Ashokrao Mane Institute of Pharmacy, Ambap–416112
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to inadequate insulin production or ineffective insulin use. Despite the availability of pharmacological treatments, managing diabetes without adverse effects remains challenging. Current therapies, including insulin and oral antidiabetic agents, are often associated with significant side effects, necessitating the exploration of alternative approaches. In recent years, medicinal plants have garnered increasing attention as potential therapeutic agents for diabetes management. Traditional systems of medicine, such as Ayurveda, continue to play a crucial role in healthcare, particularly in developing countries, where plant-based treatments are culturally accepted and widely used. This review explores various plant species with documented antidiabetic properties, focusing on their ability to regulate glucose levels, enhance insulin secretion, or inhibit carbohydrate metabolism. Compounds such as glycosides, alkaloids, flavonoids, and terpenoids have demonstrated potential in reducing hyperglycemia and associated complications. By investigating plant-based remedies, we aim to provide an alternative, complementary approach to diabetes management, emphasizing the importance of ethnobotanical research in discovering new, safer treatments for this global health challenge.
Diabetes mellitus is a group of metabolic disorders with one common manifestation -hyperglycemia (1, 2). Diabetes mellitus, being a multifactorial disease, demands multiple therapeutic approaches. Global studies on diabetes mellitus have reiterated that primary prevention is necessary and drastic steps must be taken to diagnose the disease early on, provide effective management and also take steps to prevent the onset of disease in high-risk subjects. According to WHO, plant-based traditional system of medicine is still the mainstay of about 75– 80% of the world population, mainly in the developing countries, for primary healthcare because of better cultural acceptability, better compatibility with the human body and lesser side effects (3) . According to the fifth edition of the World Diabetes Atlas released by the International Diabetes Federation (IDF), as of 2011, the total adult population in the age group of 20-79 years stands at 4.3 billion, out of which 366 million live with diabetes, which is set to increase to 552 million by 2030 (4). Ayurveda is an ancient system of medicine originating in India, and is an extension of yoga. Its two most famous treatises, Charak Samhita and Sushruta provide evidence of a rich tradition of herbal medicine in India. Historical and anthropological studies have repeatedly demonstrated the importance of yoga’s ‘upanishadic’ roots and philosophical basis. In India, there is a high degree of reliance on and cultural acceptability of Ayurveda medicine in favour of traditional systems of medicine. The rural population in India is heavily dependent on traditional medical systems (5). In an earlier study, we found that 67.7% of patients with diabetes attending our outpatient department used CAM, in particular naturopathy (6).Currently available therapies for diabetes include insulin and various oral antidiabetic agents such as sulfonylureas, biguanides, a-glucosidase inhibitors, and glinides, which are used as monotherapy or in combination to achieve better glycemic regulation. Many of these oral antidiabetic agents have a number of serious adverse effects; thus, managing diabetes without any side effects is still a challenge (7). An estimated 143 million people suffer from diabetes worldwide and the number is growing rapidly (8). Recently, some medicinal plants have been reported to be useful in diabetes worldwide and have been used empirically in antidiabetic and antihyperlipidemic remedies. Antihyperglycemic activity of the plants is mainly due to their ability to restore the function of pancreatic tissues by causing an increase in insulin output or inhibit the intestinal absorption of glucose or to the facilitation of metabolites in insulin dependent processes. More than 400 plant species having hypoglycemic activity have been available in literature, however, searching for new antidiabetic drugs from natural plants is still attractive because they contain substances which demonstrate alternative and safe effects on diabetes mellitus. Most of plants contain glycosides, alkaloids, terpenoids, flavonoids, carotenoids, etc., that are frequently implicated as having antidiabetic effect (9). The severity of damage triggered by hyperglycemia on the respective organ systems may be related to how long the disease has been present and how well it has been controlled. Several symptoms such as thirst, polyuria, blurring of vision, and weight loss also accompany diabetes (10).
Classification of Diabetes Mellitus
Type 1: Associated with absolute insulin deficiency
A. Immune-mediated
B. Idiopathic
Type 2: Adult-onset, Associated with insulin resistance
Type 3:
A. Genetic defects of -cell function
B. Genetic defects in insulin action
C. Diseases of exocrine pancreas
D. Endocrinopathies
E. Drug-or chemical-induced
F. Infections
G. Uncommon forms of immune-mediated diabetes
H. Other genetic syndromes sometimes associated with diabetes
Type 4: Gestational diabetes mellitus (11)
Management of diabetics :
Effectively managed through lifestyle modifications such as
When these interventions are insufficient to control blood sugar levels, medications or insulin therapy may be recommended (12).
