View Article

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia due to inadequate insulin production or ineffective insulin use. Despite the availability of pharmacological treatments, managing diabetes without adverse effects remains challenging. Current therapies, including insulin and oral antidiabetic agents, are often associated with significant side effects, necessitating the exploration of alternative approaches. In recent years, medicinal plants have garnered increasing attention as potential therapeutic agents for diabetes management. Traditional systems of medicine, such as Ayurveda, continue to play a crucial role in healthcare, particularly in developing countries, where plant-based treatments are culturally accepted and widely used. This review explores various plant species with documented antidiabetic properties, focusing on their ability to regulate glucose levels, enhance insulin secretion, or inhibit carbohydrate metabolism. Compounds such as glycosides, alkaloids, flavonoids, and terpenoids have demonstrated potential in reducing hyperglycemia and associated complications. By investigating plant-based remedies, we aim to provide an alternative, complementary approach to diabetes management, emphasizing the importance of ethnobotanical research in discovering new, safer treatments for this global health challenge.

Keywords

Diabetes mellitus, Hyperglycemia, Polyherbs, Herbs, Ayurveda.

Introduction

Diabetes mellitus is a group of metabolic disorders with one common manifestation -hyperglycemia (1, 2). Diabetes mellitus, being a multifactorial disease, demands multiple therapeutic approaches. Global studies on diabetes mellitus have reiterated that primary prevention is necessary and drastic steps must be taken to diagnose the disease early on, provide effective management and also take steps to prevent the onset of disease in high-risk subjects. According to WHO, plant-based traditional system of medicine is still the mainstay of about 75– 80% of the world population, mainly in the developing countries, for primary healthcare because of better cultural acceptability, better compatibility with the human body and lesser side effects (3) . According to the fifth edition of the World Diabetes Atlas released by the International Diabetes Federation (IDF), as of 2011, the total adult population in the age group of 20-79 years stands at 4.3 billion, out of which 366 million live with diabetes, which is set to increase to 552 million by 2030 (4). Ayurveda is an ancient system of medicine originating in India, and is an extension of yoga. Its two most famous treatises, Charak Samhita and Sushruta provide evidence of a rich tradition of herbal medicine in India. Historical and anthropological studies have repeatedly demonstrated the importance of yoga’s ‘upanishadic’ roots and philosophical basis. In India, there is a high degree of reliance on and cultural acceptability of Ayurveda medicine in favour of traditional systems of medicine. The rural population in India is heavily dependent on traditional medical systems (5). In an earlier study, we found that 67.7% of patients with diabetes attending our outpatient department used CAM, in particular naturopathy (6).Currently available therapies for diabetes include insulin and various oral antidiabetic agents such as sulfonylureas, biguanides, a-glucosidase inhibitors, and glinides, which are used as monotherapy or in combination to achieve better glycemic regulation. Many of these oral antidiabetic agents have a number of serious adverse effects; thus, managing diabetes without any side effects is still a challenge (7). An estimated 143 million people suffer from diabetes worldwide and the number is growing rapidly (8). Recently, some medicinal plants have been reported to be useful in diabetes worldwide and have been used empirically in antidiabetic and antihyperlipidemic remedies. Antihyperglycemic activity of the plants is mainly due to their ability to restore the function of pancreatic tissues by causing an increase in insulin output or inhibit the intestinal absorption of glucose or to the facilitation of metabolites in insulin dependent processes. More than 400 plant species having hypoglycemic activity have been available in literature, however, searching for new antidiabetic drugs from natural plants is still attractive because they contain substances which demonstrate alternative and safe effects on diabetes mellitus. Most of plants contain glycosides, alkaloids, terpenoids, flavonoids, carotenoids, etc., that are frequently implicated as having antidiabetic effect (9). The severity of damage triggered by hyperglycemia on the respective organ systems may be related to how long the disease has been present and how well it has been controlled. Several symptoms such as thirst, polyuria, blurring of vision, and weight loss also accompany diabetes (10).

Classification of Diabetes Mellitus

Type 1: Associated with absolute insulin deficiency

A. Immune-mediated

B. Idiopathic

Type 2: Adult-onset, Associated with insulin resistance

Type 3:

A. Genetic defects of -cell function

B. Genetic defects in insulin action

C. Diseases of exocrine pancreas

D. Endocrinopathies

E. Drug-or chemical-induced

F. Infections

G. Uncommon forms of immune-mediated diabetes

H. Other genetic syndromes sometimes associated with diabetes

Type 4: Gestational diabetes mellitus (11)

Management of diabetics :

Effectively managed through lifestyle modifications such as

  1. Weight loss,
  2. Balanced diet,
  3. Regular exercise.

When these interventions are insufficient to control blood sugar levels, medications or insulin therapy may be recommended (12).

Medicinal Plants as an Alternative Source of Antidiabetic Agents

Natural products, particularly of plant origin, are the main quarry for discovering promising lead candidates and play an imperative role in the upcoming drug development programs [13-15]. Ease of availability, low cost, and least side e_ects make plant-based preparations the main key player of all available therapies, especially in rural areas. For centuries, many plants have been considered a fundamental source of potent antidiabetic drugs. In developing countries, particularly, medicinal plants are used to treat diabetes to overcome the burden of the cost of conventional medicines to the population [16]. Nowadays, treatments of diseases including diabetes using medicinal plants are recommended [17] because these plants contain various phytoconstituents such as flavonoids, terpenoids, saponins, carotenoids, alkaloids, and glycosides, which may possess antidiabetic activities [18]. The antihyperglycemic e_ects resulting from treatment with plants are usually attributed to their ability to improve the performance of pancreatic tissue, which is done by increasing insulin secretions or by reducing the intestinal absorption of glucose [16]. Herbal medicines and plant components with insignificant toxicity and no side effects are notable therapeutic options for the treatment of diabetes around the world [19].

