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Abstract

The most frequent modifiable risk factor for death and disability is hypertension. Other modifiable risk factors include stroke, accelerated coronary and systemic atherosclerosis, heart failure, chronic kidney disease, lowering blood pressure with antihypertensive medications, and lowering the prevalence of cardiovascular disease. The 2017 American college of cardiology (ACC)/American heart association (AHA) hypertension recommendations define hypertension as systolic blood pressure (BP) greater than 130 mmHg or diastolic blood pressure (BP) less than 80 mmHg. In patients with CHD, CHF, following kidney transplantation, diabetes mellitus, and stroke, BP should be less than 130/80 mmHg. The patient was advised to modify their lifestyle by reducing their salt intake, losing weight if they were overweight, exercising regularly, drinking alcohol in moderation, and consuming more potassium-rich foods. The first antihypertensive medication should often come from one of the four types listed below: calcium channel blockers, thiazide diuretics, ACE inhibitors, and ARBs. These drugs have been found to lower cardiovascular events. Renal denervation and baroreflex activation therapy are the two interventional methods utilised in clinical practise to treat a variety of treatment-resistant hypertensions. Carotid body ablation and the implantation of an AVF are two other interventional techniques, although none of them can stop the progression of cardiovascular disease or a hypertensive patient's mortality.

Keywords

Target Blood Pressure, Carotid Body Ablation Therapy, Renal Denervation, and Antihypertensive Drug Therapy