Medicinal Plants as an Alternative Source of Antidiabetic Agents
Natural products, particularly of plant origin, are the main quarry for discovering promising lead candidates and play an imperative role in the upcoming drug development programs [13-15]. Ease of availability, low cost, and least side e_ects make plant-based preparations the main key player of all available therapies, especially in rural areas. For centuries, many plants have been considered a fundamental source of potent antidiabetic drugs. In developing countries, particularly, medicinal plants are used to treat diabetes to overcome the burden of the cost of conventional medicines to the population [16]. Nowadays, treatments of diseases including diabetes using medicinal plants are recommended [17] because these plants contain various phytoconstituents such as flavonoids, terpenoids, saponins, carotenoids, alkaloids, and glycosides, which may possess antidiabetic activities [18]. The antihyperglycemic e_ects resulting from treatment with plants are usually attributed to their ability to improve the performance of pancreatic tissue, which is done by increasing insulin secretions or by reducing the intestinal absorption of glucose [16]. Herbal medicines and plant components with insignificant toxicity and no side effects are notable therapeutic options for the treatment of diabetes around the world [19].
Herb–Drug interactions in diabetes:
The co-administration of antidiabetic herbs and pharmaceutical agents may result in HDIs leading to enhanced effects (which may be desirable clinically), decreased pharmacological effects, or adverse drug events, such as hypoglycaemia [20].
Conventional antidiabetic drugs
Low levels (or absence) of insulin leads to type 1 diabetes, and administration of insulin is indicated for treatment of this condition. Type 2 diabetes, the most common type of diabetes, is caused by insulin resistance; conventional pharmaceutical medications against type 2 diabetes include: i) sensitizers that increase the sensitivity of target organs to insulin, ii) secretagogues that increase the level of insulin secreted from the pancreas, and iii) ?-glycosidase inhibitors (e.g., acarbose) that reduce the gastrointestinal absorption of glucose. The sensitizers include biguanides (e.g., metformin) and thiazolidinediones (e.g., pioglitazone), while the secretagogues include sulfonylureas (e.g., glibenclamide, glimepiride, gliclazide, tolbutamide) and meglitinides (e.g., repaglinide). [21].
Genus |
Species |
Geographic Zone |
Activity |
Reference |
||||
Acacia |
Acacia catechu |
Nepal, India |
antihyperglycemic |
[22] |
||||
|
Acacia modesta |
India and Pakistan |
antihyperglycemic |
[23] |
||||
|
Acacia arabica |
India |
hypoglycemic and antihyperglycemic |
[24] |
||||
Acalypha |
Acalypha indica |
India |
antidiabetic |
[25] |
||||
|
Acalypha langiana |
|
antidiabetic |
[26] |
||||
Achillea |
Achillea millefolium |
India |
antidiabetic |
[27] |
||||
|
Allium sativum |
India (Ayurveda), Indonesia, Iran, Cuba, Mauritius, Togo, China (TCM) |
?-amylase inhibitor, hypoglycemic, ?-glucosidase inhibitor, antihyperglycemic |
[28,29] |
||||
Aloe |
Aloe ferox |
India (Ayurveda) |
antidiabetic |
[30] |
||||
|
Aloe vera |
India (Ayurveda), Ghana, Mauritius, Uganda, Tanzania, Traditional Chinese medicines, Trinidad and Tobago, Iran, Pakistan, Philippines, Saudi Arabia |
?-amylase inhibitor, hypoglycemic |
[31-33] |
||||
Alpinia |
Alpinia calcarata |
India, Sri Lanka |
antidiabetic |
[34,35] |
||||
|
Alpinia galanga |
India |
antidiabetic |
[36] |
||||
|
Artemisia parviflora |
India |
antidiabetic |
[37] |
||||
|
Artocarpus heterophyllus |
