View Article

  • Formulation And Evaluation of Erythromycin Delayed Release Tablets
  • 1Department of Pharmaceutics, Mallareddy college of Pharmacy, Dhulapally, Secunderabad.
    2Department of Pharmaceutics, JNTU, Kakinada.
    3Department of Pharmacognosy, Mallareddy college of Pharmacy, Dhulapally, Secunderabad

Abstract

The present study is to formulate and evaluate Erythromycin enteric coated tablets prepared by wet granulation method by using Povidone k30 as polymer, Tricetin as plasticizer ,titanium dioxide as opacifer ,aqueous coating Eudragit 100-55 as coating agent and opadry red as coloring agent .The physico - chemical incompatibity was studied by using Hplc and physical parameters of prepared enteric coated tablets were evaluated as pharmacopeia standards .The dissolution studies of prepared enteric coated tablets was evaluated as pharmacopeia standards .The dissolution studies were performed by using ph 4 acetate buffer for 2hrs and then transfer to phosphate buffer 6.8 for 1 hr. The release order kinetics was studied for the best formulation and was found zero order. The stability studies were performed as per ICH guidelines and results was found satisfactory.

Keywords

Hypermellose, Eudragit 100-55, HPLC, Tricetin, titanium dioxide

Reference

  1. Introduction of tablets by Pharma tips http://pharmatips.doyouknow.in/Articles/Pharmaceutics/ Tablet/Introduction-Of-Tablet-Manufacturing-Process.aspx 4-May-2011.
  2.  Lachman L, Lieberman HA, Joseph LK. “The Theory and Practice of Industrial Pharmacy”. Varghese Publishing House; Mumbai; Third Edition: 297-321. 
  3. Techniques of Tablet Coating: Concepts and Advancements: A Comprehensive Review Aalok Basu , Anjan De, Suddhasattya Dye 
  4. G. Sowjanya, P. Ramaa Bharathi, and Dr.A.M.S.Sudhakar Babu Film coating technology: an over view Pharma tutor. 
  5. wikipedia.org/wiki/Enteric coating 
  6. Vyas S, Khar R. Controlled Drug Delivery Concepts and Advances; First Edition: 219- 256.
  7.  Alfonso R Gennaro, Remington’s “The science and practice of pharmacy”, 20th edition, 2000:903-929. 
  8. Theory and practice of industrial by Leon Lachman, Herbert A Liebermann, Joseph L.Kanig, pharmacy, 3rd edition:431- 439 
  9. Chien Y W. In Novel Drug Delivery Systems,2nd edition,Chien Y W, Ed, New York, Dekker, 1992:1. 
  10. James Swarbrick, James C.Boylan, Encyclopedia of Pharmaceutical Technology, Vol. 1 Pg: 369-394. 
  11. M. J. Romansky, R. V. CHRISTIE, M.sc.mcgill, D.Sc.Lond., M.D., F.R.C.P by “Section of Experimental Medicine and Therapeutics by erythromycin”, “Proceedings of the Royal Society of Medicive”, page no:15, Vol:46. 
  12. Gupta Ankit*, Bilandi Ajay, Kataria Mahesh Kumar, Khatri Neetu “Tablet Coating Techniques: Concepts and Recent Trends”, “International Research Journal of Pharmacy”, 2012, 3 (9). 
  13. Singh Deep Hussan, Roychowdhury Santanu, Verma P, Bhandari V, “A review on recent advances of enteric coating”, “IOSR Journal of Pharmacy “, 2 (6), 2012. Pg: 5-11
  14. Surya Bhan Singh Rathore, Anshu Sharma, Ayush Garg, Dharmendra Singh Sisodiya, “Formulation and Evaluation Of Enteric Coated Tablet Of Ilaprazole”, “International Current Pharmaceutical Journal”, June 2013, 2(7), 126-130. 
  15. Jagadeesh Kumar Ega, Ravinder Vadde “Formulation And Evaluation Of Esomeprazole Magnesium Delayed Release Tablets”, “international journal of research and applications” 2014,2(6).242-252 
  16. Pranav Palshikar, Anshu Sharma, Chetan Singh Chauhan ,Ravindra Kamble “preparation and evaluation of enteric coated tablet of sodium valproate” “ Ijrpc” 2013, 3(3).
  17.  Singh Chhater, Kumar Rajesh, Agarwal Kshitij, Nema R.K“Development and Evaluation of Enteric Coated Tablet Containing Diclofenac Sodium” “international journal of pharmaceutical sciences and nano technology “2009, 2(1). 
  18. N. damodharan, V.manimaran, B.sravanthi “formulation development and evaluation of delayed release doxycycline tablets”, “International Journal of Pharmacy and Pharmaceutical Sciences”, 2010, 2 (1), 
  19. Abhinav Singh Rana, S.L. hari Kumar by “manufacturing defects of tablets - a Review”, “Journal of Drug Delivery & Therapeutics” 2013, 3(6). pg: 200-206. 
  20. Halba PD, Patel JB, Patel KN, Patel BA, Patel PA by” Formulation And Evaluation Of Enteric Coated Delayed Release Tablets Of Omeprazole For Duodenal Ulcer”, “International Journal for Pharmaceutical Research Scholars” 2013, 2(2). 
  21. V.kalvimoorthi, N.narasimhan“Formulation Development And Evaluation Of Aspirin Delayed Release Tablets”, “International Journal of Pharmaceutical Sciences Review and Research” March – April 2011, 7(1). 
  22. Arti Kandalgaonkar, Jivani N.P, Singhvi Indrajeet, Roy S.B “Enteric Coating Formulation Design Of Omeprazole Tablets”, “International Journal of Pharmaceutical Erudition” Aug 2014, 4(2), Pg: 7-17. 
  23. B.Rama, Shalem Raju Talluri, Grace Rathnam “Formulation Development and Evaluation of Enteric Coated Tablets of Rabeprazole Sodium”, “Iosr Journal of Pharmacy and Biological Sciences” Sep -Oct. 2014, 9 (5) Pg: 14-20.

