prescribed formulation due to its easy Administration, palatability, better shelflife and convenience in its dispensing & transport. Powdered raw drugs (Herbal or Herbo-mineral) are triturated along with water, certain Swarasa, Gomutra, Godugdha, jaggery, guggulu or honey as binding agents and then molded into spherical form by hands or machine, the final product is known as Vati, Vatak or Gutika. Binding agents used also have their own medicinal values. [1] Present work mainly focuses on the details of this ancient formulations i.e., Vati Kalpana as transcript in Ayurveda. “Kalpana means Yojna” According to Acharya Vagbhatta Vati Kalpana is a derived form of Kalka Kalpanas. Panchvidha kasaya kalpana are the Fundamental preparation. All other formulations are derived from Panchvidha kasaya Kalpana. [3]
Type of Vati
In the Ayurvedic Pharmaceutical text two types of Vati preparation methods are mentioned Sagnisadhya Vati and Anagnisadhya Vati.
Sagnisadhya Vati (Heat Processed Vati)
Preparation: These Vati formulations involve the use of heat during their preparation. Process: Ingredients like jaggery, sugar or guggulu are melted and mixed with powdered herbs before shaping them into pills.
Examples
Jaggery Vati (contains jaggery resin, prepared using heat)
Parpati Vati (contains purified metals and minerals processed with heat)
Advantages
Anagnisadhya Vati (Non Heat Processed Vati) Preparation: These Vati are prepared without using heat.
Process: Medicinal powders are triturated with liquids like Swarasa (fresh juice), Kwatha (decoctions) or honey, then rolled into pills.
Examples
Triphala Vati (prepared by mixing Triphala powder with decoction and rolling into pills) Chandraprabha Vati (herbal mineral tablet prepared without heat)
Advantages
Often used for delicate herbal formulations that do not require heat processing.
MATERIALS
Table No. 1 - Material
Sr. No. |
Material |
Quantity |
Purpose |
1. |
Haritaki |
10 g |
Active ingredient part of Triphala |
2. |
Bibhitaki |
10 g |
Active ingredient part of Triphala |
3. |
Amalaki |
10 g |
Active ingredient part of Triphala |
4. |
Jaggery |
30 g |
Natural binder, sweetener, enhances stability |
5. |
Water (if needed) |
q.s. |
For making a cohesive mass during vati preparation |
METHOD & EVALUATION
Preparation of Herbal Ingredients
Purpose: Drying the herbal ingredients is crucial to prevent moisture content that can cause microbial growth, spoilage or uneven texture during compression.
Process
Purpose: Grinding the dried herbs into a fine powder helps in uniform mixing and compression during tablet formation. A fine powder also ensures faster absorption in the body. Process: Use a grinder or impact mill to break down the dried ingredients into a fine powder. An impact mill, which uses highspeed rotating blades to shatter the plant material, is more efficient for grinding herbs with tough exteriors like Haritaki and Bibhitaki. The grinding process should be done in batches to prevent overheating of the powders, as excessive heat can destroy the active principles in the herbs.
Grinding Speed: The grinding speed should be controlled to avoid excessive friction that could heat the powder. A fine powder will aid in compressing and ensure uniformity in the final Vati.
Purpose: Sieving ensures that the particle size of the powder is uniform, which is important for consistency in tablet hardness, dissolution and uniform distribution of active ingredients. Process: After grinding, the powder must be sieved through an 80 mesh sieve to remove any coarse particles. The sieve size should be consistent, as larger particles can result in uneven compression, leading to variable tablet strength, dissolution time and content uniformity.
Purpose: Accurate weighing ensures the correct proportion of jaggery to herbal powders, which is crucial for the consistency of the Vati.
Process: Weigh exactly 30 grams of jaggery. The use of jaggery in this formulation serves as a natural binder and sweetener. It helps in binding the herbal powder into a cohesive paste and gives the Vati its characteristic taste and medicinal properties.
Purpose: Melting jaggery ensures that it mixes uniformly with the herbal powders to create a consistent doughlike mass.
Process: Heat the jaggery on low heat to ensure it melts without burning. Jaggery has a delicate consistency and burns easily, which can result in a bitter taste and degrade its medicinal properties. The melted jaggery should be smooth and free from any crystallized chunks. Stir the jaggery gently as it melts to achieve a smooth, liquid consistency.
Optimal Temperature: Maintain a temperature of approximately 60–70°C to prevent overheating. Excessive heat could cause caramelization, which may affect the flavor and medicinal efficacy.
Purpose: Cooling the melted jaggery helps achieve the right consistency for blending with herbal powders.