India (Ayurveda), Mauritius |
hypoglycemic, ?-amylase inhibitor |
[38-40] |
||||
Berberis |
Berberis aristata |
India (Ayurveda) |
antidiabetic |
[41] |
||||
|
Berberis asiatica |
India |
antidiabetic |
[42] |
||||
Brassica |
Brassica juncea |
India (Ayurveda) |
antidiabetic |
[43] |
||||
|
Brassica oleracea |
|
antihyperglycemic |
[44] |
||||
|
Brassica rapa |
India |
antidiabetic |
[45] |
||||
Buddleja |
Buddleja asiatica |
India |
antidiabetic |
[46] |
||||
Butea |
Butea monosperma |
India |
antidiabetic |
[27] |
||||
|
Butea frondosa |
India |
antidiabetic |
[47] |
||||
Caesalpinia |
Caesalpinia bonducella |
India |
?-amylase inhibitor |
[48] |
||||
Calamus |
Calamus tenuis |
India |
antidiabetic |
[49] |
||||
|
Calamus erectus |
India |
Antidiabetic |
[50] |
||||
|
Calotropis procera |
|
Antidiabetic |
[51] |
||||
Capparis |
Capparis aphylla |
|
antihyperglycemic |
[52] |
||||
|
Capparis decidua |
India, Pakistan |
Antidiabetic |
[53] |
||||
|
Capparis sepiaria |
India |
Antidiabetic |
[54] |
||||
|
Capparis spinosa |
India (Ayurveda and Unani) |
Antidiabetic |
[55] |
||||
Caralluma |
Carallumaadscendens |
India |
Antidiabetic |
[56] |
||||
|
Carallumaumbellata |
India |
antihyperglycemic |
[57] |
||||
Carissa |
Carissa carandas |
India (Ayurveda, Unani, and Homoeopathy) |
Antidiabetic |
[58] |
||||
Cassia |
Cassia auriculata |
India, Tanzania |
Antidiabetic |
[59] |
||||
|
Cassia fistula |
India |
Antidiabetic |
[60] |
||||
|
Cinnamomum cassia |
India (Unani, Ayurveda) Japan, China, South Africa |
antidiabetic |
[61] |
||||
|
Cinnamomum impressinervium |
India |
antidiabetic |
[62] |
||||
|
Cinnamomum tamala |
India (Ayurveda) |
hypoglycemic |
[63] |
||||
|
Cinnamomum verum |
India (Ayurveda) |
?-amylase inhibitor |
[28] |
||||
|
Cinnamomum zeylanicum |
|
?-glucosidase |
[64] |
||||
|
Citrus sinensis |
India |
antidiabetic |
[65] |
||||
Clerodendrum |
Clerodendrum glandulosum |
India |
antidiabetic |
[66] |
||||
|
Clerodendrum colebrookianum |
India |
antidiabetic |
[46] |
||||
|
Clerodendrum infortunatum |
India |
antidiabetic |
[67] |
||||
|
Clerodendrum phlomidis |
India (Ayurveda) |
antidiabetic |
[68] |
||||
Coccinia |
Coccinia cordifolia |
India |
antidiabetic |
[69] |
||||
|
Coccinia grandis |
India (Ayurveda), Sri Lanka |
antihyperglycemic, ?-glucosidase inhibitor, ?-amylase inhibitor |
[28,70-72] |
||||
|
Coccinia indica |
India (Ayurveda) |
antidiabetic |
[43,63] |
||||
Costus |
Costusigneus |
India |
antidiabetic |
[73] |
||||
|
Costus pictus |
India |
antidiabetic |
[74] |
||||
|
Croton klozchianus |
India (Ayurveda) |
antidiabetic |
[75] |
||||
|
Croton zambesicus |
|
antidiabetic |
[76] |
||||
Cucumis |
Cucumis callosus |
India |
antidiabetic |
[77] |
||||
|
Curculigoorchioides |
India (Ayurveda) |
antidiabetic |
[78] |
||||
Curcuma |
Curcuma angustifolia |
India |
antidiabetic |
[79] |
||||
|
Curcuma domestica |
India |
antidiabetic |
[27] |
||||
|
Curcuma longa |
China, Bangladesh, India (Ayurveda), Indonesia, Laos |
antidiabetic |
[33,80] |
||||
Cuscuta |
Cuscutareflexa |
India, Bangladesh |
antidiabetic |
[49,81] |
||||
|
Cuscuta chinensis |
China |
antidiabetic |
[82] |
||||
|
Cuscuta americana |
Trinidad and Tobago |
antidiabetic |
[83] |
||||
Cyperus |
Cyperus kyllinga |
India (Ayurveda) |
antidiabetic |
[84] |
||||
|
Cyperus laevigatus |
India (Ayurveda) |
antidiabetic |
[85] |
||||
|
Cyperus rotundus |
India (Ayurveda) |
antidiabetic |
[86] |
||||
|
Delonixelata |
|
antidiabetic |
[87] |
||||
Desmodium |
Desmodiumgangeticum |
India (Ayurveda), Sri Lanka |
antidiabetic |
[70,88] |
||||
|
Dioscorea opposita |
China, India (Ayurveda), China (TCM) |
antidiabetic |
