View Article

  • A Prospective Study On Drug Utilization Review Of Prescriptions Among Hypertensive Subjects At A Tertiary Care Hospital In Dakshina Kannada
  • 1Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, INDIA
    2Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, INDIA

Abstract

Hypertension, is one of the diseases that has severe impact on body and economy. Main aim and objective of our study was to find out the prescribing patterns of drugs among hypertensive patients. Materials and method: A prospective observational study was conducted at a tertiary care hospital in Dakshina Kannada for period of 6 months. 150 hypertensive patients who were on at least one antihypertensive medication, admitted to in-patient department were included for drug utilization study. Result: According to the study, 54% of hypertensive subjects were above 60- 75 years of age. 86% of prescription had more than 6 drugs. 66% of prescription had at least one antibiotic among which cephalosporin (37.84%) was the most common one. 81.33% of the patients received at least one injection. 64% of the prescriptions were not prescribed in generic name. As per the study, the most frequently prescribed antihypertensive drug was calcium channel blocker (36.10%) - Amlodipine. Conclusion: In the present study, drug utilization parameters were carried out using WHO core drug indicators which showed overprescription of antibiotics and injections which is a leading cause for increase in economic burden and majority of prescriptions did not have drugs prescribed in generic name. Prescribing drugs using generic names, decreases medical confusion and allows selection of better alternatives.

