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  • Post Traumatic Stress Disorder and Associated Psychological Disorders: A Comprehensive Review
  • *Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore
    2Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore 
    3Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore
     

Abstract

Post-traumatic stress disorder (PTSD) is a complex mental health condition that can develop after experiencing or witnessing a traumatic event. The symptoms of PTSD include intrusive thoughts, avoidance, negative changes in mood and cognition and changes in arousal and reactivity. PTSD is commonly caused by traumatic events such as combat exposure, assault, natural disasters, accidents, or sudden loss. Explored are its symptoms, causes, and diverse treatment options, emphasizing both pharmacological (e.g., SSRIs, SNRIs, and prazosin) and non-pharmacological approaches (e.g., CBT, EMDR, and MBIs). The intricate interplay of biological and psychological factors contributing to PTSD's onset, along with nuanced DSM-5 diagnostic criteria, highlights the disorder's complexity. Vigilant screening for PTSD is crucial, given the prevalence of traumatic events. Integrated care is essential, recognizing the nexus between PTSD and associated disorders such as acute stress disorder, generalized anxiety disorder, depressive disorders, and substance use disorders. This review underscores the imperative for a holistic, patient-centered approach, integrating clinical advances for improved PTSD identification, treatment, and overall mental health outcomes.

Keywords

Post traumatic stress disorder, acute stress disorder, generalized anxiety disorder, depressive disorders, and substance use disorders.