[33,80,89] |
||||
|
Diospyros melanoxylon |
India, Sri Lanka |
antidiabetic |
[90] |
||||
|
Diospyros peregrina |
India |
antidiabetic |
[91] |
||||
Elephantopus |
Elephantopusscaber |
India |
antidiabetic |
[92] |
||||
|
Elephantopusmollis |
|
antidiabetic |
[93] |
||||
Embelia |
Embelia madagascariensis |
|
hypoglycemic |
[94] |
||||
|
Embeliaribes |
India (Ayurveda) |
antidiabetic |
[95] |
||||
Enicostema |
Enicostemaaxillare |
India (Ayurveda) |
antidiabetic |
[96] |
||||
|
Enicostemalittorae |
|
antidiabetic |
[97] |
||||
Erythrina |
Erythrina indica |
India |
antidiabetic |
[98] |
||||
|
Erythrina variegeta |
India |
antidiabetic |
[87] |
||||
Eugenia |
Eugenia jambolana |
India (Ayurveda) |
?-amylase inhibitor |
[83,99] |
||||
|
Eugenia polyantha |
India, Indonesia |
antidiabetic |
[100,101] |
||||
Euphorbia |
Euphorbia caducifolia |
India |
antidiabetic |
[102] |
||||
|
Euphorbia dioeca |
|
?-glucosidase inhibitor |
[103] |
||||
|
Euphorbia drumondii |
India (Ayurveda) |
hyperglycemic |
[104] |
||||
|
Euphorbia hirta |
India, Bangladesh, Nepal |
?-glucosidase |
[105-107] |
||||
|
Euphorbia ligularia |
India |
antidiabetic |
[62] |
||||
|
Euphorbia neriifolia |
India (Ayurveda) |
antidiabetic |
[108] |
||||
|
Euphorbia prostrata |
|
antihyperglycemic |
[109] |
||||
Ferula |
Ferulaassa-foetida |
India (Ayurveda), Iran, Afghanistan |
antidiabetic |
[110,111] |
||||
Ficus |
Ficus amplissima |
India (Ayurveda, Siddha, Unani) |
antidiabetic |
[112] |
||||
|
Ficus benghalensis |
India (Ayurveda, Siddha, Unani, homoeopathy), Southeast Asia |
antidiabetic |
[101, 113] |
||||
|
Ficus carica |
India (Ayurveda, Siddha, Unani, homoeopathy) |
antidiabetic |
[114, 115] |
||||
|
Ficus cunia |
India |
?-glucosidase inhibitor |
[116] |
||||
|
Ficus glomerata |
India (Ayurveda, Siddha, Unani, homoeopathy) |
antidiabetic |
[63,117] |
||||
|
Ficus palmata |
|
antidiabetic |
[118] |
||||
|
Ficus racemosa |
India (Ayurveda, Siddha, Unani, homoeopathy), Bangladesh, Southeast Asia |
antihyperglycemic, hypoglycemic, ?-glucosidase and ?-amylase inhibitor |
[119,120] |
||||
|
Ficus religiosa |
India (Ayurveda) |
antidiabetic |
[113] |
||||
|
Ficus virens |
India (Ayurveda) |
antidiabetic |
[121] |
||||
Glycyrrhiza |
Glycyrrhiza glabra |
China, India |
antidiabetic |
[33,122] |
||||
|
Glycyrrhiza uralensis |
India |
antidiabetic |
[123] |
||||
Grewia |
Grewia asiatica |
India (Ayurveda) |
antidiabetic |
[124] |
||||
|
Grewia hirsuta |
India |
antidiabetic |
[125] |
||||
|
Grewia nervosa |
|
antidiabetic |
[126] |
||||
Helicteres |
Helicteresisora |
India (Ayurveda) |
antidiabetic |
[127] |
||||
Holarrhena |
Holarrhenaantidysenterica |
India (Ayurveda) |
antidiabetic |
[128] |
||||
Hydnocarpus |
Hydnocarpusalpina |
|
hypoglycemic |
[129] |
||||
|
Hydnocarpuswightiana |
India (Ayurveda) |
antidiabetic |
[130] |
||||
Leucas |
Leucas aspera |
India, Bangladesh |
antidiabetic |
[36,131] |
||||
|
Leucas cephalotes |
India (Ayurveda), Nepal, Pakistan |
antidiabetic |
[132] |
||||
|
Luffa echinata |
India |
Antidiabetic |
[64] |
||||
Mangifera |
Mangifera indica |
India (Ayurveda), Nigeria |
?-amylase inhibitor, antihyperglycemic |
[28,133] |
||||
|
Melia dubia |
India |
antidiabetic |
[134] |
||||
|
Melia orientalis |
India (Ayurveda) |
antidiabetic |
[135] |
||||
Mentha |
Mentha arvensis |
India |
antidiabetic |
[136] |
||||
|
Mentha longifolia |
India |
antidiabetic |
[27] |
||||
Mimusops |
Mimusopselengi |
India (Ayurveda) |
antidiabetic |
[137] |
||||
|
Momordica charantia |
Philippines, Vietnam, Mauritius, Trinidad and Tobago, India (Ayurveda), Nigeria, Bangladesh, Taiwan, central America |
?-amylase inhibitor, hypoglycemic, antihyperglycemic |
