View Article

Abstract

The leaves of Syzygium guineense have been founded useful for the control and cure of malaria, and performed antiplasmodial activity in vitro. Investigation of this plant was carried out to analyse antioxidant and antimicrobial properties of characterized essential oil of the leaf of Syzgium guineense (S. guineense). Essential oil obtained by hydrodistillation was identifyed by gas chromatography coupled with mass spectrometry (GC-MS). The antioxidant potential was discovered by measuring the inhibition of 2,2-diphenyl-1-picrylhydrazyl hydrate radical (DPPH). The essential oil were tested against five bacteriafor gives their inhibitory effects : “Mycobacterium bovis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Staphylococcus aureus” and one fungus: Candida albicans using broth microdilution method. The GC-MS analysis revealed the presence of 46 components accounting for 92.63% of the essential oil constituents. Sesquiterpenoids (73.15%) and monoterpenoids (14.17%) were the main classes of the essential oil. Aromadendrene (6.98%), germacrene B (5.52%) and ?-selinene (3.94%) were the predominant sesquiterpene hydrocarbons. The oxygenated sesquiterpenes were ?-cadinol (6.68%), ?-cadinol (6.64%) and caryophyllene oxide (5.44%). Butylated hydroxytoluene (BHT) exhibited higher antioxidant activity compare to the essential oil. The essential oil revealed strong antimicrobial activities against the tested microorganism with MIC ranging between 25- 100?g/mL. Results showed that the leaf essential oil of S. guineense had high amount of sesquiterpenoids (73.15%) with strong antioxidant and antimicrobial activities.

