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Abstract

The creation of innovative drug delivery systems (NDDS) for plant actives and extracts has made significant strides in recent years. Bioactive and plant extracts have been used to create a range of innovative herbal formulations, such as polymeric nanoparticles, nanocapsules, liposomes, phytosomes, nanoemulsions, microspheres, transferosomes, and ethosomes. Compared to the traditional formulations, these innovative formulations have advantages. NDDS include improvements to solubility, bioavailability, toxicity protection, pharmacological activity and stability, better tissue macrophage distribution, and chemical degradation protection. In order to improve medicine efficiency and safety throughout the delivery process and give patients greater convenience, it is crucial to develop alternative drug delivery methods. More information on innovative herbal formulations is provided in the current study.

Keywords

Liposomes, Phytosomes, Nanoemulsion, Ethosomes, Microspheres

Reference

  1. Ajazuddin, S Saraf, Application of novel drug delivery system for Herbal formulation, Fioterpia, 2010; 81(7): 680-689. DOI: https://10.1016/j.fitote.2010.05.001;PMID:20471457.
  2. Prasad NS, et al. Augmentation of dissolution profile of poorly soluble Olmesartan medoximil formulating into pronisomes. European JBPS. 2016; 3(2): 122-128.
  3. Chari SS, Murari R, Ahmad I, Liposomes: A Review. Journal of Biopharmaceutics, 14(11): 10-14.
  4. Cheriyan P, et al. Formulation and characterization of maltodextrin based proniosomes of cephalosporins. Pharm. Sci. 2015; 3(1): 62-74. 16
  5. Jangde R, Singh D. Preparation and optimization of quercetin-loaded liposomes for wound healing, using response surface methodology. Artif Cells, Nanomedicine Biotechnol. 2016;44(2):635–41.
  6. Wu Q, Zhang Z, Yuan L, Liu X, Zhou L. Preparation of curcumin-loaded liposomes and evaluation of their skin permeation and pharmacodynamics. Molecules. 2012;17(5):5972–87
  7. Gortzi O, Lalas S, Chinou I, Tsaknis J. Reevaluation of bioactivity and antioxidant activity of Myrtus communis extract before and after encapsulation in liposomes. Eur Food Res Technol. 2008;226(3):583–90
  8. VARSHEYA A, RAVIKUMAR P. Formulation and Characterization of Rutin trihydrate Liposomes for Topical Delivery Formulation and Characterization of Rutin trihydrate Liposomes for Topical Delivery. Int J Pharm Res. 2015;(October)
  9. Sebaaly C, Jraij A, Fessi H, Charcosset C, Greige-Gerges H. Preparation and characterization of clove essential oil-loaded liposomes. Food Chem [Internet]. 2015;178:52–62
  10. THORAT YS, KOTE NS, PATIL V V., HOSMANI AH. Formulation and Evaluation of Liposomal Gel Containing Extract of Piprine. Int J Curr Pharm Res. 2020;12(3):126–9.
  11. Zhu Y, Wang M, Zhang J, Peng W, Firempong CK, Deng W, et al. Improved oral bioavailability of capsaicin via liposomal nanoformulation: Preparation, in vitro drug release and pharmacokinetics in rats. Arch Pharm Res. 2015;38(4):512–21
  12. Brem H, Stojadinovic O, Diegelmann RF, Entero H, Lee B, Pastar I, et al. Cholinergic Anti Inflammatory Pathway Activity and High High Mobility Group Box-1 (HMGB1) Serum Levels in Patients with Rheumatoid Arthritis. Mol Med [Internet]. 2007;13(9):30–9.
  13. Sharma S, Gupta N, Review on phytosomes: As a emerging strategy to improve the bioavailability of phytoconstituents, American journal of pharmatech research, 2020; 10(5): 122-134. DOI: https://10.46624/ajptr.2020.V10.i5.009.
  14. Gandhi A., Dutta A., Pal A., Paromita, “Recent Trends of Phytosomes for Delivering Herbal Extract with Improved Bioavailability”, Journal of Phytochemistry,2012; 1 (4): 06-14.
  15. Lather V, Sharma D, Pandita D. Proniosomal gel-mediated transdermal delivery of bromocriptine: in vitro and ex vivo evaluation. J Exp Nanosci. 2016; 11(13): 1044-1057