Herb–Drug interactions in diabetes:

The co-administration of antidiabetic herbs and pharmaceutical agents may result in HDIs leading to enhanced effects (which may be desirable clinically), decreased pharmacological effects, or adverse drug events, such as hypoglycaemia [20].

Conventional antidiabetic drugs

Low levels (or absence) of insulin leads to type 1 diabetes, and administration of insulin is indicated for treatment of this condition. Type 2 diabetes, the most common type of diabetes, is caused by insulin resistance; conventional pharmaceutical medications against type 2 diabetes include: i) sensitizers that increase the sensitivity of target organs to insulin, ii) secretagogues that increase the level of insulin secreted from the pancreas, and iii) ?-glycosidase inhibitors (e.g., acarbose) that reduce the gastrointestinal absorption of glucose.  The sensitizers include biguanides (e.g., metformin) and thiazolidinediones (e.g., pioglitazone), while the secretagogues include sulfonylureas (e.g., glibenclamide, glimepiride, gliclazide, tolbutamide) and meglitinides (e.g., repaglinide). [21].


 

Genus

Species

Geographic Zone

Activity

Reference

Acacia

Acacia catechu

Nepal, India

antihyperglycemic

[22]

 

Acacia modesta

India and Pakistan

antihyperglycemic

[23]

 

Acacia arabica

India

hypoglycemic and antihyperglycemic

[24]

Acalypha

Acalypha indica

India

antidiabetic

[25]

 

Acalypha langiana

 

antidiabetic

[26]

Achillea

Achillea millefolium

India

antidiabetic

[27]

 

Allium sativum

India (Ayurveda), Indonesia, Iran, Cuba, Mauritius, Togo, China (TCM)

?-amylase inhibitor, hypoglycemic,

?-glucosidase inhibitor, antihyperglycemic

[28,29]

Aloe

Aloe ferox

India (Ayurveda)

antidiabetic

[30]

 

Aloe vera

India (Ayurveda), Ghana, Mauritius, Uganda, Tanzania, Traditional Chinese medicines, Trinidad and Tobago, Iran, Pakistan, Philippines, Saudi Arabia

?-amylase inhibitor, hypoglycemic

[31-33]

Alpinia

Alpinia calcarata

India, Sri Lanka

antidiabetic

[34,35]

 

Alpinia galanga

India

antidiabetic

[36]

 

Artemisia parviflora

India

antidiabetic

[37]

 

Artocarpus heterophyllus

India (Ayurveda), Mauritius

hypoglycemic, ?-amylase inhibitor

[38-40]

Berberis

Berberis aristata

India (Ayurveda)

antidiabetic

[41]

 

Berberis asiatica

India

antidiabetic

[42]

Brassica

Brassica juncea

India (Ayurveda)

antidiabetic

[43]

 

Brassica oleracea

 

antihyperglycemic

[44]

 

Brassica rapa

India

antidiabetic

[45]

Buddleja

Buddleja asiatica

India

antidiabetic

[46]

Butea

Butea monosperma

India

antidiabetic

[27]

 

Butea frondosa

India

antidiabetic

[47]

Caesalpinia

Caesalpinia bonducella

India

?-amylase inhibitor

[48]

Calamus

Calamus tenuis

India

antidiabetic

[49]

 

Calamus erectus

India

Antidiabetic

[50]

 

Calotropis procera

 

Antidiabetic

[51]

Capparis

Capparis aphylla

 

antihyperglycemic

[52]

 

Capparis decidua

India, Pakistan

Antidiabetic

[53]

 

Capparis sepiaria

India

Antidiabetic

[54]

 

Capparis spinosa

India (Ayurveda and Unani)

Antidiabetic

[55]

Caralluma

Carallumaadscendens

India

Antidiabetic

[56]

 

Carallumaumbellata

India

antihyperglycemic

[57]

Carissa

Carissa carandas

India (Ayurveda, Unani, and Homoeopathy)

Antidiabetic

[58]

Cassia

Cassia auriculata

India, Tanzania

Antidiabetic

[59]

 

Cassia fistula

India

Antidiabetic

[60]

 

Cinnamomum cassia

India (Unani, Ayurveda) Japan, China, South Africa

antidiabetic

[61]

 

Cinnamomum impressinervium

India

antidiabetic

[62]

 

Cinnamomum tamala

India (Ayurveda)

hypoglycemic

[63]

 

Cinnamomum verum

India (Ayurveda)

?-amylase inhibitor

[28]

 

Cinnamomum zeylanicum

 

?-glucosidase

[64]

 

Citrus sinensis

India

antidiabetic

[65]

Clerodendrum

Clerodendrum glandulosum

India

antidiabetic

[66]

 

Clerodendrum colebrookianum

India

antidiabetic

[46]

 

Clerodendrum infortunatum

India

antidiabetic

[67]

 

Clerodendrum phlomidis

India (Ayurveda)

antidiabetic

[68]

Coccinia

Coccinia cordifolia

India

antidiabetic

[69]

 

Coccinia grandis

India (Ayurveda), Sri Lanka

antihyperglycemic, ?-glucosidase inhibitor, ?-amylase inhibitor

[28,70-72]

 

Coccinia indica

India (Ayurveda)

antidiabetic

[43,63]

Costus

Costusigneus

India

antidiabetic

[73]

 

Costus pictus

India

antidiabetic

[74]

 

Croton klozchianus

India (Ayurveda)

antidiabetic

[75]

 

Croton zambesicus

 

antidiabetic

[76]

Cucumis

Cucumis callosus

India

antidiabetic

[77]

 

Curculigoorchioides

India (Ayurveda)

antidiabetic

[78]

