View Article

Abstract

This study outlines the preparation of a digitalis suspension for congestive heart failure (CHF) management. The method involves extracting digitalis glycosides from Digitalis purpurea leaves, followed by meticulous processing to achieve a stable suspension. The formulation's efficacy in addressing CHF symptoms is assessed, providing insights into its potential therapeutic value. This research contributes to the exploration of alternative formulations for digitalis administration in congestive heart failure patients. Digitalis, commonly derived from the foxglove plant, is a medication used to treat congestive heart failure. It helps strengthen the heart's contractions, improve circulation, and alleviate symptoms. However, it should be prescribed and monitored by a healthcare professional due to its narrow therapeutic range and potential for toxicity. Regular check-ups are essential to ensure the medication is effective and safe for the individual.

Keywords

Digitalis, CHF(congestive heart failures), Digoxin, Digitoxin,etc.

Reference

  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds (1997). American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press.
  2. Nesher, M., Spolansky, U., Rosen, H. and Lichtstein, D(2007). The endogenous digitalis- like compounds -A new family of steroid hormones. Life Sci. Vol.80:2093- 2107.
  3. Shumaik GM, Wu AW, Ping AC (1988). Oleander poisoning: treatment with digoxin-specific Fab antibody fragments. Ann Emerg Med. Vol.17:732-735.
  4. Schoner, W (2002). Endogenous cardiac glycosides, a new class of steroid hormones. Eur J Biochem Vol.269:2440-2448.
  5. Schoner, W., Bauer, N., Muller-Ehmsen, J., Kramer, U., Hambarchian, N., Schwinger, R., Moeller, H., Kost, H., Weitkamp, C., Schweitzer, T., Kirch, U., Neu, H., Grunbaum, E.G (2003). Ouabain as a mammalian hormone. Ann N Y Acad Sci. Vol.986:678-684. 
  6. Schoner, W. and Scheiner-Bobis, G (2007). Endogenous and exogenous cardiac glycosides and their mechanisms of action. Am J Cardiovasc Drugs. Vol.7:173-189.
  7. Dick M, Curwin J, Tepper D (1991). Digitalis intoxication recognition and management. J Clin Pharmacol .Vol.31:444-447.
  8. Hood WB, Dans A, Guyatt GH, Jaeschke R, McMurray JJ(2004). Digitalis for treatment of congestive heart failure in patients in sinus rhythm. Cochrane Database Syst Rev (2):CD002901.
  9. Johansson S, Lindholm P, Gullbo J, Larsson R, Bohlin L, Cleason P(2001). Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells. Anticancer Drugs. Vol. 12:475-483.
  10. Lopez-Lazaro M, Palma De La Pena N, Pastor N, et al(2003). Anti-tumour activity of Digitalis purpurea L. subsp.heywoodii. Planta Med .Vol.69:701-704.
  11. Lindholm P, Gullbo J, Claeson P, et al(2002). Selective cytotoxicity evaluation in anticancer drug screening of fractionated plant extracts. J Biomol Screen . Vol.7:333-340.
  12. Lacassie E, Marquet P, Martin-Dupont S, Gaulier JM, Lachatre G(2000). A non-fatal case of intoxication with foxglove, documented by means of liquid chromatography-electrospray-mass-spectrometry. J Forensic Sci .Vol.45:1154-1158.
  13. Bagrov, A.Y., Fedorova, O.V (2005). Cardenolide and bufadienolide ligands of the sodium pump. How they work together in NaCl sensitive hypertension. Front Biosci Vol.10: 2250-2256. 
  14. Buckalew, V.M (2005). Endogenous digitalis-like factors. An historical overview. Front Biosci 1,Vol.0:2325-2334.
  15. Blaustein, M.P., Zhang, J., Chen, L., Hamilton, B.P (2006). How does salt retention raise blood pressure? Am J Physiol Regul Integr Comp Physiol; Vol.290:R514-R523.
  16. Dec GW (2003). Digoxin remains useful in the management of chronic heart failure. Med Clin North Am .Vol.87:317
  17. Tatro DS, ed. Drug Interaction Facts. St. Louis, MO(2002): Wolters Kluwer Health, Inc.; 2004. Jowett N. Foxglove poisoning. Hosp Med.Vol.63:758-759.
  18. Wickersham RM, Novak K (2004), managing eds. Drug Facts and Comparisons. St. Louis, MO: Facts and Comparisons
  19. Meyer JE (2002). The Herbalist. Hammond, IN: Hammond Book Co; 1934: 96.Belcastro PF. Digitalis: from folklore remedy to valuable drug. J Am Pharm Assoc.Vol. 42:857.

