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Abstract

Alopecia areata is an autoimmune disorder characterized by transient, non-scarring hair loss and preservation of the hair follicle. Hair loss can take many forms ranging from loss in well-defined pat\ches to diffuse or total hair loss, which can affect all hair-bearing sites.Pfizer is developing ritlecitinib (LITFULOTM), an oral kinase inhibitor, to treat Crohn's disease, vitiligo, alopecia areata, and ulcerative colitis. Ritlecitinib was approved in the United States on June 23, 2023, for the treatment of severe alopecia areata in adults and adolescents aged 12 and above. On June 26, 2023, ritlecitinib received approval in Japan to treat alopecia areata, a condition limited to incurable cases resulting in extensive hair loss. Ritlecitinib is undergoing regulatory reviews in China and the UK and has also been given a positive opinion in the EU. The key developments in ritlecitinib's development that led to its initial approval for the treatment of severe alopecia areata are outlined in this article.

Keywords

CYP enzymes, cytotoxic clusters, Pharmacokinetics, Janus kinase inhibitor, immunosuppressants

Reference

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Mayur P. Narode
Corresponding author

Nandkumar Shinde college of pharmacy

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Shweta R. Agrawal
Co-author

Nandkumar Shinde college of pharmacy

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Pallavi R. Thombare
Co-author

Nandkumar Shinde college of pharmacy

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Nikita R. Kuhile
Co-author

Nandkumar Shinde college of pharmacy

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Omkar M. Kadam
Co-author

Nandkumar Shinde college of pharmacy

S. R. Agrawal, M. P. Narode, P. R. Thombare, N. R. Kuhile, O. M. Kadam, Litfulo : Is An Innovative Medication, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 919-925. https://doi.org/10.5281/zenodo.10442173

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