Process: Allow the melted jaggery to cool for a few minutes before adding it to the powdered herbs. The temperature should be just enough to be easily handled, around 40–50°C, so it can be mixed thoroughly with the powders without causing the mass to become too sticky or too dry.
Purpose: Mixing the powdered herbs with jaggery ensures uniform distribution of all ingredients and helps form a doughlike consistency for easy compression.
Process: In a large, clean mixing bowl or industrial mixer, combine the Haritaki, Bibhitaki and Amalaki powders. Gradually add the melted jaggery to the powder, mixing continuously. The jaggery acts as a binder and helps hold the herbal powders together. If needed, a small amount of herbal decoction or water may be added to help create a smooth paste. However, the goal is to avoid excessive moisture, as too much water can affect the tablet's hardness and shelf life.
Purpose: Binding is the process of ensuring that the herbal powders stick together in a cohesive mass, which is essential for forming solid and stable tablets.
Process: As the jaggery is added, knead the mixture thoroughly by hand or using a mechanical mixer until it forms a cohesive, doughlike texture. The dough should not be too wet or too dry; it should be firm enough to retain its shape but pliable enough to be compressed.
If needed, add magnesium stearate (a lubricant) or colloidal silica to improve the flow of the mixture and prevent it from sticking to the tablet press.
If you desire a disintegrating agent, small amounts of starch can be added to ensure that the tablets disintegrate properly once ingested.
Purpose: Punch compression is used to compress the herbal jaggery mass into uniform tablets. This process is essential to ensure the Vatis are of consistent weight, size and hardness.
Process:
Purpose: Drying the tablets ensures they maintain stability, prevent microbial growth and achieve the correct hardness for storage and handling.
Process: After compression, the tablets should be dried to remove any remaining moisture. Place the tablets in a drying oven at a low temperature (4050°C) to prevent overheating.
Drying Duration: The drying process typically takes 12–24 hours depending on the moisture content.
Moisture Content: Use a moisture analyzer to check that the moisture content is below 8%, with an ideal range of 3–5%. If the moisture content is too high, the tablets can become prone to microbial contamination and spoilage.
Purpose: Proper storage ensures the shelflife of the tablets, preserving their potency and preventing degradation.
Process: Once the tablets are dry, store them in airtight containers to protect them from humidity, light and contaminants. Keep the storage containers in a cool, dry place, away from direct sunlight and moisture. The ideal storage temperature is 2025°C. Ensure that the storage area is wellventilated and free from pests to maintain the quality of the Vatis.
Table No. 3 - Formulation Table
SR.NO |
INGREDIENTS |
F1 |
F2 |
F3 |
1 |
HARITAKI |
15 |
20 |
10 |
2 |
BIBHITAKI |
15 |
20 |
10 |
3 |
AMLAKI |
15 |
20 |
10 |
4 |
JAGGERY |
30 |
20 |
30 |
Fig.No.5 - vati (tablet)
EVALUATION
Preformulation studies are conducted to evaluate the physical and chemical properties of raw materials before formulation. For the Vati (with Haritaki, Bibhitaki, Amla and Jaggery), the following parameters are assessed:
Table No. 4 - Organoleptic Properties
Ingedient |
Colour |
Odour |
Taste |
Appearance |
haritaki |
Brownishgreen |
Characteristic, earthy |
Astringent, slightly bitter |
Fine powder |
bibhitaki |
Light brown |
Mild, herbal |
Astringent, slightly sweet |
Fine powder |
amla |
Yellowishgreen |
Sour, fruity |
Sour and slightly astringent |
Fine powder |
jaggery |
Golden brown |
Sweet, caramellike |
Sweet |
Amorphous solid/granules |
Final mixture |
Brown |
Herbalsweet |
Astringent + sweet blend |
Uniform fine powder |
θ=tan-1 (height/radius)
Observation Table
Table No. 5 - Angle of Repose
Sr.no |
Height (h) in cm |
Radius (r) in cm |
Angle of Repose (θ) |
1 |
4.2 |
6.8 |
31.7° |
2 |
4.3 |
7.0 |
31.3° |
3 |
4.1 |
6.6 |
31.9° |
Average Angle of Repose
θavg = {31.7 + 31.3 + 31.9}/{3} = 31.63°
Result
The average angle of repose of the powder blend was found to be 31.63°, which indicates passable to fair flowability.
LOD (%) = {Initial weight Final weight}/{Initial weight} 100
Observation Table
Table No. 6 - Loss of drying
Initial Weight (g) |
Final Weight (g) |
LOD (%) |
5.000 |
4.760 |
4.80% |
Result
The Loss on Drying of the Vati was found to be 4.80%, which is within acceptable limits, indicating suitable moisture content for stability.
