View Article

Abstract

In these studies, Dapagliflozin action was seen in different disease conditions like Diabetes mellitus, Heart failure, and Renal failure. The class of Dapagliflozin is sodium-glucose cotransporter 2 inhibitors, it shows major action in the kidneys. it blocks the reabsorption of filtered glucose in the kidney, increases urinary glucose excretion, and reduces blood glucose levels. by this mechanism, it maintains the blood glucose level and excretes the excess amount of water through urine. Dapagliflozin is used in the treatment of reduced ejection fraction in heart failure patients for better improvement in the condition. In renal failure also these drugs are used for the improvement in the excretion of urine.

Keywords

Dapagliflozin, Diabetes Mellitus, Heart failure, Renal failure, Sodium glucose cotransporter 2 inhibitor

Reference

  1. Kharroubi AT, Darwish HM. Diabetes mellitus: The epidemic of the century. World J Diabetes. 2015 Jun 25;6(6):850-67. doi: 10.4239/wjd.v6.i6.850. PMID: 26131326; PMCID: PMC4478580
  2. Sapra A, Bhandari P. Diabetes. [Updated 2023 May 29]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan
  3. Klein BE, Klein R, Moss SE, Cruickshanks KJ. Parental history of diabetes in a population-based study. Diabetes Care. 1996 Aug;19(8):827-30
  4. Oparil S, Acelajado MC, Bakris GL, Berlowitz DR, Cífkova R, Dominiczak AF, Grassi G, Jordan J, Poulter NR, Rodgers A, Whelton PK. Hypertension. Nat Rev Dis Primers. 2018 Mar 22;4:18014. doi: 10.1038/nrdp.2018.14. PMID: 29565029; PMCID: PMC6477925.
  5. Bindroo S, Quintanilla Rodriguez BS, Challa HJ. Renal Failure. [Updated 2022 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan
  6. Chertow GM, Burdick E, Honour M, Bonventre JV, Bates DW. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients. J Am Soc Nephrol. 2005 Nov;16(11):3365-70 
  7. Dapagliflozin Tablet -Uses, Interaction, Mechanism of Action , DRUGBANK  Online ,by drugbank.com
  8. Dhillon S. Dapagliflozin: A Review in Type 2 Diabetes. Drugs. 2019 Jul;79(10):1135-1146. doi 10.1007/s40265-019-01148-3. Erratum in: Drugs. 2019 Dec;79(18):2013. PMID: 31236801; PMCID: PMC6879440.
  9.  Martha K Nicholson, Randa Ghazal Asswad & John PH Wilding .(2021) Dapagliflozin for the treatment of type 2 diabetes mellitus – an update, Expert Opinion on pharmacotherapy, 22:17, 2303-2310, DOI:10.1080/14656566.2021.1953471    
  10. Balakumar P, Sundram K, Dhanaraj S.(2014) Dapagliflozin: glucuretic action and beyond. Pharmacol Res 82: 34–39.
  11.  Mudaliar S, Henry R, Boden G, Smith S, Chalamandaris A, Duchesne D, et al. (2014) Changes in insulin sensitivity and insulin secretion with the sodiumglucose cotransporter 2 inhibitor dapagliflozin. Diabetes Technol Ther 16: 137–144 
  12.  Solomon, Scott D , McMurray, John J.V, Claggett, Brian de Boer, Rudolf A, DeMets, David, Hernandez, Adrian F, Inzucchi, Silvio E, Kosiborod, Mikhail N, Lam, Carolyn S.P, Martinez, Felipe ,Shah, Sanjiv J, Desai, Akshay S, Jhund, Pardeep S, Belohlavek, Jan Chiang, Chern-En , Borleffs, C,Jan Willem,  Comin-Colet, Josep , Dobreanu, Dan, Drozdz, Jaroslaw, Fang, James C, Alcocer-Gamba, Marco Antonio, Al Habeeb, Waleed , Han, Yaling ,Cabrera Honorio, Jose Walter and Janssens, Stefan P. and Katova, Tzvetana and Kitakaze, Masafumi and Merkely,Meara, Eileen, Saraiva, Jose Francisco Kerr, Tereshchenko, Sergey N, Thierer, Jorge ,Vaduganathan, Muthiah , Vardeny, Orly, Verma, Subodh ,Pham, Vinh Nguyen, Wilder, Ulrica, Zaozerska, Natalia ,Bachus, Erasmus ,Lindholm, Daniel and Petersson, Magnus and Langkilde, Anna Maria,Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction,New England Journal of Medicine,387,12,1089-1098,2022,doi :10.1056/NEJMoa2206286, PMID: 36027570
  13. Gupta M, Rao S, Manek G, Fonarow GC, Ghosh RK. The Role of Dapagliflozin in the Management of Heart Failure: An Update on the Emerging Evidence. Ther Clin Risk Manag. 2021;17:823-830
  14. Heerspink, Hiddo J.L. and Stefnsson, Bergur V. and Correa-Rotter, Ricardo and Chertow, Glenn M. Greene, Tom, Hou, Fan-Fan, Mann, Johannes F.E. McMurray, John J.V, Lindberg, Magnus, Rossing, Peter, C. David ,Toto, Roberto D. Langkilde, Anna-Maria, Wheeler, David C. Dapagliflozin in Patients with Chronic Kidney Disease, New England Journal of Medicine,383,15,1436-1446,2020,doi = {10.1056/NEJMoa2024816} note ={PMID: 32970396}
  15. McMurray JJV, Wheeler DC, Stefansson BV, Jongs N, Postmus D, Correa-Rotter R, Chertow GM, Greene T, Held C, Hou FF, Mann JFE, Rossing P, Sjostrom CD, Toto RD, Langkilde AM, Heerspink HJL; DAPA-CKD Trial Committees and Investigators. Effect of Dapagliflozin on Clinical Outcomes in Patients With Chronic Kidney Disease, With and Without Cardiovascular Disease. Circulation. 2021 Feb 2;143(5):438-448. doi: 10.1161/CIRCULATIONAHA.120.051675. Epub 2020 Nov 13. PMID: 33186054.
  16. Dapagliflozin and metformin (oral route), drugs and supplements, MAYO CLINIC, by drug information provided by Meratives, Micromedex 
  17. Dapagliflozin (Rx), Drugs and Diseases,by Medscape.com 
  18. Dapagliflozin (Farmiga), DRUGS AND SUPPLEMENTS, by EVERYDAY HEALTH, everyday .com
  19. Dapagliflozin, Medline Plus Trusted Health Information For You,NIH, National Library of Medicine by Medline plus.com