[138-141] |
||||
Moringa |
Moringa oleifera |
South Africa, Kenya, Mexico, India (Ayurveda), Nigeria, Mauritius, Senegal |
hypoglycemic |
[63,142-45] |
||||
Morus |
Morus alba |
Iran, Philippines, Trinidad and Tobago, India (Ayurveda), China (TCM), Pakistan, Korea, Chile |
antidiabetic, hypoglycemic, ?-glucosidase and ?-amylase inhibition |
[146-154] |
||||
Mucuna |
Mucuna gigantea |
India |
antidiabetic |
[155] |
||||
|
Mucuna pruriens |
India (Ayurveda) |
Antidiabetic |
[43] |
||||
Murraya |
Murrayakoenigii |
India (Ayurveda) |
? amylase inhibitor, hypoglycemic effects, antihyperglycemic |
[156] |
||||
|
Musa Sapientum |
India |
antihyperglycemic |
[109,157] |
||||
Nymphaea |
Nymphaea nouchali |
Bangladesh, India (Ayurveda) |
Antidiabetic |
[106] |
||||
|
Nymphaea stellata |
India (Ayurveda) |
?-glucosidase inhibitor, hypoglycemic, antihyperglycemic |
[158, 159] |
||||
Ocimum |
Ocimum sanctum |
India (Ayurveda), China, Bangladesh |
hypoglycemic |
[160,161] |
||||
|
Ocimumtenuiflorum |
India (Ayurveda) |
?-amylase inhibitor, hypoglycemic, antihyperglycemic |
[28,162] |
||||
Oxalis |
Oxalis corniculata |
India |
Antidiabetic |
[27] |
||||
|
Oxalis griffithii |
India |
Antidiabetic |
[49] |
||||
Paederia |
Paederiafoetida |
China, Vietnam, India Japan |
Antidiabetic |
[162] |
||||
|
Paederia scandens |
China, Vietnam, India, Japan |
Antidiabetic |
[162] |
||||
pandanus |
Pandanus fascicularis |
India (Ayurveda) |
antihyperglycemic |
[163] |
||||
|
Pandanus tectorius |
|
Antidiabetic |
[164] |
||||
Phyllanthus |
Phyllanthus amarus |
Vietnam, India (Ayurveda, Siddha, Unani and homeopathy), Nigeria, Malaysia |
?-glucosidase inhibitor, hypoglycemic, ?-amylase inhibitor |
[114,165] |
||||
|
Phyllanthus emblica |
Thailand, Southeast Asia, India (Ayurveda) |
Antidiabetic |
[117,166,167] |
||||
|
Phyllanthus gardnerianus |
India |
Antidiabetic |
[168] |
||||
|
phyllanthusvirgatus |
|
?-amylase inhibitor |
[169] |
||||
|
Phyllanthus watsonii |
|
Antidiabetic |
[170] |
||||
Physalis |
Physalis angulata |
India |
Antidiabetic |
[171] |
||||
|
Physalis minima |
India |
Antidiabetic |
[36] |
||||
|
Physalis peruviana |
India |
Antidiabetic |
[172] |
||||
Piper |
Piper longum |
Bangladesh, India (Ayurveda) |
antihyperglycemic |
[173-175] |
||||
|
Piper nigrum |
|
?-amylase inhibitor, hypoglycemic |
[28,176] |
||||
Plantago |
Plantago ovata |
India |
Antidiabetic |
[99] |
||||
Plumeria |
Plumeria rubra |
India |
?-amylase and ?-glucosidase inhibitor |
[177] |
||||
Polygonum |
Polygonum hydropiper |
India |
antidiabetic |
[46] |
||||
Pterocarpus |
Pterocarpus santalinus |
India (Ayurveda) |
antidiabetic |
[178] |
||||
|
Pterocarpus marsupium |
India |
antidiabetic |
[179] |
||||
|
Pterocarpus soyauxii |
|
antidiabetic |
[180] |
||||
Prunus |
Prunus persica |
India |
antidiabetic |
[181] |
||||
Rheum |
Rheum emodi |
India (Ayurveda), China |
antidiabetic |
[182] |
||||
|
Rhus hirta |
|
antidiabetic |
[183] |
||||
|
Rhus mysorensis |
|
antidiabetic |
[184] |
||||
Salacia |
Salacia chinensis |
India (Ayurveda, Unani), Japan, Korea |
hypoglycemic, antihyperglycaemic |
[185, 186] |
||||
|
Salacia oblonga |
India (Ayurveda, Unani), Japan, Korea |
hypoglycemic |
[186,187] |
||||
|
Salacia prinoides |
India (Ayurveda), Sri Lanka, Southeast Asia |
antidiabetic |
[186] |
||||
|
Salacia reticulata |
India (Ayurveda, Unani), Japan, Korea, Sri Lanka |
hypoglycemic, ?-glucosidase inhibitor |
[185,187,188,189] |
||||
Sida |
Sida acuta |
India |
antidiabetic |
[190] |
||||
|
Sida cordifolia |
Bangladesh, India (Ayurveda) |
antidiabetic |
[191,192] |
||||
|
Sidarhombifolia |
|
antidiabetic |
[193] |
||||
