View Article

  • Glycosylated Hemoglobin In Cases Of Diabetes Mellitus With Microangiopathy
  • Department of Biochemistry, Sri Krishna Medical College, Muzaffarpur, Bihar, India – 842004

Abstract

Objective: To analyze glycosylated haemoglobin in patient of diabetes with microangiopathy. Method: Study done on 100 patients out of which 80 are well known case of diabetes out of which 50 are diabetes with micro-angiopathy and rest 30 are diabetes without micro-angiopathy and other 20 are non-diabetes considered as normal healthy control. Result: Out of 50 cases of diabetes with micro-angiopathy 15 cases having retinopathy in which 67% males and 33?males and the mean glycosylated Hb level is 10.89% at beginning and 8.86?ter 3 months; 19 cases having retinopathy with nephropathy in which 63% were males and 37% were females the mean glycosylated Hb is 12.73% at beginning and 10.52?ter 3 months whereas 16 cases having nephropathy in which sex distribution was 63% males and 7?males and the mean glycosylated Hb is 11.76% at beginning and 8.39?ter 3 month. Conclusion: The three months follow up study showed a significant fail in HbA1C level in all groups of diabetes with and without microangiopathy. But it does not touch to normal level 4.7% of total Hb. Assessing Glycaemic control in diabetes with high glycosylated haemoglobin levels, concurrent fasting blood glucose level estimations are essential.

Keywords

Glycosylated haemoglobin, HbA1c, Diabetes Mellitus, Microangiopathy

Reference

  1. IDF Diabetes Atlas. 2021, 10th Ed.Page No. 4. ISBN: 978-2-930229-98-0. Available Online: https://diabetesatlas.org/idfawp/resource-files/2021/07/IDF_Atlas_10th_Edition_2021.pdf(accessed on 13th June, 2023)
  2. KC Raj S. Diabetes Mellitus and Glycosylated HemoglobinA1c. Nepalese Medical Journal. 2018; 1(2): 112 -117. 
  3. Rahbar S, Blumenfeld O, Ranney HM. Studies of an unusual hemoglobin in patients with diabetes mellitus. BiochemBiophys Res Commun. 1969; 36:838–43.
  4. Bunn HF, Haney DN, Gabbay KH, Gallop PM. Further identification of the nature and linkage of the carbohydrate in haemoglobinA1c. BiochemBiophys Res Commun. 1975; 67:103–9.
  5. Koenig RJ, Peterson CM, Jones RL, Saudek C, Lehrman M, Cerami A. Co-relation of glucose regulation and hemoglobin AIc in diabetes mellitus. N Engl J Med. 1976; 295:417–20. 
  6. Kumar R, Nandhini LP, Kamalanathan SK, Sahoo JP, Vivekanadan M. Evidence for current diagnostic criteria of diabetes mellitus. World J Diabetes 2016;7(17):396-405. 
  7. Xu HB. The value of glycosylated hemoglobin detection in the evaluation of diabetic micro-angiopathy. Chin J Mod Drug Appl 2016; 18: 50-51.
  8. Zhao F. The clinical value of glycosylated he¬moglobin detection in the evaluation of dia¬betic microangiopathy. Chin J Clin Ration Drug Use 2016; 9: 139-140.
  9. Chen LQ. Application value of glycosylated he¬moglobinA1c detection in clinical evaluation of diabetic microangiopathy. World Clin Med 2016; 10: 237-238.
  10. Lauwers N, NíDhubhghaill S, Mathysen DG, Tassignon MJ. Assessment of the bag-in-the-lens implantation technique in diabetic patients. Ophthalmologica. 2013; 229(4):212-8.
  11. Cao YL. The clinical value of glycosylated hemoglobin detection in the evaluation of diabetic microangiopathy. Chin Heal Standard Management 2017; 8: 115-116.
  12. Li L. The value of HbA1c detection in the clinical evaluation of diabetic microangiopathy. Diabetes New World 2016; 19: 63-65.
  13. Ma HL. The value of HbA1c detection in the evaluation of diabetic microangiopathy. Chin J Mod Drug Appl 2016; 10: 89-90.
  14. Zhao Y, Chen SY, Chen WJ, Yang XY and Huang YM. Analysis of glycosylated hemoglobin and coagulation function in patients with type 2 diabetes. J Tropical Med 2016; 16: 1264-1266.
  15. Li SF, Shi JL, Li RX, Xu FJ, Jin NN, Gao PF, Han Y, Tian XB and Liu Y. The relationship between diabetic microangiopathy and type 2 diabetes course and glycosylated hemoglobin. PracClin Med 2016; 17: 10-13.
  16. Fei LN. Observation on the clinical value of combined detection of glycosylated hemoglobin, blood lipids, blood sugar and various biochemical indicators of renal function. Lab Med Clin 2016; 13: 290-291.
  17. Gao Y, Yuan LL and Zhang HS. Effect of safflor yellow on angiotensin II type 1 receptor in kidney cells of diabetic nephropathy model rats. J ClinRehabil Tis Eng Res 2016; 20: 2677-2683.