Curcuma

Curcuma angustifolia

India

antidiabetic

[79]

 

Curcuma domestica

India

antidiabetic

[27]

 

Curcuma longa

China, Bangladesh, India (Ayurveda), Indonesia, Laos

antidiabetic

[33,80]

Cuscuta

Cuscutareflexa

India, Bangladesh

antidiabetic

[49,81]

 

Cuscuta chinensis

China

antidiabetic

[82]

 

Cuscuta americana

Trinidad and Tobago

antidiabetic

[83]

Cyperus

Cyperus kyllinga

India (Ayurveda)

antidiabetic

[84]

 

Cyperus laevigatus

India (Ayurveda)

antidiabetic

[85]

 

Cyperus rotundus

India (Ayurveda)

antidiabetic

[86]

 

Delonixelata

 

antidiabetic

[87]

Desmodium

Desmodiumgangeticum

India (Ayurveda), Sri Lanka

antidiabetic

[70,88]

 

Dioscorea opposita

China, India (Ayurveda), China (TCM)

antidiabetic

[33,80,89]

 

Diospyros melanoxylon

India, Sri Lanka

antidiabetic

[90]

 

Diospyros peregrina

India

antidiabetic

[91]

Elephantopus

Elephantopusscaber

India

antidiabetic

[92]

 

Elephantopusmollis

 

antidiabetic

[93]

Embelia

Embelia madagascariensis

 

hypoglycemic

[94]

 

Embeliaribes

India (Ayurveda)

antidiabetic

[95]

Enicostema

Enicostemaaxillare

India (Ayurveda)

antidiabetic

[96]

 

Enicostemalittorae

 

antidiabetic

[97]

Erythrina

Erythrina indica

India

antidiabetic

[98]

 

Erythrina variegeta

India

antidiabetic

[87]

Eugenia

Eugenia jambolana

India (Ayurveda)

?-amylase inhibitor

[83,99]

 

Eugenia polyantha

India, Indonesia

antidiabetic

[100,101]

Euphorbia

Euphorbia caducifolia

India

antidiabetic

[102]

 

Euphorbia dioeca

 

?-glucosidase inhibitor

[103]

 

Euphorbia drumondii

India (Ayurveda)

hyperglycemic

[104]

 

Euphorbia hirta

India, Bangladesh, Nepal

?-glucosidase

[105-107]

 

Euphorbia ligularia

India

antidiabetic

[62]

 

Euphorbia neriifolia

India (Ayurveda)

antidiabetic

[108]

 

Euphorbia prostrata

 

antihyperglycemic

[109]

Ferula

Ferulaassa-foetida

India (Ayurveda), Iran, Afghanistan

antidiabetic

[110,111]

Ficus

Ficus amplissima

India (Ayurveda, Siddha, Unani)

antidiabetic

[112]

 

Ficus benghalensis

India (Ayurveda, Siddha, Unani, homoeopathy), Southeast Asia

antidiabetic

[101, 113]

 

Ficus carica

India (Ayurveda, Siddha, Unani, homoeopathy)

antidiabetic

[114, 115]

 

Ficus cunia

India

?-glucosidase inhibitor

[116]

 

Ficus glomerata

India (Ayurveda, Siddha, Unani, homoeopathy)

antidiabetic

[63,117]

 

Ficus palmata

 

antidiabetic

[118]

 

Ficus racemosa

India (Ayurveda, Siddha, Unani, homoeopathy), Bangladesh, Southeast Asia

antihyperglycemic, hypoglycemic, ?-glucosidase and ?-amylase inhibitor

[119,120]

 

Ficus religiosa

India (Ayurveda)

antidiabetic

[113]

 

Ficus virens

India (Ayurveda)

antidiabetic

[121]

Glycyrrhiza

Glycyrrhiza glabra

China, India

antidiabetic

[33,122]

 

Glycyrrhiza uralensis

India

antidiabetic

[123]

Grewia

Grewia asiatica

India (Ayurveda)

antidiabetic

[124]

 

Grewia hirsuta

India

antidiabetic

[125]

 

Grewia nervosa

 

antidiabetic

[126]

Helicteres

Helicteresisora

India (Ayurveda)

antidiabetic

[127]

Holarrhena

Holarrhenaantidysenterica

India (Ayurveda)

antidiabetic

[128]

Hydnocarpus

Hydnocarpusalpina

 

hypoglycemic

[129]

 

Hydnocarpuswightiana

India (Ayurveda)

antidiabetic

[130]

Leucas

Leucas aspera

India, Bangladesh

antidiabetic

[36,131]

 

Leucas cephalotes

India (Ayurveda), Nepal, Pakistan

antidiabetic

[132]

 

Luffa echinata

India

Antidiabetic

[64]

Mangifera

Mangifera indica

India (Ayurveda), Nigeria

?-amylase inhibitor, antihyperglycemic

[28,133]

 

Melia dubia

India

antidiabetic

[134]

 

Melia orientalis

India (Ayurveda)

antidiabetic

[135]

Mentha

Mentha arvensis

India

antidiabetic

[136]

 

Mentha longifolia

India

antidiabetic

[27]

Mimusops

Mimusopselengi

India (Ayurveda)

antidiabetic

[137]

 

Momordica charantia

Philippines, Vietnam, Mauritius,

Trinidad and Tobago, India (Ayurveda), Nigeria, Bangladesh, Taiwan, central

America

?-amylase inhibitor, hypoglycemic, antihyperglycemic

[138-141]

Moringa

Moringa oleifera

South Africa, Kenya, Mexico, India

(Ayurveda), Nigeria, Mauritius, Senegal

hypoglycemic

[63,142-45]