Photo
P. Shaheera
Corresponding author

Department of Pharmacy Practice, Hindu College of Pharmacy, Guntur -522002, Andhra Pradesh, India.

Photo
G. Anjani Tejaswi
Co-author

Department of Pharmacy Practice, Hindu College of Pharmacy, Guntur -522002, Andhra Pradesh, India.

Photo
A. Navyasree
Co-author

Department of Pharmacy Practice, Hindu College of Pharmacy, Guntur -522002, Andhra Pradesh, India.

Photo
M. Bala Tripur Sundari
Co-author

Department of Pharmacy Practice, Hindu College of Pharmacy, Guntur -522002, Andhra Pradesh, India.

Photo
P. Seetharamaiah
Co-author

Department of Pharmacy Practice, Hindu College of Pharmacy, Guntur -522002, Andhra Pradesh, India.

P. Shaheera, G. Anjani Tejaswi, A. Navyasree, M. Bala Tripur Sundari, P. Seetharamaiah, A Review of Dapagliflozin Effect On Disease Conditions Like Diabetes Mellitus, Heart Failure, Renal Failure, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 71-76. https://doi.org/10.5281/zenodo.8322377

More related articles
Review On: Alternative Natural Treatment For Psori...
Gayatri vikram salunke, A D khajekar, A K Hatkar , R M kawade, ...
A Review on Advances in Anticancer Pharmacology ...
Ravindrasing Patil, Tushar Ambhore, Hariom Chankhore, Tejas Sh...
Phytochemical Profiling, Comparative Evaluation of...
Sudddagoni Santhosh, Maddineni Sarika, Dr Akula Ganesh, ...
A Systemic Review on Neuroprotective Activity of Various Herbal Plants...
Pallavi N, Iyswarya G M, Kavya P Reddy, Karthik S, Kiran G M, ...
Enhance Penetration Of Diclofenac Gel With Using Hemp Seed Oil As A Penetration ...
Raj Kumar, Vipin Kumar Sharma, Raghav Dixit , Madhav Mohan, ...
An Evaluation On Medicinal Plant Practice For Management Of Diabetes: A Short Re...
Saurabh T. Shinde, Arun D. Shinde, Pritam S. Shinde, Shravani J. Shinde, Vaishnavi T. Shinde, Vinod ...
Related Articles
Aspirin Redesigned: A CADD-Guided Exploration of Optimized Aspirin Analogs for T...
Ranjeet V Pingale , Raj R Jagtap , Rohan B chavan , Pratik B lakade, ...
Evaluation And Determination of Azadirachtin and Fatty Acid Constants from The L...
Dr. Raja Kumar Parabathina, Nidhi Dubey, Sanika Girgaonkar, Vishal Lolge, Sunil Kothargasti, ...
A Review On To Expose The Effect Of Plant Ghee And Animal Ghee On Biochemical Pa...
Shubham Kshirsagar, Nikhil Bondhare, Ankita Shinde, Jagruti Shinde, ...
Herbal Drugs Used as Anticancer Agent ...
Aarti Harjan, Atharva Pusalwar, Dr. Ashish Kandalkar, Supriya Bhagat, Dr. Nilesh Chachda, ...
Review On: Alternative Natural Treatment For Psoriasis...
Gayatri vikram salunke, A D khajekar, A K Hatkar , R M kawade, ...
More related articles
Review On: Alternative Natural Treatment For Psoriasis...
Gayatri vikram salunke, A D khajekar, A K Hatkar , R M kawade, ...
A Review on Advances in Anticancer Pharmacology ...
Ravindrasing Patil, Tushar Ambhore, Hariom Chankhore, Tejas Sharma, Vinod Chaware, Dr. Shivshanka...
Phytochemical Profiling, Comparative Evaluation of The Non-Dependent Antidiabeti...
Sudddagoni Santhosh, Maddineni Sarika, Dr Akula Ganesh, ...
Review On: Alternative Natural Treatment For Psoriasis...
Gayatri vikram salunke, A D khajekar, A K Hatkar , R M kawade, ...
A Review on Advances in Anticancer Pharmacology ...
Ravindrasing Patil, Tushar Ambhore, Hariom Chankhore, Tejas Sharma, Vinod Chaware, Dr. Shivshanka...
Phytochemical Profiling, Comparative Evaluation of The Non-Dependent Antidiabeti...
Sudddagoni Santhosh, Maddineni Sarika, Dr Akula Ganesh, ...