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  • Karkatshringi Pistacia Integerrima Significant Role In Cancer Treatment
  • Photo Vaidhshiromani.Dheeraj Sharma* Photo Pransu gupta Photo Tanishka Gupta Photo Rajesh K. Mishra Photo M. K. Yadav Photo Ramakant Marde

  • 1B.A.M.S. Scholar, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Patanjali Yogpeeth Phase 1 Haridwar, Uttarakhand, India.
    2Assistant Professor, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Patanjali Yogpeeth Phase 1 Haridwar, Uttarakhand, India
    3HOD Of Ras shastra Department, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Patanjali Yogpeeth Phase 1 Haridwar, Uttarakhand, India
    4HOD Of Dravyaguna Department, Patanjali Bhartiya Ayurvigyan Evam Anushandhan Sansthan, Patanjali Yogpeeth Phase 1 Haridwar, Uttarakhand, India
     

Abstract

Karkatshringi is an excellent and effective medicine of ayurvedic medical science. It is used in treatment of many diseases but it proves to be one of the best cure for cancer .Karkatshringi is also called ‘Baal Bhaisajya’ . According to the ayurvedic scriptures, it works specifically on glands and their secretions . It plays a significant role in balancing the aggrevated doshas in the body and maintains the health. Karkatshringi is used in preventing the growth of tumours. Due to the dominance of tikta rasa, it exhibits anti-viral and anti-fungal properties. Karkatshringi is the only medicine of ayurveda science which we can use uninterruptedly in cancer treatment. According to ayurveda science, karkatshringi also exhibits the qualities similar to its nomenclature such as in sanskrit language, cancer or arbuda is called as Karka Roga and being karka the first name of karkatshringi , it is also known as “KARKA ROGA NASHINI”. It implies that the medicine which suppress the cancerous or tumourous cells in the body is known as KARKATSHRINGI or KARKA ROGA NASHINI . Karkatshringi has the anti- cancerous properties that prevents the growth and spread of tumours and cancer ; and took the body to its natural healthy state. Karkatshringi due to its fundamental properties works as a dextoxification agent and balances the vitiated doshas . Being kaphaghna and vatashamak , it act to be the anti- tumourous and anti-cancerous agent ; that is why karkatshringi has a specific place in ayurveda science .

Keywords

Antitumour, Anticancerous ,Cytotoxic, Michigan Cancer Foundation-7 cell line, Pistacia integerrima, Phytochemistry, Galls, Constituents, Toxicity , Karkatshringi, Physiochemical analysis, KARKA ROGA NASHINI

