View Article

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by elevated levels of blood glucose (hyperglycemia) due to either insufficient insulin production by the pancreas or the body's inability to effectively use insulin. Insulin, a vital hormone, plays a pivotal role in the regulation of blood sugar levels by facilitating the absorption of glucose into cells, where it is utilized for energy. The increasing prevalence of diabetes mellitus poses a significant global health challenge, with a lack of a permanent remedy despite the availability of chemicals and biochemical agents for diabetes control. The adverse effects associated with the prolonged use of certain synthetic agents underscore the ongoing need for non-toxic and cost-effective pharmaceutical alternatives. Throughout human history, traditional treatments have held immense value as a source of medicine. Their widespread global use underscores the growing integration of herbs into modern, high-tech medical practices. Extensive research has led to the discovery of various traditional medicines, and substances derived from natural resources, particularly plants, stand out as a promising arsenal for effectively managing and treating diabetes and its associated complications. This review will highlight recent advancements in the realm of herbal drugs for diabetes treatment, the prevention of secondary complications associated with diabetes, and the exploration of various herbal medication currently undergoing different stages of clinical trial.

Keywords

Diabetic mellitus, insufficient insulin, herbal medicines, synthetic agent

Reference

  1. Modak, M., Dixit, P., Londhe, J., Ghaskadbi, S., & Devasagayam, T. (2007). Indian herbs and herbal drugs used for the treatment of diabetes. Journal of Clinical Biochemistry and Nutrition, 40(3), 163–173. https://doi.org/10.3164/jcbn.40.163
  2. Moradi, B., Abbaszadeh, S., Shahsavari, S., Alizadeh, M., & Beyranvand, F. (2018). The most useful medicinal herbs to treat diabetes. Biomedical Research and Therapy, 5(8), 2538–2551. https://doi.org/10.15419/bmrat.v5i8.463
  3. Wikipedia contributors. (2001, August 15). Diabetes. Wikipedia. https://en.wikipedia.org/wiki/Diabetes
  4. Taylor, R. B. (2008, August 12). Types of diabetes mellitus. WebMD. https://www.webmd.com/diabetes/types-of-diabetes-mellitus
  5. Shubham Namdeo Karle et al. Ijppr.Human, 2023; Vol. 27 (1): 430-446. https://ijppr.humanjournals.com/the-use-of-herbal-preparation-in-the-management-of-type-ii-diabetes-mellitus-a-review-article/
  6. World Health Organization: WHO. (2019, May 13). Diabetes. https://www.who.int/health-topics/diabetes#tab=tab_1
  7. Ye, J., Wu, Y., Yang, S., Zhu, D., Chen, F., Chen, J., Ji, X., & Hou, K. (2023). The global, regional and national burden of type 2 diabetes mellitus in the past, present and future: a systematic analysis of the Global Burden of Disease Study 2019. Frontiers in Endocrinology, 14. https://doi.org/10.3389/fendo.2023.1192629
  8. Wikipedia contributors. (2023g, October 28). Type 2 diabetes. Wikipedia. https://en.wikipedia.org/wiki/Type_2_diabetes
  9. Ptruong. (2023, February 21). Type 2 Diabetes | Diabetes Australia. Diabetes Australia. https://www.diabetesaustralia.com.au/about-diabetes/type-2-diabetes/
  10. Type 2 Diabetes | ADA. (n.d.-b). https://diabetes.org/about-diabetes/type-2
  11. Catholic Health Initiatives. (n.d.). Type 2 diabetes: symptoms, causes, & treatment. Chi-health. https://www.chihealth.com/en/services/primary-care/diabetes/type-2-diabetes.html
  12. Homage, T. (2022, May 31). Diabetes 101: Symptoms, Types, causes and Prevention. Homage Australia. https://www.homage.com.au/health/diabetes/
  13. Symptoms & Causes of Diabetes. (2023, February 28). National Institute of Diabetes and Digestive and Kidney Diseases. https://www.niddk.nih.gov/health-information/diabetes/overview/symptoms-causes#type2
  14. IDF SCHOOL OF DIABETES. (n.d.). https://www.idfdiabeteschool.org/type-2-diabetes
  15. Type 2 diabetes - Diagnosis and treatment - Mayo Clinic. (2023, March 14). https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/diagnosis-treatment/drc-20351199
  16. Type 2 diabetes: symptoms, causes, treatment. (2006, December 31). WebMD. https://www.webmd.com/diabetes/type-2-diabetes
  17. Website, N. (2023, July 11). Understanding medicine. nhs.uk. https://www.nhs.uk/conditions/type-2-diabetes/understanding-medication/
  18. UpToDate. (n.d.). UpToDate. https://www.uptodate.com/contents/type-2-diabetes-treatment-beyond-the-basics/print
  19. BridgetChapple. (n.d.). Type 2 diabetes treatments. Diabetes UK. https://www.diabetes.org.uk/diabetes-the-basics/types-of-diabetes/type-2/treatments
  20. NHS inform. (2023, March 16). Type 2 diabetes - Illnesses & conditions | NHS inform. NHS Inform. https://www.nhsinform.scot/illnesses-and-conditions/diabetes/type-2-diabetes#treating-type-2-diabetes
  21. Professional, C. C. M. (n.d.). Oral diabetes medications. Cleveland Clinic. https://my.clevelandclinic.org/health/articles/12070-oral-diabetes-medications
  22. Table 1 . Conventional antidiabetic drugs and their major adverse effects. (n.d.). ResearchGate. https://www.researchgate.net/figure/Conventional-antidiabetic-drugs-and-their-major-adverse-effects_tbl1_287450181
  23. Moradi, B., Abbaszadeh, S., Shahsavari, S., Alizadeh, M., & Beyranvand, F. (2018b). The most useful medicinal herbs to treat diabetes. Biomedical Research and Therapy, 5(8), 2538–2551. https://doi.org/10.15419/bmrat.v5i8.463
  24. Chang, C., Lin, Y., Bartolome, A. P., Chen, Y. C., Chiu, S., & Yang, W. (2013). Herbal therapies for Type 2 diabetes mellitus: chemistry, biology, and potential application of selected plants and compounds. Evidence-based Complementary and Alternative Medicine, 2013, 1–33. https://doi.org/10.1155/2013/378657
  25. Hypoglycemic activity of Eugenia jambolana and Ficus bengalensis: mechanism of action. (1991, April 1). PubMed. https://pubmed.ncbi.nlm.nih.gov/1768783/
  26. Ghorbani, A. (2013d). Best herbs for managing diabetes: a review of clinical studies. Brazilian Journal of Pharmaceutical Sciences, 49(3), 413–422. https://doi.org/10.1590/s1984-82502013000300003
  27. Akash, M. S. H., Rehman, K., & Chen, S. (2014). Spice plant Allium cepa: Dietary supplement for treatment of type 2 diabetes mellitus. Nutrition, 30(10), 1128–1137. https://doi.org/10.1016/j.nut.2014.02.011
  28. Ravari, S. S., Talaei, B., & Gharib, Z. (2021). The effects of silymarin on type 2 diabetes mellitus: A systematic review and meta-analysis. Obesity Medicine, 26, 100368. https://doi.org/10.1016/j.obmed.2021.100368

