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Abstract

Millions of people worldwide suffer from asthma, a disease that causes inflammation and bronchial hyperreactivity, and in the upcoming years, it will be more fatal to control. Factors such as prenatal tobacco smoke, genetics, antibiotic use, lung function, environmental tobacco exposure, allergic sensitization, sex and gender, and smoking contribute to its prevalence, morbidity, mortality, and economic burden. Treatment includes bronchodilators, inhibitors of IgE, and other medications. However, current treatments can cause adverse effects, leading to the search for low-risk, non-drug strategies, such as herbal remedies. Traditional herbs have a greater impact on illness with minimal side effects and have been widely used in developing nations. Certain herbs, such as haridra/turmeric, lobelia, black seed, adhatoda, and camphor, have the potential to mitigate symptoms by decreasing inflammation. Herbs like cardamom, garlic, and tulsi also have potent antiasthmatic action and anti-inflammatory, immunomodulatory, antihistaminic, smooth-muscle relaxant, and allergic properties.

Keywords

Asthma, Mast cells, widespread illness, hyperreactivity, Inflammation, IGE

Reference

  1. Masoli M, Fabian D, Holt S, Beasley R. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004; 59:469–478. [PubMed] [Google Scholar]
  2. Bousquet J, Bousquet PJ, Godard P, Daures JP. The public health implications of asthma. Bull World Health Organ. 2005;83:548–554. [PMCfree article] [PubMed] [Google Scholar]
  3. Review of Pharmacology 14th edition by Gobind Rai Garg and Sparsh Gupta.
  4. Stein RT, Holberg CJ, Sherrill D, et al. Influence of parental smoking on respiratory symptoms during the first decade of life: the Tucson Children’s Respiratory Study. Am J Epidemiol 1999; 149:1030-7.
  5. Lewis S, Richards D, Bynner J, et al. Prospective study of risk factors for early and persistent wheezing in childhood. Eur Respir J 1995; 8:349-56.
  6. Lau S, Nickel R, Niggemann B, et al. The development of childhood asthma: lessons from the German Multicentre Allergy Study (MAS). Paediatr Respir Rev 2002; 3:265-72.
  7. Willemsen G, van Beijsterveldt TCEM, van Baal CGCM, et al. Heritability of self-reported asthma and allergy: a study in adult Dutch twins, siblings, and parents. Twin Res Hum Genet 2008; 11:132-42.
  8. Jedrychowski W, Galas A, Whyatt R, et al. The prenatal use of antibiotics and the development of allergic disease in one-year-old infants. A preliminary study. Int J Occup Med Environ Health 2006; 19:70-6.
  9. Benn CS, Thorsen P, Jensen JS, et al. Maternal vaginal microflora during pregnancy and the risk of asthma hospitalization and use of antiasthma medication in early childhood. J Allergy Clin Immunol 2002; 110:72-7.
  10. Dezateux C, Stocks J, Dundas I, et al. Impaired airway function and wheezing in infancy: the influence of maternal smoking and a genetic predisposition to asthma. Am J Respir Crit Care Med 1999; 159:403-10.
  11. Lødrup Carlsen KC. The Environment and Childhood Asthma (ECA) Study in Oslo: ECA-1 and ECA-2. Pediatr Allergy Immunol 2002;13(Suppl 15):29-31.
  12. Lin RY, Rehman A. Clinical characteristics of adult asthmatics requiring intubation. J Med 1995; 26:261-77.
  13. James AL, Palmer LJ, Kicic E, et al. The decline in lung function in the Busselton Health Study: the effects of asthma and cigarette smoking. Am J Respir Crit Care Med 2005; 171:109-
  14. Sears MR, Burrows B, Flannery EM, et al. Relation between airway responsiveness and serum IgE in children with asthma and apparently normal children. N Engl J Med 1991; 325:1067-71
  15. Tariq SM, Arshad SH, Matthews SM, et al. Elevated cord serum IgE increases the risk of aeroallergen sensitization without increasing respiratory allergic symptoms in early childhood. Clin Exp Allergy 1999; 29:1042-8.
