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Abstract

The appearance of white patches is a sign of the skin disorder vitiligo. Segmental vitiligo usually becomes dormant after two years of stabilization of the condition. Non-segmental vitiligo can reactivate even after extended periods of stability. Vitiligo is the most common depigmenting skin disorder, affecting 0.5–2% of people worldwide, including both adults and children. the hands, face, and areas close to bodily openings and the genitalia are frequent starting points. premature whitening or greying of your beard, eyebrows, or scalp hair. The mucous membranes, which line the inside of the mouth and nose, have turned grey. The aetiology of vitiligo starts in melanocytes that have been altered and exhibit an enhanced cellular stress response. This triggers an immunological response that eliminates melanocytes and results in localized depigmentation. During repigmentation, melanocytes, which typically come from hair follicles, must grow and migrate. The main histological finding in vitiligo is the absence of any functioning melanocytes in the lesions, and the inflammatory cells that are most frequently found at the edges of the lesions are CD4+ and CD8+ T lymphocytes. Currently, topical, oral, surgical, phototherapy, and other treatments are used to treat vitiligo. One may claim that the best nano-lipid carrier systems for vitiligo treatments use nanotechnology. The quality of life (QoL) of vitiligo sufferers is negatively impacted, according to subsequent studies carried out globally. Vitiligo causes social isolation, shame, low self-esteem, depressed symptoms, and self-consciousness.

Keywords

Vitiligo disease, Pathophysiology, Treatments, Nanotechnology, Quality of life (QoL), Challenges

Reference

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Yash Srivastav
Corresponding author

Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India

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Akhandnath Prajapati
Co-author

Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India

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Adityanath Prajapati
Co-author

BBDNIIT, Lucknow, Uttar Pradesh, India.

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Madhaw Kumar
Co-author

Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India

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Mohammad Aqil Siddiqui
Co-author

Goel Institute of Pharmacy & Sciences (GIPS), Lucknow, Uttar Pradesh, India

Yash Srivastav, Akhandnath Prajapati, Adityanath Prajapati, Madhaw Kumar, Mohammad Aqil Siddiqui, A study of challenges and quality of life (QoL) issues related to Vitiligo disease's current treatments, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 17-30. https://doi.org/10.5281/zenodo.8312051

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