Comparative study of Herbal Pain Relief Balm with Patanjali Herbal Balm

The pain balm works on the counter irritancy principal the where the instead of relieving the pain, the pain sensation is suppressed by causing the irritation to the point where formulation has been applied. The balm in common sense is defined as semisolid formulation (generally having medicament) and which is to be applied externally. Pain balm is such formulation that is intended to be used for the relief of mild to moderate rate pain. Tension headaches are very common, affecting up to 78% of people. Unfortunately, there are also among the most neglected and difficult types of headaches to treat. Herbal balm is an ayurvedic formulation of powerful essential oils for quick relief from head ache, back ache, cold and in relieving pain. Herbal balm composition comprising organic essential oils, organic bees wax and other desired herbal components has medicated topical preparations for application to skin of human beings. Balms are topical preparations for application to skin to relieve pain and stiffness. This balm contains counter irritant chemical compounds such as methyl salicylate. Petroleum jelly is the common base for any kind of balms. Pain is an unpleasant feeling often caused by intense or damaging stimuli, such has stubbed a toe, burning a finger, putting alcohol on a cut and bumping the funny bone. The international association for the study of pains widely used definition states, pain is an unpleasant sensory and emotional experience associated with actual or potential tissue damage, or described in terms of such damage. Pain motivates the individual to withdrawn from damaging situations, to protect a damaged body parts while it kills and to avoid similar experiences in future. Most pain resolves promptly hence the pain stimulus is removed and the body has healed, but sometimes pain persists despite removal of stimulus and apparent healing of the body and sometimes pain arrive in the absence of any detectable stimulus, damage or disease.

Advantages Of Herbal Facial Scrub:

1. Avoidance of first pass metabolism.
2. Convenient and easy to apply.
3. Ability to deliver drug more selectively to a specific site.
4. Improving physiological and pharmacological response.
5. Providing utilization of drug with short biological half-life.
6. Provide suitability for self-medication.
7. Ability to easily terminate the medication when needed

Uses Of Herbal Pain Relief Balm:

1. 1. Herbal pain balms can help relieve pain from headaches,backaches, colds.
   2. Herbal pain balms can help treat rheumatoid arthritis.
   3. Herbal pain balm was effective in reducing pain, swelling,tenderness, and headache.

Other Uses:

1. Arthritis.
2. Backches.
3. Sore muscle.
4. Joint pain.
5. Leg cramps

Review Of Literature

1. Pratiksha Salunke, Shital Markad, Komal Magar, et al (2024) Acute pain servesas a warning, but chronic pain is a syndrome that n ecessitates careful selection of highly bioavailable analgesic medications for longterm treatment. Topical dru gs are designed to address these issues by providing a stable plasma level, allowing for gradual delivery of th e active ingredient, and having a high safety profile.

2. Riya Sangelia, Neelam Dhankhar, Shoaib Khan and Sunil Kumar et al (2024) The cosmetic industry has witnessed a significant shift towards natural and herbal. products in recent years, aligning with the global trend of embracing a moresustainable lifestyle. This transition is evident in the growing demand for herbal cosmetics, which are regarded as invaluable gifts from nature.

3. PM Kumarapperuma", SASD Senanayake, MMPM Hasanthi, NTB Dias¹, S K Hettihewa et al (2024)Inflammation is a pathological condition that may lead to various chronic diseases. This study evaluates the anti-inflammatory effect of gulmohar plant flowers, screens its preliminary phytochemistry, and the plant materialis subsequently used in a herbal balm formulation

4. Geeta Patel, Nakshi Patel, Anvi Patel and Karina Satwani et al (2024)The homogenous mixing method was employed to address challenges in formulating thepain reliefbalm

5. Pratiksha Salunke, Shital Markad, Komal Magar,et al (2024)Topical drugs are designed to address these issues by providing a stable plasma level, allowing for gradual delivery of th e active ingredient, and having a high safety profile. The most popular medications topical formulations for t he treatment of pain are reviewed here,along with new research findings

6. Dr. Sakthivel M, Dr. Mohamed Halith S", Karthikeyan R, Kaviya M, Kiruthika M, Kowsalya S,Krishnapriya R , et al (2023)Even in areas where modern medicine is available, the interest on herbal medicines and their utilization have been increasing rapidly in recent years. Plant derived substances and herbal medicines have recently attracted.

7. Getha Devi, S. Yamuna, Sk. Nourin, K. Naveen², Sk. Salma, D. swathi, K. Gayathri, P. subrahmanyam et al (2023) There has been an increasing focus on development of new routes of drug administration to provide tailored treatments for patients, without decreasing efficacy of analgesia, in proportion to the progression ofthe knowledge of pain mechanisms.

