View Article

  • Microbes Drug Delivery System A Comprehensive Review

  • 1B. Pharma, Pharmacy College Azamgarh
    2B. Pharma, Pharmacy College Azamgarh
    3Assistant Professor (Pharmaceutics), Pharmacy College Azamgarh
    4Associate Professor (Pharmaceutical Chemistry), Pharmacy College Azamgarh
    5Associate Professor (Pharmaceutics), Pharmacy College Azamgarh
     

Abstract

This review article focuses on the Microbes Drug Delivery System. The Microbial drug delivery system is an emerging form of drug administration characterized by the use of commensal microbes that have been genetically modified to produce medications for chronic diseases in humans. The drug delivery system now a days, very popular for its therapeutic effects and prolonged action. The most prominent route of administration used for it, is topical route of administration due to which it avoids first pass metabolism. There are various forms available for drug delivery system, which contributes to enhance the patient compliance. Drug delivery system is a method of administration for pharmaceutical medication to achieve a therapeutic effect in humans or animals. There are various routes available for drug delivery such as the oral, topical, parentral, inhalation, transdermal, transmucosal and implantable systems. The drug delivery system further divided into two types, Conventional drug delivery system is the classical method for the delivery of drug into the body and Novel drug delivery system is a new approach that utilizes new technologies, innovative ideas and methodologies to deliver the active molecules in safe yet effective concentration to produce desired pharmacological action. The human microbiome is known to play an essential role in influencing host health. Extracellular vehicles (EVs) have also been reported to act on a variety of signaling pathways, distally transport cellular components such as proteins, lipids, and nucleic acid, and have immunomodulatory effects. In this review article we have discussed about the Microbes based drug delivery system by taking the examples of Human microbiome and extracellular vesicles.

Keywords

Microorganism, drug delivery system, Microbes drug delivery system, Microbiome-derived EVS, etc.

Reference

  1. Belkaid,Yasmine, And Timothy W Hand.“Role Of The Microbiota In Immunity And Inflammation.” Cell Vol. 157,1 (2014): 121-41. Doi:10.1016/J.Cell. 2014.03.01.
  2. Krithaksha V.*, Thamizharasan S. Microorganism – Essentieal For Human Life  Paripex – Indian Journal Of Research| Volume  -9 | Issue -12 |  December – 2020 | Print Issn No. 2250 -1991 | Doi : 10.36106/Paripex
  3.  Langer R. Implantable Controlled Release Systems. Pharmacol Ther 1983;21:35–51
  4. Park K. Controlled Drug Delivery: Challenges And Strategies. Washington (DC): American Chemical Society; 1997.
  5. Park K, Mersny RJ. Controlled Drug Delivery: Present And Future. Controlled Drug Delivery: Designing Technology For The Future, 2–13. Washington (DC): American Chemical Society; 2000.
  6. Juliano RL. Controlled Delivery Of Drugs: An Overview And Prospectus. Drug Delivery Systems: Characteristics And Biomedical Application 310. Oxford University Press; 1980.
  7. Langer R. Implantable Controlled Release Systems. Pharmacol Ther 1983;21:35–51.
  8. Langer R. Drug Delivery And Targeting. Nature (London) 1998;392:5–10.
  9. Kost J, Langer R. Responsive Polymeric Delivery Systems. Adv Drug Deliv Rev 2001;46:125–148.
  10. Breimer DD. Future Challenges For Drug Delivery. J Control Rel 1999;62:3–6.
  11. Park K, Mersny RJ. Controlled Drug Delivery: Present And Future. Controlled Drug Delivery: Designing Technology For The Future, 2–13. Washington (DC): American Chemical Society; 2000
  12. Breimer DD. Future Challenges For Drug Delivery. J Control Rel 1999;62:3–6. 8. Klausner EA, Et Al. Novel Levodopa Gastroretentive Dosage Form: In-Vivo Evaluation In Dogs. J Control Rel 2003;88:117–126.
  13. Park K. Controlled Drug Delivery: Challenges And Strategies. Washington (DC): American Chemical Society; 1997.
  14. Park K, Mersny RJ. Controlled Drug Delivery: Present And Future. Controlled Drug Delivery: Designing Technology For The Future, 2–13. Washington (DC): American Chemical Society; 2000.
  15. National Human Genome Research Institute. An Overview Of The Human Genome Project. Https://Www.Genome.Gov/12011238/An-Overview-Of-Thehuman-Genome-Project/Accessed 03 Oct 2018 12. Hillier LW, Coulson A, Murray JI, Bao Z, Sulston JE, Waterston RH. Genomics In C. Elegans: So Many Genes, Such A Little Worm. Genome Res 2005;15:1651-1660.
  16. Azmi AS, Bao B, Sarkar FH. Exosomes In Cancer Development, Metastasis, And Drug Resistance: A Comprehensive Review. Cancer Metastasis Rev 2013;32:623-642. Doi: 10.1007/S10555-013-9441-9.
  17. Cocucci E, Meldolesi J. Ectosome And Exosomes: Shedding The Confusion Between Extracellular Vesicles. Trends Cell Biol 2015;6:364-372. Doi: 10.1016/J.Tcb.2015.01.004
  18. Deatherage BL, Cookson BT. Membrane Vesicle Release In Bacteria, Eukaryotes, And Archaea: A Conserved Yet Underappreciated Aspect Of Microbial Life. Infect Immun 2012;80:1948-1957. Doi: 10.1128/IAI.06014-11.
  19. Kulp A, Kuehn MJ. Biological Functions And Biogenesis Of Secreted Bacterial Outer Membrane Vesicles. Annu Rev Microbiol 2010; 64:163-184. Doi: 10.1146/Annurev.Micro.091208.073413.
  20. Lee EY, Choi DY, Kim DK, Kim JW, Park JO, Kim S, Et Al. Gram-Positive Bacteria Produce Membrane Vesicles: Proteomics-Based Characterization Of Staphylococcus Aureus-Derived Membrane Vesicles. Proteomics 2009;9:5425- 5436. Doi: 10.1002/Pmic.200900333. Rivera J, Cordero RJ, Nakouzi AS, Frases S, Nicola A, Casadevall A. Bacillus Anthracis Produces Membrane-Derived Vesicles Containing Biologically Active Toxins. Proc Natl Acad Sci U S A 2010;107:19002-19007. Doi: 10.1073/Pnas.1008843107.8
  21. Allocati N, Masulli M, Di Ilio C, De Laurenzi V. Die For The Community: An Overview Of Programmed Cell Death In Bacteria. Cell Death Dis 2015;6:E1609. Doi: 10.1038/Cddis.2014.570.
  22.  Zaborowski MP, Balaj L, Breakefield XO, Lai CP. Extracellular Vesicles: Composition, Biological Relevance, And Methods Of Study. Bioscience 2015;65:783-797Kulp A, Kuehn MJ. Biological Functions And Biogenesis Of Secreted Bacterial Outer Membrane Vesicles. Annu Rev Microbiol 2010; 64:163-184. Doi: 10.1146/Annurev.Micro.091208.0734134. Brown L, Wolf JM, Prados-Rosales R, Casadevall A. Through The Wall: Extracellular Vesicles In Gram-Positive Bacteria, Mycobacteria And Fungi. Nat Rev Microbiol 2015;13:620-630. Doi: 10.1038/Nrmicro3480...
  23. https://Www.Google.Com/Search?Q=Microorganisms&Sca_Esv=592428276&Rlz=1C1VDKB_Enin1040in1040&Tbm=Isch&Sxsrf=AM9HkKmIZU24tP7D8vef_4d8ymhr7f4eyg:1703052605184&Source=Lnms&Sa=X&Sqi=2&Ved=2ahukewje8sksrz2daxuhtgwghy6hchaq_Auoaxoecauqaw&Biw=1280&Bih=551&Dpr=1.5#Imgrc=Usjcpw5tntb3tm
  24. Kulp A, Kuehn MJ. Biological Functions And Biogenesis Of Secreted Bacterial Outer Membrane Vesicles. Annu Rev Microbiol 2010; 64:163-184. Doi: 10.1146/Annurev.Micro.091208.073413.
  25. Krithaksha V.*, Thamizharasan S. Microorganism – Essentieal For Human Life  Paripex – Indian Journal Of Research| Volume  -9 | Issue -12 |  December – 2020 | Print Issn No. 2250 -1991 | Doi : 10.36106/Paripex
  26. Krithaksha V.*, Thamizharasan S. Microorganism – Essentieal For Human Life  Paripex – Indian Journal Of Research| Volume  -9 | Issue -12 |  December – 2020 | Print Issn No. 2250 -1991 | Doi : 10.36106/Paripex