Principle
The difference between bulk density (loose powder) and tapped density (after tapping) gives an estimate of how compressible the powder is. A lower index indicates better flowability and compressibility.
Procedure
Observation Table
Table No. 7 - Carr’s Index
Parameter |
Value |
Weight of powder (W) |
10 g |
Bulk Volume (V?) |
20.0 mL |
Tapped Volume (Vt) |
16.5 mL |
Bulk Density (BD) |
0.50 g/mL |
Tapped Density (TD) |
0.61 g/mL |
Carr's Index |
18.03% |
Result: The Carr’s Index of the Vati powder blend was found to be 18.03%, indicating fair to good flowability and acceptable compressibility for manual or mechanical preparation of Vati.
E. Hausner Ratio
Formula:
Hausner Ratio = Tapped Density/Bulk Density
Procedure
Observation Table
Table No. 8 - Hausner Ratio
Parameter |
Value |
Weight of powder |
10 g |
Bulk Volume (V?) |
20.0 mL |
Tapped Volume (Vt) |
16.5 mL |
Bulk Density |
0.50 g/mL |
Tapped Density |
0.61 g/mL |
Hausner Ratio |
1.22 |
Result
The Hausner Ratio of the Vati powder blend was found to be 1.22, indicating fair flowability.
F. solubility profile
Procedure
Observation Table
Table No. 9 - Solubility profile
Solvent |
Solubility Status |
Distilled Water |
Partially soluble |
Ethanol |
Soluble |
Methanol |
Soluble |
Chloroform |
Insoluble |
Acetone |
Slightly soluble |
Result
The Vati formulation was found to be soluble in ethanol and methanol, partially soluble in water and insoluble in chloroform, indicating that the formulation contains both hydrophilic and lipophilic phytoconstituents.
G. pH determination
Procedure
Observation
Table No. 10 – pH Value
Sample |
pH Value |
Vati Solution |
4.8 |
Result
The pH of the aqueous solution of the Vati formulation was found to be 4.8, indicating a mildly acidic nature.
2. Postcompression Assessment of Powder Blend
A. Hardness Test
Procedure
Procedure
Observation
Table No. 10 – pH Value
Sample |
pH Value |
Vati Solution |
4.8 |
Result
The pH of the aqueous solution of the Vati formulation was found to be 4.8, indicating a mildly acidic nature.
2. Postcompression Assessment of Powder Blend
A.Hardness Test
To assess the mechanical strength of Vati and ensure it can withstand mechanical stress during handling and transportation.
Procedure
Observation Table
Table No. 11 – Hardness Test
Sample No. |
Hardness (kg/cm²) |
1 |
4.5 |
2 |
4.7 |
3 |
5.0 |
4 |
4.8 |
5 |
4.6 |
6 |
4.9 |
Average |
4.75 kg/cm² |
B. Friability test
Procedure
Observation Table
Table No. 12 - Friability test
Parameter |
Value |
Initial weight (W?) |
4.80 g |
Final weight (W?) |
4.76 g |
Weight loss |
0.04 g |
Friability (%) |
0.83% |
C. Weight Variation Test
Procedure
Observation Table
Table No. 13 - Weight Variation Test
Vati No. |
Weight (mg) |
1 |
580 |
2 |
585 |
3 |
595 |
4 |
590 |
5 |
588 |
6 |
594 |
7 |
582 |
8 |
589 |
9 |
586 |
10 |
591 |
Average |
588 |
Disintegration Time Test
Procedure
Observation Table
Table No. 14 - Disintegration Time Test
Vati No. |
Disintegration Time (min) |
1 |
12 |
2 |
11 |
3 |
13 |
4 |
12 |
5 |
12 |
6 |
11 |
Average |
11.8 minutes |
E. Dissolution Test
Heat 900 ml of the dissolution medium to 37 ± 0.5°C to simulate body temperature. Place the medium in a beaker or use the dissolution apparatus.
Place one vati into the dissolution medium.
Begin gentle stirring (50 rpm if using apparatus or manual stirring at regular intervals).
Sampling
At time intervals of 5, 10, 15, 30, 45 and 60 minutes, observe the solution visually.
Note the color change, turbidity and breakdown of the vati. If needed, collect small samples in test tubes to observe how well the herbal ingredients have dissolved.
Repeat the same process for 6 vatis to ensure uniformity.
Observation Table (Visual Method)
Table No. 15 - Dissolution Test
Time (min) |
Observation |
5 |
Light color change, partial disintegration |
10 |
Medium color change, some particles dissolved |
15 |
Significant dissolution, most of vati dispersed |
30 |
Nearly complete dissolution |
45 |
Uniform color, clear solution with few particles |
60 |
Completely dissolved, uniform appearance |
Organoleptic Evaluation
Organoleptic properties are essential in Ayurvedic formulations to assess the quality and consumer acceptability of the final product.
