Crafting and Advancements of Pippali and Cissus Quadrangularis Anti- Inflammatory & Anti-Rheumatic Herbal Ointment

Aim:

The aim of this project is to develop an ointment using Pippali (Long Pepper) and Cissus quadrangularis (Veldt Grape) Fine Powder, which have Anti-Inflammatory and Anti-Rheumatic properties. “Crafting and Advancements of Pippali and Cissus Quadrangularis Anti-Inflammatory & Anti-Rheumatic Herbal Ointment”

Objective:

To standardize Pippali and Cissus quadrangularis for their active Anti- Inflammatory and Anti-Rheumatic compounds. To formulate a stable and effective ointment using these plant Fine Powders. To evaluate the Anti-Inflammatory and Anti-Rheumatic activity of the developed ointment through in vitro and in vivo testing. To assess the physical properties of the ointment, such as texture, spread ability, and skin compatibility. To conduct stability studies to ensure the ointment’s shelf-life and efficacy. To determine the safety and tolerability of the ointment through skin irritation and irritation tests.

Description Of Materials and Equipment’s:

Materials Used:

Equipment’s Used:

Table No :02

Uses Of the Materials Used in The Formulation:

Description Of Materials: -

Pippali: -

Fig No :01

Biological source: -it consists of dried flowering vine of piper longum linn.

Family: - Piperaceae

Uses:

The fruit of long pepper are claimed to be efficacious in cold, cough, asthma, hiccough, splenic disorders and also as liver tonic. It is used in digestive issues, respiratory problems and infections

Cissus Quadrangularis: -

Fig No:02

Biological source: -Cissus Quadrangularis is obtained from the stems of the Perennial plant of the Grape family.

Family: - Vitaceae

Uses: -

Cissus plays role in improving bone health, heal fractures, sprains. Cissus is rich in vitamin C and vitamin E.

Wool Fat: -

Fig no: 03

Biological source:- it is obtained from the wool of the sheep Ovis aries linn., belonging to the family bovidae .it is the secretion of sebaceous gland of sheep deposited on to the wool fibres. The chief constituents of wool fat are cholesterol and oxocholesterol , unsaturated monohydric alcohols of the formula C27H45OH. Wool fats also contain aliphatic alcohols such as cetyl ceryl and carnaubyl alcohol. Wool alcohols BP/EP are prepared by the saponification of crude lanolin and the separation of the alcohol fraction. Wool fat is used as an emollient base for cream and ointment.

Uses: -

It is used as water absorbable ointment base. Used as common ingredient and base for water soluble creams and cosmetics.

Hard Paraffin:

Fig no :04

It is purified mixture of solid hydrocarbons and obtained from petroleum.

it is colorless or white translucent, odorless, tasteless waxlike substance.

it is used to harden or soften the ointment base.

Uses: -

it is used to stiffen ointments and creams and to coat capsules and tablets.

it can also open pores and remove dead skin cells.

Paraffin wax may be used to help relieve pain in people with osteoarthritis, rheumatoid arthritis, fibromyalgia, and other joint mobility issues.

White Bees Wax:

Fig no :05

Biological source :-beeswax is obtained from the honey comb of the bees apis mellifera .

Family: - apidae

Uses: -

Beeswax helps in water incorporation to form an emulsion.

it is used in preparation of ointments, plasters, and polishes.

it used in the manufacturing of candle, molds in dental and electronic industries, cosmetic for lipstick, face cream.

Cetosteryl Alcohol: -

Fig No :06

Cetearyl alcohol is a chemical found in cosmetic products. it is a white, waxy mixture of cetyl alcohol and stearyl alcohol, both are fatty alcohols. they are found in animals and plants like coconut and palm oil.

Uses:-

It is used in the cosmetic industry as an opacifier in shampoos, or as an emollient, emulsifier or thickening agent in the manufacture of skin creams and lotions. it imparts an emollient feel to the skin and can be used in w/o emulsion and o/w emulsion, anhydrous formulations.

Preliminary Test for Pippali:

Preliminary Test for Cissus Quadrangularis: -

Formulation And Development

Formulation of ointment using pippali and cissus quadrangularis: -

Ointments are homogeneous translucent semi-solid preparation, most commonly a greasy, thick oil (oil 80 % - water 20%) intended for external application to three skin or mucous membrane. Drug ingredients can be dissolved, emulsified, or suspended in the ointment base. Ointment is mainly used as a emollient or protective for skin. Comparative formulation and development of piper longum and cissus quadrangularis ointment

Ingredients