  16. de Marco R, Locatelli F, Sunyer J, et al. Differences in incidence of reported asthma related to age in men and women. A retrospective analysis of the data of the European Respiratory Health Survey. Am J Respir Crit Care Med 2000; 162: 68-74.
  17. Crawford WA, Beedham CG. The changing demographic pattern in asthma related to sex and age. A study of 13,651 patients on sodium cromoglycate (Intal). Med J Aust 1976; 1:430-4.
  18. Bjornson CL, Mitchell I. Gender differences in asthma in childhood and adolescence. J Gend Specif Med 2000; 3:57-61.
  19. Gilliland FD, Islam T, Berhane K, et al. Regular smoking and asthma incidence in adolescents. Am J Respir Crit Care Med 2006; 174:1094-100.
  20. Tetrault JM, Crothers K, Moore BA, et al. Effects of marijuana smoking on pulmonary function and respiratory complications: a systematic review. Arch Intern Med 2007; 167:221-8.
  21. Taylor DR, Fergusson DM, Milne BJ, et al. A longitudinal study of the effects of tobacco and cannabis exposure on lung function in young adults. Addiction 2002; 97: 1055-61.
  22. Review of Pharmacology 14th edition by Gobind Rai Garg and Sparsh Gupta.
  23. Tripathi KD. Essentials of medical pharmacology. 4th ed. New Delhi, India: Jaypee Brothers Medical Publishers Ltd; 2001.
  24. Greenberger PA. Therapy in the management of rhinitis asthma complex. Allergy Asthma Proc. 2003; 24:403–407. [PubMed] [Google Scholar]
  25. Lyengar MA, Jambaiah KM, Rao GM. Studies on an anti-asthma kada: A Proprietary Herbal Combination Part-I Clinical Study. Indian Drug. 1994;31(5):183–186. [Google Scholar]
  26. Kobayashi T, Hashimoto S, Horie T. Curcumin inhibition of Dermatophagoides farina-induced interleukin-5 (IL-5) and granulocyte-macrophage- colony-stimulating factor (GM-CSF) production by lymphocytes from bronchial asthmatics. Biochem Pharmacol. 1997; 54:819-24.
  27. Ram A, Das M, Ghosh B. Curcumin attenuates allergen-induced airway hyperresponsiveness in sensitized guinea pigs. Biol Pharm Bull. 2003; 26:1021 24.
  28. 28 Itokawa H, Shi Q, Akiyama T, Morris-Natschke SL, Lee KH. Recent advances in the investigation of Curcuminoids. Chin Med. 2008; 3:11.
  29. Subarnas A, Tadano T, Oshima Y, Kisara K, Ohizumi Y. Pharmacological properties of beta-amyrin palmitate, a novel centrally acting compound, isolated from lobelia inflata leaves. J Pharm Pharmacol. 1993; 45(6):545-550.
  30. Gandevia SC, Butler JE, Hodges PW, Taylor JL. Balancing acts: respiratory sensations, motor con trol and human posture. Clinical and Experimental Pharmacology and Physiology. 2002; 29(1-2):118-121.
  31. Jaju DS, Dikshit MB, Agrawal MJ, Gupte NA. Comparison of respiratory sensations induced by J receptor stimulation with lobeline in left handers & right handers. Indian J Med Res. 1998; 108:291-295.
  32. Silva Carvalho L, Moniz de Bettencourt J, Silva Carvalho J, Bravo Pimentao J, Pinto BG. Effect of propranolol and pindolol on carotid reflexes induced by lobeline. C R Seances Soc Biol Fil. 1981; 175(3):416-9.
  33. Raj H, Singh VK, Anand A, Paintal AS. Sensory origin of lobeline-induced sensations - a correlative study in man and cat. Journal of Physiology-London. 1995; 482(1:235-246.
  34. Mahfouz, M., El-Dakhakhny, M., 1960. Chemical and pharmacological properties of the new anti-asthmatic drug, nigellone. Egypt Pharm. Bull. 42, 411–424. Pendry, Y.D., 1993. Neural control of airways smooth muscle. Pharmacol. Ther. 57, 171–202.
  35. El-Tahir, K.E.H., Ashour, M.M.S., Al-Harbi, M.M., 1993. The respiratory effect of the volatile oil of the Black seed (Nigella sativa) in guinea pig: elucidation of the mechanism(s) of action. Gen. Pharmacol. 24, 1115–1122.
  36. Houghton, P.J., Zarka, R., B, De las Heras, Hoult, J.R., 1995. Fixed oil of Nigella sativa and derived thymoquinone inhibit eicosanoid generation in leukocytes and membrane lipid peroxidation. Planta Med. 61, 33–36.