8. Anuj N.Nahata, Nazma M. Ansari, Shivani Nahar, Sanjay G. Walode, Vibhavari M. Chatur, et al (2022) These are the products of healthcare that are biologically active ingredients that impersonates to medical or drug like benefits. Thedesign, quality, formulation of herbal pain relief balm made from natural ingredients was studied.

9. Miss.Telange-Patil P.V., Miss. Bendgude P.D., Miss. Chavan M.R., Miss. Jadhav S.T.,et al (2022)Modern life is stressful, and tension headaches are one resultof that stress. Cosmetics have great demand sinse ancient time, Now a days, a focus has been shifted more towards derived cosmetic products.

10. Nishigandha Waykule, Prachet Bagewadikar and Somasharan Kale, et al (2022)The rising global demand for natural products whose production is harmless tothe human body and environment has developed the novel method of formulations ofjoin pain balm.

11. Yati Sumiyati, Safira Nafisa", Wiwi Winarti, Esti Mumpuni,Diah Kartika Pratami, Desi Nadya Aulena', Novi Yantih'et al (2022)The purpose of this study was to obtain the best formulation of redginger oil halm that can be used for aromatherapy as an analgesic.

12. Miss. Telange-Patil P.V., Miss. Bendgude P.D., Miss. Chavan M.R., Miss. Jadhav S.T.,et al (2022)Modern life is stressful, and tension headaches are one resultof that stress. Cosmetics have great demand since ancient time, Now a days, a focus has been shifted more towards derived cosmetic products

13. Fitria Nugrahaeni", Kriana Efendi, Abdul Kholik Aziz et al (2022)This means a preparation is needed to deliver the extract. Balm stick is an innovation in a stem- shaped balm that makes it easier to be used so that gulmohar flower extract is made into a balm.

14. Yadav A., Karmokar K., Gop R., Mudartha D., Maheshwari V. et al (2022)The cosmetic industry has witnessed a significant shift towards natural and herbal. products in recent years, aligning with the global trend of embracing a moresustainable lifestyle. This transition is evident in the growing demand for herbal cosmetics, which are regarded as invaluable gifts from nature.

15. Yadav Abhishek and Samanta Krishanu et al (2021) Herbal medicine prepare various part of plant are used like flower, leaves, seeds, root etc. Instead off an herbaldrug is design as the alternative formulation for the external use in the form of balm. For the medicinal use the herbal ointment apply externally on human body.

16.Sujeewa Krishanthi Hettihewa, Thotawaththage Loshadhi Indunika Srilal etal. (2021) The demand for the utilization of herbal medicine is rising due to their high efficacy, affordability, ease of use, better adaptability with human body and lesser side effects.

17. Hafizh Fadhullah, Anisa Megantika, Kanya Citta Hana Alifia, Pandu Nugroho, Talitha Zada Gofara et al (2019)Our product provides the following benefits: it is a uniquely patented product; it contains a combination of a a humectant,an emollient, and counter irritant to maintain relief on the joints; and it is manufactured using 100% herbal ingredients.

18. Lusi Putri Dwita, Kori Yati and Sri Nevi Gantini et al (2019)This research aimed to determine the anti-inflammation activity of Nigella sativa oil in a simplebalm stick by topical application.

19. Katarzyna Seidler-Laskowski, Romuald Mursalski, Wojciech Kucharski, Elzbieta K?dzia¹, Kamila Nowosad.Jan Bieganowski et al (2015) The raw material of medicinal plants should fulfill thegrowing demands of herbal and cosmetic industries about its quality esp active substance content, sufficient yield, lack of pesticides and heavy metals residues and microbiologically clean.

20. Mayuri Kadu' Dr Suruchi Vishwas Rao, and Dr Sonia Singh et al (2015) Cosmetics are incredibly in demand since historical time. These days focusshifted more towards naturally derived cosmetic products.

1. 4. Rational Of the Study: - Need of Work: -

In line with the advancement of our understanding of pain mechanisms, there has been a growing emphasis o n the creation of novel drug delivery systems that can offer patients individualized treatments without compromising the effectiveness of analgesics. Acute pain serves as a warning, but chronic pain is a syndrome that necessitates careful selection of highly bioavailable analgesic medications for long term treatment. Topical drugs are designed to address these issues by providing a stable plasma level, allowing for gradual delivery of the active ingredient, and having a high safety profile. The mostpopular medications topical formulations for the treatment of pain are reviewed here, along with new research findings.