Reference

  1. Sareen J. Posttraumatic stress disorder in adults: impact, comorbidity, risk factors, and treatment. Can J Psychiatry. 2014; 59(9):460-7.
  2. Bremner JD, Southwick SM, Johnson DR, Yehuda R, Charney DS. Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans. Am J Psychiatry. 1993; 150(2):235-9.
  3. Mann SK, Marwaha R. Posttraumatic stress disorder. StatPearls Publishing LLC; [cited 2023 Dec 15]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK559129/
  4. Wang Z, Zhu H, Yuan M, Li Y, Qiu C, Ren Z, Yuan C, Lui S, Gong Q, Zhang W. The resting-state functional connectivity of amygdala subregions associated with post-traumatic stress symptom and sleep quality in trauma survivors. European archives of psychiatry and clinical neuroscience. 2021; 271:1053-64.
  5. Yehuda R, Hoge CW, McFarlane AC, Vermetten E, Lanius RA, Nievergelt CM, Hobfoll SE, Koenen KC, Neylan TC, Hyman SE. Post-traumatic stress disorder. Nature reviews Disease primers. 2015; 1(1):1-22.
  6. Lok A, Frijling JL, van Zuiden M. [posttraumatic stress disorder: current insights in diagnostics, treatment and prevention]. Ned Tijdschr Geneeskd. 2018; 161: D1905.
  7. Bryant RA, Friedman MJ, Spiegel D, Ursano R, Strain J. A review of acute stress disorder in DSM-5. Depress Anxiety. 2011; 28(9):802-17.
  8. Posttraumatic stress disorder. In: Diagnostic and Statistical Manual of Mental Disorders DSM-5. 5th ed. Arlington, Va.: American Psychiatric Association; 2013. http://www.psychiatryonline.org. Accessed Dec.13, 2016.
  9. North CS, Suris AM, Davis M, Smith RP, Toward Validation of the Diagnosis of Posttraumatic Stress Disorder. Am. J. Psychiatry. 2009; 166:34–41.
  10. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. American Psychiatric Association; Arlington, VA, USA: 2013.
  11. Foa EB, Asnaani A, Zang Y, Capaldi S, Yeh R. Psychometrics of the Child PTSD Symptom Scale for DSM-5 for Trauma-Exposed Children and Adolescents. J Clin Child Adolesc Psychol. 2018; 47(1):38-46.
  12. Flory JD, Yehuda R. Comorbidity between post-traumatic stress disorder and major depressive disorder: alternative explanations and treatment considerations. Dialogues Clin Neurosci. 2015; 17(2):141-50.
  13. Friedman MJ, Marmar CR, Baker DG, Sikes CR, Farfel GM. Randomized, double-blind comparison of sertraline and placebo for posttraumatic stress disorder in a Department of Veterans Affairs setting. Journal of Clinical Psychiatry. 2007; 68(5):711-20.
  14. Alexander W. Pharmacotherapy for post-traumatic stress disorder in combat veterans: focus on antidepressants and atypical antipsychotic agents. Pharmacy and Therapeutics. 2012; 37(1):32.
  15. Davidson JR, Rothbaum BO, Tucker P, Asnis G, Benattia I, Musgnung J J, Venlafaxine Extended Release for the Treatment of Posttraumatic Stress Disorder: A Single-Blind, 12-Week, Flexible-Dose, Placebo-Controlled Study. Journal of Clinical Psychopharmacology, 26(3), 259–267.
  16. Davidson JR, Rothbaum BO, van der Kolk BA, Sikes CR, Farfel GM. Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder. Archives of general psychiatry. 2001; 58(5):485-92.
  17. Raskind MA, Peskind ER, Chow B, Harris C, Davis-Karim A, Holmes HA, Hart KL, McFall M, Mellman TA, Reist C, Romesser J. Trial of prazosin for post-traumatic stress disorder in military veterans. New England Journal of Medicine. 2018; 378(6):507-17.
  18. PA, Nishith P, Weaver TL, Astin MC, Feuer CA. A comparison of cognitive-processing therapy with prolonged exposure and a waiting condition for the treatment of chronic posttraumatic stress disorder in female rape victims. Journal of consulting and clinical psychology. 2002; 70(4):867.
  19. Shapiro F. Efficacy of the eye movement desensitization procedure in the treatment of traumatic memories. Journal of traumatic stress. 1989; 2(2):199-223.
  20. Lee CW, Cuijpers P. A meta-analysis of the contribution of eye movements in processing emotional memories. Journal of behavior therapy and experimental psychiatry. 2013; 44(2):231-9.
  21. Kearney DJ, McDermott K, Malte C, Martinez M, Simpson TL. Association of participation in a mindfulness program with measures of PTSD, depression and quality of life in a veteran sample. Journal of clinical psychology. 2012; 68(1):101-16.
  22. Polusny MA, Erbes CR, Thuras P, Moran A, Lamberty GJ, Collins RC, Rodman JL, Lim KO. Mindfulness-based stress reduction for posttraumatic stress disorder among veterans: a randomized clinical trial. Jama. 2015; 314(5):456-65.
  23. Bryant RA, O’Donnell ML, Creamer M, McFarlane AC, Silove D. A multisite analysis of the fluctuating course of posttraumatic stress disorder. JAMA psychiatry. 2013; 70(8):839-46.
  24. Hofmann SG, Smits JA, Asnaani A, Gutner CA, Otto MW. Cognitive enhancers for anxiety disorders. Pharmacology Biochemistry and Behavior. 2011; 99(2):275-84
  25. Ruscio AM, Chiu WT, Roy-Byrne P, Stang PE, Stein DJ, Wittchen H-U, et al. Broadening the definition of generalized anxiety disorder: Effects on prevalence and associations with other disorders in the National Comorbidity Survey Replication. J Anxiety Disord. 2007;21(5):662–76
  26. Campbell DG, Felker BL, Liu CF, Yano EM, Kirchner JE, Chan D, Rubenstein LV, Chaney EF. Prevalence of depression–PTSD comorbidity: Implications for clinical practice guidelines and primary care-based interventions. Journal of general internal medicine. 2007; 22:711-8.
  27. Back SE, Brady KT, Jaanimägi U, Jackson JL. Cocaine dependence and PTSD: A pilot study of symptom interplay and treatment preferences. Addictive behaviors. 2006; 31(2):351-4.

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Abhirami Jayaram
Corresponding author

Department of Pharmacy Practice, Srinivas College of Pharmacy, Valachil, Mangalore

Photo
K. Vineetha
Co-author

Department of Pharmacy Practice, Srinivas College of Pharmacy, Valachil, Mangalore

Photo
A. R. Shabaraya
Co-author

Department of Pharmacy Practice, Srinivas College of Pharmacy, Valachil, Mangalore

Abhirami Jayaram*, K. Vineetha, A. R. Shabaraya, Post Traumatic Stress Disorder and Associated Psychological Disorders: A Comprehensive Review, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 880-887. https://doi.org/10.5281/zenodo.10436017

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