  16. Soujanya CP, Ravi P. Development and in vivo evaluation of lovastatin loaded transdermal proniosomal gel by design of experiment. Int. J. Pharm. Sci. Drug Res. 2018; 10(4): 252-259.
  17. Singh A, Saharan V.A., Singh M, Bhandari A., Phytosomes: Drug Delivery System Polyphenolic Phytoconstituent, Iranian journal of pharmaceutical science, 2011; 7(4): 209-219
  18. Maiti K, Mukherjee K, Gantait A, Saha, BP, Mukherjee P. K., Curcumin-Phospholipid complex: preparation therapeutic evaluation and pharmacokinetic study in rats, international journal of pharmaceutics, 2007; 330(1-2): 155-63. https://10.1016/j.ijpharm.2006.09.025;PMID:17112692.
  19. Vandana SP, Suresh RN. Exp Toxicol Pathol 2008;60:397–404.
  20. Yanyu X,YunmeiS,Zhipeng C,QuinengP.Int JPharm2006; 3;307(1): 77–82
  21. Bhattacharya S. Pharma Times 2009;41(3):9–12.
  22. Maiti K, Mukherjee K, Gantait A, Ahamed HN, Saha BP, Mukherjee PK. Iran J Pharmacol Ther 2005;4:84–90. [60] Maiti K, Mukherjee K, Gantait A, Saha BP, Mukherjee PK. Int J Phar
  23. Zhang Y. Chin Tradition Herbal Drugs 2006;37:641–7.
  24. Lu MF, Cheng YQ, Li LJ, Wu JJ. Mater Rev 2005;19:108–10.
  25. Y Huang, T Wang, Q Tan, D He, M Wu,J Zhang, Original research- A highly efficient one-for-all nanodroplet for ultrasound imaging guided and cavitation- enhanced photothermal therapy, International Journal of Nanomedicine 2020; 15: 2391-2402.
  26. VK, Mishra N, Yadav KS, Yadav NP. Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery, Journal of Control Release,2018 Jan 28; 270: 203-225. DOI: 10.1016/j.jconrel.2017.11.049;PMID: 29199062
  27. Mehra NK, Tekwal R R, Palakurthi S, development and evaluation of talazoparib nanoemulsion for systemic therapyof BRCA1- mutant cancer. Mini Rev Med Chem,2017;17(18):1778-
  28. N Ahmad, R Ahmad, A Al Qudaihi, A novel self- nanoemulsifying drug delivery system for curcumin used in the treatment of wound healing and inflammation, 2019; 9(10): 360. DOI: 10.1007/s13205 019-1885-3; PMID:31544014
  29. Beg S, Saini S, Imam S.S., Nano emulsion for the effective treatment and management of anti-tubercular drug therapy, Recent Patents on Anti infect Drug Discovery, 2017; 12(2): 85-94. DOI: 10.2174/1574891X12666170504094330.
  30. Kadappan AS, Guo C, the efficacy of Nano emulsion-based delivery to improve vitamin D adsorption: comparison of in vitro amd in vivo studies, Molecular nutrition, and food research, 2018; 62(4): DOI: 10.1002/mnfr.201700836; PMID: 29266712.
  31. Zhaoa Y, Wanga C, Albert HL, Chowb KR, Gongc T, Zhangc Z, et al. Int J Pharm 2010;383(1–2):170–7.
  32. Zhinan M, Huabing C, Ting W, Yajiang Y, Xiangliang Y. Eur J Pharm Biopharm 2003;56:189–96.
  33. Li L, Wang DK, Li LS, Jia J, Chang D, Ai L. J Shenyang Pharm Univ 2007;12:736–9. Ajazuddin, S. Saraf / Fitoterapia 81 (2010) 680–689 689
  34. Sun HW, Ouyang WQ. J Shanghai Jiaotong Univ (Agric Sci) 2007;1: 60–5.
  35. Song YM, Ping QN, Wu ZH. J China Pharm Univ 2005;5:427–31
  36. Fabiana TMCV, Tha?´s RMS, Jose ODC, Nilce OW, Dimitrius LP, Mamie
  37. Pawar P., Kalamkar R., Jain A., Amberkar S., “Ethosomes: A Novel Tool for Herbal Drug Delivery”, International journal of pharmacy and pharmaceutical research, 2015; 3(4): 191-202. DOI: https://10.1016/j.jconrel.2016.09.017.
  38. Aggarwal D, Nautiyal U, Ethosomes: A Review, International journal of pharmaceutical and medicinal research, 2016; 4(4): 354-363.
  39. Nimbalwar MG, Upadhye K, Dixit G. Fabrication and evaluation of ritonavir Proniosomal transdermal gel as a vesicular drug delivery system. Pharmacophore. 2016; 7(2): 82-95.
  40. Bhokare S.G., Dongaonkar C.C., Lahane S.V., Salunke P.S., Sawale V.S., Thombare M.S., Herbal Novel Drug Delivery – A Review, World journal of pharmacy and pharmaceutical science, 2016; 5(8): 593 611. DOI: https://10.20959/wjpps20168-7461
