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Abstract

The main issue that the researchers are dealing with is the targeted medication delivery to specified areas. A big step towards solving these issues has been the development of nanosponges. These tiny sponges may move through the body until they reach the intended place, where they adhere to the skin and start to release the medication in a regulated and predictable manner, which is more efficient for a certain dosage. The use of nanosponges, their manufacture, and assessment have all been covered in this review paper. Targeting medication distribution in a regulated manner depends heavily on nanosponges. For targeted medication delivery, a variety of pharmaceuticals can be put into nanosponge. Drugs that are hydrophilic and lipophilic can both be put into nanosponges.

Keywords

Targeted Drug Delivery, Controlled Drug Delivery, Nanosponges

Reference

  1. Ramnik S, Nitin B, Jyotsana M, Horemat SN. Characterization of Cyclodextrin Inclusion complexes –A Review. J Pharm Sci Tech, 2010; 2(3): 171-183. 
  2. Rajeswari C, Alka A, Javed A, Khar R K. Cyclodextrins in drug delivery: an update review. AAPS pharmSci Tech, 2005; 6(2): E329-E357. 
  3. Moya-Ortega MD, Alvarez LC, Concheiro A, Loftsson T. Cyclodextrin-based nanogels for pharmaceutical and biomedical applications. Int J Pharm, 2012; 428: 152-163. 
  4. Swaminathan S, Vavia PR, Trotta F, Torne S. Formulation of betacyclodextrin based nanosponges of itraconazole. J Incl Phenom Macrcycl Chem, 2007; 57(1-4): 89-94.
  5. Vavia PR, Swaminathan S, Trotta F, Cavalli R. Application of nanosponges in drug delivery system. In proceeding XII international cyclodextrin symposium, 2006; 14-17. 
  6. Sapino S, Carlotti ME, Cavalli R, Ugazio E, Berlier G, Gastaldi L. Photochemical and antioxidant properties of gammaoryzanol in beta-cyclodextrin-based nanosponges. J Inc lPhenom Macrocycl Chem, 2013; 75: 69-76. 
  7. Sharma R, Roderick B. Walker, Kamla P. Evaluation of Kinetics and Mechanism of Drug Release from Econazole nitrate Nanosponge Loaded Carbapol Hydrogel. Ind J Pham Edu Res, 2011; 45(1): 25-31. 
  8. Nacht S, Kantz M. The Microsponge: A Novel Topical Programmable Delivery System, In: Topical Drug Delivery Systems. David WO, Anfon H A editors; New York: Marcel Dekker, 1992; 42: 299-325. 
  9. David F. Nanosponge drug delivery system more effective than direct injection. www.physorg.com 2010. 
  10. Eki S., Lei T., Jingquan L., Zhongfan J., Cyrille B and Thomas PD. (2009) Biodegradable Star Polymers Functionalized With ?-Cyclodextrin Inclusion Complexes. Bio macromolecules, 10(9): 2699–270.
  11. Jenny A, Merima P, Alberto F, Francesco T. Role of ?-cyclodextrin nanosponges in propylene photooxidation. Carbohydrate Polymers, 2011; 86: 127-135. 
  12. Leslie Z, Benet., BCS and BDDCS. Bioavailability and Bioequivalence: Docus on Physiological Factors and Variability. Department of pharmaceutical sciences, University of California, San Francisco, USA, 2007. 
  13. Aritomi H, Yamasaki Y, Yamada K, Honda H, Khoshi M. Development of sustained release formulation of chlorpheniramine maleate using powder coated microsponges prepared by dry impact blending method. Journal of Pharma Sci and Tech, 1996; 56(1): 49-56. 
  14. Selvamuthukumar, Subramanian et al. Nanosponges: A Novel Class of Drug Delivery System – Review. J Pharm Pharma Sci, 2012; 15(1): 103–111. 
  15. Kerali S V, Machevas P. Van P A,and Shah V P. Bioavailibility and bioequivalence: Focus on physiological factors and variability. Pharmaceutical research, 2008; 1956-1962. 