Reference

  1. 2017 Whelton, P.K., et al. Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines (ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA). American College of Cardiology Journal, 71, e127–e248. https://doi.org/10.1016/j.jacc.2017.11.006 
  2. Muntner, P., et al. (2018) Potential Impact of the 2017 ACC/AHA High Blood Pressure Guideline on the US Population. 109–118. In circulation, 137. https://doi.org/10.1161/CIRCULATIONAHA.117.032582 
  3. S.S. Lim and others, 3. (2012) A Systematic Analysis for the 2010 Global Burden of Disease Study: Comparative Risk Assessment of Burden of Disease and Injury Attributable to 67 Risk Factors and Risk Factor Clusters in 21 Regions, 1990–2010. 380, 2224-2260, Lancet. https://doi.org/10.1016/S0140-6736(12)61766-8 
  4. David Lloyd-Jones et al. (2009) A Report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Heart Disease and Stroke Statistics—2009 Update. 119, 480–486, circulation. https://doi.org/10.1161/CIRCULATIONAHA.108.191259 
  5. A Propensity-Matched Study of the Association of Peripheral Arterial Disease with Cardiovascular Outcomes in Community-Dwelling Older Adults, Aronow, W.S., et al. Journal of American College of Cardiology, 103, 130–135. https://doi.org/10.1016/j.amjcard.2008.08.037 
  6. W. S. Aronow et al. (2011) ACCF/AHA A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents, 2011 Expert Consensus Document on Hypertension in the Elderly. 123, 2434–2506 of circulation. https://doi.org/10.1161/CIR.0b013e31821daaf6 
  7. Prevalence of Resistant Hypertension in the United States, 2003–2008. Persell, S.D. 1076–1080 in Hypertension, 57. https://doi.org/10.1161/HYPERTENSIONAHA.111.170308 
  8. Sim, J.J., et al. Resistant Hypertension in a Large, Ethnically Diverse Hypertension Population in an Integrated Health System: Characteristics of Resistant Hypertension. https://doi.org/10.1016/j.mayocp.2013.06.017 Mayo Clinic Proceedings, 88, 1099–1107.
  9. Refractory Hypertension: Determination of Prevalence, Risk Factors, and Comorbidities in a Large, Population-Based Cohort. Hypertension, 63, 451-458. Calhoun, D.A., et al. https://doi.org/10.1161/HYPERTENSIONAHA.113.02026 
  10. High Rates of Non-Adherence to Antihypertensive Treatment Revealed by High-Performance Liquid Chromatography-Tandem Mass Spectrometry (HP LC-MS/MS) Urine Analysis, Tomaszewski, M., et al. (2014). Heart, 100, 855-861. https://doi.org/10.1136/heartjnl-2013-305063 
  11. J. Ceral et al. (2011) Arterial hypertension that is challenging to control or uncooperative patients? The evaluation of serum antihypertensive drug concentrations to distinguish between non-responsiveness and non-adherence to advised therapy. 34, 87–90, Hypertension Research. https://doi.org/10.1038/hr.2010.183 
  12. Resistant Hypertension? 12. Jung, O., et al. Analyzing Adherence Using Toxicological Urine. 31, 766-774, Journal of Hypertension. https://doi.org/10.1097/HJH.0b013e32835e2286 
  13. Therapeutic Drug Monitoring Facilitates Blood Pressure Control in Resistant Hypertension, S. Brinker et al. (2014). American College of Cardiology Journal, 63, 834–835. https://doi.org/10.1016/j.jacc.2013.10.067 
  14. Ettehad, D., et al., "Blood Pressure Lowering for Prevention of Cardiovascular Disease and Death: A Systematic Review and Meta-Analysis," Lancet, 387, 957-967 (2016). https://doi.org/10.1016/S0140-6736(15)01225-8 
  15. A Randomized Trial of Intensive vs Standard Blood-Pressure Control, Wright Jr., J.T., et al. (2015). 373, 2103-2116; New England Journal of Medicine. https://doi.org/10.1056/NEJMoa1511939 
  16. James, P.A., et al. (2014) Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report from the Panel Members Appointed to the Eighth Joint National Committee (JNC 8). JAMA, 311, 507-520. https://doi.org/10.1001/jama.2013.284427 
  17. Ogedegbe, G., Lackland, D.T., Wright Jr., J.T., Fine, L.J., and Dennison Himmelfarb, C.R. (2014) The Minority View on the Evidence for a Systolic Blood Pressure Goal of Less than 150 mmHg in Patients Aged 60 Years or Older. Internal Medicine Annals, 160(4):499-503. https://doi.org/10.7326/M13-2981 
  18. NICE Guideline on Hypertension, Jaques, H. 34, 406-408, European Heart Journal. 
