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  • Modern Review On Diabetic Wound Healing Potential Of Some Medicinal Herbs
  • 1Research Scholar Geetanjali University Udaipur, Rajasthan
    2Principle Geetanjali University Udaipur, Rajasthan
    3Maharaja Agrasen University Baddi, Himachal Pradesh
     

Abstract

Injuries pose a significant challenge to healthcare in developing nations with limited resources. Approximately 80% of individuals in underdeveloped Nations depend on traditional medicines, predominantly sourced from therapeutic plants, for primary healthcare. In regions like Africa, where traditional knowledge about wound healing is abundant, many people utilize medicinal plants to address diabetic wounds and associated issues. The vast reservoir of medicinal plants in these areas serves as a valuable resource for healthcare solutions. Integrating traditional practices with modern healthcare approaches can be crucial in addressing health challenges, especially in contexts where access to conventional medical resources is constrained. Both internal and external biological organs undergo intricate wound healing processes involving efficient cell-to-cell communication. The stages include haemostasis, inflammation, proliferation, and remodelling, exhibiting high control and organization. By 2040, the global diabetic population is projected to surpass 650 million. Vascular issues and the impaired wound-healing mechanisms associated with diabetes drive increased morbidity and mortality. Understanding and addressing these complex processes are crucial in developing effective strategies for managing diabetic wounds and mitigating the broader health impacts of diabetes on a global scale. This review explores various strategies for treating diabetic wounds, with a particular focus on the international interest in using medicinal plants. It examines factors influencing wound healing in diabetics, the impact of medicinal plants on this process, and the underlying mechanisms of action employed by these plants.

