View Article

  • A Retrospective Observational Study To Determine The Percentage Of Drugs Prescribed By Generic Names In ICU Of A Tertiary Care Hospital In Dakshina Kannada
  • 1Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, INDIA
    2Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, INDIA 
    3Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, INDIA

Abstract

Background: Prescription pattern analysis provides information on current drug use in order to ensure rational drug therapy. WHO developed core drug use indicators which considered as the first line indicator for evaluation of drug use in health care settings. ICUs represents an important platform for conducting prescription pattern studies as patients are seriously ill and are often suffering from chronic critical illness. Multiple medications from a variety of pharmacological classes are prescribed to these patients and this significantly raises their health care costs, and patient’s morbidity and mortality .Hence prescribing drugs in generic names in the intensive care unit (ICU) promotes the rational use of drugs and also enhances patient safety. Methods: A retrospective study analyzed the prescription pattern of patients admitted to intensive care unit of tertiary care hospital in Dakshina Kannada which was aimed to determine the percentage of drugs prescribed by generic names. The study was carried out for a period of 6 months and the data of 100 patients who met study criteria were extracted from patient’s case records in a preformed performa after taking approval from institutional ethics committee and analysed by using Microsoft excel. The parameters assessed were demographic profile of the patients, indication, and utilization of different drugs. Results: A total of 100 patients were evaluated consisting 61% of males. Cardiovascular disease was involved in the majority of patients. The average number of drugs per prescription was 11.2 more than WHO recommendation. The average stay of patients in ICU was 3 days. Of drugs prescribed 158 (14%) drugs were prescribed by generic names which includes antibiotics, anticoagulant mannitol and 962(85.89%) by brand names. Conclusion: Study concludes that prescription pattern was not optimal in accordance with the standard values of WHO prescribing indicator. The findings underline that there is need to rationalize the drug therapy in terms of increasing prescribing of drugs by generic names instead of brand names.