Morus

Morus alba

Iran, Philippines, Trinidad and Tobago,

India (Ayurveda), China (TCM),

Pakistan, Korea, Chile

antidiabetic, hypoglycemic, ?-glucosidase and ?-amylase inhibition

[146-154]

Mucuna

Mucuna gigantea

India

antidiabetic

[155]

 

Mucuna pruriens

India (Ayurveda)

Antidiabetic

[43]

Murraya

Murrayakoenigii

India (Ayurveda)

? amylase inhibitor, hypoglycemic effects, antihyperglycemic

[156]

 

Musa Sapientum

India

antihyperglycemic

[109,157]

Nymphaea

Nymphaea nouchali

Bangladesh, India (Ayurveda)

Antidiabetic

[106]

 

Nymphaea stellata

India (Ayurveda)

?-glucosidase inhibitor, hypoglycemic, antihyperglycemic

[158, 159]

Ocimum

Ocimum sanctum

India (Ayurveda), China, Bangladesh

hypoglycemic

[160,161]

 

Ocimumtenuiflorum

India (Ayurveda)

?-amylase inhibitor, hypoglycemic, antihyperglycemic

[28,162]

Oxalis

Oxalis corniculata

India

Antidiabetic

[27]

 

Oxalis griffithii

India

Antidiabetic

[49]

Paederia

Paederiafoetida

China, Vietnam, India Japan

Antidiabetic

[162]

 

Paederia scandens

China, Vietnam, India, Japan

Antidiabetic

[162]

pandanus

Pandanus fascicularis

India (Ayurveda)

antihyperglycemic

[163]

 

Pandanus tectorius

 

Antidiabetic

[164]

Phyllanthus

Phyllanthus amarus

Vietnam, India (Ayurveda, Siddha,

Unani and homeopathy), Nigeria,

Malaysia

?-glucosidase inhibitor, hypoglycemic, ?-amylase inhibitor

[114,165]

 

Phyllanthus emblica

Thailand, Southeast Asia, India (Ayurveda)

Antidiabetic

[117,166,167]

 

Phyllanthus gardnerianus

India

Antidiabetic

[168]

 

phyllanthusvirgatus

 

?-amylase inhibitor

[169]

 

Phyllanthus watsonii

 

Antidiabetic

[170]

Physalis

Physalis angulata

India

Antidiabetic

[171]

 

Physalis minima

India

Antidiabetic

[36]

 

Physalis peruviana

India

Antidiabetic

[172]

Piper

Piper longum

Bangladesh, India (Ayurveda)

antihyperglycemic

[173-175]

 

Piper nigrum

 

?-amylase inhibitor, hypoglycemic

[28,176]

Plantago

Plantago ovata

India

Antidiabetic

[99]

Plumeria

Plumeria rubra

India

?-amylase and ?-glucosidase inhibitor

[177]

Polygonum

Polygonum hydropiper

India

antidiabetic

[46]

Pterocarpus

Pterocarpus santalinus

India (Ayurveda)

antidiabetic

[178]

 

Pterocarpus marsupium

India

antidiabetic

[179]

 

Pterocarpus soyauxii

 

antidiabetic

[180]

Prunus

Prunus persica

India

antidiabetic

[181]

Rheum

Rheum emodi

India (Ayurveda), China

antidiabetic

[182]

 

Rhus hirta

 

antidiabetic

[183]

 

Rhus mysorensis

 

antidiabetic

[184]

Salacia

Salacia chinensis

India (Ayurveda, Unani), Japan, Korea

hypoglycemic, antihyperglycaemic

[185, 186]

 

Salacia oblonga

India (Ayurveda, Unani), Japan, Korea

hypoglycemic

[186,187]

 

Salacia prinoides

India (Ayurveda), Sri Lanka, Southeast Asia

antidiabetic

[186]

 

Salacia reticulata

India (Ayurveda, Unani), Japan, Korea, Sri Lanka

hypoglycemic, ?-glucosidase inhibitor

[185,187,188,189]

Sida

Sida acuta

India

antidiabetic

[190]

 

Sida cordifolia

Bangladesh, India (Ayurveda)

antidiabetic

[191,192]

 

Sidarhombifolia

 

antidiabetic

[193]

Solanum

Solanum indicum

Uganda, India

antidiabetic

[62,194]

 

Solanum trilobatum

India (Ayurveda, Siddha)

antidiabetic

[195]

 

Solanum tuberosum

 

antidiabetic

[196]

 

Solanum viarum

India

antidiabetic

[49]

Stereospernum

Stereospermumsuaveolens

India

Antidiabetic

[197]

Swertia

Swertia chirayita

India (Ayurveda)

Hypoglycemic

[63,198]

 

Swertia cordata

 

Antidiabetic

[199]

 

Swertia longifolia

 

?-amylase inhibitor

[200]

Syzygium

Syzygiumdensiflorum

India

Antidiabetic

[201]

 

Syzygiumcumini

Bangladesh, India (Ayurveda), Brazil

?-glucosidase and ?-amylase inhibitor, antihyperglycemic

[30,49,120,202,203]

 

Syzygiumdensiflorum

India

antidiabetic

[201]

 

Syzygiumjambolanum

India (Ayurveda)

hypoglycemic

[204,205]

 

Tabernaemontanadivaricata

India

antidiabetic

[62]

 

Tabernaemontanaheyneana

 

antidiabetic

[206]

Taxus

Taxus baccata

India

antidiabetic

[27]

 

Terminalia arjuna

Bangladesh, India (Ayurveda)

?-amylase inhibitor, antihyperglycemic

[87,207]

 

Terminalia bellirica

Bangladesh, Vietnam, India (Ayurveda, Siddha, Unani), Sri Lanka, Southeast Asia

antidiabetic

[106,208,209]

 

Terminalia catappa

 

antidiabetic

[210]

 