Keywords

Diabetes, wounds, medicinal herbs, recovery and infection

Reference

  1. Goboza, M., Meyer, S., Aboua, Y.G. and Oguntibeju, O.O. (2017) Diabetes mellitus: Economic and health burden, treatment and the therapeutical effects of Hypoxis hemerocallidea plant. Med. Technol. SA, 30(2): 39-46.
  2. Kim, L.E., Lee, J.H., Kim, S.H. and Jung, Y. (2018) Skin regeneration with self-assembled peptide hydrogels conjugated with substance in a diabetic rat model. Tissue Eng., 24(1-2): 1-15.
  3. WHO. (2018) Global Reports on Diabetes. World Health Organization, Geneva, Switzerland. Available from: http:// www.who.int.org Last accessed on 12/12/2018.
  4. Akash, M.S.H., Rehman, K. and Chen, S. (2013) Role of inflammatory mechanisms in pathogenesis of Type 2 diabetes mellitus. J. Cell. Biochem., 114(3): 525-531.
  5. Guo, R., Liu, B., Wang, K., Zhou, S., Li, W. and Xu, Y. (2014) Resveratrol ameliorates diabetic vascular inflammation and macrophage infiltration in db/db mice by inhibiting the NF-?B pathway. Diabetes Vasc. Dis. Res., 11(2): 92-102.
  6. Brownlee, M. (2005) The pathobiology of diabetic complications. Diabetes, 54(6): 1615-1625.
  7. Alvarado-Vazquez, N., Zamudio, P., Ceron, E., Vanda, B., Zenteno, E. and Carvajal Sandoval, G. (2003) Effect of glycine in streptozotocin induced diabetic rats. Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol.,134(4): 521-527.
  8. Attah, M.O., Jacks, T.W., Jacob, A., Eduitem, O. and John, B. (2016) The effect of Aloe vera on cutaneous wound healing and wound contraction rate in adult rabbits. Nova J. Med. Biol. Sci., 5(3): 1-8.
  9. Arise, R.O., Akapa, T., Adigun, M.A., Yekeen, A.A. and Oguntibeju, O.O. (2016) Normoglycaemic, normolipidemic and antioxidant effects of ethanolic extract of Acacia ataxacantha root in STZ-induced diabetic rats. Not. Sci. Biol., 8(2): 9970.
  10. Oguntibeju, O.O., Meyer, S., Aboua, Y.G. and Goboza, M. (2016) Hypoxis hemerocallidea significantly reduced hyperglycemia and hyperglycaemic-induced oxidative stress in the liver and kidney tissues of streptozotocin-induced diabetic male Wistar rats. Evid. Based Complement. Alternat. Med., 2016: 1-10.
  11. Chah, K.F., et al. “Antibacterial and wound-healing properties of methanolic extracts of some Nigerian medicinal plants.” Journal of Ethnopharmacology, Vol. 104, No. 1-2, 2006, pp.164-67.
  12. Fabricant, Daniel S. and Norman R. Farnsworth. “The value of plants used in traditional medicine for drug discovery.” Environmental Health Perspectives, Vol. 109, Suppl 1, 2001, p. 69.
  13. Principe PP. “Monetizing the pharmacological benefits of plants.” Medicinal Resources of the Tropical Forest: Biodiversity and Its Importance to Human Health, edited by Michael J. Balick, Elaine Elisabetsky, Sarah A. Laird, Columbia University Press, 1996, pp. 191-219.
  14. Jiang, Xudong, et al. “Effect of Bauhinia championii (Benth.) Benth extract on Streptococcus mutants in vitro.” Biomedical Research, Vol. 27, No. 3, 2016.
  15. Gurib-Fakim, Ameenah. “Medicinal plants: Traditions of Yesterday and drugs of tomorrow.” Molecular Aspects of Medicine, Vol. 27, No. 1, 2006, pp. 1-93.
  16. Senthil Kumar, Muthusamy. “Wound healing potential of Cassia fistula on infected albino rat model.” Journal of Surgical Research, Vol. 131, No. 2, 2006, pp. 283-89.
  17. Singh Meenakshi, et al. “Antimicrobial, wound healing and antioxidant activity of Plagiochasma appendiculatum Lehm. et Lind.” Journal of Ethnopharmacology, Vol. 107, No. 1, 2006, pp. 67-72.
  18. Enoch, Stuart and David John Leaper. “Basic science of wound healing.” Surgery (Oxford), Vol. 26, No. 2, 2008, pp. 31-37.
  19. Sumitra, Miriyala, Panchatcharam Manikandan and Lochin Suguna. “Efficacy of Butea monosperma on dermal wound healing in rats.” The International Journal of Biochemistry & Cell Biology, Vol. 37, No. 3, 2005, pp. 566-73.
  20. Krishnan, P. “The scientific study of herbal wound healing therapies: Current state of play.” Current Anaesthesia & Critical Care, Vol. 17, No. 1-2, 2006, pp. 21-27.
  21. Gupta AK, Tandon N. Reviews on Indian Medicinal Plants, New Delhi: Indian Council of Medical Research, 2004.
  22. Tiwari NN, Joshi MP. Medicinal plants of Nepal: Volumes I, II and III, J Nepal Med Assoc. 1990; 28:181- 190, 221-232, 266-279.
