Formulation And Evaluation of An Herbal Cream of Psoriasis

Abstract

Psoriasis is a chronic, genetically influenced, remitting and relapsing scaly and inflammatory skin disorder that affects 1 to 3 percent of the world's population. The diagnosis is made on clinical grounds, although histologic examination of a skin-biopsy specimen may be helpful. Psoriasis is a disabling, though rarely life-threatening, disease with a social and economic impact that is underestimated by physicians and other health care providers. Recently, progress has been made in understanding the pathogenesis of psoriasis, and therapeutic advances are improving the care of even severely affected patients. There are several types of psoriasis, including pustular, guttate, and arthritic variants.

Keywords

Introduction

Step 2: Oil phase

• Cocoa butter was taken and weigh 6gm
• Stearic acid was taken and weigh 6gm
• Cetyl alcohol was taken and weigh 5gm
• Vit E oil was taken 4ml
• Tea tree oil was taken 3ml
• Stearic acid, cocoa butter, coconut oil, cetyl alcohol, olive oil, vit E oil  are mixed together and oil phase is prepared.

Step 3: Aqueous phase

Neem extract, Methyl paraben are mixed together and heated on 75⁰C.

Figure 3: Aqueous Phase

Step 4: After heating, the aqueous phase (Part B) and heated to 75⁰C.  After heating, the aqueous phase was added in portions to the oil phase with continuous stirring and perfume was added.

Formulation Table:

Ingredients	F1	F2	F3
Neem	6ml	7ml	8ml
Cocoa butter	4gm	5gm	6gm
Stearic acid	4gm	5gm	6gm
Cetyl alcohol	3gm	4gm	5gm
Coconut oil	3ml	4ml	5ml
Vit E oil	2ml	3ml	4ml
Tea tree oil	1ml	1gm	1gm
Turmeric	1gm	3ml	3ml
Methyl paraben	1gm	2gm	2gm

Evaluation Test for Cream

1. Stability
2. pH of the cream
3. Viscosity
4. Spreadability

PH of the cream: the ph meter was calibrated using standard buffer solution. About 1 g of the cream was weighted and dissolved in 50ml of distilled water. The ph of the suspension was determined at 270c.

Fig: 4 (PH Test)

Stability: the prepared formulation in the final container was kept in the room temperature at 260+2 and refrigerator at 40C+2  for 2 month at the end of studies samples were analysed for the physical properties and viscosity.

Viscosity: viscosity of the formulation was determined by Brookfield viscometer at 100rpm, using spindle no 7.

Fig: 5 (Brook Field Viscometer)

Spreadability:

CONCLUSION:

Psoriasis is a chronic, immune-mediated skin disorder characterized by hyperproliferation of keratinocytes and systemic inflammation. It presents with well-defined, scaly, erythematous plaques and can significantly affect a patient's quality of life. Although its exact cause remains multifactorial—combining genetic, immunological, and environmental factors—advances in understanding its pathophysiology have led to more targeted and effective treatments. While there is currently no cure, various therapies, including topical agents, phototherapy, systemic medications, and biologics, can help manage symptoms and reduce flare-ups. Early diagnosis, patient education, and a comprehensive, individualized treatment approach are essential for optimal disease control and improved patient outcomes.

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