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  • Phytopharmaceutical Development of a Pain-Relieving Herbal Roll-On

  • Department of Pharmacy Dr. C. V. Raman University, Khandwa

Abstract

This study involves the formulation and evaluation of a herbal roll-on aimed at providing relief from migraine pain. "Migraine is a neurological condition that causes repeated, severe headaches, often interfering with an individual’s daily routine and quality of life.". In search of a natural, side-effect-free solution, a herbal roll-on was developed using essential oils known for their analgesic, anti-inflammatory, and soothing properties. The selected essential oils—Tulsi, Lavender, and Mint—were blended with a suitable carrier oil to ensure proper absorption and skin compatibility. The oils were extracted through oil distillation to preserve their natural potency and purity. The final formulation was assessed based on parameters such as physical appearance, spreadability, stability, and user acceptability. The roll-on showed smooth texture, appealing aroma, and was easy to apply. Upon application to the forehead and temples, it provided a cooling sensation and noticeable relief from migraine symptoms, attributed to the synergistic action of the herbal components. This formulation presents a convenient, natural alternative to conventional migraine treatments, promoting the use of plant-based therapies in pain management. The study supports further research into herbal solutions for effective and safe therapeutic applications.

Keywords

Herbal roll on, essential oil, Migraine, Formulation, Evaluation

Introduction

Herbal roll-ons are the natural liquid preparation containing volatile oils used to relieve pain and stress.

Tulsi-Tulsi has a scared and highly valued herb in Hinduism and ayurveda. Tulsi has a wide range of traditional uses in Ayurveda, from treating respiratory ailments and digestive problems to promoting long variety and spiritual well- being. It is known for its various therapeutic properties including anti-inflammatory, anti-microbial , and antioxidant properties..

Peppermint- Mentha piperita L. is an important medicinal herb worldwide, apart from its potent Uses as flavouring agent in cosmetics, pharmaceutical products amongst others. Quality of M. piperita L. and efficacy are reported to be best. It’s widely cultivated for it’s essential oil , which is used in various products, including culinary, medicinal and cosmetic applications. Peppermint is known for its potential benefits in relieving digestive issues and headaches.

Lavender oil- Inhalation of lavender oil is also reported to be of benefit in pain relief. Lavender oil ass been shown into an effective short-term treatment for lower back pain.

Coconut oil-It has a moisturizing effect when applied to the skin. People commonly use coconut oil for eczema and growth in premature infants. It’s also used for psoriasis, obesity, breast cancer, heart disease, MS and many conditions.

MATERIALS AND REQUIREMENT-

Peppermint oil [20ml] , Lavender oil [20ml] , Tulsi oil [ 20 ml] ,Coconut oil [ 40ml]

GLASSWARES-Beakers , Glass rod, Conical flask , Volumetric flask.

Table no 1: List of ingredients used in the preparations of Herbal Roll-on

s.no.

Name   of the essential oil

Biological source

Purpose/ uses

References

1.

Lavender oil

Flowers            of Lavandula angustifolia belongs            to         the family Lamiaceae

lavender can help treat headaches, migraine and is used in aromatherapy.

[6]

2.

Tulsi  oil

Tulsi plant biological name is ocium tenuiflorium and belongs to the family Laminaceae

Respiratory and digestive support, as well as its potential to boost the immune system and reduce stress.

[1]

3.

Peppermint oil

Peppermint plant belons to Mentha piperita L. and belongs  to family Laminaceae

To aid digestion , relieve symptoms of IBS , and reduce headaches, also used for muscle and nerve pain.

[3]

4.

Coconut oil

The scientific name for coconut oil is cocos nucifera belongs to family Areaceae

Moisturizing , Anti-inflammatory and antimicrobial properties.

[7]

METHOD OF PREPARATION- the technique used to prepare herbal roll-on is a simple blending process. It involves the simple mixing of all the ingredients based on the formulation mentioned in table no.2.                                                 

Table no 2: Formulation for Herbal Roll-on:

Ingredients

Quantity required

Lavender oil

20 ml

Tulsi oil

20 ml

Peppermint oil

20 ml

Coconut oil

40 ml

Evaluation tests of herbal roll on:

Organoleptic Evaluation:  the herbal roll-on was evaluated for its organoleptic properties such as color, odor, and texture.

Removal: Roll-on is applied on the skin and removed by washing with tap water.