  23. Das S, Choudhury M, Ethnomedicinal uses of some traditional medicinal plants found in Tripura, Ind J Med Pl Res. 2012; 6(35):4908-4914.
  24. Rashed Khaled Nabih. Medicinal Plants as a Safe Target for Treatment of Cancer, Natural Products Chemistry &Research, 2014.
  25. Sejal G Patel. A Review on Medicinal Plants for Cancer Therapy, International Journal of Medi Pharm Research. 2016; 2(2):105-112.
  26. Lokhande PD, Jagdale SC, Chabukswar AR. Natural remedies for heart diseases, Indian Journal of Traditional Knowledge. 2006; 5(3):420-427
  27. Okpala Blessing. 18 Medicinal Plants for Treating Diabetes, Global food book, Published On, 2015.
  28. Gupta AK, Tandon N. Reviews on Indian Medicinal Plants, New Delhi Indian Council of Medical Research, 2004.
  29. Shinwari SK, Gilani SS. Sustainable harvest of medicinal plants at Bulashbar Nullah, Astore (Pakistan), J Ethnopharmacol. 2003; 84:289.
  30. Antony Joseph Raj, Saroj Biswakarma, Nazir A Pala, Gopal Shukla, Vineeta, Munesh Kumar et al. Indigenous uses of ethnomedicinal plants among forest-dependent communities of Northern Bengal, India, Journal of Ethnobiology and Ethnomedicine. 2018; 14:8.
  31. Eming SA, Krieg T, Davidson JM (2007) Inflammation in wound repair: molecular and cellular mechanisms. J Invt Derm 127:514–525
  32. Humar R, Kiefer FN, Berns H, Resink TJ, Battegay EJ (2002) Hypoxia enhances vascular cell proliferation and angiogenesis in vitro via rapamycin (mTOR)- dependent signaling. FASEB J 16:771–780
  33. Jain S, Shrivastave S, Nayak S (2007) Recent trends in Curcuma longa Linn. Ph Cog Rev 1:119
  34. Ameri A, Rajive BB, Vaidya JG, Apte K, Deokule SS (2013) Anti-staphylococcal and wound healing activities of Ganoderma praelongum and Glycyrrhiza glabra formulation in mice. Int J Appl Res Natural Prod 6(1):27–31
  35. Shukla A, Rasik AM, Jain GK, Shankar R, Kulshrestha DK, Dhawan BN (1999) In vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J Ethnopharmacol 65(1):1–11
  36. Chen YJ, Dai YS, Chen BF (1999) The effect of tetrandrine and extracts of Centella asiatica on acute radiation dermatitis in rats. Biol Pharm Bull 22(7): 703–706
  37. Kumarasamyraja D, Jeganathan NS, Manavalan RA (2012) Review on medicinal plants with potential wound healing activity. J Pharm Sci 2(4): 105–111
  38. Georgescu M, Chifiriuc CM, Marutesc L (2017) Bioactive wound dressings for the management of chronic wounds. Curr Org Chem 21:53–63
  39. Yang CS, Chen G, Wu Q (2014) Recent scientific studies of a traditional Chinese medicine tea on prevention of chronic diseases. J Tradit Complement Med 4(1):17–23
  40. Rani S, Amanjot G, Surya P, Kanwar K, Kaur S (2016) Wound healing potential of medicinal plants with their screening models: a comprehensive review. J Drug Deliv Ther 6(1):56–56
  41. Osunwokeemek O, Allison J, Theodore AO, Julius C (2013) The wound healing effects of aqueous leave extracts of Azadirachta indica on Wistar rats. Int J Nat Res 3:181–186
  42. Kiran K, Asad M (2008) Wound healing activity of Sesamum indicum L seed and oil in rats. Indian J Exp Biol 46(11):777–782
  43. Sapna S, Anju D, Sanju NS (2016) Traditional Indian medicinal plants with potential wound healing activity: a review. Int J Pharm Sci Res 7(5):1809–1819
  44. Himesh S, Singhai AK (2012) A recent update of botanical for wound healing activity. Res J Pharm 3(7):1–7
  45. Muhammad AA, Karthivashan G, Arulselvan P, Fakurazi S (2015) In vitro antioxidant properties of bioactive fraction of Moringa oleifera. J Natprod. Biomed Res 1(2):51–56
  46. Nayak BS, Isito GN, Maxwell A, Bhogadi V, Ramdath DD (2007) Wound healing activity of Morinda citrifolia fruit juice on diabetes induced rats. J Wound Care 16(2):83–86
  47. Manjunatha K, Vidya V, Mankani S, Manohara Y (2007) Wound healing activity of Lycopodium serratum. Indian J Pharm Sci 69(2):283–287
  48. Nayak BS, Pinto Pereira LM (2006) Catharanthus roseus flower extract has wound healing activity in Sprague Dawley rats. BMC Comp Alt Med 6(41):1–6
  49. Mittal A, Sardana S, Pandey A (2013) Herbal boon for wounds. Int J Pharm Sci 5(2):1–12
  50. Yogesh SG, Jeyabalan RSA (2013) Potential wound healing agents from medicinal plants: a review. Pharmacol 4(5):349–358