Solanum |
Solanum indicum |
Uganda, India |
antidiabetic |
[62,194] |
||||
|
Solanum trilobatum |
India (Ayurveda, Siddha) |
antidiabetic |
[195] |
||||
|
Solanum tuberosum |
|
antidiabetic |
[196] |
||||
|
Solanum viarum |
India |
antidiabetic |
[49] |
||||
Stereospernum |
Stereospermumsuaveolens |
India |
Antidiabetic |
[197] |
||||
Swertia |
Swertia chirayita |
India (Ayurveda) |
Hypoglycemic |
[63,198] |
||||
|
Swertia cordata |
|
Antidiabetic |
[199] |
||||
|
Swertia longifolia |
|
?-amylase inhibitor |
[200] |
||||
Syzygium |
Syzygiumdensiflorum |
India |
Antidiabetic |
[201] |
||||
|
Syzygiumcumini |
Bangladesh, India (Ayurveda), Brazil |
?-glucosidase and ?-amylase inhibitor, antihyperglycemic |
[30,49,120,202,203] |
||||
|
Syzygiumdensiflorum |
India |
antidiabetic |
[201] |
||||
|
Syzygiumjambolanum |
India (Ayurveda) |
hypoglycemic |
[204,205] |
||||
|
Tabernaemontanadivaricata |
India |
antidiabetic |
[62] |
||||
|
Tabernaemontanaheyneana |
|
antidiabetic |
[206] |
||||
Taxus |
Taxus baccata |
India |
antidiabetic |
[27] |
||||
|
Terminalia arjuna |
Bangladesh, India (Ayurveda) |
?-amylase inhibitor, antihyperglycemic |
[87,207] |
||||
|
Terminalia bellirica |
Bangladesh, Vietnam, India (Ayurveda, Siddha, Unani), Sri Lanka, Southeast Asia |
antidiabetic |
[106,208,209] |
||||
|
Terminalia catappa |
|
antidiabetic |
[210] |
||||
|
Terminalia chebula |
Thailand, India (Ayurveda), Bangladesh, Iran |
?-amylase inhibitor |
[28,166,211,212] |
||||
Trichosanthes |
Trichosanthescucumerina |
India (Ayurveda) |
hypoglycemic |
[62] |
||||
|
Trichosanthes dioica |
India (Ayurveda) |
antidiabetic |
[213] |
||||
|
Vaccinium vitis |
|
antidiabetic |
[214] |
||||
Withania |
Withania coagulans |
India (Ayurveda), Pakistan |
antihyperglycemic |
[215,216] |
||||
z |
Withania somnifera |
India (Ayurveda) |
hypoglycemic |
[100,217] |
||||
Zanthoxylum |
Zanthoxylum alatum |
|
antidiabetic |
[218] |
||||
|
Zanthoxylum armatum |
India (Ayurveda) |
antidiabetic |
[60] |
||||
|
Zanthoxylum humile |
India (Ayurveda) |
antidiabetic |
[219] |
||||
Zingiber |
Zingiber officinale |
India (Ayurveda), Latin America Africa |
?-amylase inhibitor, hypoglycemic |
[28,63,220,221] |
||||
|
Ziziphus nummularia |
India |
antidiabetic |
[102] |
||||
|
Ziziphus xylopyrus |
India (Ayurveda), Pakistan, China |
antidiabetic |
[222] |
||||
Plant Name |
Country/Region |
Activity |
Reference |
Abrus precatorius |
India (Ayurveda, Unani, Siddha) |
antidiabetic |
[223] |
Acorus calamus |
India, Indonesia, America |
?-glucosidase inhibitor |
[105,224] |
Adansonia digitata |
India (Ayurveda) |
?-amylase inhibitor |
[28] |
Adiantum capillus-veneris |
India |
antidiabetic |
[27] |
Ailanthus excelsa |
India |
antidiabetic |
[225] |
Alangiumsalvifolium |
India (Ayurveda) |
hypoglycemic |
[226,227] |
Alstoniascholaris |
India, Thailand |
?-glucosidase inhibitor |
[227] |
Andrographis paniculata |
India (Ayurveda), Bangladesh, Nepal, Malaysia, Southeast Asia |
antihyperglycemic |
[81,107,116,228,229] |
Anthocephalus cadamba |
India (Ayurveda), Australia, China, Indonesia, Malaysia, Papua New Guinea, Philippines, Singapore, Vietnam |
antidiabetic |
[230] |
Aphanamixispolystachya |
India (Ayurveda) |
antidiabetic |
[231] |
Argyreia nervosa |
India (Ayurveda) |
Antidiabetic |
[232] |
Asanadigana |
India (Ayurveda) |
Antidiabetic |
[233] |
Barringtonia acutangula |
India (Ayurveda) |
antidiabetic |
[234] |
Basella rubra |
India |
?-amylase inhibitor |
[235] |
Begonia roxburghii |
India |
antidiabetic |
[49] |
Blepharismolluginifolia |
India |
antidiabetic |
[236] |
Boerhaviadiffusa |
India (Ayurveda) |
antidiabetic |
[80] |
Boswellia ovalifoliolata |