  19. Clinical Practice Guidelines for the Management of Hypertension in the Community: A Statement by the American Society of Hypertension and the International Society of Hypertension, published by the M.A. Weber et al. group in 2014. 16, 14–26, Journal of Clinical Hypertension. https://doi.org/10.1111/jch.12237 
  20. The American Heart Association, American College of Cardiology, and American Society of Hypertension (2015) Treatment of Hypertension in Patients with Coronary Artery Disease: A Scientific Statement. 20. Rosendorff, C., et al. American College of Cardiology Journal, 65, 1998-2038. https://doi.org/10.1016/j.jacc.2015.02.038 
  21. Guideline for the Diagnosis and Management of Hypertension in Adults—2016, G.M. Gabb et al., Medical Journal of Australia, 205, 85–89. https://doi.org/10.5694/mja16.00526 
  22. Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older to Higher Versus Lower Blood Pressure Targets: A Clinical Practice Guideline from the American College of Physicians and the American Academy of Family Physicians. 22. Qaseem, A., et al. 166, 430-437, Annals of Internal Medicine. https://doi.org/10.7326/M16-1785 
  23. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Whelton, P.K., Carey, R.M., Aronow, W.S., Casey Jr., D.E. e13–e115 in Hypertension. 
  24. (2017) Lifestyle Measures for Treating Hypertension. Aronow, W.S. 12, 1241–1243, Archives of Medical Science. https://doi.org/10.5114/aoms.2017.68650 
  25. Thompson, A.M. et al., "Antihypertensive Treatment and Secondary Prevention of Cardiovascular Disease Events among Persons without Hypertension: A Meta-Analysis," 2011. JAMA, 305, 913-922. https://doi.org/10.1001/jama.2011.250 
  26. The Effects of Blood Pressure Reduction and of Different Blood Pressure-Lowering Regimens on Major Cardiovascular Events according to Baseline Blood Pressure: Meta-Analysis of Randomized Trials, S. Czernichow et al., 2011, p. 26. 29, 4-16 of the Journal of Hypertension. https://doi.org/10.1097/HJH.0b013e32834000be 
  27. American College of Cardiology/American Heart Association Task Force on Practice Guidelines, 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk: A Report, Goff Jr., D.C., et al. American College of Cardiology Journal, 63, 2935–2959. https://doi.org/10.1016/j.jacc.2013.11.005 
  28. Intensive versus Standard Blood Pressure Control and Cardiovascular Disease Outcomes in Adults Aged 75 Years: A Randomized Clinical Trial, Williamson, J.D., et al. (2016). JAMA, 315, 2673-2682. https://doi.org/10.1001/jama.2016.7050 
  29. The Collaboration of Blood Pressure Lowering Treatment Trialists (2014) A meta-analysis of patient data on blood pressure-lowering therapy based on cardiovascular risk. The Lancet 384(5):591–598. https://doi.org/10.1016/S0140-6736(14)61212-5 
  30. Lewington, S., et al., "A Meta-Analysis of Individual Data for One Million Adults in 61 Prospective Studies: Age-Specific Relevance of Usual Blood Pressure to Vascular Mortality." The Lancet, 360, from 1903 to 1913. https://doi.org/10.1016/S0140-6736(02)11911-8 
  31. Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis, Bundy, J.D., et al. 2017, 31. 775-781 in JAMA Cardiology. https://doi.org/10.1001/jamacardio.2017.1421 
  32. 2017 ACC/AHA/HFSA, Yancy, C.W., et al. A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America, Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure. American College of Cardiology Journal, 70, 776–803. https://doi.org/10.1016/j.jacc.2017.04.025 
  33. Systematic Review: Blood Pressure Target in Chronic Kidney Disease and Proteinuria as an Effect Modifier, by A. Upadhyay, A. Earley, S. M. Haynes, and K. Uhlig. Internal Medicine Annals, 154, 541-548. https://doi.org/10.7326/0003-4819-154-8-201104190-00335 
  34. Blood-Pressure Targets in Patients with Recent Lacunar Stroke: The SPS3 Randomized Trial, O.R. Benavente et al., 2013. 507–515 in The Lancet, 382. https://doi.org/10.1016/S0140-6736(13)60852-1 
  35. (2015) Blood Pressure Lowering in Type 2 Diabetes: A Systematic Review and Meta-Analysis. Emdin, C.A., et al. JAMA, 313, 603-615. https://doi.org/10.1001/jama.2014.18574 