  51. Chaudhary G, Goya S, Poonia P (2010) Lawsonia inermis Linnaeus: a phytopharmacological review. Int J Pharm Sci Drug Res 2(2):91–98
  52. Asif A, Kakub G, Mehmood S, Khunum R, Gulfraz M (2007) Wound healing activity of root extracts of Berberis lyceum Royle in rats. Phytother Res 21(6): 589–591
  53. Galehdari H, Negahdari S, Kesmati M, Rezaie A, Shariati G (2016) Effect of the herbal mixture composed of Aloe vera Henna Adiantum capillus-veneris and Myrrha on wound healing in streptozotocin-induced diabetic rats. BMC Comp Alt Med 16(1):386
  54. Orue G, Gainza G, Gutierrez FB (2017) Novel nanofibrous dressings containing rhEGF and Aloe vera for wound healing applications. Int J Pharma 523(2):556–566
  55. Balekar N, Nakpheng T, Katkam NG, Srichana T (2012) Wound healing activity of ent-kaura-9(11)16-dien-19-oicacid isolated from Wedelia trilobata (L.) leaves. Phytomed 19(13):1178–1184
  56. Govindappa M (2011) Antimicrobial, antioxidant and in vivo antiinflammatory activity of ethanol extract and active phytochemical screening of Wedelia trilobata (L.) Hitchc. J Med Plants Res 5(24):5718–5729
  57. Vinothapooshan G, Sundar K (2010) Wound healing effect of various extracts of Adhatoda vasica. Int J Pharma Bio Sci 1(4):530–536
  58. Mahmood A, Salmah I (2005) Wound healing activity of Carica papaya L. aqueous leaf extract in rats. Int J Mol Med 1(4):398–401
  59. Selvaraj N, Lakshmanan B, Mazumder PM, Karuppasamy M, Jena SS, Pattnaik AK (2011) Evaluation of wound healing and antimicrobial potentials of Ixora coccinea root extract. Asian Pac J Trop Med 4(12):959–963
  60. Le Thi L, Tho NT, Ha DM, Hang PL, Nghia PT, Thang ND (2015) Influence of phytochemicals in Piper betle Linn leaf extract on wound healing. Burns Trauma 3:s41038-015-0023-7
  61. Akilandeswari S, Senthamarai R, Valarmathi R, Prema S (2010) Wound healing activity of Sida acuta in rats. Int J Pharmtech Res 2(1):585–587
  62. Muhammad AA, Pauzi NAS, Arulselvan P, Fakurazi S (2013) In vitro wound healing potential and identification of bioactive compounds from Moringa oleifera Lam. Biomed Res Int 974580
  63. Koca U, Süntar I, Akkol E, Yilmazer D, Alper M (2011) Wound repair potential of Olea europaea L. leaf extracts revealed by in vivo experimental models and comparative evaluation of the extracts’ antioxidant activity. J Med Food 14(1-2):140–146
  64. Nair RV (1995) Indian medicinal plants- a compendium of 500 species.(Mentha arvensis Linn, Warrier PK, Nambiar VPK, Ramankutty C editors). Hyd: Ori Long Pvt Ltd 4:15–17.
  65. Viji CS, Trikkurmadom SA, Rajalekshmi G, Pandimadevi M (2015) Collagen Azadirachta indica (neem) leaves extract hybrid film as a novel wound dressing: in vitro studies. Int J Pharm Sci Rev Res 32(2):193–199
  66. Behrooz M, Payam Z, Iraj R, Morvarid M, Abdolghaffari HA, Mohammad AZ (2013) Morphology drug release, antibacterial, cell proliferation and histology studies of chamomile-loaded wound dressing mats based on electrospun nanofibrous poly(e-caprolactone)/polystyrene blends. J Biomed Mater Res Part B 102(5):977–987
  67. van Rijswijk L (2006) Ingredient-based wound dressing classification: a paradigm shift that is passe and in need of replacement. J Wound Care 15:11–14
  68. Sharma A, Singh I, Puri V (2019) Preparation and characterization of biocomposite films of carrageenan/locust bean gum/montmorrillonite for transdermal delivery of curcumin. Bioimpacts 9(1):37–43
  69. Waring MJ, Parsons D (2001) Physico-chemical characterisation of carboxymethylated spun cellulose fibers. Biomaterials 22:903–912
  70. Sharma A, Mittal A, Puri V, Singh I (2020) Curcumin-loaded, alginate-gelatin composite fibres for wound healing applications. 3 Biotech 10:464.

Photo
Shoket Ali
Corresponding author

Research Scholar Geetanjali University Udaipur, Rajasthan

Photo
Mahendra S. Rathod
Co-author

Principal Geetanjali University Udaipur, Rajasthan

Photo
Ankita Sharma
Co-author

Maharaja Agrasen University Baddi, Himachal Pradesh

Shoket Ali , Mahendra S. Rathore, Ankita Sharma, Modern Review On Diabetic Wound Healing Potential Of Some Medicinal Herbs, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 330-338. https://doi.org/10.5281/zenodo.10653899

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