  16. Yurtdas G, Demirel M, Genc L. Inclusion complexes of fluconazole with b-cyclodextrin: physicochemical characterization and in vitro evaluation of its formulation. J. Incl. Phenom. Macrocycl. Chem, 2011; 70: 429–435. 
  17. Embil K, Nacht S, The microsponge delivery system a topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives. J Microencapsule, 1996; 13: 575–88. 
  18. Mishra MK, Shikhri M, Sharma R, Goojar MP. Optimization, formulation, development and characterization of Eudragit RS 100 loaded microsponges and subsequent colonic delivery. Int J of Drug Discovery And herbal Research, 2011; 1(1): 8-13. 
  19. Jenny A, Merima P, Alberto F, Francesco T. Role of ?- cyclodextrin nanosponges in polypropylene photooxidation. Carbohydrate Polymers, 2011; 86: 127– 135. 
  20. Lala R, Thorat A, Gargote C. Current trends in ?- cyclodextrin based drug delivery systems. Int J Res Ayur Pharm, 2011; 2(5): 1520-1526. 
  21. Trotta F, Cavalli R, Tumiatti W, Zerbinati O, Rogero C, Vallero R. Ultrasound-assisted synthesis of Cyclodextrin-based nanosponges, 2007 B1, EP 1 786-841. 
  22. Shankar S, Linda P, Loredana S, Francesco T, Pradeep V, Dino A, Michele T, Gianpaolo Z, Roberta C. Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity. Eur J Pharm Biopharm, 2010; 74: 193-201. 
  23. Amber V, Shailendra S, Swarnalatha S, J Incl Phenom Macrocycl Chem, 2008; 62: 23-42.
  24. Krishnamoorthy K, Rajappan M. Nanosponges: a novel class of drug delivery systemreview. J Pharm Pharm Sci, 2012; 15(1): 103-11. 
  25. Cavalli R, Trotta F, Tumiatti W. Cyclodextrin-based Nanosponges for Drug Delivery. J of Inclusion Phenomena and Macro Chemistry, 2012; 56(1-2): 209-213. 
  26. Vyas SP, Khar RK. Targeted and Controlled Drug Delivery- Novel Carrier Systems. Molecular Basis of Targeted Drug Delivery. CBS Publishers and Distributors; New Delhi, 2008; 38- 40. 
  27. Aldawsari H M, Badar-Eldin S M, Labib G S and El-Kamel A H. Design and formulation of topical hydrogel integrating lemongrass loaded nanosponges with an enhanced antifungal effect : In vitro/In vivoevaluation. International journal of nanomedicine, 2015; 10: 893-902
  28. Vyas A, Saraf S and Saraf S. Cyclodextrin based novel drug delivery system. J Incl Phenom Macrcycl Chem, 2008; 23-42. 
  29. Torne S, Darandale S, Vavia P, Trotta F, Cavalli R. Cyclodextrin based nanosponges: effective nanocarrier for tamoxifen delivery. Pharm Dev Technol, 2013; 18(3): 619-625. 
  30. Ansari KA, Vavia PR, Trotta F, Cavalli R. Cyclodextrin-based nanosponges for delivery of resveratrol: in vitro characterisation, stability, cytotoxicity and permeation study. AAPS Pharm Sci Tech, 2011; 12(1): 279-286. 
  31. Shende PK, Trotta F, Gaud RS, Deshmukh K, Cavalli R, Biasizzo M. Influence of different techniques on formulation and comparative characterization of inclusion complexes of ASA with ?-cyclodextrin and inclusion complexes of ASA with PMDA cross-linked ?-cyclodextrin nanosponges. J Incl Phenom Macrocycl Chem, 2012; 74: 447-454. 
  32. Darandale SS, Vavia PR. Cyclodextrin-based nanosponges of curcumin: formulation and physicochemical characterization. J Incl Phenom Macrocycl Chem, 2013; 75: 315-322. 
  33. Torne SJ, Ansari KA, Vavia PR, Trotta F, Cavalli R. Enhanced oral Paclitaxel bioavailability after administration of Paclitaxel loaded nanosponges. Drug Delivery, 2010; 17(6): 419–425. 
  34. Mateo C, Palomo JM, Fernandez-Lorente G, Guisan JM, Fernandez-Lorente R. Improvement of enzyme activity, stability and selectivity via immobilization techniques. Enzyme Microb Technol, 2007; 40: 1451-1463. 