Photo
Archana chauhan
Corresponding author

B. Pharma, Pharmacy College Azamgarh

Photo
Pradeep Yadav
Co-author

B. Pharma, Pharmacy College Azamgarh

Photo
Kakli Rai
Co-author

Assistant Professor (Pharmaceutics), Pharmacy College Azamgarh

Photo
Jitendra Jena
Co-author

Associate Professor (Pharmaceutical Chemistry), Pharmacy College Azamgarh

Photo
Jitendra K. Rai
Co-author

Associate Professor (Pharmaceutics), Pharmacy College Azamgarh

Archana chauhan, Pradeep Yadav, Kakli Rai, Jitendra Jena, Jitendra Kumar Rai, Microbes Drug Delivery System- A Comprehensive Review, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 1, 23-32. https://doi.org/10.5281/zenodo.10455555

More related articles
Nano-Engineering of Ketorolac Tromethamine for Inf...
Sandhya Jaiswal , Dr. Ritesh Jain, Pankaj Kumar...
Revolutionizing Rheumatoid Arthritis Therapy: The ...
Pankaj Kumar, Ritesh Jain, Shreya Pathak ...
4D Bioprinting: Shaping the Future of Dynamic and ...
Tanaya Markande, Snehal Nage , Pranjali Narwade , Aarti More, San...
The Formulation and Evaluation of Poly Herbal Soap for Treatment of Acne and It...
Kiran Makwana, Abdul Basit, Shivam Singh , Rahal Shah, Dhara Siddhpuria, Krushal Sapariya...
Preliminary Physicochemical Characterization of Iguratimod Using UV Spectroscopy...
Sankar C., Babitha L., Vasanthkumar A., Sabitha S., Naresh Kumar...
Related Articles
Formulation and Evaluation of a Natural Nutritional Bar...
Sanika Soor, Nilesh Chachda, Snehal Vaidya, Sapna Akhade...
RP-HPLC Method Development and Validation for the simultaneous estimation of Cob...
Dr. P. V. Madhavi Latha , Dr. P Uma Devi, K Suvarna, P. Siva Lalitha...
Development and Evaluation of Herbal Gel Formulations Using Advanced Analytical ...
Ajeet Kumar Yadav, Dr. Pavan Kumar, Dr. Vipin Kesarwani, Vasim Khan...
More related articles
4D Bioprinting: Shaping the Future of Dynamic and Smart Tissue Regeneration...
Tanaya Markande, Snehal Nage , Pranjali Narwade , Aarti More, Sanika Nalande, Sumeet Bhilwade ...
4D Bioprinting: Shaping the Future of Dynamic and Smart Tissue Regeneration...
Tanaya Markande, Snehal Nage , Pranjali Narwade , Aarti More, Sanika Nalande, Sumeet Bhilwade ...