Photo
Surisetty Sridevi
Corresponding author

Department of Pharmaceutics, Mallareddy college of Pharmacy, Dhulapally, Secunderabad

Photo
D. Vinay Kumar
Co-author

Department of Pharmaceutics, JNTU, Kakinada

Photo
SNVL Sirisha
Co-author

Department of Pharmacognosy, Mallareddy college of Pharmacy, Dhulapally, Secunderabad.

Surisetty Sridevi*, D. Vinay Kumar, SNVL Sirisha, Formulation And Evaluation Of Erythromycin Delayed Release Tablets, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 152-161. https://doi.org/10.5281/zenodo.8330907

More related articles
Qualitative and Quantitative Phytochemical Analysi...
Aditya Ubhale, Sakshi Madavi, Vaishanvi Lawane, Shivani Wagh, Pan...
A Review On Insights Of Professional Sales Represe...
Sayali V. Pawar, Pratiksha N. Sapkal, Dhanaji A. Jadhav, Rutuja A...
Evaluation of Phytochemicals in crude extracts der...
Arnab Roy, Sajid Ansari, Subham Kumar Lohani , Ayush Kumar, Makhm...
Evaluation And Management Of Urolithiasis...
Pittu Vishnu Priya, Palle Sai Sharanya, Nanubothula Kushala Yadav, Gangavarapu Hari Priya, Kurva Nav...
Concept And Recent Advancement In Tablet Coating Technologies: A Comprehensive R...
Shrikant S. Dongare, Mr. Dnyaneshwar S. Vyavhare, Dr. Megha T. Salve, ...
Related Articles
Green Synthesis And Biological Evaluation Of A, B - Unsaturated Carbonyl Compoun...
Shaikh Sabiya khalil , Md.Rayees Ahmad, Vishweshwar Dharashive, Dachawar Saiprasad, Shaikh Ghafurunn...
Formulation And Evaluation Of Polyherbal Cream In Acne Treatment...
Shraddha Tandale , Shrikant Gosavi , Mohini suryawanshi , Pooja Wankhede , ...
To Study The Preparation Formulation And Evaluation Of Medicated Lollipop...
Khandagale Sandip suresh, Madane Somnath Jotiram, Patil Onkar Ganpat, Dabhade Sakshi kailasrao, Salv...
Qualitative and Quantitative Phytochemical Analysis Of Wedelia Trilobata Linn...
Aditya Ubhale, Sakshi Madavi, Vaishanvi Lawane, Shivani Wagh, Pankaj Chaudhary, Prashant Burange, Di...
More related articles
Qualitative and Quantitative Phytochemical Analysis Of Wedelia Trilobata Linn...
Aditya Ubhale, Sakshi Madavi, Vaishanvi Lawane, Shivani Wagh, Pankaj Chaudhary, Prashant Burange, Di...
A Review On Insights Of Professional Sales Representative And Marketing Strategi...
Sayali V. Pawar, Pratiksha N. Sapkal, Dhanaji A. Jadhav, Rutuja A. Jadhav, Mayur R. More, Rahul D. M...
Evaluation of Phytochemicals in crude extracts derived from the Aerial parts of ...
Arnab Roy, Sajid Ansari, Subham Kumar Lohani , Ayush Kumar, Makhmur Hayat, ...
Qualitative and Quantitative Phytochemical Analysis Of Wedelia Trilobata Linn...
Aditya Ubhale, Sakshi Madavi, Vaishanvi Lawane, Shivani Wagh, Pankaj Chaudhary, Prashant Burange, Di...
A Review On Insights Of Professional Sales Representative And Marketing Strategi...
Sayali V. Pawar, Pratiksha N. Sapkal, Dhanaji A. Jadhav, Rutuja A. Jadhav, Mayur R. More, Rahul D. M...
Evaluation of Phytochemicals in crude extracts derived from the Aerial parts of ...
Arnab Roy, Sajid Ansari, Subham Kumar Lohani , Ayush Kumar, Makhmur Hayat, ...