  36. Orthostatic Hypotension in Diabetics in the ACCORD. 36. Aronow, W.S. (Action to Control Cardiovascular Risk in Diabetes) Test of blood pressure. 851–852 in Hypertension, 68. https://doi.org/10.1161/HYPERTENSIONAHA.116.07605 
  37. Wang, W.T., et al. (2016) Traditional and Bayesian Network Meta-Analysis of Randomized Trials: Comparative Effectiveness of Blood Pressure-Lowering Drugs in Patients Who Have Already Suffered from Stroke. 95, e3302 in medicine. https://doi.org/10.1097/MD.0000000000003302 
  38. Obstructive sleep apnea is the most prevalent secondary cause of hypertension associated with resistant hypertension, according to Pedrosa, R.P., et al. 811–817 in Hypertension, 58. 
  39. Screening for Primary Aldosteronism in Essential Hypertension: Diagnostic Accuracy of the Ratio of Plasma Aldosterone Concentration to Plasma Renin Activity. Schwartz, G.L. and Turner, S.T. 2005. 51, 386-394, Clinical Chemistry. https://doi.org/10.1373/clinchem.2004.041780 
  40. A Comparison of Biochemical Tests for Pheochromocytoma: Measurement of Fractionated Plasma Metanephrines Compared with the Combination of 24-Hour Urinary Metanephrines and Catecholamines. Sawka, A.M., Jaeschke, R., Singh, R.J., and Young, W.F. 2003. 88, 553-558, Journal of Clinical Endocrinology and Metabolism. https://doi.org/10.1210/jc.2002-021251 
  41. A. Oliveras et al. (2010) found that true resistant hypertension is associated with urinary albumin excretion. 24, 27–33, Journal of Human Hypertension. https://doi.org/10.1038/jhh.2009.35
  42. Resistant Hypertension: Diagnosis, Evaluation, and Treatment, D.A. Calhoun et al., 2008. A Scientific Statement from the Council for High Blood Pressure Research and the American Heart Association Professional Education Committee. 51: 1403–1419 in Hypertension. https://doi.org/10.1161/HYPERTENSIONAHA.108.189141 
  43. Clinical Differences between Resistant Hypertensives and Patients Treated and Controlled with Three or Less Drugs, De la Sierra, A., et al. (2012). 30, 1211–16, Journal of Hypertension. https://doi.org/10.1097/HJH.0b013e328353634e 
  44. Campese, V.M., N. Mitra, and D. Sandee, "Hypertension in Renal Parenchymal Disease: Why Is It So Resistant to Treatment" (2006). 69, 967-973, Kidney International. https://doi.org/10.1038/sj.ki.5000177 
  45. Effect of Lower Sodium Intake on Health: Systematic Review and Meta-Analyses. N. J. Aburto et al. BMJ, 346, f1326. https://doi.org/10.1136/bmj.f1326 
  46. He, F.J., Li, J. and Macgregor, G.A. (2013) Effect of Longer Term Modest Salt Reduction on Blood Pressure: Cochrane Systematic Review and Meta-Analysis of Randomised Trials. BMJ, 346, f1325. https://doi.org/10.1136/bmj.f1325 
  47. (2003) Influence of Weight Reduction on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials. Neter, J.E., et al. 878–884 in Hypertension, 42. https://doi.org/10.1161/01.HYP.0000094221.86888.AE 
  48. Exercise Training for Blood Pressure: A Systematic Review and Meta-Analysis, by Cornelissen, V.A., and Smart, N.A. (2013). doi:10.1161/JAHA.112.004473 Journal of the American Heart Association, 2(e004473). 
  49. (2014) Isometric Exercise Training for Blood Pressure Management: A Systematic Review and Meta-Analysis. Carlson, D.J., et al. Proceedings of the Mayo Clinic, 89, 327-334. https://doi.org/10.1016/j.mayocp.2013.10.030 
  50. Effects of Alcohol Reduction on Blood Pressure: A Meta-Analysis of Randomized Controlled Trials, Xin, X., et al., 2001. 38, 1112-1127. Hypertension. https://doi.org/10.1161/hy1101.093424 
  51. The impact of a reduction in alcohol consumption on blood pressure: A systematic review and meta-analysis, Roerecke, M., et al., 2017. e108–e120 in Lancet Public Health, 2. https://doi.org/10.1016/S2468-2667(17)30003-8 
  52. Effects of Oral Potassium on Blood Pressure. Whelton, P.K., et al. Randomized Controlled Clinical Trials Meta-Analysis. JAMA, 277, 1624-1632. https://doi.org/10.1001/jama.1997.03540440058033
  53. Major Outcomes in High-Risk Hypertensive Patients from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) (2002) Rando-mized to Calcium Channel Blocker vs. Diuretic vs. Angiotensin-Converting Enzyme Inhibitor:. JAMA, 288, 2981–2997 (DOI: 10.1001/jama.288.23.2981). 