Terminalia chebula

Thailand, India (Ayurveda), Bangladesh, Iran

?-amylase inhibitor

[28,166,211,212]

Trichosanthes

Trichosanthescucumerina

India (Ayurveda)

hypoglycemic

[62]

 

Trichosanthes dioica

India (Ayurveda)

antidiabetic

[213]

 

Vaccinium vitis

 

antidiabetic

[214]

Withania

Withania coagulans

India (Ayurveda), Pakistan

antihyperglycemic

[215,216]

z

Withania somnifera

India (Ayurveda)

hypoglycemic

[100,217]

Zanthoxylum

Zanthoxylum alatum

 

antidiabetic

[218]

 

Zanthoxylum armatum

India (Ayurveda)

antidiabetic

[60]

 

Zanthoxylum humile

India (Ayurveda)

antidiabetic

[219]

Zingiber

Zingiber officinale

India (Ayurveda), Latin America Africa

?-amylase inhibitor, hypoglycemic

[28,63,220,221]

 

Ziziphus nummularia

India

antidiabetic

[102]

 

Ziziphus xylopyrus

India (Ayurveda), Pakistan, China

antidiabetic

[222]

                 

Plant Name

Country/Region

Activity

Reference

Abrus precatorius

India (Ayurveda, Unani, Siddha)

antidiabetic

[223]

Acorus calamus

India, Indonesia, America

?-glucosidase inhibitor

[105,224]

Adansonia digitata

India (Ayurveda)

?-amylase inhibitor

[28]

Adiantum capillus-veneris

India

antidiabetic

[27]

Ailanthus excelsa

India

antidiabetic

[225]

Alangiumsalvifolium

India (Ayurveda)

hypoglycemic

[226,227]

Alstoniascholaris

India, Thailand

?-glucosidase inhibitor

[227]

Andrographis paniculata

India (Ayurveda), Bangladesh, Nepal, Malaysia, Southeast Asia

antihyperglycemic

[81,107,116,228,229]

Anthocephalus cadamba

India (Ayurveda), Australia, China,

Indonesia, Malaysia, Papua New Guinea,

Philippines, Singapore, Vietnam

antidiabetic

[230]

Aphanamixispolystachya

India (Ayurveda)

antidiabetic

[231]

Argyreia nervosa

India (Ayurveda)

Antidiabetic

[232]

Asanadigana

India (Ayurveda)

Antidiabetic

[233]

Barringtonia acutangula

India (Ayurveda)

antidiabetic

[234]

Basella rubra

India

?-amylase inhibitor

[235]

Begonia roxburghii

India

antidiabetic

[49]

Blepharismolluginifolia

India

antidiabetic

[236]

Boerhaviadiffusa

India (Ayurveda)

antidiabetic

[80]

Boswellia ovalifoliolata

India

antidiabetic

[237]

Cajanus cajan

India (Ayurveda)

antidiabetic

[43]

Callicarpa arborea

India

antidiabetic

[49]

Canna indica

 

antidiabetic

[238]

Casia fistula

India (Ayurveda)

?-amylase inhibitor

[28]

Cayratiatrifolia

India

antidiabetic

[239]

 

 

Ceiba pentandra

India, Nigeria

?-amylase inhibition, hypoglycemic, antihyperglycemic

[240-242]

Centella asiatica

India (Ayurveda), Bangladesh, Malaysia, Laos, Southeast Asia

antidiabetic

[106,117,243-245]

Centratherumanthelminticum

India (Ayurveda)

hypoglycemic

[191,246]

Chlorophytum borivilianum

India (Ayurveda)

antidiabetic

[247]

Clitoriaternatea

India (Ayurveda)

?-glucosidase, ?-amylase inhibitor hypoglycemic

[164,248,249]

Cocculus hirsutus

India

?-amylase inhibitor

[235]

Coldenia procumbens

India

antidiabetic

[250]

Commiphorawightii

India (Ayurveda)

antidiabetic

[80]

Cosciniumfenestratum

India, Sri Lanka

antidiabetic

[251,252]

Cuminum cyminum

India

antidiabetic

[253]

Cyamopsis tetragonoloba

India (Ayurveda)

antidiabetic

[254]

Dendrocalamushamiltonii

India (Ayurveda)

hypoglycemic

[63]

Desmostachyabipinnata

India (Ayurveda)

antidiabetic

[255]

Dillenia indica

India

antidiabetic

[49]

Diplazium esculentum

India

antidiabetic

[49]

Elaeocarpus ganitrus

India (Ayurveda), Nepal

antidiabetic

[256]

Emblica officinalis

India (Ayurveda), Bangladesh

antidiabetic

[132,257,258]

Enhydra fluctuans

India

antidiabetic

[259]

Feronia limonia

India

antidiabetic

[260]

Gloriosa superba

India (Ayurveda)

antidiabetic

[261]

Glycosmis pentaphylla

Siddha, India (Ayurveda)

antidiabetic

[262]

Gmelina arborea

India, Sri Lanka

antidiabetic

[263,264]

Gymnemasylvestre

Ayurveda, Pakistan, Southeast Asia

hypoglycemic and antihyperglycemic

[117,265,266]

Hemidesmus indicus

India (Ayurveda)

antidiabetic

[267]

Heritiera fomes

India

antidiabetic

[268]

Ichnocarpus frutescens

India (Ayurveda)

antidiabetic

[269]

Imperata cylindrica

India (Ayurveda)

antidiabetic

[270]

Lagenaria sicereria

Mauritius, India (Ayurveda)

antihyperglycemic

[38,271,272]

Lactuca gracilis

India

antidiabetic

[49]

Linum usitatisumum

India (Ayurveda)

?-amylase inhibitor

[28]

Meynalaxiflora

India

antidiabetic

[273]