  41. Patil NV, Wadd NV, Thorat SS, Sudarshan U.P., Microspheres: A novel drug delivery system, American journal of pharmatech research, 2020; 10(2): https://10.46624/ajptr.2020.v10.i2.024. 287-301. DOI
  42. Ramteke K.H, Jadhav V.B, Dhole S.N., Microspheres: as carriers used for novel drug delivery system, IOSR Journal of Pharmacy: 2012; 2(4): 44-48.
  43. Sanli O, Karaca I, Isiklan N. J Appl Polym Sci 2009;111:2731–40.
  44. Kataria Sahil1, Middha Akanksha1, Sandhu Premjeet1, Ajay Bilandi and Bhawana Kapoor, MICROSPHERE: A REVIEW, International journal of research in pharmacy and chemistry, 2011; 1(4): 1184 1198.
  45. Prasad B. Sree Giri, Gupta V.P.M., Devanna N., Jayasurya K., Microsphere as drug delivery system- A review, Journal of global trends in pharmaceutical science, 2014; 5(3): 1961-1972.
  46. K Saravana kumar, P Jayachandra Reddy, K.B. Chandra sehkhar, A review on microsphere for novel drug delivery system, Journal of pharmacy research, 2012; 5(1): 420-424.
  47. Gunasekaran T, Haile T, Nigusse T, Dhana Raju M.D., Nanotechnology: An effective tool for enhancing bioavailability and bioactive of phytomedicine, Asian pacific journal of tropical medicine, 2014; 4(suppl1): S1-S7. https://10.12980/APJTB.4.2014C980;PMID:25183064. DOI:
  48. S Dilpreet, Application OF Novel Drug Delivery System In Enhancing The Therapeutic Potential Of Phytoconstituents, Asian journal of pharmaceutics, 2015; 9(4): S1-S12.
  49. Khan Ibrahim, Saeed Khalid, Khan Idrees, Review: Nanoparticles: Properties, applications and toxicities, Arabian Journal of chemistry, 2019; 12(7): https://10.1016/j.arabjc.2017.05.011. 908-931. DOI
  50. J Jaison, B Ahmed, C Yen S., D Alain, D Michael K., Review on nanoparticles and nanostructured materials: history, sources, toxicity, and regulations, Beilstein journal of nanotechnology, 2018; 9: 1050-1074. DOI: https://doi.org/10.3762/bjnano.9.98.
  51. Yuksel N, et al. In situ niosome forming maltodextrin proniosomes of candesartan cilexetil: In vitro and in vivo evaluations. Int. J. Biol. Macromol. 2016; 82: 453-63.
  52. Bonifiacio BV, Bento PS, Dos MA, Ramos S Nanotechnology- based drug delivery systems and herbal medicines: a review, international journal of nanomedicines,2014; 9: 1-5. DOI: 10.2147/IJN.S5263;PMID:24363556.
  53. Saleem S, Zhuang H, Biswal S, Christen Y, Dore S, Ginkgo biloba extract neuroprotective action is dependent on heme oxygenase 1 in ischemic reperfusion brain injury, Journal of American heart association, 2008; 39(12): 3389-3396. https://10.1161/STROKEAHA.108.523480;PMID:18845796. DOI:
  54. Lertsutthiwong P, Noomun K, Jongaroonngamsang N, Rojsitthisak P., Preparation of alginate nanocapsules containing turmeric oil, journal of carbohydrate polymer, 2008; 74: 209-214. DOI: https://10.1016/j.carbpol.2008.02.009.
  55. Ajazuddin, S Saraf, Application of novel drug delivery system for Herbal formulation, Fioterpia, 2010; 81(7): 680-689. DOI: https://10.1016/j.fitote.2010.05.001;PMID:20471457

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Rutuja Patil
Corresponding author

Ashokrao Mane Institute of Pharmacy, Ambap

Photo
Poonam Madane
Co-author

Ashokrao Mane Institute of Pharmacy, Ambap

Photo
Namrata Satkar
Co-author

Ashokrao Mane Institute of Pharmacy, Ambap

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Uday Kore
Co-author

Ashokrao Mane Institute of Pharmacy, Ambap

Photo
Nilesh B. Chougule
Co-author

Ashokrao Mane Institute of Pharmacy, Ambap

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Pranjal D. Chougule
Co-author

Ashokrao Mane Institute of Pharmacy, Ambap

Rutuja Patil*, Poonam Madane, Namrata Satkar, Uday Kore, Pranjal Chaugule, Nilesh Chougule, Application Of Novel Drug Delivery System For Herbal Formulation, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 758-770 https://doi.org/10.5281/zenodo.10403953

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