India |
antidiabetic |
[237] |
Cajanus cajan |
India (Ayurveda) |
antidiabetic |
[43] |
Callicarpa arborea |
India |
antidiabetic |
[49] |
Canna indica |
|
antidiabetic |
[238] |
Casia fistula |
India (Ayurveda) |
?-amylase inhibitor |
[28] |
Cayratiatrifolia |
India |
antidiabetic |
[239] |
Ceiba pentandra |
India, Nigeria |
?-amylase inhibition, hypoglycemic, antihyperglycemic |
[240-242] |
Centella asiatica |
India (Ayurveda), Bangladesh, Malaysia, Laos, Southeast Asia |
antidiabetic |
[106,117,243-245] |
Centratherumanthelminticum |
India (Ayurveda) |
hypoglycemic |
[191,246] |
Chlorophytum borivilianum |
India (Ayurveda) |
antidiabetic |
[247] |
Clitoriaternatea |
India (Ayurveda) |
?-glucosidase, ?-amylase inhibitor hypoglycemic |
[164,248,249] |
Cocculus hirsutus |
India |
?-amylase inhibitor |
[235] |
Coldenia procumbens |
India |
antidiabetic |
[250] |
Commiphorawightii |
India (Ayurveda) |
antidiabetic |
[80] |
Cosciniumfenestratum |
India, Sri Lanka |
antidiabetic |
[251,252] |
Cuminum cyminum |
India |
antidiabetic |
[253] |
Cyamopsis tetragonoloba |
India (Ayurveda) |
antidiabetic |
[254] |
Dendrocalamushamiltonii |
India (Ayurveda) |
hypoglycemic |
[63] |
Desmostachyabipinnata |
India (Ayurveda) |
antidiabetic |
[255] |
Dillenia indica |
India |
antidiabetic |
[49] |
Diplazium esculentum |
India |
antidiabetic |
[49] |
Elaeocarpus ganitrus |
India (Ayurveda), Nepal |
antidiabetic |
[256] |
Emblica officinalis |
India (Ayurveda), Bangladesh |
antidiabetic |
[132,257,258] |
Enhydra fluctuans |
India |
antidiabetic |
[259] |
Feronia limonia |
India |
antidiabetic |
[260] |
Gloriosa superba |
India (Ayurveda) |
antidiabetic |
[261] |
Glycosmis pentaphylla |
Siddha, India (Ayurveda) |
antidiabetic |
[262] |
Gmelina arborea |
India, Sri Lanka |
antidiabetic |
[263,264] |
Gymnemasylvestre |
Ayurveda, Pakistan, Southeast Asia |
hypoglycemic and antihyperglycemic |
[117,265,266] |
Hemidesmus indicus |
India (Ayurveda) |
antidiabetic |
[267] |
Heritiera fomes |
India |
antidiabetic |
[268] |
Ichnocarpus frutescens |
India (Ayurveda) |
antidiabetic |
[269] |
Imperata cylindrica |
India (Ayurveda) |
antidiabetic |
[270] |
Lagenaria sicereria |
Mauritius, India (Ayurveda) |
antihyperglycemic |
[38,271,272] |
Lactuca gracilis |
India |
antidiabetic |
[49] |
Linum usitatisumum |
India (Ayurveda) |
?-amylase inhibitor |
[28] |
Meynalaxiflora |
India |
antidiabetic |
[273] |
Millingtonia hortensis |
India |
antidiabetic |
[49] |
Mukiamaderaspatana |
India (Ayurveda, Siddha) |
antidiabetic |
[274] |
Nelumbo nucifera |
India (Ayurveda), China (TCM), Southeast Asia |
?-glucosidase, ?-amylase inhibitor, hypoglycemic |
[117,275-277] |
Nicotiana plumbaginifolia |
India |
antidiabetic |
[27] |
Nigella sativa |
Algeria, India (Ayurveda, Siddha, Unani), Pakistan, Morocco, Middle East, Mediterranean, North Africa |
antidiabetic |
[278-281] |
Nycantus arbor-tristis |
India (Ayurveda), Sri Lanka |
hypoglycemic |
[282] |
Odina wodier |
India |
antidiabetic |
[283] |
Oreocnide integrifolia |
India |
antidiabetic |
[284] |
Oroxylum indicum |
Bangladesh, India (Ayurveda) |
antidiabetic |
[106,285] |
Pavonia zeylanica |
India (Ayurveda) |
antidiabetic |
[227] |
Pergulariadaemia |
India (Ayurveda) |
antidiabetic |
[286] |
Peucedanumpraeruptorum |
India (Ayurveda), China |
antidiabetic |
[287] |
Phoenix dactylifera |
Jordan, India (Ayurveda), Pakistan, Egypt |
antidiabetic |
[288-290] |
Pisonia grandis |
India |
antidiabetic |
[291] |
Plumbago zeylanica |
India |
antidiabetic |
[27] |
Polyalthia longifolia |
India |
antidiabetic |
[292] |
Pongamia pinnata |
India (Ayurveda) |
antihyperglycemic |
[293,294] |