  37. Boskabady, M.H., Kiani, S., Jandaghi, P., Ziaei, T., Zarei, A., 2004a. Antitussive of Nigella sativa. Pak. J. Med, Sci. 20, 224–228.
  38. Boskabady, M.H., Javan, H., Sajadi, M., Rakhshandah, H., 2007. The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients. Fund. Clinic. Pharmacol. 21, 559–566.
  39. Atal CK, 1980. Chemistry and Pharmacology of Vasicine-A New Oxytocic and Abortifacient, Regional Research Laboratory, Jammu- Tawi.
  40. Lal SD and BK Yadav, 1983. Folk medicine of Kurukshetra district (Haryana), India. Econ. Bot., 37: 299-305.
  41. Shah NC and MC Joshi, 1971. Ethnobotanical study of the Kumaon region of India. Econ. Bot., 25: 414-422.
  42. Bhat VS, DD Nasavatl and BR Mardikar, 1978. Adhatoda vasica-an Ayurvedic plant. Indian Drugs,15: 62-66.
  43. Dymock W, 1972. India pharmacographia of plants. Hamdard National Foundation Pak, 3: 343-344.
  44. Roberts E, 1931.Vegetable materia medica of India and Ceylon. Plate Limited, Colombo, pp. 16-17.
  45. Dorsch W and H Wagner, 1991. New antiasthmatic drugs from traditional medicine. Int. Arch. Allergy Appl. Immunol., 94: 262-265.
  46. Dhuley JN, 1999. Antitussive effect of Adhatoda vasica extract on mechanical or chemical stimulation-induced coughing in animals. J. Ethnopharmacol., 67: 361-365.
  47. Lahiri PK and SN Pradhan, 1964. Pharmacological investigation of vasicinol, an alkaloid from Adhatoda vasica Nees. Indian Journal of Experimental Biology, 2: 219.
  48. Choi, J.K., 1997. Longevity Way with Traditional Ethnophamacology in Korea (Tojong Yakcho Jangsubeob). Taeil Publication, Seoul, p. 255.
  49. Sekut, L., Connolly, K.M., 1996. Pathophysiology and regulation of TNF-alpha in inflammation. Drug News and Perspectives 9, 261–269.
  50. Bingham 3rd., C.O., 2002. The pathogenesis of rheumatoid arthritis: pivotal cytokines involved in bone degradation and inflammation. Journal of Rheumatology Supplement 65, 3–9.
  51. Loizzo MR, Menichini F, Tundis R, Bonesi M, Conforti F, et al. (2009) In Vitro Biological Activity of Salvia Lerrifolia Benth Essential Oil Relevant to the Treatment of Alzheimer’s Disease. Journal of Oleo Science 58: 443-449.
  52. Perry NS, Bollen C, Perry EK, Ballard C (2003) Salvia for Dementia Therapy: Review of Pharmacologyical Activity and Pilot Tolerability Clinical Trial. Pharmacology, Biochemistry and Behavior 75: 651-659.
  53. Kapoor LD. Handbook of Ayurvedic medicinal plants. CRC Press, Boca Raton, 1990, p 172.
  54. Duke JA, Bogenschutz-Godwin MJ, DuCelliar J, Duke PK. Hand book of medicinal herbs. 2nd ed. Boca Raton, CRC Press, 2002, pp 153-54.
  55. Fleckenstein A. Specific pharmacology of Ca++ in cardiac pacemakers and vascular smoothmuscle.RevPharmacolToxicol.1977;17:14966.doi:10.1146/annurev.pa.17.040177.001053.
  56. Gilani SN, Khan A, Gilani AH. Pharmacological basis for the medicinal use of Zanthoxylum armatum in gut, airways and cardiovascular disorders. Phytother Res. 2010; 24: 553-58. doi: 10.1002/ptr.2979.
  57. Twiss MA, Harman E, Chesrown S, Handeles L. Efficacy of calcium channel blockers as maintenance therapy for asthma. Br J Clin Pharmacol. 2002; 53: 243-49. doi: 10.1046/ j.0306-5251.2001.01560. x.
  58. Ghayur MN, Khan H, Gilani AH. Antispasmodic, bronchodilator and vasodilator activites of (+)-catechin, a naturally occurring flavonoid. Arch Pharm Res. 2007; 30: 970-75. doi: 10.1007/BF02993965.
  59. Vanaclocha B, Cañigueral S. Fitoterapia, Vademécum de prescripción. 5a ed. Barcelona: Elsevier; 2019.37p.
  60. World Health Organization. WHO monographs on selected medicinal plants. Vol 1. Geneva; 1999. p.16-26.
  61. Allii sativi bulbus (Garlic). ESCOP Monographs: The Scientific Foundation for Herbal Medicinal Products; 2019