Photo
Dnyandeep Jadhav
Corresponding author

Nandkumar Shinde Collage of Pharmacy, Vaijapur, Chhatrapati Sambhajinagar.

Photo
Dipak S. Borse
Co-author

Nandkumar Shinde Collage of Pharmacy, Vaijapur, Chhatrapati Sambhajinagar.

Photo
Chaitanya G. Baviskar
Co-author

Nandkumar Shinde Collage of Pharmacy, Vaijapur, Chhatrapati Sambhajinagar.

Photo
Arvind K. Hatkar
Co-author

Dr. Babasaheb Ambedkar Tecnological University Lonere ,Raigad, Maharashtra.

Photo
Rajendra M. Kawade
Co-author

Dr. Babasaheb Ambedkar Tecnological University Lonere ,Raigad, Maharashtra.

Dnyandeep Jadhav* , Dipak Borse, Chaitanya Baviskar,  Arvind K. Hatkar, Rajendra M. Kawade.*, To Prepare Suspension Of Digitalis For Congestive Heart Failures, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 714-721.https://doi.org/10.5281/zenodo.10426636

More related articles
Exploring Novel Drug Delivery Platforms: Enhancing...
Satyam Ambardekar, Mayuri Rupnawar, Viraj jadhav, ...
Stability Indicating RP-HPLC Method For Simultaneo...
Chaluvaraju K. C., Bandhavya H. D., Munishama Gowda Y. N., ...
An Updated Review On Herbal Drugs Used In Alzheime...
Pranav Manik Sonawane , Saurabh Arjun Khairnar , Pranav Bhausaheb...
A Review on Optimization Techniques Used in Pharmaceutical Formulations...
Km. Shveta Yadav, Pooja Bhardwaj, Ashirvad Chauhan, Shweta Mishra, ...
Analytical Method (HPLC) for Determination of Digitalis as a Cardiotonic Drug...
Lokesh Mahajan, Mansi Mahajan, Nandini Mahale, Meenaz Sayyed, Ravindra Patil, ...
Related Articles
A Review on Systematic Study of Digitalies ...
Bhagyashri Randhawan, Atole S. S, Mudgal A. S, Salunke S. S, ...
Exploring the Potential of Antioxidants in Reducing Free Radicals: A Comprehensi...
Lokesh A. Gurav , Kishan A. Zodage, Amit P. Sinhal , Atish A. Salunkhe, Jitendra D. More, ...
Antioxidant and Antimicrobial Activities of Methanolic Extract of Sorghum Bicolo...
Ganesh Sonawane, Anil Thakare, Kirti Sonare, Kajal Pansare, Chandrashekhar Patil, Mayur Bhamare, Rus...
Review On: Food And Diet Brings Chenges In Gene Expression...
Mane Anant. M, Parsewar Hrushikesh B, Lomte Pratik B., Sirsikar Nikita P, O. G. Bhusnure, ...
More related articles
Stability Indicating RP-HPLC Method For Simultaneous Estimation of Ranolazine an...
Chaluvaraju K. C., Bandhavya H. D., Munishama Gowda Y. N., ...
An Updated Review On Herbal Drugs Used In Alzheimer’s Disease ...
Pranav Manik Sonawane , Saurabh Arjun Khairnar , Pranav Bhausaheb Sanap , ...
Stability Indicating RP-HPLC Method For Simultaneous Estimation of Ranolazine an...
Chaluvaraju K. C., Bandhavya H. D., Munishama Gowda Y. N., ...
An Updated Review On Herbal Drugs Used In Alzheimer’s Disease ...
Pranav Manik Sonawane , Saurabh Arjun Khairnar , Pranav Bhausaheb Sanap , ...