1. Safety and Gentleness:
   • Conventional Herbal pain relief balm often contain harsh chemicals, artificial lfragrances, and microplastics that can irritate the skin and cause allergic reactions, especially for individuals with sensitive skin.
   • Herbal balm utilize natural ingredients like bee wax , Menthol , Castor oil , and herbs, making them gentle and safer for most skin types.
2. Effectiveness:
   • • Herbal ingredients possess inherent properties that are beneficial for the skin.
     • For example, Eucalyptus oil inflammation and moisturizes, camphor has antibacterial and antiinflammatory properties.
3. Multifaceted Benefits:
   • • Conventional balm often contain harsh chemical that pose a threat to the environment and marine life.
     • Herbal balm are often formulated with biodegradable ingredients and sustainable packaging, making them more eco-friendly choice.
4. Affordability:

Compared to expensive commercial balm , herbal balm can be made at home using readily available ingredients, making them a more affordable option.

Objectives: -

• • • To study avoidance of first pass metabolism.
    • To ease the patients' joint and muscular pain.
    • To Greatly Improve Headache Patients Experience
    • To treat common colds in comparison to other product types.
    • To reduce tension and encourage rest.
    • Temporarily relieves the minor aches and pains of muscles andjoints associated with: arthritis, Sprains, Muscle strains.
  • Plan Of Work: -
    • Selection of pure drug
    • Identification tests of drug:
      1. Dragendroff’s test
      2. Hager test
      3. Test for Menthol
      4. Test for Bee Wax
      5. Test for Castor Oil
      6. Test for Camphor
    • Preparation of reagents
    • Experimental design
    • Result & discussion
    • Conclusion
    • Reference

5. Drug Profile: -

1. Royal Poinciana

Figure no. 5.1 Royal Poinciana

Scientific Name: Delonix Regia.

Synonym: Gulmohar, Peacock Tree.

Family: Leguminosae.

Chemical Constituents: Mainly alkaloids, flavonoids, triterpenes, and steroids. The flowers also contain anthocyanins, such as cyanidin 3-0- rutinoside and pelargonidin 3-O- rutinoside.,

Uses:

1. The Royal Poinciana has anti-inflammatory properties.
2. mainly used to The Royal Poinciana has antidiabetic properties.
3. The extract from flower treat joint pains.

2. Menthol:

Fig no 5.2 (Menthol)

Scientific Name: Hexahydrothymol.

Synonym: Peppermint camphor.

Family: Lamiaceae.

Chemical    constituents:     Menthol(40.7%), Menthone(23.4%), menthyl acetate,1,8cineole, limonine, beta pinene, an beta-caryophllene

Uses:

1. Reduces spasm and pain caused by endoscopy.

2. In migraine headache.

3. To treat nausea.

4. To reduce inflammation

Bees Wax:

Fig no 5.3 (Bees Wax)

Scientific name: Ceraalba.

Synonym: Yellow wax.

Family: Apidea.

Chemical constituents:

Myricylpalmitate (80%), free cerotic acid (15%), melissic acid, cerolein

Uses:

1. 1. It has anti-inflammatory and anti- allergic properties.
   2. It mainly use as an emulsifying agents, stiffener and gentle skin
   3. Relieves stress and promote relaxation.
   4. Relieves pain

Castor Oil:

Fig no 5.4(Castor Oil)

Scientific name: Ricinuscommunis.

Synonym: Ricinus oil.

Family: Euphorbiacea.

Chemical constituents: Triglyceride of ricinoleic acid 80%.

Uses:

1. Castor oil is commonly used as the laxative

2. Castor oil promote the wound healing.
3. Castor oil is a cathartic.
4. Castor oil used in arthritis and joint pains.
5. Castor oil helps to improve blood circulation

Eucalyptus Oil:

Fig no 5.5 (Eucalyptus oil)

Scientific name: Eucalyptus globules.

Synonym: Lemon scented gum.

Family: Myrtaceae.

Uses:

1. Relieves stuff nose.

2. Eases sore muscle and joint pain.

3. Clears respiratory complaints.

4. Reduces stress.

5. Disinfects wounds and cuts

Camphor

Fig no 5.6(Camphor)

Scientific name: Cinnamomum camphor.

Synonym: Alcindor.

Family: Lauraceae.

Chemical constituents: D-camphor (51.3%), 1,8-cineole (4.3%), and alpha terpinol

Uses:

1. Provide relief from cold cough, chest congestion, bronchitis and asthma.
2. Improves blood circulation and help to curb muscular and joint aches.
3. Powerful analgesic oil that produces a cooling sensation to numb
4. pain and awarming sensation to increase circulation.

MATERIALS AND METHODS:

Table 6.1: List of materials

• Drugs and chemicals:

Royal Poinciana, Bees Wax, Menthol, Castor Oil, Eucalyptus Oil, Camphor.

• Glassware’s and instruments:

Beaker’, Stirrer , Measuring Cylinder , Weighing Balance, Motar And Pestle,

6. Authentification tests of drug:

1. Test For Drug Extract : (Royal Poinciana)
   1. Dragendroff 's test. By adding 1 mL of dragndorff's reagent to 2 mL of extract, an orange red precipitatewas formed, indicating the presence of alkaloids.