Portulaca oleracea |
Trinidad and Tobago, India (Ayurveda), Algeria, Iran, China (TCM), Mexico |
hypoglycemic |
[295-298] |
Premna integrifolia |
India (Ayurveda) |
hypoglycemic |
[74] |
Psoralea corylifolia |
India (Ayurveda) |
antidiabetic |
[299] |
Punica granatum |
India (Ayurveda, unani) |
antidiabetic |
[300-303] |
Roylea cinerea |
India |
antidiabetic |
[304] |
Rubia cordifolia |
India |
antidiabetic |
[305] |
Saccharum spontaneum |
India |
antidiabetic |
[49] |
Sesbeniaaegyptiaca |
India (Ayurveda) |
hypoglycemic |
[63] |
Sphaeranthus indicus |
India |
antidiabetic |
[306] |
Stevia rebaudiana |
India, Paraguay, Brazil, south America |
antidiabetic |
[307,308] |
Tamarindus indica |
India (Ayurveda), Trinidad and Tobago, Africa |
? amylase inhibitor |
[37,309, 310] |
Tephrosia purpurea |
India (Ayurveda) |
antihyperglycemic |
[311, 312] |
Thespesia populnea |
India (Ayurveda) |
antihyperglycemic and hypoglycemic |
[313] |
Tragiainvolucrata |
India (Ayurveda) |
antidiabetic |
[314] |
Viola odorata |
India |
antidiabetic |
[27] |
Wedeliatrilobata |
South America, China, Japan, India |
antidiabetic |
[315] |
Centhratherum |
India |
Antidiabetic |
[316] |
Casalpinia bonduc |
India |
Antidiabetic |
[316] |
Marketed herbal Antidiabetic products:
Sr. NO. |
Product |
Manufacturer |
Mechanism |
Ref. |
1 |
Sharang Dyab-Tea |
Plant Med. Lab Pvt. Ltd |
Stimulate insulin production |
[317] |
2 |
Herbal hill jambu |
Isha Agro Devlopers |
Reduce blood and urine sugar level |
[318] |
3 |
Stevia-33 |
Vitalize herbs |
Maintain proper blood sugar level |
[319] |
4 |
Diab-FIT |
Herbal FIT |
Maintain proper blood sugar level |
[320] |
5 |
Madhumar capsule |
Kangrd Hills Care and Cure Products |
Control chronic diabetes mellitus |
[321] |
6 |
Daya Stone Powder |
Jignesh and co. |
Lowers the blood sugar level |
[322] |
7 |
Diabetone Tablet |
Shelter Pharma Ltd. |
Reduce blood sugar level by neutralize the level of pituitary secretion |
[323] |
8 |
Kumari-SAAR |
Krishna herbal company |
Maintain diabetic complication |
[324] |
9 |
Spenai |
Shriji Herbal Products |
Antidiabetic |
[325] |
10 |
Blue berry |
A1-Hikma FZCO |
Antidiabetic |
[326] |
11 |
Episulin |
Varuna biocell Pvt.Ltd |
Antidiabetic |
[327] |
CONCLUSION:
The global rise in diabetes prevalence has highlighted the need for innovative and holistic approaches to its management. While conventional antidiabetic medications are effective, their side effects often lead patients to seek alternative therapies. This review underscores the therapeutic potential of medicinal plants in diabetes management, with over 400 species demonstrating hypoglycemic properties. Many of these plants offer mechanisms that address key aspects of diabetes, such as enhancing insulin activity, inhibiting glucose absorption, and protecting pancreatic function. Importantly, traditional medicine systems like Ayurveda and Unani have long recognized the benefits of these plants, especially in rural populations that rely heavily on herbal remedies. As research into these botanical treatments continues, there is significant promise in integrating them with conventional medical approaches to provide a more comprehensive, side-effect-free management of diabetes. However, more clinical studies are needed to validate their efficacy and safety. The future of diabetes treatment may well lie in the synergy between modern pharmacology and traditional plant-based medicine
REFERENCES
Sammed Sangale*, Abhishek Desai, Dr. Nilesh Chougule, Harnessing Nature’s Power: Antidiabetic Medicinal Plants, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 11, 1008-1042. https://doi.org/10.5281/zenodo.14209619