Millingtonia hortensis

India

antidiabetic

[49]

Mukiamaderaspatana

India (Ayurveda, Siddha)

antidiabetic

[274]

Nelumbo nucifera

India (Ayurveda), China (TCM), Southeast Asia

?-glucosidase, ?-amylase inhibitor, hypoglycemic

[117,275-277]

Nicotiana plumbaginifolia

India

antidiabetic

[27]

Nigella sativa

Algeria, India (Ayurveda, Siddha,

Unani), Pakistan, Morocco, Middle East,

Mediterranean, North Africa

antidiabetic

[278-281]

Nycantus arbor-tristis

India (Ayurveda), Sri Lanka

hypoglycemic

[282]

Odina wodier

India

antidiabetic

[283]

Oreocnide integrifolia

India

antidiabetic

[284]

Oroxylum indicum

Bangladesh, India (Ayurveda)

antidiabetic

[106,285]

Pavonia zeylanica

India (Ayurveda)

antidiabetic

[227]

Pergulariadaemia

India (Ayurveda)

antidiabetic

[286]

Peucedanumpraeruptorum

India (Ayurveda), China

antidiabetic

[287]

Phoenix dactylifera

Jordan, India (Ayurveda), Pakistan, Egypt

antidiabetic

[288-290]

Pisonia grandis

India

antidiabetic

[291]

Plumbago zeylanica

India

antidiabetic

[27]

Polyalthia longifolia

India

antidiabetic

[292]

Pongamia pinnata

India (Ayurveda)

antihyperglycemic

[293,294]

Portulaca oleracea

Trinidad and Tobago, India (Ayurveda), Algeria, Iran, China (TCM), Mexico

hypoglycemic

[295-298]

Premna integrifolia

India (Ayurveda)

hypoglycemic

[74]

Psoralea corylifolia

India (Ayurveda)

antidiabetic

[299]

Punica granatum

India (Ayurveda, unani)

antidiabetic

[300-303]

Roylea cinerea

India

antidiabetic

[304]

Rubia cordifolia

India

antidiabetic

[305]

Saccharum spontaneum

India

antidiabetic

[49]

Sesbeniaaegyptiaca

India (Ayurveda)

hypoglycemic

[63]

Sphaeranthus indicus

India

antidiabetic

[306]

Stevia rebaudiana

India, Paraguay, Brazil, south America

antidiabetic

[307,308]

Tamarindus indica

India (Ayurveda), Trinidad and Tobago, Africa

? amylase inhibitor

[37,309, 310]

Tephrosia purpurea

India (Ayurveda)

antihyperglycemic

[311, 312]

Thespesia populnea

India (Ayurveda)

antihyperglycemic and hypoglycemic

[313]

Tragiainvolucrata

India (Ayurveda)

antidiabetic

[314]

Viola odorata

India

antidiabetic

[27]

Wedeliatrilobata

South America, China, Japan, India

antidiabetic

[315]

Centhratherum

India

Antidiabetic

[316]

Casalpinia bonduc

India

Antidiabetic

[316]


Marketed herbal Antidiabetic products:


Sr. NO.

Product

Manufacturer

Mechanism

Ref.

1

Sharang Dyab-Tea

Plant Med. Lab Pvt. Ltd

Stimulate insulin production

[317]

2

Herbal hill jambu

Isha Agro Devlopers

Reduce blood and urine sugar level

[318]

3

Stevia-33

Vitalize herbs

Maintain proper blood sugar level

[319]

4

Diab-FIT

Herbal FIT

Maintain proper blood sugar level

[320]

5

Madhumar capsule

Kangrd Hills Care and Cure Products

Control chronic diabetes mellitus

[321]

6

Daya Stone Powder

Jignesh and co.

Lowers the blood sugar level

[322]

7

Diabetone Tablet

Shelter Pharma Ltd.

Reduce blood sugar level by neutralize the level of pituitary secretion

[323]

8

Kumari-SAAR

Krishna herbal company

Maintain diabetic complication

[324]

9

Spenai

Shriji Herbal Products

Antidiabetic

[325]

10

Blue berry

A1-Hikma FZCO

Antidiabetic

[326]

11

Episulin

Varuna biocell Pvt.Ltd

Antidiabetic

[327]


CONCLUSION:

The global rise in diabetes prevalence has highlighted the need for innovative and holistic approaches to its management. While conventional antidiabetic medications are effective, their side effects often lead patients to seek alternative therapies. This review underscores the therapeutic potential of medicinal plants in diabetes management, with over 400 species demonstrating hypoglycemic properties. Many of these plants offer mechanisms that address key aspects of diabetes, such as enhancing insulin activity, inhibiting glucose absorption, and protecting pancreatic function. Importantly, traditional medicine systems like Ayurveda and Unani have long recognized the benefits of these plants, especially in rural populations that rely heavily on herbal remedies. As research into these botanical treatments continues, there is significant promise in integrating them with conventional medical approaches to provide a more comprehensive, side-effect-free management of diabetes. However, more clinical studies are needed to validate their efficacy and safety. The future of diabetes treatment may well lie in the synergy between modern pharmacology and traditional plant-based medicine