Fig no 6.1(Dragendorff Test)

1. 2. Hager's test. Two milliliters of extract were treated with few drops of Hager's reagent. A yellow precipitatewas formed, in- dicating the presence of alkaloids.

Fig no 6.2(Hager’s Test)

2. Test For Menthol:

1. Take few crystals of menthol and mix with 5ml nitric acid and heat on water bath. Withina few minutes, the solution develops blue colour and after sometime, it becomes golden yellow colour which indicates the presence of menthol.
2. 10mg crystals of methanol first dissolved in 4 drops of conc. H2SO4, then add few dropsof Vanilline-H2SO4 reagent. Formation of yellowish orange colour which on addition to water changes to violet.

3. Test For Bees Wax:

1. Take few crystals of menthol and mix with 5ml nitric acid and heat on water bath. Withina few minutes, the solution develops blue colour and after sometime, it becomes golden yellow colour which indicates the presence of menthol.
2. 1 gm drug +10 ml alcohol, reflux for 1 hour with continues stirring. Cloudy liquid getappears which indicates the presence of bees’ wax.

4 . Test for Castor oil:

1. Castor oil + petroleum ether = Completely soluble in petroleum ether=Castor oil ispresent
2. Castor oil + equal volume of alcohol = Clear liquid upon cooling at 0°c for (3 hours) =Castor oil is present

5. Test for Camphor:
   1. Add 5 ml of acetone to 1 g of camphor in a test tube, shake well for 3-5 minutes, and let itstand for 30 minutes. If the crystals dissolve completely

Method of Preparation:

Weighing all the required herbal ingredients for herbal pain-relieving balm preparation wereaccurately weighed by using digital balance.

Fig no 10.1 (herbal Pain Relief Balm)

Marketed Product for Comparative study: Patanjali Balm

Patanjali Ayurveda Balm consists of pain-relieving ingredients that provide a cool and soothing sensation to help reduce pain and cramps. It has anti- inflammatory properties which minimise inflammation and swelling.

Product Highlights:

• Provides relief from aches and pains
• Has anti-inflammatory properties
• Provides a cooling sensation

Formulation:

• Gaultheria fragrantissima 750gm
• Mentha piperita    500gm
• Eucalyptus globulus         400 gm
• Petroleum jelly
• Hard paraffin

Gandhpurataila (Gaultheria fragrantissima): Used to relieve spasms of involuntary muscle, acts as an anti-inflammatory, and gives relief in pain and exhibits antiarthritic, antiseptic and astringent properties.

Pudina sat (Mentha piperita): Gives a cooling sensation and has a calming effect on the body, which can relieve sore muscles when used topically.

Nigiri tail (Eucalyptus globulus): Has anti-inflammatory properties that help ease muscle and joint pain and helps to reduce pain, inflammation and stiffness.

Manufacturer:

PATANJALI FOODS LIMITED Non-Food Division, Block-B, Patanjali Food and Herbal Park, Partha, Laskar Road, Haridwar- 249404, Uttarakhand.

Batch No.: AV1037 Mfg. Date :12/24 MRP?: 60.00

Evaluation Tests:

5. Colour- The colour of the herbal balm was checked by visually.
5. Odour- The formulation was evaluated for its odour by smelling it.
5. Consistency: The consistency of the formulation and particles were used to check thetexture and homogeneity of preparation on the skin such as stiffness, grittiness, greasiness effect.
5. Texture: It was tested by pressing a small quantity of the formulatedbalm between the thumb and index finger.
5. pH: pH of 1% solution of the formulation was measured by using a calibrated digitalpH meter at constant temperature.
5. Spread ability: Spread ability of the formulations was determined by measuring the spreading diameter by keeping 1 g of sample between two horizontal glass plates (10cm x 20 cm). The standard weight 20 gm applied on the upper glass plate. The spreading quality checked by visual inspection.
5. Wash ability: This test was performed directly on skin, formulation applied on skin and wash with normal water, after washing oily skin observed.
5. Grittiness: The product was checked for the presence of any gritty particles by applying it on the skin.

RESULT:

In the presence of study, the pain balm of Royal Poinciana was formulated by using various excipients. The balm was then evaluated for the Given physical parameters and was found to be satisfactory in terms of appearance and texture. It was easily spreadable with fingers without any roughness felt to touch. The smell of the balm was found to be characteristics. Only thing was the colour was faded as the natural colorant with origin of Flower petals was incorporated. The balm was dense with the optimized melting point. In general, oral or topical antibiotic formulation is used for the treatment of skin diseases. Traditional medicinal and aromatic plants are interesting and explore its various bioactive natural organic compounds for various treatments. In the last two decades, more research has been carried out towards the identification of the bioactive compound from medicinal plants and developing into drug for the various treatments.

Comparative Study between Formulated Product & Marketed Product