View Article

  • Multifarious Effects Of Benidipine In Vitro And In Vivo A Review
  • 1M Pharm, Assistant Professor, Department of Pharmacy Practice, PSG College of Pharmacy, 2295+PCJ, Peelamedu, Avinashi Rd, Coimbatore, Tamil Nadu- 641004.
    2-4Doctor of Pharmacy, Student, PSG College of Pharmacy,2295+PCJ, Peelamedu, Avinashi Rd, Coimbatore, Tamil Nadu- 641004.
     

Abstract

BACKGROUND: Worldwide, around 25% of individuals suffer from Hypertension is an elevated blood pressure in arteries. Benidipine is an anti-hypertensive drug and it is a long-acting agent. It blocks all the L,N and T-type calcium channels. MAIN TEXT: Other than anti-hypertensive action, benidipine has other pharmacological effects. In-vivo basic research has shown that benidipine has anti-oxidative properties,stimulatesnitric oxide production, promotes osteoblast differentiation, prevents the formation of mesangial cells, prevents the proliferation of smooth muscles in the vascular system, and safeguards the kidney and muscular tissue of the heart. The purpose of the review is to study the effects of benidipine in in-vitro and in-vivo and its beneficial actions in different disease states. CONCLUSION: Benidipine is therapeutically well effective such as Reno-protective, Cardioprotective, and Neuro-protectivehas a stronger inhibitory impact on ureteric contractility in the distal ureter also effective in osteogenesis and osteoporosis conditions

Keywords

Hypertension, Benidipine, Cardio-protective, Reno-protective, Neuro-protective, osteoporosis