REFERENCES

  1. WHO Expert committee on diabetes mellitus: second report, World Health Organ. Tech. Rep. Ser., 646, pp.1-80 (1980). 
  2. Diabetes Mellitus: Report of a WHO Study Group, World Health Organ. Tech. Rep. Ser. 727, pp. 1-113 (1985).
  3. Central Council for Research in Ayurveda and Siddha, Department of AYUSH, Ministry of Health and Family Welfare, New Delhi: HPTLC-Fingerprint atlas of Ayurvedic Single Plant Drugs mentioned in Ayurvedic Pharmacopoeia Vol-III and IV. Submitted to World Health Organization (WHO), India 2008;1-106.
  4. International Diabetes Federation: IDF diabetes Atlas, FifInternational Diabetes Federation: IDF diabetes Atlas, Fifth Edition 2011.
  5. Madur G. Mandatory rural practice proposed in India. BMJ 1995;311:1186. 
  6. Mehrotra R, Bajaj S, Kumar D. Use of complementary and alternative medicine by patients with diabetes mellitus. Natl Med J India 2004;17:243–5.
  7. Saxena, A.; Kishore V. N.; J. Alternat. Complement. Med. 2004, 10(2), 369. [4] Lee, H-S. J. Agric. Food Chem. 2002, 50, 7013.
  8. Matsuda, H.; Morikawa, T.; Yoshikawa, M. Pure Appl. Ch.
  9. Agrawal DP, Diabetes and traditional medicine: new research. [Online]. (2003). Available: www.infinityfoundation.com/ t es/t es agraw diabetes.html [November 3 2003]
  10. Malviya N, Jain S, Malviya S. Antidiabetic potential of medicinal plants. Acta Pol Pharm 2010; 67(2): 113-118.
  11. Zaloya GP,. Catecholamines in anesthetic and surgical stress.  Int Anesthesiol Clin. 1988;26:187-198.
  12. Nistrup-Madsen S, Engqueist A, Badawi I, Kehlet H, Cyclic AMP, glucose and cortisol in plasma drug during surgery, Horm Metab Res. 1976;69:1010-1018.
  13. Sharifi-Rad, M.; Nazaruk, J.; Polito, L.; Morais-Braga, M.F.B.; Rocha, J.E.; Coutinho, H.D.M.; Salehi, B.; Tabanelli, G.; Montanari, C.; del Mar Contreras, M.; et al. Matricaria genus as a source of antimicrobial agents: From farm to pharmacy and food applications. Microbiol. Res. 2018, 215, 76–88.
  14. Salehi, B.; Kumar, N.V.A.; ¸Sener, B.; Sharifi-Rad, M.; K?l?ç, M.; Mahady, G.B.; Vlaisavljevic, S.; Iriti, M.; Kobarfard, F.; Setzer, W.N. Medicinal plants used in the treatment of human immunodeficiency virus. Int. J. Mol. Sci. 2018, 19, 1459.
  15. Sharifi-Rad, M.; Salehi, B.; Sharifi-Rad, J.; Setzer, W.N.; Iriti, M. Pulicaria vulgaris Gaertn. essential oil: An alternative or complementary treatment for leishmaniasis. Cell. Mol. Biol. 2018, 64, 18–21.
  16. Arumugam, G.; Manjula, P.; Paari, N. A review: Anti diabetic medicinal plants used for diabetes mellitus. J. Acute Dis. 2013, 2, 196–200.
  17. Kooti, W.; Moradi, M.; Akbari, S.; Sharafi-Ahvazi, N.; AsadiSamani, M.; Ashtary-Larky, D. Therapeutic and pharmacological potential of Foeniculum vulgare Mill: A review. J. HerbMed Pharm. 2015, 4, 1–9.
  18. Afrisham, R.; Aberomand, M.; Gha_ari, M.; Siahpoosh, A.; Jamalan, M. Inhibitory e_ect of Heracleum persicum and Ziziphus jujuba on activity of alpha-amylase. J. Bot. 2015, 2015, 824683.
  19. Gupta, P.; De, A. Diabetes mellitus and its herbal treatment. Int. J. Res. Pharm. Biomed. Sci. 2012, 3, 706–721.
  20. Ni Y, Turner D, Yates KM, Tizard I. Isolation and characterization of structural components of Aloe vera L. leaf pulp. Int Immunopharmacol. 2004;4(14):1745–55.
  21. Krentz AJ, Bailey CJ (2005) Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 65:385–411
  22. Rahmatullah, M.; Hossain, M.; Mahmud, A.; Sultana, N.; Rahman, S.M.; Islam, M.R.; Khatoon, M.S.; Jahan, S.; Islam, F. Antihyperglycemic and antinociceptive activity evaluation of ‘khoyer’ prepared from boiling the wood of Acacia catechu in water. Afr. J. Tradit. Complement. Altern. Med. 2013, 10, 1–5.
  23. Jawla, S.; Kumar, Y.; Khan, M.S.Y. Antimicrobial and antihyperglycemic activities of Acacia modesta leaves. Pharmacologyonline 2011, 2, 331–347.
  24. Yasir, M.; Jain, P.; Debajyoti, D.; Kharya, M.D. Hypoglycemic and antihyperglycemic effect of different extracts of Acacia arabica lamk bark in normal and alloxan induced diabetic rats. Int. J. Phytomed. 2010, 2, 133–138.
  25. Zahidin, N.S.; Saidin, S.; Zulkifli, R.M.; Muhamad, I.I.; Ya’akob, H.; Nur, H. A review of Acalypha indica L.(Euphorbiaceae) as traditional medicinal plant and its therapeutic potential. J. Ethnopharmacol. 2017, 207, 146–173.
  26. Latiff, A.A.; Teoh, S.L.; Das, S. Wound healing in diabetes mellitus: Traditional treatment modalities. Clin. Ter. 2010, 161, 359–364.
  27. Rao, P.K.; Hasan, S.S.; Bhellum, B.L.; Manhas, R.K. Ethnomedicinal plants of Kathua district, J&K, India. J. Ethnopharmacol. 2015, 171, 12–27.