Keywords

Phytochemical, Pharmacological, Extract

Reference

  1. Mulyaningsih S, Sporer F, Zimmermann S, Reichling J, Wink M. Synergistic properties of the terpenoids aromadendrene and 1,8-cineole from the essential oil of Eucalyptus globulus against antibiotic-susceptible andantibiotic-resistant pathogens. Phytomedicine 2010; 17(13):1061–1066
  2. Swamy MK, Sinniah UR. A comprehensive review on the phytochemical constituents and pharmacological activities of Pogostemon cablin Benth.: an aromatic medicinal plant of industrial importance. Molecules 2015; 20(5): 8521–8547.
  3. Ali B, Al-Wabel NA, Shams S, Ahamad A, Khan SA, Anwar F. Essential oils used in aromatherapy: a systemic review. Asian Pac J Trop Biomed 2015; 5(8): S601–S61137.
  4. Ior LD, Otimenyin O, Umar M. Anti-inflammatory and analgesic activities of the ethanolic extract of the leaf of Syzygium guineense in rats and mice. J Pharm. 2012
  5. E. J. Adjanohoun, V. Adjakidjè, M. R. A. Ahyi, L. Aké Assi, A. Akoègninou, J. d’Almeida, F. Apovo, K. Boukef, M. Chadaré, G. Cusset, K. Dramane, J. Eymé, J.-N. Gassita, N. Gbaguidi, E. Goudoté, S. Guinko, P. Houngnon, Issa Lo, A. kéita, H. V. Kiniffo, D. Koné-Bamba, A. Musampa Nseyya, M. Saadou, Th. Sodogandji, S. de Souza, A. Tchabi, C. Zinsou Dossa, Th. Zohoun (1989). Médecine Traditionnelle et Pharmacopée - Contribution aux études ethnobotaniques et floristiques en République Populaire du Bénin, ACCT, 359
  6. G.-A. Ambé (2001). Les fruits sauvages comestibles des savanes guinéennes de Côte- d’Ivoire: état de la connaissance par une population locale, les Malinké. Biotechnol. Agron. et Soc. Environ. 5(1), 43-58.
  7. P. S. Segawa and J. M. Kasenene (2007). Plants for malaria treatment in Southern Uganda: traditional use, preference and ecological viability. Journal of Ethnobiology, 27, 110-131.
  8. T. M. Tsakala, O. Penge and K. John (1996). Screening of in vitro antibacterial activity from Syzygium guineense (Willd) hydrosoluble dry extract. Ann. Pharm. Fr. 54, 276-279.
  9. F. A. Hamil, S. Apio, N. K. Mubiru, M. Mosango, R. Bukenya-Ziraba, O. W. Maganyi, D. D. Soejarto (2000). Traditional herbal drugs of southern Uganda, I. Journal of Ethnopharmacology, 70, 281 - 300.
  10. O. G. A. Oluwolé, S. D. Pricilla, D. M. Jerome, P. M. Lydia (2002). Some herbal remedies from Manzini region of Swaziland. Journal of Ethnopharmacology, 79, 109- 112.
  11. M. W. Koné, K. K. Atindehou, H. Tere, D. Traoré, (2002). Quelques plantes médicinales utilisées en pédiatrie traditionnelle dans la région de Ferkessedougou (Côte-d’Ivoire). Bioterre, Rev. Inter. Sci. de la Vie et de la Terre, Editions Universitaires de Côte d’Ivoire, N° spécial, 30-36.
  12. Sheila M, Godeliver K, Charles WM, Lucy M. Determination of mineral content, cytotoxicity and anthelmintic activity of Syzygium guineense Fruits. Saudi J. Med. Pharmaceut. Sci. 2016; 2:95-99
  13. Tiwari P, Kumar B, Kaur M, Kaur H. Phytochemical screening and extraction: A review. Int. Pharmaceut. Sci., 2011; 1:98-106.
  14. Alebiosu CO. Phytochemical screening, thin-layer chromatographic studies and UV analysis of extracts of Citrullus lanatus. J Pharmaceut. Chem. Biol. Sci. 2015; 3:214-220.
  15. Wozniak L, Pska SS, Marsza?e K. Ursolic acid: A pentacyclic triterpenoid with a wide spectrum of pharmacological activities. Molecules. 2015; 20:20614- 206419.
  16. Djoukeng JD, Abou-Mansour E, Tabacchi R, Tapondjou AL, Bouda H, Lontsi D. Antibacterial triterpenes from Syzygium guineense (Myrtaceae). J. Ethnopharmacol. 2005. 101(1–3): 283–286.
  17. Musabayane CT, Mahlalela N, Shode FO, Ojewole JA. Effects of Syzygium cordatum (Hochst.) [Myrtaceae] leaf extract on plasma glucose and hepatic glycogen in streptozotocin-induced diabetic rats. J. Ethnopharmacol.
  18. IOR LD, Otimenyin 1SO, Umar M. Anti-Inflammatory and Analgesic Activities of the Ethanolic Extract of the Leaf of Syzygium Guineense in Rats and Mice. IOSR J Pharm. 2012. 4(2): 33-36.
  19. Yumi Y, Richard BG. Therapeutic Potential of I
  20. Anatole Pieme C, Ngoupayo J, Nkoulou CHK, Bruno MM, Legrand B, Nono N, et al., Syzyguim guineense Extracts Show Antioxidant Activities and Beneficial Activities on Oxidative Stress Induced by Ferric Chloride in the Liver Homogenate. Antioxidants. 2014. 3(3): 618-635
  21. Tsakala TM, Penge O, John K. Screening of in vitro antibacterial activity from Syzygium guineense (Willd) hydrosoluble dry extract. Ann Pharm Fr. 1996. 54(6): 276-279
  22. Djoukeng JD, Abou-Mansour E, Tabacchi R, Tapondjou AL, Bouda H, Lontsi D. Antibacterial triterpenes from Syzygium guineense (Myrtaceae). J. Ethnopharmacol. 2005. 101(1–3): 283–286