  54. Law, M.R., Morris, J.K., and Wald, N.J. (2009). "Use of Blood Pressure Lowering Drugs in the Prevention of Cardiovascular Disease: Meta-Analysis of 147 Randomised Trials in the Context of Expectations from Prospective Epidemiological Studies." BMJ, 338, b1665. https://doi.org/10.1136/bmj.b1665 
  55. AHA/ACCF Secondary Prevention and Risk Reduction Therapy for Patients with Coronary and Other Atherosclerotic Vascular Disease: 2011 Update, Smith Jr., SC, et al. a recommendation from the American College of Cardiology Foundation and the American Heart Association. 124, 2458–2473; circulation. https://doi.org/10.1161/CIR.0b013e318235eb4d 
  56. (2006) Current Role of Beta-Blockers in the Treatment of Hypertension. 56. Aronow, W.S. 11, 2599–2607, Expert Opinion on Pharmacotherapy. https://doi.org/10.1517/14656566.2010.482561 
  57. Pitt, B., et al., 57. (2005) In patients with acute myocardial infarction and left ventricular systolic dysfunction, eplerenone decreases mortality 30 days after randomization. American College of Cardiology Journal, 46, 425-431. https://doi.org/10.1016/j.jacc.2005.04.038 
  58. Effect of Metoprolol CR/XL in Chronic Heart Failure: Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure, MERIT-HF Study Group (1999). (MERIT-HF). The Lancet, 353, from 2001 to 2007. https://doi.org/10.1016/S0140-6736(99)04440-2 
  59. Effect of Carvedilol on Survival in Severe Chronic Heart Failure, Packer, M., et al. (2001). 344, 1651-1658, New England Journal of Medicine. https://doi.org/10.1056/NEJM200105313442201 
  60. Investigators and Committees for CIBIS-II at 60 (1999) A Randomized Trial of the Cardiac Insufficiency Bisoprolol Study II (CIBIS-II). pp. 9–13 in The Lancet 353. https://doi.org/10.1016/S0140-6736(98)11181-9 
  61. (1997) Effect of Propranolol versus No Propranolol on Total Mortality Plus Nonfatal Myocardial Infarction in Older Patients with Prior Myocardial Infarction, Congestive Heart Failure, and Left Ventricular Ejection Fraction  40% Treated with Diuretics Plus Angiotensin-Converting Enzyme Inhibitors. American Journal of Cardiology, 1980, 80, 207–209. https://doi.org/10.1016/S0002-9149(97)00320-2 
  62. Regional Variation in Patients and Outcomes in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) Trial, M.A. Pfeffer et al. (2015), 62. 34–42. In circulation, 131. https://doi.org/10.1161/CIRCULATIONAHA.114.013255 
  63. J.T. Wright Jr., et al., "Effect of Blood Pressure Lowering and Antihypertensive Drug Class on Progression of Hypertensive Kidney Disease: Results from the AASK Trial," 2002. JAMA, 288, 2421-2431. https://doi.org/10.1001/jama.288.19.2421 
  64. T.H. Jafar et al., "Progression of Chronic Kidney Disease: The Role of Blood Pressure Control, Proteinuria, and Angiotensin-Converting Enzyme Inhibition: A Patient-Level Meta-Analysis," 2003. Internal Medicine Annals, 139, 244–252. https://doi.org/10.7326/0003-4819-139-4-200308190-00006 
  65. Intensive Blood-Pressure Control in Hypertensive Chronic Kidney Disease, L.J. Appel et al. (2010). 363: 918-929 in the New England Journal of Medicine. 
  66. Antihypertensives for Kidney Transplant Recipients: Systematic Review and Meta-Analysis of Randomized Controlled Trials, Cross, N.B., et al., 2009. 88:7–18 in Transplantation. https://doi.org/10.1097/TP.0b013e3181a9e960 
  67. The PROGRESS Collaborative Group (2001) Randomized Trial of a Perindopril-Based Blood-Pressure-Lowering Regimen Among 6,105 Patients with a History of Stroke or Transient Ischaemic Attack. 1033–1041 in The Lancet, 358. https://doi.org/10.1016/S0140-6736(01)06178-5 
  68. L. Liu et al., "Blood Pressure Reduction for the Secondary Prevention of Stroke: A Chinese Trial and a Systematic Review of the Literature," (2009). Research on hypertension, 32, 1032–1040. https://doi.org/10.1038/hr.2009.139 
  69. Lakhan, S.E., and Sapko, M.T. (2009) A Systematic Review and Meta-Analysis of Blood Pressure Lowering Treatment for Preventing Stroke Recurrence. international medical archives, 2, 30. https://doi.org/10.1186/1755-7682-2-30 
  70. Outcomes Among Hypertensive Patients with Concomitant Peripheral and Coronary Artery Disease: Findings from the International VErapamil-SR/Trandolapril Study, Hypertension, 55, 48–53, 2010. https://doi.org/10.1161/HYPERTENSIONAHA.109.142240