Table No. 16 - Organoleptic Evaluation
Parameter |
Observation |
Appearance |
Smooth, round, dark brown vatis |
Odor |
Characteristic herbal smell |
Taste |
Astringent with mild sweetness |
Texture |
Hard and uniform |
The dark brown color was attributed to the combination of Triphala powders and jaggery. The natural aroma and taste remained intact, indicating that the method of preparation did not degrade the phytoconstituents. The addition of jaggery also masked the strong astringent taste of Triphala, improving patient compliance.
A number of quality control tests were performed to ensure the pharmaceutical acceptability of the Vati.
Table No. 17 - Physical Evaluation Parameters
Parameter |
Result |
Pharmacopoeial Standard |
Average Weight (10 Vatis) |
588.4 mg |
5% variation acceptable |
Weight Variation |
| ±3.1% |
Within limit |
Hardness |
4.5 kg/cm² |
3–6 kg/cm² |
Friability |
0.71% |
Not more than 1% |
Disintegration Time |
11.8 minutes |
NMT 30 minutes |
The uniformity in weight confirmed the even distribution of the formulation ingredients. Hardness and friability tests confirmed that the tablets were mechanically strong and did not break or crumble during handling. The disintegration time was well within limits, ensuring rapid breakdown in the gastrointestinal tract. These results confirm the reproducibility and consistency of the formulation process.
3. Role and Evaluation of Jaggery in the Formulation Function of Jaggery
Observations
Unlike synthetic binders such as starch paste or PVP, jaggery offers a dual advantage being a functional excipient and a therapeutic adjuvant. The jaggery used in the formulation not only contributed to the mechanical integrity of the vatis but also offered synergistic effects with Triphala, especially in gastrointestinal health. The successful use of jaggery supports the Ayurvedic principle of “Anupana”, where the carrier enhances both delivery and activity of the main ingredients.
4. Stability Study (30 days, Room Temperature) Parameters Observed
Shortterm stability study indicated that the formulation was chemically and physically stable under normal room conditions. The moisture content of the jaggery did not lead to microbial contamination or degradation. This validates the use of jaggery as a safe and effective natural excipient.
SUMMARY AND CONCLUSION
SUMMARY
Formulation and Evaluation of Ayurvedic Solid Dosage Form of Vati” focuses on developing a traditional Ayurvedic tablet using Triphala (Haritaki, Bibhitaki, Amalaki) and Jaggery (Guda) as a natural binder and sweetener. The study emphasizes the importance of Vati Kalpana in Ayurveda due to its ease of administration, longer shelf life and precise dosing. Both heat-based (Sagnisadhya) and non-heat-based (Anagnisadhya) methods of preparation are described in detail, adhering to classical Ayurvedic principles. The project includes a plant profile of each Triphala ingredient, their pharmacological properties and the role of jaggery as a functional excipient. The prepared Vati is evaluated for various pharmaceutical parameters such as organoleptic properties, angle of repose, loss on drying, hardness, friability and disintegration time, all of which fall within acceptable limits, indicating good stability and quality. Overall, the report bridges traditional Ayurvedic practices with modern scientific methods, validating the formulation’s therapeutic potential, safety and standardization for future application in herbal medicine.
CONCLUSION
The present study successfully formulated and evaluated an Ayurvedic solid dosage form (Vati) using Triphala a classical polyherbal formulation consisting of Haritaki, Bibhitaki and Amla in combination with Jaggery as a natural binder and sweetening agent. The prepared Vati tablets exhibited acceptable physical characteristics including uniform weight, appropriate hardness, friability, disintegration time and aligning with Ayurvedic pharmacopeial standards. The inclusion of Jaggery not only enhanced palatability but also contributed to the therapeutic properties due to its Rasayana (rejuvenating) nature. The formulation demonstrated stability and ease of administration, making it a suitable dosage form for patient compliance. This study supports the potential of traditional Ayurvedic formulations to be adapted into standardized, solid dosage forms using simple techniques, bridging the gap between ancient wisdom and modern pharmaceutical practices. Further studies including pharmacological evaluation and clinical validation may enhance its therapeutic acceptance and integration into mainstream healthcare
REFERENCES
Saurabh Swami*, Shubham Tikait, Swati Deshmukh, Formulation And Evaluation of Ayurvedic Solid Dosage Form of Vati, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 5, 1908-1922. https://doi.org/10.5281/zenodo.15387758