Photo
Kokate Rohit
Corresponding author

Saraswati Institute of Pharmacy Kurtadi , Hingoli

Photo
Kharbe Vitthal
Co-author

Saraswati Institute of Pharmacy Kurtadi , Hingoli

Photo
Kirtankar Tejaswini
Co-author

Saraswati Institute of Pharmacy Kurtadi , Hingoli

Photo
Lashkar Priti
Co-author

Saraswati Institute of Pharmacy Kurtadi , Hingoli

Photo
Sumit S. Bodkhe
Co-author

Assistant Professor Saraswati Institute of Pharmacy , Kurtadi Dist. Hingoli, Maharashtra , India (Pharmacognosy Department)

Kharbe vitthal, Kirtankar Tejaswini, Kokate Rohit, Lashkar Priti, Sumit S. Bodkhe, Review On Phytochemical And Pharmacological Investigation of Syzygium Guineense Extract, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 50-55. https://doi.org/10.5281/zenodo.10459289

More related articles
Exploring the Therapeutic Potential of Cassia alat...
SINDHU V., Dr. ARUN KUMAR K. V., ANAGHA MOHAN, HARITHA K., MEGHA ...
Phytochemical Study And Evaluation Of The Antimicr...
Amoussatou Sakirigui, Franck Yovo , Raymond Houssou Fatondji, Sè...
Phytochemical, Macroscopic, And Pharmacological Insights into Medicago Sativa: A...
Nawaz Shariff, Dr. Deepak Kumar Jha, Kusu Susan Cyriac, ...
Phytochemical Screening and Biological Evalution OF Daucus Carota Root & Stem Ex...
Satish Ponnada, Tompala Bhavani, Palla Janaki, Seela Likitha, Varanasi Swetha, Tamarapalli Sneha, Tu...
Formulation And Evaluation Of Herbal Cough Syrup...
Lodwal Pavanraj Bhagwan, Tejaswini Kanhaiyasing Pardeshi, asst. prof. Ram B Ingle, Kale Dipak Raju, ...
Related Articles
Development of Alcohol-Free Herbal Sanitizer Using Silver Nanoparticles: A Susta...
Nikhil Kadam, Prassanna Bhadange, Vinayak Bhavsar, Vaishnavi Bohade, Yash Bachhav, Ritesh Karmarkar,...
Gastric Ulcers: Understanding Pathophysiology and Advances in Treatment...
Gaurav Sawant, Prashant Kumbhar, Dr. Sanganna Burli, Vikas Dhole, ...
Exploring The Impact of Euphorbia Milii in The Medicine: A Comprehensive Review...
D. Sushma, Vadlamanu Priyanka, Bikkannagari Hari Vardhan, Jellala Pranitha, Hanumadri Nithin, Kulla ...
Benzimidazole: A Versatile Pharmacophore For Diverse Therapeutic Applications...
Rubayyath.k, Shafnaz Abdul Rahman, Rahila, Digi Davis C, Neeshma k, Ramsiya k, Razana Binth Yoosuf P...
More related articles
Exploring the Therapeutic Potential of Cassia alata: A Comprehensive Review of I...
SINDHU V., Dr. ARUN KUMAR K. V., ANAGHA MOHAN, HARITHA K., MEGHA V. S., M. ROSHNI, SANDHRA S., ...
Phytochemical Study And Evaluation Of The Antimicrobial Agonist Effect Of A. Sat...
Amoussatou Sakirigui, Franck Yovo , Raymond Houssou Fatondji, Sèmiyou Osseni, Kamirou Chabi Sika, C...
Exploring the Therapeutic Potential of Cassia alata: A Comprehensive Review of I...
SINDHU V., Dr. ARUN KUMAR K. V., ANAGHA MOHAN, HARITHA K., MEGHA V. S., M. ROSHNI, SANDHRA S., ...
Phytochemical Study And Evaluation Of The Antimicrobial Agonist Effect Of A. Sat...
Amoussatou Sakirigui, Franck Yovo , Raymond Houssou Fatondji, Sèmiyou Osseni, Kamirou Chabi Sika, C...