Keywords

Drug, Prescription pattern, Intensive care unit, Generic drugs, Branded drugs

Reference

  1. Kolasani BP, Sasidharan P, Divyashanthi C. M, Rajaseharan A, Jayabal P. Prescribing pattern and who core prescribing indicators in post-operative patients of Gynecology Department of a tertiary care teaching hospital. International Journal of Basic and Clinical Pharmacology. 2017;6(1):53-60.
  2. Gawali U, Khobragade R. Drug utilization and prescription pattern study in medicine intensive care unit at tertiary care teaching hospital. National Journal of Physiology, Pharmacy and Pharmacology. 2019;9(7):674-7.
  3. Shinde RM, Kale A, Chube S, Sawant M. Drug utilization study in medical intensive care unit in a rural tertiary care teaching hospital in Maharashtra. International Journal of Medical Science and Public Health. 2017;6(4):733-7.
  4. Smythe MA, Melendy S, Jahns B, Dmuchowski C. An exploratory analysis of medication utilization in a medical intensive care unit. Critical Care Medicine.1993;21(9):1319-23
  5. Sharma N, Parakh R, Sharma D, Sharma P, Sharma PNS. A Drug utilization study in Critically Ill Patients in a Tertiary care Teaching Hospital in North India. American Journal of PharmTech Research. 2014;4(1):780-9
  6. Kacha HV, Mundhava SG, Kubavat AR. Assessment of  drug  use  pattern,  their  cost  and  safety  in emergency  department  at  a  tertiary  care  teaching hospital,  Rajkot.  International Journal of Pharmaceutical Sciences and Research. 2018;9(4):1638-43.
  7. Irajpour A, Farzi S, Saghaei M, Ravaghi H. Causes of medication errors in intensive care units from the perspective of healthcare professionals. Journal of Research in Pharmacy Practice. 2017;6(3):158-165
  8. Hoffman JM, Proulx SM. Medication errors caused by confusion of drug names. Drug Safety. 2003;26(7):445–52.
  9. Flannery AH, Pandya K, Laine ME, Almeter PJ, Flynn JD. Managing the rising costs and high drug expenditures in Critical Care Pharmacy Practice. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy. 2016;37(1):54–64.
  10. Dalton K, Byrne S. Role of the pharmacist in reducing healthcare costs: Current insights. Integrated Pharmacy Research and Practice. 2017;6:37–46.
  11. Benjamin DM. Reducing medication errors and increasing patient safety: Case studies in clinical pharmacology. The Journal of Clinical Pharmacology. 2003;43(7):768–83.
  12. Horsky J, Schiff GD, Johnston D, Mercincavage L, Bell D, Middleton B. Interface design principles for usable decision support: A targeted review of best practices for clinical prescribing interventions. Journal of Biomedical Informatics. 2012;45(6):1202–16.
  13. Sisay M, Mengistu G, Molla B, Amare F, Gabriel T. Evaluation of rational drug use based on World Health Organization core drug use indicators in selected public hospitals of eastern Ethiopia: a cross sectional study. BMC Health Services Research. 2017;17(1):161
  14. Ofori-Asenso R, Brhlikova P, Pollock AM. Prescribing indicators at primary health care centers within the WHO African region: A systematic analysis . BMC Public Health. 2016;16(1):1-14.
  15. Pichala PT, Kumar BM, Zachariah S, Thomas D, Saunchez L, Gerardo AU. An interventional study on intensive care unit drug therapy assessment in a rural district hospital in India. Journal of Basic and Clinical Pharmacy. 2013;4(3):64-7.
  16. Sharma P, Kapoor B. Study of prescribing pattern for rational drug therapy. JK science.2003;5(3):107-9.
  17. Kaur S, Rajagopalan S, Kaur N, Shafiq N, Bhalla A, Pandhi P et al. Drug Utilization Study in Medical Emergency Unit of a Tertiary Care Hospital in North India. Emergency Medicine International. 2014; 2014:1-5.
  18. Patel MK, Barvaliya MJ, Patel TK, Tripathi C. Drug utilization pattern in critical care unit in a tertiary care teaching hospital in India. International Journal of Critical Illness and Injury Science. 2013;3(4):250-5.
  19. Shankar PR, Partha P, Dubey AK, Mishra P, Deshpande VY. Intensive care unit drug utilization in a teaching hospital in Nepal. Kathmandu University Medical Journal(KUMJ).2005;3(2):130-7.
  20. Federal Ministry of Health, The Assessment of the Pharmaceutical Sector in Ethiopia Commissioned by the Federal Ministry of Health and conducted with the Financial and Technical Assistance of the World Health Organization, World Health Organization, Addis Ababa,Ethiopia,2003.
  21. World Health Organization, Promoting Rational Use of Medicines; Core Components, Policy Perspectives on Medicines, World Health Organization, Geneva, Switzerland, 2002.
  22. Patidar R, Pichholiya M. Analysis of drugs prescribed in emergency medicine department in a tertiary care teaching hospital in southern Rajasthan. International Journal Basic and Clinical Pharmacology. 2016;5(6):2496-9.
  23. Shinde RM, Kale A, Chube S, Sawant M. Drug utilization study in medical intensive care unit in a rural tertiary care teaching hospital in Maharashtra. International Journal of Medical Science and Public Health. 2017;6(4):733-7.
  24. Adhikari K, Phukan S. Drug utilization pattern in ICU in a tertiary health care institution. International Journal of Basic & Clinical Pharmacology.2018;7(7):1396-402.
  25. Mittal N, Mittal R, Singh I, Shafiq N, Malhotra S. Drug utilization study in a tertiary care center: Recommendations for improving hospital drug dispensing policies. Indian Journal of Pharmaceutical Science. 2014;76(4):308-14.
  26.  Haas JS, Phillips KA, Gerstenberger EP, Seger AC. Potential savings from substituting generic drugs for brand-name drugs: Medical expenditure panel survey, 1997–2000. Annals of Internal Medicine. 2005;142(11):891-7.
  27. Generic Bulletin NMIC. Available from: http://www.15no1 web with refs.pdf. [Last accessed on 2016 Oct 25]
  28. Gardiner P, Dvorkin L. Promoting medication adherence in children. The American Family Physician. 2006;74(5):793–8.