Photo
Asavari S. Dumbre
Corresponding author

Department of Bachelor in Pharmacy Samarth Institute of pharmacy, Pune- 424304

Photo
Archana T. Chaskar
Co-author

Department of Bachelor in Pharmacy Samarth Institute of pharmacy, Pune- 424304

Photo
Basavraj C. Hatpakki
Co-author

Department of Bachelor in Pharmacy Samarth Institute of pharmacy, Pune- 424304

Asavari S. Dumbre*, Archana T. Chaskar, Basavraj C. Hatpakki, Utilization Of Herbal Medication & Home Remedies In The Management Of Diabetes Mellitus Type-II: A Comprehensive Review, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 11, 517-526. https://doi.org/10.5281/zenodo.10207256

More related articles
An Overview on Artificial Blood...
Rajnandini Ahire, Mukesh Ratnaparkhi, Shital Kshirsagar, Devang M...
Hepatoprotective Role of Flavonoids from Ocimum Sa...
Suddagoni Santhosh, Narsapuram Bharathi, Thalla Likesh Goud, Guni...
Evaluation Parameters Of Tigecycline : Tetracyclin...
Sakshi D. Surade, Vikas S. Shinde, ...
An Overview of Poisoning...
SK. Manisha, P. Aruna, SK. Bibi Hazara, D. Akhil, Dr. D. Krishna Priyanka, ...
FORMULATION AND EVALUATIONS OF HERBAL FACE PACK ...
Sakshi Ramesh Unhawane , Vishal Ambadas Narsale , Prof. Nikhil Nilkanth Jadhav , ...
Related Articles
Formulation Development And Evaluation Of Gastroretentive Floating Tablets Of Cl...
Kajal A Choursiya, Sachin M Nikam, Khanderao R Jadhav, Rishikesh S Bachhav, ...
Development And Evaluation Of Cyperus Rotundus Based Hair Removal Cream...
Gauri Beldar, Shravan Somani ., Abhijit Rode., ...
Formulation and Evaluation of multipurpose herbal cream ...
Aman Anis Shaikh , Tejashree kedar, Abubakar Shaikh , Sohel shaikh, Naziya pathan, ...
An Overview on Artificial Blood...
Rajnandini Ahire, Mukesh Ratnaparkhi, Shital Kshirsagar, Devang Mahale, ...
More related articles
An Overview on Artificial Blood...
Rajnandini Ahire, Mukesh Ratnaparkhi, Shital Kshirsagar, Devang Mahale, ...
Hepatoprotective Role of Flavonoids from Ocimum Sanctum Against Halothane Induce...
Suddagoni Santhosh, Narsapuram Bharathi, Thalla Likesh Goud, Gunisetti Sri Anjali, Pitla Maheshwari,...
An Overview on Artificial Blood...
Rajnandini Ahire, Mukesh Ratnaparkhi, Shital Kshirsagar, Devang Mahale, ...
Hepatoprotective Role of Flavonoids from Ocimum Sanctum Against Halothane Induce...
Suddagoni Santhosh, Narsapuram Bharathi, Thalla Likesh Goud, Gunisetti Sri Anjali, Pitla Maheshwari,...