Reference

  1. Oparil, S., Acelajado, M. C., Bakris, G. L., Berlowitz, D. R., Cífková, R., Dominiczak, A. F., Grassi, G., Jordan, J., Poulter, N. R., Rodgers, A., & Whelton, P. K. (2018). Hypertension. Nature reviews. Disease primers, 4, 18014. https://doi.org/10.1038/nrdp.2018.14
  2. Yao, K., Nagashima, K., & Miki, H. (2006). Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker. Journal of pharmacological sciences, 100(4), 243–261. https://doi.org/10.1254/jphs.dtj05001x
  3. Koçak, M. N., Arslan, R., Albayrak, A., Tekin, E., Bayraktar, M., Çelik, M., Kaya, Z., Bekmez, H., &Tavaci, T. (2021). An antihypertensive agent benidipine is an effective neuroprotective and antiepileptic agent: an experimental rat study. Neurological research, 43(12), 1069–1080. https://doi.org/10.1080/01616412.2021.1949685
  4. Yang, Y., Chen, W., Wen, N., Cai, C., Liu, Q. H., & Shen, J. (2019). Benidipine, an anti-hypertensive drug, relaxes mouse airway smooth muscle. Life sciences, 227, 74–81. https://doi.org/10.1016/j.lfs.2019.04.036
  5. Akinaga, S., Kobayashi, H., Kobayashi, S., Inoue, A., Nakamizo, N., & Oka, T. (1988). Determination of the calcium antagonist benidipine hydrochloride in plasma by sensitive radioimmunoassay. Arzneimittel-Forschung, 38(11A), 1738–1741.
  6. Matsunaka, K., Imai, M., Sanda, K., Yasunami, N., Furuhashi, A., Atsuta, I., Wada, H., & Ayukawa, Y. (2022). Therapeutic Effect of Benidipine on Medication-Related Osteonecrosis of the Jaw. Pharmaceuticals (Basel, Switzerland), 15(8), 1020. https://doi.org/10.3390/ph15081020
  7. Ma, Z. P., Liao, J. C., Zhao, C., & Cai, D. Z. (2015). Effects of the 1, 4-dihydropyridine L-type calcium channel blocker benidipine on bone marrow stromal cells. Cell and tissue research, 361(2), 467–476. https://doi.org/10.1007/s00441-015-2115-x
  8. Cakir, T., Yucetas, S. C., Yazici, G. N., Sunar, M., Arslan, Y. K., & Suleyman, H. (2021). Effects of Benidipine Hydrochloride on Ischemia Reperfusion Injury of Rat Brain. Turkish neurosurgery, 31(3), 310–317. https://doi.org/10.5137/1019-5149.JTN.27372-19.3
  9. Liu, H. R., Gao, F., Tao, L., Yan, W. L., Gao, E., Christopher, T. A., Lopez, B. L., Hu, A., & Ma, X. L. (2004). Antiapoptotic mechanisms of benidipine in the ischemic/reperfused heart. British journal of pharmacology, 142(4), 627–634. https://doi.org/10.1038/sj.bjp.0705847
  10. Yao, K., Ina, Y., Sonoda, R., Nagashima, K., Ohmori, K., & Ohno, T. (2003). Protective effects of benidipine on hydrogen peroxide-induced injury in rat isolated hearts. The Journal of pharmacy and pharmacology, 55(1), 109–114. https://doi.org/10.1111/j.2042-7158.2003.tb02440.x
  11. Kazama, I., Baba, A., Matsubara, M., Endo, Y., Toyama, H., &Ejima, Y. (2014). Benidipine suppresses in situ proliferation of leukocytes and slows the progression of renal fibrosis in rat kidneys with advanced chronic renal failure. Nephron. Experimental nephrology, 128(1-2), 67–79. https://doi.org/10.1159/000368080
  12. Wu, G., Xu, M., Xu, K., & Hu, Y. (2013). Benidipine protects kidney through inhibiting ROCK1 activity and reducing the epithelium-mesenchymal transdifferentiation in type 1 diabetic rats. Journal of diabetes research, 2013, 174526. https://doi.org/10.1155/2013/174526
  13. Abe, M., Okada, K., Maruyama, N., Matsumoto, S., Maruyama, T., Fujita, T., Matsumoto, K., & Soma, M. (2011). Benidipine reduces albuminuria and plasma aldosterone in mild-to-moderate stage chronic kidney disease with albuminuria. Hypertension research : official journal of the Japanese Society of Hypertension, 34(2), 268–273. https://doi.org/10.1038/hr.2010.221
  14. Ohta, M., Sugawara, S., Sato, N., Kuriyama, C., Hoshino, C., & Kikuchi, A. (2009). Effects of benidipine, a long-acting T-type calcium channel blocker, on home blood pressure and renal function in patients with essential hypertension: a retrospective, 'real-world' comparison with amlodipine. Clinical drug investigation, 29(11), 739–746. https://doi.org/10.2165/11320000-000000000-00000
  15. Makino, H., Aoki, M., Hashiya, N., Yamasaki, K., Shimizu, H., Miwa, K., Ogihara, T., & Morishita, R. (2005). A calcium-channel blocker, benidipine, improves forearm reactive hyperemia in patients with essential hypertension. Blood pressure. Supplement, 1, 39–44. https://doi.org/10.1080/08038020510040612
  16. Matsubara, M., & Hasegawa, K. (2004). Effects of benidipine, a dihydropyridine-Ca2+ channel blocker, on expression of cytokine-induced adhesion molecules and chemoattractants in human aortic endothelial cells. European journal of pharmacology, 498(1-3), 303–314. https://doi.org/10.1016/j.ejphar.2004.07.086
  17. Wang, B., Yang, J., Fan, L., Wang, Y., Zhang, C., & Wang, H. (2021). Osteogenic effects of antihypertensive drug benidipine on mouse MC3T3-E1 cells in vitro. Journal of Zhejiang University. Science. B, 22(5), 410–420. https://doi.org/10.1631/jzus.B2000628
  18. Mathew, S. K., Naik, G. S., &Peedicayil, J. (2017). Inhibition by Benidipine of Contractility of Isolated Proximal and Distal Caprine Ureter. International journal of applied & basic medical research, 7(3), 155–159. https://doi.org/10.4103/ijabmr.IJABMR_87_16

Photo
Vishnupriya S.
Corresponding author

M Pharm, Assistant Professor, Department of Pharmacy Practice, PSG College of Pharmacy, 2295+PCJ, Peelamedu, Avinashi Rd, Coimbatore, Tamil Nadu- 641004.

Photo
Dhinesh M.
Co-author

Doctor of Pharmacy, Student, PSG College of Pharmacy,2295+PCJ, Peelamedu, Avinashi Rd, Coimbatore, Tamil Nadu- 641004.