  71. F. Turnbull et al. (2005) Results of Prospectively Designed Reviews of Randomized Trials: Impact of Various Blood Pressure-Lowering Regimens on Major Cardiovascular Events in People with and Without Diabetes Mellitus. 165:1410-1419, Internal Medicine Archives. https://doi.org/10.1001/archinte.165.12.1410 
  72. Comparative Efficacy and Safety of Blood Pressure-Lowering Agents in Adults with Diabetes and Kidney Disease: A Network Meta-Analysis. Palmer, S.C., et al. The Lancet 385:2047–2056. https://doi.org/10.1016/S0140-6736(14)62459-4 
  73. Renin-Angiotensin System and Cardiovascular Risk by R.E. Schmieder et al. doi:10.1016/S0140-6736(07)60242-6 The Lancet, 369, 1208–1219. 
  74. (2012) Type-Selective Benefits of Drugs in the Treatment of Acute Aortic Dissection. Suzuki, T., et al. (from the International Registry of Acute Aortic Dissection [IRAD]). 109, 122-127, American Journal of Cardiology. https://doi.org/10.1016/j.amjcard.2011.08.012 
  75. Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Women of Childbearing Age: Risks vs Benefits, Pucci, M., et al. (2015). 22, 221-231 in Expert Review of Clinical Pharmacology. https://doi.org/10.1586/17512433.2015.1005074 
  76. (2000) Management of Mild Chronic Hypertension during Pregnancy: A Review. Ferrer, R.L. Obesity and gynecology, 96, 849–860. 
  77. The Fetal Safety of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers, Moretti, M.E., et al. (2012). International Journal of Obstetrics and Gynecology, 2012, Article ID: 658310. https://doi.org/10.1155/2012/658310 
  78. (2004) Management of Hypertension Before, During, and After Pregnancy. James, P.R. and Nelson-Piercy, C. https://doi.org/10.1136/hrt.2004.035444 Heart, 90, 1499–1504 
  79. A Systematic Review of Add-On Pharmacologic Therapy in the Treatment of Resistant Hypertension, Tataru, A.P. and Barry, A.R. 2017, p. 79. 311-318. American Journal of Cardiovascular Drugs. https://doi.org/10.1007/s40256-017-0224-5 
  80. Aldosterone, Hypertension, and cardiovascular disease: An Endless Story, L.M. Ruilope, 2008. 52, 207–208. Hypertension. 
  81. Kawamoto, T., and others, 81. (1992) The function of steroid 11 beta-hydroxylase and steroid 18 hydroxylase in human glucocorticoids and mineralocorticoids biosynthesis. United States of America, Proceedings of the National Academy of Sciences, 89, 1458–1462. https://doi.org/10.1073/pnas.89.4.1458 
  82. J. Fagart, et al., "82" (2010) A Potent and Selected Nonsteroidal Molecule's New Mode of Mineralocorticoid Receptor Antagonism. 285, 29932-29940, Journal of Biological Chemistry. https://doi.org/10.1074/jbc.M110.131342 
  83. 2012 saw the discovery of BAY 94-8862, a non-steroidal mineralocorticoid receptor antagonist used to treat cardiorenal diseases. ChemMedChem, 7, 1385–1403, Barfacker, L., et al., https://doi.org/10.1002/cmdc.201200081 
  84. Finerenone, a Novel Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Protects against Rat Cardiorenal Injury, Kolkhof, P., et al. (2014). 64, 69–78, Journal of Cardiovascular Pharmacology. https://doi.org/10.1097/FJC.0000000000000091 
  85. Investigation of Aldosterone-Synthase Inhibition in Rats. Menard, J., Marie-Françoise, G., Thanh-Tam, G., and Alvine, B. 2006. 24:1147–1155. Journal of Hypertension. https://doi.org/10.1097/01.hjh.0000226205.65442.f2 
  86. Aldosterone Antagonism or Synthase Inhibition Reduces End-Organ Damage Induced by Treatment with Angiotensin and High Salt, Lea, W.B., et al., 2009, p. 86. 75, 936–944 of Kidney International. https://doi.org/10.1038/ki.2009.9 
  87. Aldosterone Synthase Inhibition: Cardiorenal Protection in Animal Disease Models and Translation of Hormonal Effects to Human Subjects, Menard, J., et al. (2014). 12, 340. Journal of Translational Medicine. https://doi.org/10.1186/s12967-014-0340-9
  88. Aldosterone Synthase Inhibition with LCI699: A Proof-of-Concept Study in Patients with Primary Aldosteronism, L. Amar et al. (2010). 831–838. Hypertension, 56. https://doi.org/10.1161/HYPERTENSIONAHA.110.157271 