  62. Zare, A.; Farzaneh, P.; Pourpak, Z.; Zahedi, F.; Moin, M.; Shahabi, S.; Hassan, Z.M. Purified aged garlic extract modulates allergic airway inflammation in BALB/c mice. Iran. J. Allergy Asthma Immunol. 2008, 7, 133–141.
  63. 71. Tao Z., Jin W., Ao M., Zhai S., Xu H., Yu L. Evaluation of the anti-inflammatory properties of the active constituents in Ginkgo biloba for the treatment of pulmonary diseases. Food & Function. 2019; 10:2209–2220. doi: 10.1039/c8fo02506a. [PubMed] [CrossRef] [Google Scholar]
  64. 109. Maleki S. J., Crespo J. F., Cabanillas B. Anti-inflammatory effects of flavonoids. Food Chemistry. 2019;299: p. 125124. doi 10.1016/j.foodchem.2019.125124. [PubMed] [CrossRef] [Google Scholar]
  65. Z. Tao, W. Jin, M. Ao, S. Zhai, H. Xu, L. Yu, Evaluation of the anti-inflammatory properties of the active constituents in Ginkgo biloba for the treatment of pulmonary diseases, Food Funct. 10 (4) (2019) 2209–2220.
  66. F. Wu, W. Shi, G. Zhou, H. Yao, C. Xu, W. Xiao, J. Wu, X. Wu, Ginkgolide B functions as a determinant constituent of Ginkgolides in alleviating lipopolysaccharide-induced lung injury, Biomed. Pharmacother. 81 (2016) 71–78.
  67. L. Pan, Y. Lu, Z. Li, Y. Tan, H. Yang, P. Ruan, R. Li, Ginkgo biloba extract EGb761 attenuates bleomycin-induced experimental pulmonary fibrosis in mice by regulating the balance of M1/M2 macrophages and nuclear factor kappa B (NF?B)-mediated cellular apoptosis, Med. Sci. Monit. 26 (2020), e922634.
  68. C.Y. Lee, J.J. Yang, S.S. Lee, C.J. Chen, Y.C. Huang, K.H. Huang, Y.H. Kuan, Protective effect of Ginkgo biloba leaves extract, EGb761, on endotoxin-induced acute lung injury via a JNK- and Akt-dependent NF?B pathway, J. Agric. Food Chem. 62 (27) (2014) 6337–6344.
  69. Sen P. Therapeutic potentials of Tulsi: from experience to facts. Drugs News & Views 1993; 1(2): 15–21.
  70. Ocimum sanctum. The Indian home remedy. In: Current Medical Scene, March-April 1992 (Edited and published by S. Rajeshwari, Cipla Ltd., Bombay Central, Bombay).
  71. Mukherji S.P. Ocimum- a cheap source of Eugenol. Science Reporter 1987, p. 599. 31. Eugenol-rich Ocimum variety released. In: CSIR NEWS (Published by PID CSIR, New Delhi), 1995; 45: 256
  72. Hannan JMA, Marenah L, Ali L. OS leaf extracts stimulate insulin secretion from perfused pancreas, isolated islets and clonal pancreatic ? cells. J Endocrin. 2006; 189:127-36
  73. Study of anti-tussive activity of Ocimum sanctum Linn in guinea pigs. Indian J Physiol Pharmacol. 2005;49(2):243-5.
  74. Mediratta PK. Effect of Ocimum sanctum Linn. on humoral immune responses. Ind J Med Res. 1988;4:384-6.
  75. Singh N. A new concept on the possible therapy of stress diseases with “adaptogens” (Anti-stress drugs) of indigenous plant origin. Current Medical Practice. 1981;25(1):50.
  76. Singh H, Kapoor VK. In: Medicinal and Pharmaceutical chemistry. Delhi: Vallabh Prakashan; 1995.

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Shyam Rangari
Corresponding author

Department of pharmaceutical Chemistry , Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur Pin- 441002

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Divyanshu Gahane
Co-author

Department of pharmaceutical Chemistry , Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur Pin- 441002

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Aishwarya Deshmukh
Co-author

Department of pharmaceutical Chemistry , Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur Pin- 441002

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Milind Umekar
Co-author

Department of pharmaceutical Chemistry , Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur Pin- 441002

Divyanshu Gahane, Aishwarya Deshmukh, Shyam Rangari, Milind Umekar, A Review Of The Impact Of Different Herbs As An Anti-Asthmatics, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 285-296. https://doi.org/10.5281/zenodo.10652917

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