Reference

  1. Grover M: Pistacia integerrima (Shringi)- A plant with significant pharmacological Activities. The Journal of Phytopharmacology 2021; 5: 323-330.
  2. Uddin G, Rauf A, Arfan M, Waliullah I, Khan M. Ali M, Taimur I, Ur-Rehman S. Pistagremic acid a new leishmanicidal triterpene isolated from Pistacia integerrima Stewart. J Enzyme Inhib Med Chem Enzyme 2012;27:646-8.
  3. Pant S, Samant SS. Ethnobotanical observations in the mornaula reserve forest of kumoun, west Himalaya, India. Ethnobot Leaf 2010;14:193.
  4. Anonymous. The Database on Medicinal Plants used in Ayurveda. New Delhi: Central Council for Research in Ayurveda and Siddha, Government of India; 2005. p. 169.
  5. Orwa C, Mutua A, Kindt R, Jamnadass R, Simons A. Agroforestree Database: A Tree Reference and Selection Guide Version 4.0. 1981;58:731-2.
  6. Chopra RN, Chopra IC. Chopra’s Indigenous Drug of India. 2nd ed. Kolkata: Academic Publishers; 2006. p. 377-8.
  7. Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants. New Delhi: Council of Scientific and Industrial Research; 1956. p. 260-1.
  8. Vashist H, Jindal A. Pharmacognostical evalution of Pistacia integerrima stew Ex Band. Int J Recent Adv Pharm Res 2012;2:70-7
  9. Amhamdi H, Aouinti F, Elbachiri JP. Chemical composition of the essential oil of Pistacia lentiscus L. from Eastern Morocco. Records Nat Prod 2009;3:90-5.
  10. Ahmad NS, Waheed A, Farman M, Qayyum A. Analgesic and antiinflammatory effects of Pistacia integerrima extracts in mice. J Ethnopharmacol 2010;129:250-3.
  11. Ahmad NS, Farman M, Najmi MH, Mian KB, Hassan A. Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout. J Ethnopharmacol 2008;117:478-82.
  12. Caputo R, Mangoni L, Monaco P, Palumbo G. Triterpenes from the galls of Pistacia palestina. Phytochemistry 1979;18:896-8.
  13. Caputo R, Mangoni L. Triterpenic acids of Pistacia terebinthus galls. Gazz Chim Ital 1970;100:317-25.
  14. Vickery JR. The occurrence of dihydromalavalic acid in some seed oils. J Am Oil Chem Soc 1981;58:731-2.
  15. Kalidhar SH, Sharma P. Chemical components of Pistacia integerrima. J Indian Chem Soc 1985;62:261.
  16. Ansari SH, Ali M, Qadry JS, Siddiqui N. Analgesic activity of tetracyclic triterpenoids isolated from Pistacia integerrima galls. Update Ayurveda 1994;94:73.
  17. Ansari SH, Ali M, Qadry JS. New tetracyclic triterpenoids from Pistacia integerrima galls. Pharmazie 1994;49:356-7.
  18. Monaco PL, Mangoni L. Terpenes in Pistacia plants: A possible defence role for monoterpenes against gall-forming aphids. Phytochemistry 1982;21:1408.
  19. Tabacik-Wlotzka C, Imbert JL, Pistre P. Isolation of polyisoprenols from the neutral extract of Pistacia terebinthus. CR. Hebd. Sci Acad Sci D 1967;265:708.
  20. Monaco PR, Caputo G, Mangoni L. Triterpene components of galls on the leaves of Pistacia terebinthus, produced by Pemphigus semilenarius. Phytochemistry 1974;13:1992.
  21. Hiroi T, Takahashi T, Imamura H. Wood extractives. XV. Constituents of Pistacia chinensis Wood, Nippon Mokuzai. Gakkaishi 1966;12:324-6.
  22. Warrier PK, Nambiar VP, Ramankutty C. Indian Medicinal Plants: A Compendium of 500 Species. Vol. 4. Hyderabad: Orient Blackswan; 1955. p. 304.
  23. Ghias UA, Ur Rehman T, Qaisar M. Phytochemical screening of Pistacia chinensis var. integerrima. Middle East J Sci Res 2011;7:707-11.
  24. AL-Saghir M. Porter D. Taxonomic revision of the genus Pistacia L. (Anacardiaceae). Am J Plant Sci 2012;3:12-32.
  25. Padulosi S, Hodgkin T, Williams J, Haq N. Managing Plant Genetic Diversity. Wallingford: IPGRI/CABI Publishing; 2002. p. 323-38.
  26. Farman M. Contribution to the Study of Flavonoids from Two Species of Pistacia (Anacardiaceae). A Doctoral Thesis, Quaid-i-Azam University, Islamabad, Pakistan: Flora of Pakistan; 2005.
  27. Kaur B, Singh S, A review on gall karkatshringi. J Med Plants Res 2015;9:636- 40.
  28. Bibi Y, Qayyum A. An overview of Pistacia integerrima a medicinal plant species: Ethnobotany, biological activities and phytochemistry. Pak J Pharm Sci 2015;28:1009-13.
  29. Uddin G, Rauf A, Rehman TU, Qaisar M. Phytochemical screening of Pistacia chinensis var integerrima. Middle East J Sci Res 2011;7:707-11.
  30. Bibi Y, Qayyum A, Nisa S, Waheed A and Choudhary MF: Isolation studies from stem extract of Pistacia integerrima stew. Ex brand. Journal of the Chilean Chemistry Society 2016; 61: 2916-2920
  31. Bagheri F, Hassanshahi G, Falahatipour SK, Ali Dini, Mohamadi M, Ahmadi Z, Karimabad MN, Khanamani S and Falahati-Pour: Effect of Pistachios and their different plant parts on various disorders: Evidence about Their therapeutic effect on Diabetes Mellitus, Gastrointestinal and Liver disorders, as well as blood pressure. Pistachios and Health Journal 2021; 4: 28-47.
  32. Kaur B and Singh S: A review on gall karkatshringi. Academic Journals 2015; 9(21): 636-640
  33. Rauf A, Uddin G, Muhammad A and Muhammad N: Chemical composition and biological screening of essential oils from Pistacia integerrima. Academic Journals 2013; 7(20): 1220-1224.
  34. Sharma R: A therapeutic review of karkatshringi (Pistacia integerrima). Parveshana International Journal of Ayurvedic Research 2019; 4(1): 28-31.
  35. Thakur V, Guleria R and Singh R: Anti-inflammatory activities of methanolic extract of galls of Pistacia integerrima. Journal of Pharmacognosy and Phytochemistry 2017; 6(6): 2144-2146.
  36. Ahmad S, Ali M, Ansari SH. Phenolic constituents from galls of Pistacia integerrima Stewart. Ind J Chem 2010;50B:115-8.
  37. Upadhye AS and Rajopadhye AA: Pharmacognostic and phytochemical evaluation of leaf galls of kakadshingi used in Indian system of medicine. Journal of Scientific and Industrial Research 2010; 69: 700-704.
  38. Acharya B, Mulay VP, Verma S, Srivastava J, Lochab S and Varshney A: Penta- O-Galloyl-?-D-Glucose in Pistacia integerrima Targets AMPK-ULK1 and ERK/STAT3 Signaling Axes to Induce ROS-Independent Autophagic Cell Death in Human Lung Cancer Cells. Frontiers in Pharmacology 2022; 13: 1-18.
  39. McLaughlin JL. Crown gall tumors on potato discs and brine shrimp lethality: Two single bioassays for plant screening and fraction. In:Hostetsmann K, editor. Methods in Plant Biochemistry. London: London Academic Press; 1991, p. 1-31
  40. Aisha AF, Sahib HB, Abu-Salah KM, Darwis Y, Abdul-Majid AM. Cytotoxic and anti-angiogenic properties of the stem bark extract of Sandoricum koetjape. Int Cancer Res 2009;5:105-14.
  41. Jagetia GC, Rao SK. Evaluation of cytotoxic effects of dichloromethane extract of Guduchi (Tinospora cordifolia Miers ex Hook F and THOMS) on cultured HeLa cells. Evid Based Complement Alternat Med 2006;3:267-72.
  42. Kohn LK, Pizao PE, Foglio MA, Antonio MA, Amaral MCE, Bittric V, et al. Antiproliferative activity of crude extract and fractions obtained from Aspidosperma tomentosum. Rev Bras Pl Med 2006;8:110-5
  43. Ripa FA, Haque M, Bulbul IJ. In vitro antibacterial, cytotoxic and antioxidant activities of plant Nephelium longan. Pak J Biol Sci 2010;13:22-7.
  44. Ghosh T, Maity TK, Bose A, Dash GK, Das M. Antimicrobial activity of various fractions of ethanol extract of Bacopa monnieri Linn. aerial parts. Indian J Pharm Sci 2007;69:312-4.
  45. Chowdhury JA, Islam MS, Asifuzzaman SK, Islam MK. Antibacterial and cytotoxic activity screening of leaf extracts of Vitex negundo (Fam: Verbenaceae). J Pharm Sci Res 2009;1:103-8.