Photo
Anjitha P. S.
Co-author

Doctor of Pharmacy, Student, PSG College of Pharmacy,2295+PCJ, Peelamedu, Avinashi Rd, Coimbatore, Tamil Nadu- 641004.

Photo
Eniya A. A.
Co-author

Doctor of Pharmacy, Student, PSG College of Pharmacy,2295+PCJ, Peelamedu, Avinashi Rd, Coimbatore, Tamil Nadu- 641004.

Vishnupriya S , Dhinesh M. , Anjitha P. S. , Eniya A. A. , Multifarious Effects Of Benidipinein Vitro And In Vivo - A Review, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 676-683. https://doi.org/10.5281/zenodo.10702076

More related articles
Recent Advance Study On Antifungal Drug Evaluation...
Sarthak Kothali, Sourabh Patil, Shreyash Koli, Suvarna Deshmukh, ...
Formulation And Evaluation Of Herbal Face Gel Usin...
Savri A. Jadhav, Sadhana Dnyaneshwar Gachande, Dinesh Sanjay Jadh...
Cognitive Proficiency Evaluation In Haemodialysis ...
V. Sathish Kumar, T. Sai Swapna, D. Sumalatha, M. Lakshmi Surya P...
Safety And Efficacy Of Diuretics With Reduced Ejection Fraction In Heart Failure...
G. Anjani Tejaswi, P. Shaheera, A. Navya Sree, M. Bala Tripura Sundari, P. Seetaramayya, Velaga Mahe...
Formulation And Evaluation Of Floating Sustain Release Tablet Of Ranolazine ...
Samrudh kiran Shinde, Shivaji Patil, Namrata Satkar, Pritam Salokhe, Nilesh Chougule, ...
Related Articles
Harmonizing Tulsi: The Quest For Standardization...
Prerna Sharma, Satish Kumar Sharma, ...
Formulation and Evaluation of Polyherbal Lozenges...
Abhilash Kutlehria, Koushal Kumar, Kapil Kumar Verma, ...
Formulation and Development of Metformin Sustained Release Tablets by Hydrophili...
Subhajit Roy, Mayukh Jana, Amlan Bishal, Anwesha Adak, ...
Decoding Breast Cancer Complexity: Insights Into Pathogenesis And Emerging Treat...
Arnab Roy, K. Rajeswar Dutt, Ankita Singh, Mahesh Kumar Yadav, Anupama Kumari, Anjali Raj, Umaira Sa...
Recent Advance Study On Antifungal Drug Evaluation Method...
Sarthak Kothali, Sourabh Patil, Shreyash Koli, Suvarna Deshmukh, Tejas Kapase, Sachin Navale, Nilesh...
More related articles
Recent Advance Study On Antifungal Drug Evaluation Method...
Sarthak Kothali, Sourabh Patil, Shreyash Koli, Suvarna Deshmukh, Tejas Kapase, Sachin Navale, Nilesh...
Formulation And Evaluation Of Herbal Face Gel Using Cucumber Fruit Extract ...
Savri A. Jadhav, Sadhana Dnyaneshwar Gachande, Dinesh Sanjay Jadhav, Mayur Sakharam Gangurde, ...
Cognitive Proficiency Evaluation In Haemodialysis Patients: Unveiling Insights W...
V. Sathish Kumar, T. Sai Swapna, D. Sumalatha, M. Lakshmi Surya Prabha, P. Srikanth, ...
Recent Advance Study On Antifungal Drug Evaluation Method...
Sarthak Kothali, Sourabh Patil, Shreyash Koli, Suvarna Deshmukh, Tejas Kapase, Sachin Navale, Nilesh...
Formulation And Evaluation Of Herbal Face Gel Using Cucumber Fruit Extract ...
Savri A. Jadhav, Sadhana Dnyaneshwar Gachande, Dinesh Sanjay Jadhav, Mayur Sakharam Gangurde, ...
Cognitive Proficiency Evaluation In Haemodialysis Patients: Unveiling Insights W...
V. Sathish Kumar, T. Sai Swapna, D. Sumalatha, M. Lakshmi Surya Prabha, P. Srikanth, ...