Photo
Shreya S
Corresponding author

Department of Pharmacy practice ,Srinivas college of Pharmacy

Viresh K. Chandur, Shreya S.*, Ashitha Ephrem, Ramakrishna Shabaraya A., A Retrospective Observational Study To Determine The Percentage Of Drugs Prescribed By Generic Names In ICU Of A Tertiary Care Hospital In Dakshina Kannada, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 234-239. https://doi.org/10.5281/zenodo.10107374

More related articles
A Comprehensive Review On Complexities And Directi...
MAHESH KUMAR T, Vetrivel Rajan M. , Gowsalya K., ...
SPLENOPROTECTIVE EFFECT OF KUDZU ROOT EXTRACT IN A...
Aman Upaganlawar, Sumitkumar Sharma, Aakif Bagwan, Mangesh Tatar,...
Design And in Silico Screening of Thiazolidine-2,4...
Swathi Naraparaju, Sandeep Manda, Tejasree Dasagiri, Vaishnavi Dh...
Formulation and Evaluation of Herbal cookies containing Moringa Leaves ...
Shetal B Desai, Sachin B Narkhede, Jinal B Vanjara, Nisha V Yadav, Khushi P Patel, Krupa K Bhanushal...
Assessing The Benefits, Risks, Psychological Issues And Costeffective Analysis I...
Nivetha B., Manivannan R. , Arunkumar P. , Gokul V, Satheeshkumar R. , Sathya V., Sudharsanan G., ...
Related Articles
Formulation And Evaluation Of Buccoadhesive Drug Delivery System Containing A Br...
Akshay V. Patil, Dr. Gautam Mehetre, Vishal Murkute, Preeti More, ...
Analytical Techniques in Pharmaceutical Analysis ...
Nayana Shinde, Sakshi Thakare, Vishal Wagh, Sakshi Gurav, Gorakh Pawar, Swapnil Mali, ...
Formulation and Evaluation of Herbal Shampoo ...
Sanket Ashokrao Hood , Ganesh Tulshidas Harkal, Aman Girish Ghivdhonde, Nilesh Gajanan Lokhande, Har...
Shaping Health Horizons: The Dynamic Impact Of Innovative Public Health Awarenes...
Nilima N. Khakal, Udayanraj M. Bhosale, Suraj B. Kumbhar, Vikram R. Shinde, N. H. Aloorkar, Dipak D....
More related articles
SPLENOPROTECTIVE EFFECT OF KUDZU ROOT EXTRACT IN ANILINE INDUCED SPLEEN TOXICITY...
Aman Upaganlawar, Sumitkumar Sharma, Aakif Bagwan, Mangesh Tatar, Chandrashekar Upasani, ...
Design And in Silico Screening of Thiazolidine-2,4-Dione Analogs as Potential Al...
Swathi Naraparaju, Sandeep Manda, Tejasree Dasagiri, Vaishnavi Dhabde, Yogasree Tiruvaipati, ...
SPLENOPROTECTIVE EFFECT OF KUDZU ROOT EXTRACT IN ANILINE INDUCED SPLEEN TOXICITY...
Aman Upaganlawar, Sumitkumar Sharma, Aakif Bagwan, Mangesh Tatar, Chandrashekar Upasani, ...
Design And in Silico Screening of Thiazolidine-2,4-Dione Analogs as Potential Al...
Swathi Naraparaju, Sandeep Manda, Tejasree Dasagiri, Vaishnavi Dhabde, Yogasree Tiruvaipati, ...