View Article

Abstract

The groundbreaking TEMPO 3:4 trial, which served as the basis for tolvaptan's approval, represented a revolution in the treatment of autosomal dominant polycystic kidney disease (ADPKD). Through this advancement, patient management for ADPKD has evolved from using broad strategies to stop the progression of chronic kidney disease to focusing on disease-specific mechanisms. Evidence-based strategies to start treatment only in patients with quickly worsening disease are essential, though, given the long-term nature of this medication and associated side effects. The European Renal Association (ERA) policy statement, released in 2016, was the first society-based guideline on the usage of tolvaptan and has been a popular resource for nephrologists when making decisions. Since then, there has been a significant accumulation of practical knowledge regarding the use of tolvaptan in ADPKD.

Keywords

ADPKD; polycystic kidney disease; position statement; tolvaptan; vasopressin V2 receptor antagonist

Reference

  1. Zilberberg MD, Exuzides A, Spalding J, et al. Epidemiology, clinical and economic outcomes of admission hyponatremia among hospitalized patients. Curr Med Res Opin. 2008;24(6):1601–1608.
  2. Verbalis JG, Goldsmith SR, Greenberg A, et al. Hyponatremia treatment guidelines 2007: Expert panel recommendations. Am J Med. 2007;120(11A):S1–S21. 
  3. Rockville, MD: Otsuka America Pharmaceutical, Inc.; May 2009. Samsca (tolvaptan), package insert. 
  4. Schrier RW, Gross P, Gheorghiade M, et al.for the SALT Investigators Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med. 2006;355:2099–2112.
  5. Gheorghiade M, Konstam MA, Burnett JC, et al.for the EVEREST Investigators Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: The EVEREST Clinical Status Trials. JAMA. 2007;297:1332–1343.
  6. Konstam MA, Gheorghiade M, Burnett JC, et al.for the EVEREST Investigators Effects of oral tolvaptan in patients hospitalized for worsening heart failure: The EVEREST Outcome Trial. JAMA. 2007;297:1319–1331.
  7. Schrier RW, Gross P, Gheorghiade M, et al.for the SALT Investigators Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia. N Engl J Med. 2006;355:2099–2112. 
  8. Gheorghiade M, Konstam MA, Burnett JC, et al.for the EVEREST Investigators Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: The EVEREST Clinical Status Trials. JAMA. 2007;297:1332–1343
  9. Konstam MA, Gheorghiade M, Burnett JC, et al.for the EVEREST Investigators Effects of oral tolvaptan in patients hospitalized for worsening heart failure: The EVEREST Outcome Trial. JAMA. 2007;297:1319–1331.
  10. Structure of Tolvaptan - https://web.chemdoodle.com/demos/iupac-naming#customise-template
  11. Indian Pharmacopoeia - 2022,  Ninth Edition, Volume – III, Page number: 3832, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur, Andhra Pradesh, India.

Photo
Kondeti Venkata Surya Siva Kumar
Corresponding author

Department of Pharmacology and Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur, Andhra Pradesh – 522019, India

Photo
Saripella Latha Sree
Co-author

Department of Pharmacology and Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur, Andhra Pradesh – 522019, India

Photo
Saripella Jaya Sree
Co-author

Department of Pharmacology and Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chandramoulipuram, Chowdavaram, Guntur, Andhra Pradesh – 522019, India

Kondeti Venkata Surya Siva Kumar, Saripella Latha Sree and Saripella Jaya Sree, Tolvaptan - Vasopressin Antagonist for Hyponatremia, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 8, 1-8. https://doi.org/10.5281/zenodo.8206257

More related articles
Study of Synergistic Effect of Isolated extract fr...
Sahil Agrawal, Bhushan Potdar, Kiran Pimpale, Jaib Shaikh, Laxmip...
Innovations In Diuretic Treatment: A Promising Sol...
Jaya Mehetre, Kiran Dhamak, Kalpana Sable, Trupti Bhalekar, ...
Ban On Hookah Smoking- An Applaudable Law Passed B...
J.C. Balachandar, M. Jayachandran, Shiv Swaroop Singh IRS, Saanvi...
Formulation And Evaluation of Herbal Cream Containing Cassia Fistula Linn Flower...
Nanditha V. V., Nagendra R., Hema C. S., Sowbhagya M., Kavana N., K. A. Sujan, Venkatesh, Hanumantha...
Advancements in Understanding the Neuromuscular Junction: Implications for Muscl...
Arnab Roy, K. Rajeswar Dutt, Mahesh Kumar Yadav, Sudarshan Rawani, Gangadhar Singh, Suraj Kumar, Ami...
Understanding Laser Induced Breakdown Spectroscopy: An Overview...
Rose Mary Joseph, Annamma Baby, Aadiya Shanuj, Hizana Sidheek, Deepu J. S., ...
Related Articles
Stability-Indicating RP-HPLC Method Development and Validation for Estimation of...
Satyam Dhole , Prashant Mokate , Dr. P. P Jain , S. R. Ghodake , ...
Niosomes: An Advanced Drug Delivery System...
Aman Londhe, Rohan Jadhav, Aman Mulani, Pratiksha Gavade, Varsha Kale, ...
A Comprehensive Review of the Phytochemical Constituents and Pharmacological Pro...
Sukanta Debnath, Sibaji Sarkar, Dibyendu Shil, Diptendu Bhowmik, ...
Analytical Method Development And Validation For Simultaneous Estimation Of Anti...
Kartik A. Bhatkar, V. M. Waghulkar, M. P. Jadhao, M. D. Game, S. G. Jawarkar, ...
Study of Synergistic Effect of Isolated extract from Endophytic Fungi in Ashwaga...
Sahil Agrawal, Bhushan Potdar, Kiran Pimpale, Jaib Shaikh, Laxmiprasad Khochage, Dr. Nilesh Chougule...
More related articles
Study of Synergistic Effect of Isolated extract from Endophytic Fungi in Ashwaga...
Sahil Agrawal, Bhushan Potdar, Kiran Pimpale, Jaib Shaikh, Laxmiprasad Khochage, Dr. Nilesh Chougule...
Innovations In Diuretic Treatment: A Promising Solution For Chronic Diseases...
Jaya Mehetre, Kiran Dhamak, Kalpana Sable, Trupti Bhalekar, ...
Ban On Hookah Smoking- An Applaudable Law Passed By The State Of Haryana Safegua...
J.C. Balachandar, M. Jayachandran, Shiv Swaroop Singh IRS, Saanvi Agrawal, S. Irshad Ahamed, A. Ayes...
Study of Synergistic Effect of Isolated extract from Endophytic Fungi in Ashwaga...
Sahil Agrawal, Bhushan Potdar, Kiran Pimpale, Jaib Shaikh, Laxmiprasad Khochage, Dr. Nilesh Chougule...
Innovations In Diuretic Treatment: A Promising Solution For Chronic Diseases...
Jaya Mehetre, Kiran Dhamak, Kalpana Sable, Trupti Bhalekar, ...
Ban On Hookah Smoking- An Applaudable Law Passed By The State Of Haryana Safegua...
J.C. Balachandar, M. Jayachandran, Shiv Swaroop Singh IRS, Saanvi Agrawal, S. Irshad Ahamed, A. Ayes...