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Abstract

The evaluation of diclofenac potassium tablets involved rigorous testing to ensure quality and efficacy. Tests included hardness assessment to gauge tablet strength, friability testing to determine resistance to action analysis was conducted to ensure uniformity among tablets. This comprehensive evaabrasion, and disintegration tests to assess dissolution properties. Additionally, weight evaluation provides valuable insights into the tablets' physical characteristics, aiding in the assurance of product quality and consistency. This study focuses on the comprehensive evaluation of diclofenac potassium tablets, a crucial step in ensuring their quality and performance. Hardness testing was employed to measure the tablets' resistance to breakage, indicating their strength and durability. Friability assessment gauged the tablets' susceptibility to abrasion, providing insights into their structural integrity during handling and transport. Disintegration tests were conducted to examine the tablets' dissolution properties, crucial for predicting their efficacy upon ingestion. Weight variation analysis ensured uniformity in tablet mass, a critical factor in dosage accuracy and overall product consistency. The findings from these tests collectively contribute to a thorough understanding of the physical attributes of diclofenac potassium tablets. This information is essential for quality control, helping to guarantee that each tablet meets the required standards for hardness, friability, disintegration, and weight variation. As a result, this evaluation provides valuable data for pharmaceutical manufacturers, regulatory authorities, and healthcare professionals, reinforcing the reliability and effectiveness of diclofenac potassium tablets in therapeutic applications.

Keywords

Evaluation, Hardness, Tablet, Time, Disintegration

Reference

  1. Remington (Twenty-second edition)-chapter 45-Ahmed adel sakr, PhD and fars K. Alanazi, PhD (page no. 947, 948)
  2. Lachman\Lieberman’s- The Theory and Practice of Industrial pharmacy-Fourth Edition- Roop K khar, SP Vyas, Farhan j Ahmad, Gaurav K jain (page no. 449, 450)
  3. International journal of research in Engineering and science- Mohd Azam, Neha Sodiyal, Sivanadpatil
  4. http://www.webmd.com
  5. Tansel Comoglu, Aysegul Dogan, Selcuk Comoglu & Nursabah Article in drug development in industrial pharmacy. March 2011 DOI: 10.3109/03639045.2010.505929.source: PubMed
  6. Basawaraj S Patil, Upendra Kulkarni and Parikh Bhavik Formulation and evaluation of diclofenac potassium tablet (2010) ISSN: 0975-8232 http://dx.doi.org/10.13040/IJPSR.0975-8232.1(8-S).88-92
  7. Alexandre Machado Rubim, Jaqueline Bandeira Rubenick, Luciane Varine Laporta Clarice Madalena Bueno Rolim A simple method for the quantification of diclofenac potassium in oral suspension by high-performance liquid chromatography with UV-detection. Brazilian Journal of Pharmaceutical Sciences vol. 49, n. 3, jul./sep., 2013 https://www.scielo.br/j/bjps/a/55s8b39fXJpxFNqMkQf44Wq/?format=pdf?=en
  8. Divya Dhatri Kara1, Hemanth Katta Govindarajulu1, Hemamanjushree Shivaprasad1, Vamshi Krishna Tippavajhala1, Mahendra Joshi2, Girish Pai Kulyadi Detailed Research on a Comparative Evaluation of Diclofenac Sodium Tablets Manufactured by Using DC Grade Excipients and Wet Granulation Methods  issn 0019-5464
  9. Huma ali, muhammad harris shoaib, farya zafar mohammad hanif, rabia bushra asia naz and raheela khursheed rse Pharmacokinetic and bioequivalence studies of immediate release diclofenac potassium ablets (50mg) in health volunteers
  10. Advances in NSAID Development: Evolution of Diclofenac products using pharmaceutical technology Roy Altman, Bill Bosch, Kay Brune,Paola Patrignani,Clarence Young.Drugs (2015) 75:859–877 DOI 10.1007/s40265-015-0392
  11. Simultaneous Determination of Diclofenac Potassium and Drotaverine Hydrochloride in Human Plasma using Reversed-Phase High-Performance Liquid Chromatography Prasad P. Dahivelkar1*, Suvarna I. Bhoir2, Sanjay B. Bari1, Sanjay J. Surana1 and Ashok M. Bhagwat. Journal of Chromatographic Science 2012;50:694–701 doi:10.1093/chromsci/bms026 Advance Access publication May 9, 2012
  12. Diclofenac Potassium 12.5mg Tablets for Mild to Moderate Pain and Fever: A Review of Its Pharmacology, Clinical Efficacy and Safety February 2007Clinical Drug Investigation 27(3):163-95
  13. Stella Iacovides, Hon, Ingrid Avidon, PhD, Alison Bentley, MD, PhD, Fiona C. Baker, PhD Sleep, Volume 32, Issue 8, August 2009, Pages 1019–1026,Diclofenac Potassium Restores Objective and Subjective Measures of Sleep Quality in Women with Primary Dysmenorrhea Sleep, Volume 32, Issue 8, August 2009, Pages 1019–1026, https://doi.org/10.1093/sleep/32.8.1019

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Bharat Jadhav
Corresponding author

Navmaharashtra Shikshan Mandal’s Abasaheb Kakade College Of B-Pharmacy. Bodhegaon Tal- Shevgaon Dist-Ahmednagar

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Rutuja Dhas
Co-author

Navmaharashtra Shikshan Mandal’s Abasaheb Kakade College Of B-Pharmacy. Bodhegaon Tal- Shevgaon Dist-Ahmednagar

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Sahil T. Shaikh
Co-author

Navmaharashtra Shikshan Mandal’s Abasaheb Kakade College Of B-Pharmacy. Bodhegaon Tal- Shevgaon Dist-Ahmednagar

Bharat Jadhav, Rutuja Dhas, Sahil T. Shaikh, Evaluation Of The General Marketed Tablet, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 176-183. https://doi.org/10.5281/zenodo.10629019

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