Irritancy test: Roll on is applied on the skin and checked for redness, edema, inflammation, and irritation.

Test for microbial growth: The Formulated roll-on was inoculated on the agar media plates by streak plate method  and control was  prepared by excluding the cream. The plates were placed into the incubator and incubated at 37°C for 24 hours. After the incubation period, plates were taken out and checked for microbial growth by comparing them with the control.

pH Evaluation: The pH of the 1% roll-on solution was measured using a digital pH meter (Beckman, Germany).

After feel: emolliency, slipperiness and residue left after roll-on application is observed.

Stability test: Stability testing of the prepared roll- on  was  performed  to  keep  the  samples  at accelerated temperature conditions. Different roll- on  containers  were  kept  at  an  accelerated temperature of 4°C, Room temperature and 47°C, respectively.

RESULTS AND DISCUSSION

After formulating the herbal roll-on, evaluation tests were done and compared with the marketed preparation (amrutanjan roll-on). The results are tabulated in a table no.3. Based on the results of evaluation studies, the herbal roll-on shows similar reports as per marketed preparation.

         Table no 3: Comparison of formulated Herbal Roll-on with marketed roll-on

S.no.

Evaluation parameters

Observed values

Marketed prep. (amrutanjan roll-on)

1.

Organoleptic Evaluation

Strongly aromatic

Strongly aromatic

2.

After feel

Cooling effect with counter-irritant effect

Cooling  effect  with  more counter-irritant effect

3.

Removal

Easily removed

Easily removed

4.

Irritancy test

No any irritation

No any irritation

5.

Test for microbial growth

No microbial growth

No microbial growth

6.

pH Evaluation

6

6-7

7.

Stability test

More    stable   at room temperature

More    stable   at room temperature

CONCLUSION:

The main aim of formulated herbal roll-on was to relieve headache, joint pains, and neck pain and to treat cold and nasal congestion. it offers a tropical and potentially effective approach to acute migraine pain relief , it contain essentiall oils that may help alleviate nausea, anxiety, and other migraine related symptoms.

REFERENCES

  1. Pubmed centeral , National library of medicine , National center of biotechnology information , 2014 oct; dec 5; 251-259
  2. Dr. C.K. Kokate book of pharmacognosy and phytochemistry, Nirali publication , 55th addition, 1 January 2008.
  3. Journal of Pharmacognosy and phytochemistry , Peppermint a medicinal herb and treasure of health: a review article by Parv Nayak and  Tankesh kumar.
  4. MDPI, Lavendor essential oil as antibacterial treatment , published 24 December , 2022.
  5. Coconut oil ; chemistry, production and its applications , A review article by Krishna     A.G, Gaurav Raj.
  6. Australian infaction control, A review article on Lavender essential oil , by Jenny M. Wilkson , Volume 10 , issue 1, march 2005, pages- 35 to 37.
  7. Science alert, journal of pharmacology and toxicology, year 2022, volume 17, page no-36 to 42.

Reference

  1. Pubmed centeral , National library of medicine , National center of biotechnology information , 2014 oct; dec 5; 251-259
  2. Dr. C.K. Kokate book of pharmacognosy and phytochemistry, Nirali publication , 55th addition, 1 January 2008.
  3. Journal of Pharmacognosy and phytochemistry , Peppermint a medicinal herb and treasure of health: a review article by Parv Nayak and  Tankesh kumar.
  4. MDPI, Lavendor essential oil as antibacterial treatment , published 24 December , 2022.
  5. Coconut oil ; chemistry, production and its applications , A review article by Krishna     A.G, Gaurav Raj.
  6. Australian infaction control, A review article on Lavender essential oil , by Jenny M. Wilkson , Volume 10 , issue 1, march 2005, pages- 35 to 37.
  7. Science alert, journal of pharmacology and toxicology, year 2022, volume 17, page no-36 to 42.

Photo
Devyani Kanungo
Corresponding author

Department of Pharmacy Dr. C. V. Raman University, Khandwa

Photo
Sneha Meena
Co-author

Department of Pharmacy Dr. C. V. Raman University, Khandwa

Devyani Kanungo*, Sneha Meena, Aayushi Laad, Phytopharmaceutical Development of a Pain-Relieving Herbal Roll-On, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 6, 1979-1982. https://doi.org/10.5281/zenodo.15632640

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