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Abstract

An innovative technique for medication delivery is the supersaturated drug delivery system, which uses the drug's supersaturated condition in the gut to increase the drug's bioavailability. Low bioavailability, when taken orally, is caused by weak bases decreasing solubility as pH rises. Some excipients were utilized to stop or postpone the precipitation that occurs when there is change in pH. The purpose of this study is to analyze SDDS with a focus on its prospects for the future and its current advancements. This review's objectives were to compile the most recent findings on supersaturated drug delivery systems (SDDS). The most recent developments in SDDS, including the formulation of characteristics, are thoroughly explored. This review paper aims to give a thorough understanding of the biopharmaceutical foundation of the supersaturated drug delivery system. Because of their higher solubility and enhanced saturation, supersaturated drug delivery systems improve drug absorption as well as its bioavailability. This reviews the scientific and technological advancements in systems.

Keywords

Supersaturation, Bioavailability, Solid dispersion, pH.

Reference

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Photo
MANOJ R. V.
Corresponding author

Department of Pharmaceutics, Sarada Vilas College of Pharmacy, Mysore.

Photo
Parthasarathi K. Kulkarni
Co-author

Department of Pharmaceutics, Sarada Vilas College of Pharmacy, Mysore.

Photo
Nagendra R.
Co-author

Department of Pharmaceutics, Sarada Vilas College of Pharmacy, Mysore.

Photo
Venkatesh K.
Co-author

Department of Pharmaceutics, Sarada Vilas College of Pharmacy, Mysore.

Photo
Hanumanthachar Joshi
Co-author

Department of Pharmacognosy, Sarada Vilas College of Pharmacy, Mysore.

Manoj R. V., Parthasarathi K. Kulkarni, Nagendra R., Venkatesh K. , Supersaturated Drug Delivery System: An Approach To Enhance The Bioavailability, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 145-153. https://doi.org/10.5281/zenodo.10625380

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