Keywords

Hypertensive; Drug utilization review; Drug core indicators; Polypharmacy

Reference

  1. S G, Aithal S, Balaji V, ES S. Analysis of drug utilization pattern among hypertensive patients admitted to medical intensive care unit of a tertiary care hospital. World J. Pharm. Res.2015;4(3):1320-30.
  2. Jainaf NRAM, Parimalakrishnan S, Ramakrishna RM. Study on drug utilization pattern of antihypertensive medications on out-patients and inpatients in a tertiary care teaching hospital: A cross sectional Study. Afr J PharmPharmacol. 2015 Mar 22;9(11):383–96. 
  3. Sharma A, KaurBadwal T, Gupta V, Singh Rathore M, Chhabra M, Gaur A. Drug Utilization Study on Hypertensive Patients and Assessment of Medication Adherence to Jnc-8 Guidelines in North Indian Tertiary Care Hospital: A CrossSectional Study. Adv Res GastroenteroHepatol . 2018 Feb 5;9(1). 
  4. Mengistu G, Misganaw D, Tsehay T, Alemu BK, Bogale K. Assessment of Drug Use Pattern Using WHO Core Prescribing Indicators at Outpatient Settings of Governmental Hospitals in Dessie Town. Drug Healthc Patient Saf. 2020 Nov;Volume 12:237–44
  5. Ramakrishnan S, Zachariah G, Gupta K, ShivkumarRao J, Mohanan PP, Venugopal K, et al. Prevalence of hypertension among Indian adults: Results from the great India blood pressure survey. Indian Heart J. 2019 Jul 1;71(4):309–13. 
  6. Oliveros E, Patel H, Kyung S, Fugar S, Goldberg A, Madan N, et al. Hypertension in older adults: Assessment, management, and challenges. ClinCardiol. 2020 Feb;43(2):99–107. 
  7. Connelly PJ, Currie G, Delles C. Sex differences in the prevalence, outcomes and management of hypertension. CurrHypertens Rep. 2022;24(6):185–92 
  8. Choi HM, Kim HC, Kang DR. Sex differences in hypertension prevalence and control: Analysis of the 2010-2014 Korea National Health and Nutrition Examination Survey. Spracklen CN, editor. PLOS ONE. 2017 May 25;12(5):e0178334. 
  9. Sandberg K, Ji H. Sex differences in primary hypertension. Biol Sex Differ. 2012 Mar 14;3(1):7. 
  10. Everett B, Zajacova A. Gender Differences in Hypertension and Hypertension Awareness Among Young Adults. Biodemography and Social Biology.2015 Jan 2;61(1):1–17. 
  11. Moges B, Amare B, Fantahun B, Kassu A. High prevalence of overweight, obesity, and hypertension with increased risk to cardiovascular disorders among adults in northwest Ethiopia: a cross sectional study. BMC CardiovascDisord. 2014 Nov 5;14(1).
  12. Hall JE, doCarmo JM, da Silva AA, Wang Z, Hall ME. Obesity-Induced Hypertension. Circ. Res. 2015 Mar 13;116(6):991–1006
  13. Shukrala F, Gabriel T. Assessment of prescribing, dispensing, and patient use pattern of antihypertensive drugs for patients attending outpatient department of HiwotFana Specialized University Hospital, Harar, Eastern Ethiopia. Drug Des DevelTher. 2015 Jan 17;9:519-23.
  14. Shrestha B, Dixit SM. The Assessment of Drug Use Pattern Using WHO Prescribing Indicators. J Nepal Health Res Counc. 2018 Oct 30;16(3):279-284.
  15. Satish S, Rose AJ, Shabaraya AR. A study to assess the impact of comorbidities and polypharmacy in nonadherence to antihypertensives. International Journal of Research and Review. 2021; 8(2): 222-227.
  16. Rambhade S, Chakarborty A, Shrivastava A, Patil UK, Rambhade A. A survey on polypharmacy and use of inappropriate medications. Toxicol Int. 2012 Jan;19(1):68-73.
  17. Harshitha J, Satish S, Shabaraya AR. Effectiveness of Educational Interventions to Improve Medication Adherence among Hypertensive Patients. IJRAMT 2021 Sep. 25;2(9):92-5. 
  18. Preetha G, Manoj S, Thomas A, John D, ShabarayaA R. A community based study on the consequence of polypharmacy in the quality of life among geriatric population. International Journal of Research and Review. 2021; 8(5): 202-20.
  19. Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. PerspectMedicin Chem. 2014 Aug 28;6:25-64.
  20. Fair RJ, Tor Y. Antibiotics and bacterial resistance in the 21st century. PerspectMedicin Chem. 2014 Aug 28;6:25-64. 
  21. Satish S, Prakash L, Shabaraya AR. A community based study to evaluate the impact of pharmacist intervention on antibiotic use. World J PharmPharm Sci.2021:10(10); 1395-404.
  22. . World Health Organization. Antibiotic resistance Geneva (Switzerland): World Health Organization.Oct 27; 2020.
  23. Shrestha JTM, Tiwari S, Kushwaha DK, Bhattarai P, Shrestha R. Drug Prescription in the Department of Medicine of a Tertiary Care Hospital according to the World Health Organization/International Network for Rational Use of Drugs Core Indicators: A Descriptive Cross-sectional Survey. JNMA J Nepal Med Assoc. 2021 Aug 12;59(240):745-748.
  24. . Rogawski ET, Platts-Mills JA, Seidman JC, John S, Mahfuz M, Ulak M, et al. Use of antibiotics in children younger than two years in eight countries: a prospective cohort study. Bull World Health Organ. 2017 Jan 1;95(1):49–61.
  25. Sarwar MR, Atif M, Scahill S, Saqib A, Qamar-Uz-Zaman M, Babar Z. Drug utilization patterns among elderly hospitalized patients on poly-pharmacy in Punjab, Pakistan. J Pharm Policy Pract. 2017;10(1):23.
  26. Datta S. Utilization study of antihypertensives in a south Indian tertiary care teaching hospital and adherence to standard treatment guidelines. J Basic Clin Pharm. 2016;8(1):33–7.
  27. Long AN, Dagogo-Jack S. Comorbidities of diabetes and hypertension: Mechanisms and approach to target organ protection. J ClinHypertens (Greenwich). 2011;13(4):244–51. 
  28. Oparil S, Acelajado MC, Bakris GL, Berlowitz DR, Cífková R, Dominiczak AF, et al. Hypertension. Nat Rev Dis Primers. 2018;4(4):18014. 
  29. Joseph S, Verghese N, Thomas L. A study on prescribing pattern of antihypertensive medications in a tertiary care hospital in Malabar region. Der Pharmacia Lettre. 2014;6(4):132–7. 
  30. Anuradha VP, C M, Sruthy S A. drug utilization pattern of antihypertensive medications in a tertiary care hospital, South India. Asian J PharmClin Res. 2021 Dec.13;15(1):115-8. 
  31. Naik HG, S HC. Study on antihypertensive drug utilization in a tertiary care hospital. Natl J PhysiolPharmPharmacol. 2019; 9(11): 1063-7.

