1PG Student, Department Of Pharmacy, Annamalai University, Chidambaram – 608 002
2PG Student, Department Of Pharmacy, Annamalai University, Chidambaram- 608 002
Liquisolid technique is one of the technique to improve the solubility of poorly water soluble drugs. Nearly 60 % of the newly developed drugs possess the problem of low oral bioavailability due to low aqueous solubility. One of the novel approaches to overcome this problem is liquisolid technique. This technique involves mixing the solution or suspension of drug with appropriate amount of carrier and coating material to form freely flowing compressible powder. This paper briefly describes about the various components of the liquisolid formulation and also specifies the evaluation parameters of the liquisolid compacts. This paper explains about Spireas theory for calculating appropriate amount of carrier and coating material to be incorporated in the liquisolid formulation. This paper also describes the various applications of the liquisolid technique including bioavailability enhancement, prolongation of drug release, improvement of photostability. As a whole, the liquisolid technique is considered as the effective method to improve the solubility of poorly water soluble drugs.
R.Teenadhayalan*, S.Vignesh, Review On Liquisolid Compacts – An Approach To Enhance The Solubility Of Bcs Class Ii Drugs, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 416-424. https://doi.org/10.5281/zenodo.10200696