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  • Quantitative Determination Of Sofosbuvir In Pure And Pharmaceutical Dosages Form By ATR FTIR Spectroscopic As A Green Method
  • Photo Shyam W. Rangari* Photo Sanjaykumar B. Bari

  • 1Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra-441002.
    2H. R. Patel Institute of Pharmaceutical Education and Research, shirpur, dhule, Maharashtra- 425405.
     

Abstract

Background: To assess the concentration of sofosbuvir (CAS-1190307-88-0) in pharmaceutical formulations as well as in its pure form, a unique green analytical chemistry approach was developed. ATR-FTIR technique was used to quantitatively evaluate sofosbuvir, a multipurpose antiviral drug, in both tablet and bulk forms. Objective: Sofosbuvir in pharmaceutical goods may be quickly detected by the development and confirmation of an accurate, sensitive, and non-invasive attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy approach. Methods: Sofosbuvir is analysed using a method that looks for the distinctive skeletal band for C-O-C stretching in the 1170–1000 cm–1 spectral region. These procedures, which have linear ranges for SBR of 1.0 to 7.0 mg g-1, were fully verified in compliance with ICH recommendations. Results: The correlation value was 0.9993, and the linearity ranged from 1.0 to 7.0 milligrammes. The results indicated that the limits of quantification (LOQ) and detection (LOD) were 0.142 ± 0.09 mg and 0.079 ± 0.02 mg, respectively. Conclusions: Green chemistry guided the development of the analytical approach, and it was shown that the outcomes were exactly in line with destructive methods. Highlights: It was shown that the results produced were in perfect accord with destructive methods, and the analytical strategy was designed in light of green chemistry.

Keywords

Sofosbuvir, IR spectroscopy, pharmaceutical matrices, Quantitative analysis, etc.

Reference

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Photo
Shyam W. Rangari
Corresponding author

Smt. Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur, Maharashtra-441002.

Photo
Sanjaykumar B. Bari
Co-author

H. R. Patel Institute of Pharmaceutical Education and Research, shirpur, dhule, Maharashtra- 425405.

Shyam W. Rangari, Sanjaykumar B. Bari., Quantitative Determination Of Sofosbuvir In Pure And Pharmaceutical Dosages Form By ATR-FTIR Spectroscopic As A Green Method., Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 570-583. https://doi.org/10.5281/zenodo.10688689

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