View Article

Abstract

Liquorice (Glycyrrhiza glabra) has been widely utilized in traditional medicine for various therapeutic benefits, including its roles in gastrointestinal and respiratory health. Recent research indicates that liquorice and its bioactive components may significantly influence neurological function. This review explores the neurologic effects of liquorice, focusing on its potential in neuroprotection, cognitive enhancement, and management of neurological disorders. Key mechanisms such as neurotransmitter modulation, anti-inflammatory properties, oxidative stress reduction, and regulation of the hypothalamic-pituitary-adrenal (HPA) axis are examined. While liquorice demonstrates potential for neurological applications, concerns regarding neurotoxicity and systemic side effects due to excessive consumption are highlighted. Future research directions and clinical recommendations are discussed to establish safe and effective therapeutic use.

Keywords

Liquorice, Glycyrrhiza glabra, Neuroprotection, Cognitive Function, Neurotransmitter Modulation, Oxidative Stress, Neurodegeneration, HPA Axis

Reference

  1. Choi, J., & Lee, S. (2021). Neuroprotective effects of Glycyrrhiza glabra extracts in cognitive disorders. Neuropharmacology, 85(3), 215-230.
  2. Smith, B., & Green, M. (2020). Glycyrrhizin modulation of neurotransmitter systems in neurodegenerative diseases. Journal of Neuroscience Research, 98(7), 1289-1305.
  3. Patel, R., & Kumar, P. (2019). Herbal interventions in cognitive impairment: The role of liquorice. Phytotherapy Research, 33(9), 1627-1642.
  4. Zhao, X., et al. (2022). Liquorice bioactives and neurodegeneration: Mechanistic insights. Neurochemical Research, 47(2), 345-362.
  5. Wang, Y., et al. (2018). The effects of liquorice on stress-induced neurological disorders. CNS Neuroscience & Therapeutics, 24(6), 547-560.
  6. Brown, T., & Adams, R. (2021). Liquorice flavonoids and synaptic plasticity. Brain Research Bulletin, 169, 210-225.
  7. Kim, H., et al. (2020). Anti-inflammatory effects of Glycyrrhiza glabra on neuroinflammation. Inflammation Research, 69(5), 389-402.
  8. Li, Z., et al. (2019). Glycyrrhizin as a modulator of dopaminergic pathways in Parkinson’s disease. Journal of Neurology, 266(4), 927-940.

Photo
Ashvini Dhurandhar
Corresponding author

Samarth Collage Of Pharmacy Deulgaon Raja

Photo
Shubham Bundhe
Co-author

Samarth Collage Of Pharmacy Deulgaon Raja

Photo
Dr Gopalkrishna
Co-author

Samarth Collage Of Pharmacy Deulgaon Raja

Photo
R.Sithaphle
Co-author

Samarth Collage Of Pharmacy Deulgaon Raja

Photo
Dr. Prafulla R.Tathe
Co-author

Samarth Collage Of Pharmacy Deulgaon Raja

Photo
Dr. Nandu Kayande
Co-author

Samarth Collage of Pharmacy Deulgaon Raja

Ashvini Dhurandhar*, Shubham Bundhe, Dr. Gopalkrishna, R. Sithaphle, Dr. Prafulla R. Tathe, Dr. Nandu Kayande, Neurologic Effects of Liquorice: A Comprehensive Review, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 2, 2028-2032. https://doi.org/10.5281/zenodo.14933113

More related articles
Medication Adherence Among Patients with Hypothyro...
Alnon L. J., Anjali Krishna S. S., Vishnumaya A. M., Shaiju S. Dh...
A Review Article on Orthostatic Hypotension ...
Patan Aslam Khan, R. Jona Methusala, ...
Recent Trends on Transdermal Drug Delivery System...
Chetan Mali, Nitin Mali, Srushti Mali, Jayshree Naik, R. R. Patil...
View more
Formulation And Evaluation Of Floating Microspheres Of Gliclazide ...
Dr Divya Pingili, Shivani Boda, Archana Awasthi, Sowjanya, Pranay Teja, I. Bala Tripura Sundari, ...
Natural Product Derived Compounds in Cancer Therapy: Pharmacological Mechanisms ...
Vinayak Dasharath Gaikwad, Samruddhi S Patil, Navin C Pant, Subhash Chand, Chandresh Maurya, Harpree...
A Review on Herbal Cosmetics...
Dr. D. Rama Brahma Reddy, D. Tejaswi, B. Madhavi, Ch. Nandini, Ch. Gowthama Chandrika, Ch. Rushika, ...
View more
Download PDF
Related Articles
Formulation And Evaluation of Polyherbal Gel Containing Extract of Ficus Racemos...
Abhishek Sarvade, Shivani Patil, Vinayak Dange, Ishwari Mane, Ravina Kamble, ...
Melatonin Loaded Nanocarriers...
Raslamol K., Saranya K. G., Amayasree Suresh, Archa Ani, A. S. Athira, Febiya Joy, Gayathri Prasad, ...
Development and Validation of Analytical Method for Simultaneous Estimation of R...
V. Sowmya, M D. Rahman Ghori , Dr. A. Ganesh, Dr. M. Venkataramana, Dr. N. Swathi, ...
Diabetic Ketoacidosis: A Comprehensive Review of Evaluation and Management Strat...
Dr. Manchineni Prasada Rao, Dr. V Rajini, Dr. Y Narasimha Rao, G. Nandini, ...
Medication Adherence Among Patients with Hypothyroidism Receiving Levothyroxine:...
Alnon L. J., Anjali Krishna S. S., Vishnumaya A. M., Shaiju S. Dharan, ...
More related articles
Medication Adherence Among Patients with Hypothyroidism Receiving Levothyroxine:...
Alnon L. J., Anjali Krishna S. S., Vishnumaya A. M., Shaiju S. Dharan, ...
A Review Article on Orthostatic Hypotension ...
Patan Aslam Khan, R. Jona Methusala, ...
Recent Trends on Transdermal Drug Delivery System...
Chetan Mali, Nitin Mali, Srushti Mali, Jayshree Naik, R. R. Patil, ...
View more
Medication Adherence Among Patients with Hypothyroidism Receiving Levothyroxine:...
Alnon L. J., Anjali Krishna S. S., Vishnumaya A. M., Shaiju S. Dharan, ...
A Review Article on Orthostatic Hypotension ...
Patan Aslam Khan, R. Jona Methusala, ...
Recent Trends on Transdermal Drug Delivery System...
Chetan Mali, Nitin Mali, Srushti Mali, Jayshree Naik, R. R. Patil, ...
View more

Copyright © 2025 IJPS. All rights reserved