Photo
Trupthi D. Shetty
Corresponding author

Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, INDIA

Photo
Ramakrishna Shabaraya A.
Co-author

Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, INDIA

Photo
Suchetha Kumari
Co-author

Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, INDIA

Ramakrishna Shabaraya A., Trupthi D. Shetty, Suchetha Kumari, A Prospective Study On Drug Utilization Review Of Prescriptions Among Hypertensive Subjects At A Tertiary Care Hospital In Dakshina Kannada, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 10, 182-191. https://doi.org/10.5281/zenodo.10017796

More related articles
A Review On Assessment And Management Of Polycysti...
R. Thrisha, P. Udhaya Kumar , V. S. Rekha, S. Suba Varshini , A. ...
Assessment Of Free Radical In Ethyl Acetate Extrac...
Krisna Dewi, Helmina Pigai, Eva S. Simaremare, Septiani Mangiwa, ...
Related Articles
Comprehensive Review On Analytical Methods For Determination Of Chlorpheniramin...
Sonali U. Navale, Chetana A. Padekar, Sonali S. Ghuge , Monali S. Ghuge , Gayatri S. Gaikwad , ...
Review On Bryophyllum Pinnatum ...
Mahendra Siddheshwar Shendkar , Snehal Kothavale , Lahoo Palave, Leena Parkhi, Lalit Ambhore, Snehal...
Comparative Analysis Of Blood Glucose Level By Using A Semi-Auto Analyser And Gl...
Amee G. Upadhyay, Janvi Kachhia, Saraswati Thapa, Jignasa Mansuriya, ...
Hydrophilic Interaction Liquid Chromatography (Hilic)...
Ajay A, Prasanth S. S, Sanooja P. k, Jisha U, K. T. Akshara, Riya Rajan, Sibina M. K, Mohammed Faroo...
A Review On Assessment And Management Of Polycystic Ovarian Syndrome (PCOS) In T...
R. Thrisha, P. Udhaya Kumar , V. S. Rekha, S. Suba Varshini , A. Nivetha , G. Vidhya, ...
More related articles
A Review On Assessment And Management Of Polycystic Ovarian Syndrome (PCOS) In T...
R. Thrisha, P. Udhaya Kumar , V. S. Rekha, S. Suba Varshini , A. Nivetha , G. Vidhya, ...
Assessment Of Free Radical In Ethyl Acetate Extract Of Pandanus Julianettii Frui...
Krisna Dewi, Helmina Pigai, Eva S. Simaremare, Septiani Mangiwa, Aliya Rysbekova, Erpina S. M. Nadea...
A Review On Assessment And Management Of Polycystic Ovarian Syndrome (PCOS) In T...
R. Thrisha, P. Udhaya Kumar , V. S. Rekha, S. Suba Varshini , A. Nivetha , G. Vidhya, ...
Assessment Of Free Radical In Ethyl Acetate Extract Of Pandanus Julianettii Frui...
Krisna Dewi, Helmina Pigai, Eva S. Simaremare, Septiani Mangiwa, Aliya Rysbekova, Erpina S. M. Nadea...