Photo
Vaidhshiromani.Dheeraj Sharma
Corresponding author

B.A.M.S. Scholar, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Patanjali Yogpeeth Phase 1 Haridwar, Uttarakhand, India.

Photo
Pransu gupta
Co-author

B.A.M.S. Scholar, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Patanjali Yogpeeth Phase 1 Haridwar, Uttarakhand, India.

Photo
Tanishka Gupta
Co-author

B.A.M.S. Scholar, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Patanjali Yogpeeth Phase 1 Haridwar, Uttarakhand, India.

Photo
Rajesh K. Mishra
Co-author

Assistant Professor, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Patanjali Yogpeeth Phase 1 Haridwar, Uttarakhand, India

Photo
M. K. Yadav
Co-author

HOD Of Ras shastra Department, Patanjali Bhartiya Ayurvigyan Evam Anusandhan Sansthan, Patanjali Yogpeeth Phase 1 Haridwar, Uttarakhand, India

Photo
Ramakant Marde
Co-author

HOD Of Dravyaguna Department, Patanjali Bhartiya Ayurvigyan Evam Anushandhan Sansthan, Patanjali Yogpeeth Phase 1 Haridwar, Uttarakhand, India

Vaidyashiromani Dheeraj Sharma, Pranshu Gupta, Tanishka Gupta, Rajesh K. Mishra, M. K. Yadav, Ramakant Marde, Karkatshringi (Pistacia Integerrima) : Significant Role In Cancer Treatment, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 535-544. https://doi.org/10.5281/zenodo.10684897

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