  35. Boscolo B, Trotta F, Ghibaudi E. High catalytic performances of Pseudomonas fluorescens lipase adsorbed on a new type of cyclodextrin-based nanosponges. J Mol Catal B Enzym, 2010; 62: 155-161.
  36. Cavalli R, Akhter AK, Bisazza A, Giustetto P, Trotta F, Vavia P. Nanosponge formulations as oxygen delivery systems. Int J Pharm, 2010; 402: 254-257. 
  37. Sapino S, Carlotti ME, Cavalli R, Ugazio E, Berlier G, Gastaldi L. Photochemical and antioxidant properties of gammaoryzanol in beta-cyclodextrin-based nanosponges. J Incl Phenom Macrocycl Chem, 2013; 75: 69-76.
  38. Ansari KA, Torne SJ, Vavia PR, Trotta F, Cavalli R. Paclitaxel loaded nanosponges: invitro characterization and cytotoxicity study on MCF-7 cell line culture. Current Drug Delivery, 2011; 8(2): 194-202.
  39. Rosalba M, Roberta C, Roberto F, Chiara D, Piergiorgio P, Leigh E, Li S, Roberto P. Antitumor activity of nanosponge-encapsulated Camptotech in in human prostate tumors. Cancer Res, 2011; 71: 4431. 
  40. Deshpande A, Patel P. Preparation and Evaluation of Cyclodextrin based Atorvastatin Nanosponges. American Journal of Pharm Tech Research, 2014; 4(3): 2249-3387. 
  41. Prathima S, Sreeja K. Formulation and Evaluation of Voriconazole Loaded Nanosponges for Oral and Topical Delivery, Int. J. Drug Dev. & Res, 2013; 5(1): 55-69. 
  42. O’Brien JJ, Campoli-Richards DM. Acyclovir. An updated review of its antiviral activity, pharmacokinetic properties and therapeutic efficacy. Drugs, 1989; 37: 233-309. 
  43. Lemboa D, Swaminathan S, Donalisioa M, Civraa A, Pasterod L, Aquilanod D. Encapsulation of acyclovir in new carboxylated cyclodextrin-based nanosponges improves the agent’s antiviral efficacy. Int J Pharm, 2013; 443: 262-272. 
  44. Rao M, Bajaj A, Khole I, Munjapara G, Trotta F. In vitro and in vivo evaluation of ?cyclodextrin-based nanosponges of telmisartan. J Incl Phenom Macrocycl Chem, 2013; 77: 135-145. 
  45. Mognetti B, Barberis A, Marino S, Berta G, Francia SD, Trotta F, et al. In vitro enhancement of anticancer activity of paclitaxel by a cremophor free cyclodextrin-based nanosponge formulation. J Incl Phenom Macrocycl Chem, 2012; 74: 201-210. 
  46. Klibanov AM, Schefiliti JA. On the relationship between conformation and stability in solid pharmaceutical protein formulations. Biotechnol Lett, 2004; 26: 1103-1106. 
  47. Shewarts D, Sofia S, Friess W. Integrity and stability studies of precipitated rhBMP-2 microparticles with a focus on ATR-FTIR measurements. Eur J Pharm Biopharm, 2006; 63: 241-248. 
  48. Swaminathan S, Cavalli R, Trotta F, Ferruti P, Ranucci E, Gerges I, et al. In vitro release modulation and conformational stabilization of a model protein using swellable polyamidoamine nanosponges of ?-cyclodextrin. J Incl Phenom Macrocycl Chem, 2010; 68: 183-191

Photo
Siddhi J. Rakibe
Corresponding author

Department of Pharmaceutics, Mahatma Gandhi Vidyamandir Pharmacy College, panchvati Nashik – 422003

Photo
Kanchan B. Benkule
Co-author

Department of Pharmaceutics, Mahatma Gandhi Vidyamandir Pharmacy College, panchvati Nashik – 422003

Photo
Janhvi D. Borse
Co-author

Department of Pharmaceutics, Mahatma Gandhi Vidyamandir Pharmacy College, panchvati Nashik – 422003

Photo
Ashish Y. Pawar
Co-author

Department of Pharmaceutics, Mahatma Gandhi Vidyamandir Pharmacy College, panchvati Nashik – 422003

Siddhi J. Rakibe*, Kanchan B. Benkule, Janhvi D. Borse, Ashish Y. Pawar, Nanosponges: A Modern Formulation Approach In Drug Delivery System, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 7, 276-287. https://doi.org/10.5281/zenodo.8172945

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