  89. (2011) Effects of a Novel Aldosterone Synthase Inhibitor for Treatment of Primary Hypertension: Results of a Randomized, Double-Blind, Placebo- and Active-Controlled Phase 2 Trial. Calhoun, D.A., et al. 124 circulation from 1945 to 1955. https://doi.org/10.1161/CIRCULATIONAHA.111.029892 
  90. Vasopeptidase Inhibitors: A New Therapeutic Concept in Cardiovascular Disease by Corti, R., Burnett Jr., J.C., Rouleau, J.L., Ruschitzka, and Lüscher, T.F. publication number 104, 1856–1862. https://doi.org/10.1161/hc4001.097191 
  91. Chen, X.M., Vengurlekar, S.S., Silvester, K.R., Makhlina, M., et al. (2013) The in vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide that is a natriuretic peptide receptor-A antagonist and bronchodilator that is resistant to neutral endopeptidase. 229–238 in Pulmonary Pharmacology and Therapeutics. https://doi.org/10.1016/j.pupt.2012.11.001 
  92. Almeida, L., et al. (2013) Tolerability, Pharmacokinetics, and Pharmacodynamics of Etamicastat, a Novel Dopamine Beta-Hydroxylase Inhibitor in Patients with Hypertension. 35 years of Clinical Therapeutics, 1983 to 1996. https://doi.org/10.1016/j.clinthera.2013.10.012 
  93. Esler, M., et al., "Assessment of Human Sympathetic Nervous System Activity from Measurements of Norepinephrine Turnover," 1988. 11, 3-20. Hypertension. https://doi.org/10.1161/01.HYP.11.1.3
  94. Neural Control of Renal Function, G.F. DiBona and U.C. Kopp, 1997. 77, 75–197, Physiological Reviews. https://doi.org/10.1152/physrev.1997.77.1.75 
  95. Esler, M.D., et al. 95. (2010) A Randomized Controlled Trial of Renal Sympathetic Denervation in Patients with Treatment-Resistant Hypertension (The Symplicity HTN-2 Trial). The Lancet, vol. 376, pp. 1903–1909. https://doi.org/10.1016/S0140-6736(10)62039-9 
  96. R. E. Schmieder et al. (2012) ESH Renal denervation as an interventional therapy for resistant hypertension, position paper. 30, 837-841, Journal of Hypertension. https://doi.org/10.1097/HJH.0b013e328352ce78 
  97. Baroreflex Activation Therapy reduces Blood Pressure in Patients with Resistant Hypertension: Results from the Double-Blind, Randomized, Placebo-Controlled Rheos Pivotal Trial, by J.D. Bisognano et al. (2011). American College of Cardiology Journal, 58, 765-773. https://doi.org/10.1016/j.jacc.2011.06.008 
  98. Scheffers, I.J., et al., Novel Baroreflex Activation Therapy in Resistant Hypertension: Results of a European Multi-Center Feasibility Study, 2010. American College of Cardiology Journal, 56, 1254–1258. https://doi.org/10.1016/j.jacc.2010.03.089 
  99. Tonic Carotid Body Chemoreceptor Activity Contributes to the Increased Sympathetic Drive in Essential Hypertension, according to Sinski, M., et al. (2012). 35, 487-491, Hypertension Research. https://doi.org/10.1038/hr.2011.209 
  100. A.E. Burchell, M.D. Lobo, N. Sulke, P.A. Sobotka, and J.F.R. Paton. (2014) Is Arteriovenous Anastomosis the Best Method for Managing Hypertension? 64, 6, and 12 for hypertension. https://doi.org/10.1161/HYPERTENSIONAHA.114.02925 
  101. Stent Placement in Patients with Atherosclerotic Renal Artery Stenosis and Impaired Renal Function: A Randomized Trial, Bax, L., et al., 2009. 150, 840-848, Annals of Internal Medicine. https://doi.org/10.7326/0003-4819-150-12-200906160-00119 
  102. Revascularization vs medical therapy for renal-arterial stenosis. Wheatley, K., et al., 2009. 361 (1953–1962) New England Journal of Medicine. https://doi.org/10.1056/NEJMoa0905368

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Varsha Pangale
Corresponding author

Department of Pharmaceutical Quality Assurance, PRES College of Pharmacy (Women’s), Chincholi, Nashik-422102

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Neha Gaikwad
Co-author

Department of Pharmaceutical Quality Assurance, PRES College of Pharmacy (Women’s), Chincholi, Nashik-422102

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Samiksha Aher
Co-author

Department of Pharmaceutical Quality Assurance, PRES College of Pharmacy (Women’s), Chincholi, Nashik-422102

Varsha Pangale*, Neha Gaikwad, Samiksha Aher, A systematic review on Hypertension and conditions related to thereof, Int. J. in Pharm. Sci., 2024, Vol 1, Issue 4, 166-185. https://doi.org/10.5281/zenodo.7847427

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