Photo
Mithilesh Kumar Singh
Corresponding author

Department of Biochemistry, Sri Krishna Medical College, Muzaffarpur, Bihar, India – 842004

Photo
Anant Prasad
Co-author

Department of Biochemistry, Sri Krishna Medical College, Muzaffarpur, Bihar, India – 842004

Anant Prasad, Mithilesh Kumar Singh, Glycosylated Hemoglobin In Cases Of Diabetes Mellitus With Microangiopathy, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 88-94. https://doi.org/10.5281/zenodo.8328309

More related articles
Brain Tumors: Signs, Detection, and Treatment...
V. A. Chavan, V. K. Gahal, S. S. Deokar, ...
Tinospora Cordifolia – As An Anticancer Agent: ...
Arpita R. Pawar, Ashwini T. Chougule, Jaya R. Kamble, Pritam Salo...
Application Of Novel Drug Delivery System For Herb...
Rutuja Patil, Poonam Madane, Namrata Satkar, Uday Kore, Nilesh B....
Advancing HIV Prevention: A Comprehensive Analysis Of PrEP's Efficacy, Adherence...
Manav Kumar, Kajal Kumari , Nahida Khatun, Sapna Kumari, Laxman Kumar Mahto, Divya Roshni Panna, Bin...
Preparation And Evaluation Of Polyherbal Antacid Powder...
Mr. Akash D. Surve , Pooja K. Khanzode, Prathamesh S. Shinde, Samiksha M. Pakhare, Shyam G. Rekhe,...
Related Articles
Evaluation Of Different Marketed Brands Of Aspirin Tablets Using Quality Contro...
T. Ethiraj, V. Ganesan, M. Amudha, S. Abirami, B. Govendhiran, S. Keerthiga, A. Pastin Manoj, G. San...
Skin-Deep Insights: Exploring Transdermal Drug Delivery Systems in a Brief Revie...
Rudrajit Saha, S. K. Riazul, Rounak Bhattacharya, Somenath Mondal, Titin Debnath, ...
Stability Indicating Rp-HPLC Method Development And Validation For The Estimatio...
Trupti Bhalekar, Kalpana Sable, Jaya Mehetre, Kiran Dhamak , ...
Klinefelter Syndrome: Understanding The Genetic Etiology, Pathogenesis Diagnosis...
R. VIGNESWARAN, NATARAJAN P, KODISHWARAN R, PRAKASH M, MONISHA V, SINEHA M, KALYANI M, SAMPATH RAJA ...
Brain Tumors: Signs, Detection, and Treatment...
V. A. Chavan, V. K. Gahal, S. S. Deokar, ...
More related articles
Brain Tumors: Signs, Detection, and Treatment...
V. A. Chavan, V. K. Gahal, S. S. Deokar, ...
Tinospora Cordifolia – As An Anticancer Agent: Recent And Advance Study...
Arpita R. Pawar, Ashwini T. Chougule, Jaya R. Kamble, Pritam Salokhe, Nilesh B. Chougule, ...
Application Of Novel Drug Delivery System For Herbal Formulation...
Rutuja Patil, Poonam Madane, Namrata Satkar, Uday Kore, Nilesh B. Chougule, Pranjal D. Chougule, ...
Brain Tumors: Signs, Detection, and Treatment...
V. A. Chavan, V. K. Gahal, S. S. Deokar, ...
Tinospora Cordifolia – As An Anticancer Agent: Recent And Advance Study...
Arpita R. Pawar, Ashwini T. Chougule, Jaya R. Kamble, Pritam Salokhe, Nilesh B. Chougule, ...
Application Of Novel Drug Delivery System For Herbal Formulation...
Rutuja Patil, Poonam Madane, Namrata Satkar, Uday Kore, Nilesh B. Chougule, Pranjal D. Chougule, ...