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Abstract

Cardiovascular diseases (CVDs) is usually accompanying with a build-up of fatty deposits inside the arteries (atherosclerosis) and an enhanced risk of blood clots. It is mainly caused due to unhealthy diet and lack of physical activities. The recent studies showed that intake of healthy and antioxidant rich foods have the high ability to reduce and prevent the cardiovascular diseases (CVDs) now a days. Isoproterenol is broadly used for inducing CVDs in both in vitro and in vivo models. Isoproterenol is a nonselective beta-adrenergic agonist. In this study it is used as the inducer to induce CVDs in H9C2 cell line. It causes elevated level of apoptosis, mitochondrial membrane depolarization and ROS formation. The result of the study indicated that the exposure of silver nanoparticles of Tetrahydrocurcumin (THC-AgNPs) has ameliorate the, isoproterenol induced mitochondrial dysfunction, ROS formation and apoptosis due to its antioxidant properties.

Keywords

Cardiovascular diseases, Isoproterenol, apoptosis, ROS, Tetrahydrocurcumin-Silver nanoparticles, antioxidant.

Reference

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Manivasagam Thamilarasan
Corresponding author

DeDpartment Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidhambaram 608002

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Aruna D. Selvaraj
Co-author

Department Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidhambaram 608002

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Justin T. Arokiasamy
Co-author

Department Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidhambaram 608002

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Gomathi Balavinayagam
Co-author

Department Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidhambaram 608002

Gomathi Balavinayagam, Aruna Devi Selvaraj, Justin T. Arokiasamy, Manivasagam Thamilarasan, Silver nanoparticles of Tetrhydocurcumin attenuate the oxidative stress and mitochondrial mediated apoptosis in isoproterenol induced toxicity, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 228-237. https://doi.org/10.5281/zenodo.10516937

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