1Department of Pharmacology, Govt. Medical College Kathua, Jammu & Kahmir, India
2Department of Medicine, Govt. Medical College Kathua, Jammu & Kahmir, India
3Department of Physiology, Govt. Medical College Kathua, Jammu & Kahmir, India
4Hamdard Institute of Medical Sciences and Research, Jamia Hamdard, New Delhi, India
Inflammatory disease that relapses and affects the skin, joints, or both. It is linked to multiple comorbidities, including metabolic, cardiovascular, mental, and renal diseases. Psoriasis has a complex etiopathogenesis that is primarily caused by an abnormal immune response as a result of genetic susceptibility and a variety of environmental variables, including trauma, infections, and medications. Treatment options for psoriasis vary depending on the disease's severity. Treatment as well but problems still exist, including side effects, resistance to therapy, exorbitant expenses, and individual differences in response. Promising new developments in psoriasis treatment are being observed for the future. Improved efficacy is provided by new biologic medicines that target novel pathways, such as interleukin 23 inhibitors like mirikizumab. ROR?t inhibitors, among other small molecule inhibitors, offer supplementary therapeutic alternatives. Combination treatments, such as methotrexate and biologics, may enhance patient response to treatment. Personalised therapy techniques utilising biomarkers and multi-omics technology could help with diagnosis, treatment response prediction, and therapeutic decision-making.
Mohd Rafi Reshi, Mariya Muzaffar, Muzamil Muzaffar, Nusrat Nabi, Nausheen Yusuf, Management Of Psoriasis: A Global Clinical Challenge And Future Treatment, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 612-623. https://doi.org/10.5281/zenodo.10563571