  28. Sudha, P.; Zinjarde, S.S.; Bhargava, S.Y.; Kumar, A.R. Potent ?-amylase inhibitory activity of Indian Ayurvedic medicinal plants. BMC Complement. Altern. Med. 2011, 11, 5.
  29. Mootoosamy, A.; Mahomoodally, M.F. Ethnomedicinal application of native remedies used against diabetes and related complications in Mauritius. J. Ethnopharmacol. 2014, 151, 413–444.
  30. Bhaludra, C.S.S.; Bethapudi, R.R.; Murugulla, A.C.; Pullagummi, C.; Latha, T.; Venkatesh, K.; Bheemagani, A.J.; Pudutha, A.; Rani, A.R. Cultivation, phytochemical studies, biological activities and medicinal uses of Aloe ferox, grandfather of aloes an important amazing medicinal plant. Int. J. Pharmacol. 2013, 9, 405–415.
  31. Rashidi, A.A.; Mirhashemi, S.M.; Taghizadeh, M.; Sarkhail, P. Iranian medicinal plants for diabetes mellitus: A systematic review. Pak. J. Biol. Sci. 2013, 16, 401–411.
  32. Kamel, F.O.; Magadmi, R.M.; Hagras, M.M.; Magadmi, B.; AlAhmad, R.A. Knowledge, attitude, and beliefs toward traditional herbal medicine use among diabetics in Jeddah Saudi Arabia. Complement. Ther. Clin. Pract. 2017, 29, 207–212.
  33. Xie, W.; Du, L. Diabetes is an inflammatory disease: Evidence from traditional Chinese medicines. Diabetes Obes. Metab. 2011, 13, 289–301Sharma, P.; Kharkwal, A.C.; Kharkwal, H.; Abdin, M.Z.; Varma, A. A review on pharmacological properties of Aloe vera. Int. J. Pharm. Sci. Rev. Res. 2014, 29, 31–37.
  34. Tripathi, P.; Swain, S.N. In-vitro antioxidant and free radical scavenging activity of Alpinia calcaratain Andaman Islands. Plant Arch. 2016, 16, 685–694.
  35. Arawwawala, L.D.A.M.; Arambewela, L.S.R.; Ratnasooriya, W.D. Alpinia calcarata Roscoe: A rich source of phytopharmaceuticals in Sri Lanka. Nat. Prod. J. 2012, 2, 263–269.
  36. Ayyanar, M.; Ignacimuthu, S. Ethnobotanical survey of medicinal plants commonly used by Kani tribals in Tirunelveli hills of Western Ghats, India. J. Ethnopharmacol. 2011, 134, 851–864.
  37. Ahuja, J.; Suresh, J.; Paramakrishnan, N.; Mruthunjaya, K.; Naganandhini, M.N. An ethnomedical, phytochemical and pharmacological profile of Artemisia parviflora roxb. J. Essent. Oil Bear. Plant. 2011, 14, 647–657.
  38. Mahomoodally, M.F.; Ramalingum, N. An investigation into the consumption patterns, attitude, and perception of Mauritians towards common medicinal food plants. J. Herb. Med. 2015, 5, 99–112.
  39. Chandrika, U.G.; Wedage, W.S.; Wickramasinghe, S.M.D.N.; Fernando, W.S. Hypoglycaemic action of the flavonoid fraction of Artocarpus heterophyllus leaf. Afr. J. Trad. Complement. Altern. Med. 2006, 3, 42–50.
  40. Kotowaroo, M.I.; Mahomoodally, M.F.; Gurib-Fakim, A.; Subratty, A.H. Screening of traditional antidiabetic medicinal plants of mauritius for possible ?-amylase inhibitory effects in vitro. Phytother. Res. 2006, 20, 228–231.
  41. Khan, I.; Najeebullah, S.; Ali, M.; Shinwari, Z. Phytopharmacological and ethnomedicinal uses of the genus Berberis (berberidaceae): A review. Trop. J. Pharm. Res. 2016, 15, 2047–2057.
  42. Maithani, A.; Parcha, V.; Kumar, D. Quantitative estimation of berberine content of berberis asiatica from different altitude of garhwalhimalaya. Asian J. Pharm. Clin. Res. 2014, 7, 165–167.
  43. Grover, J.K.; Yadav, S.; Vats, V. Medicinal plants of India with anti-diabetic potential. J. Ethnopharmacol. 2002, 81, 81–100.
  44. Roman-Ramos, R.; Flores-Saenz, J.L.; Alarcon-Aguilar, F.J. Anti-hyperglycemic effect of some edible plants. J. Ethnopharmacol. 1995, 48, 25–32.
  45. Cui, G.; Qin, X.; Zhang, Y.; Gong, Z.; Ge, B.; Zang, Y.Q. Berberine differentially modulates the activities of erk, p38 mapk, and jnk to suppress th17 and th1 t cell differentiation in type 1 diabetic mice. J. Biol. Chem. 2009, 284, 28420–28429.
  46. Namsa, N.D.; Mandal, M.; Tangjang, S.; Mandal, S.C. Ethnobotany of the monpa ethnic group at arunachalpradesh, india. J. Ethnobiol. Ethnomed. 2011, 7, 31.
  47. Kumar, M.; Malik, J. Pharmacognostical studies and evaluation of quality parameters of butea frondosa leaves. Int. J. Pharmcy Pharm. Sci. 2012, 4, 610–614.
  48. Bhutkar, M.A.; Bhise, S.B. In vitro assay of alpha amylase inhibitory activity of some indigenous plants.Int. J. Chem. Sci. 2012, 10, 457–462.
  49. Tag, H.; Kalita, P.; Dwivedi, P.; Das, A.K.; Namsa, N.D. Herbal medicines used in the treatment of diabetes mellitus in Arunachal Himalaya, Northeast, India. J. Ethnopharmacol. 2012, 141, 786–795.
  50. Ghosal, M.; Mandal, P. In-vitro antidiabetic and antioxidant activity of Calamus erectus roxb. Fruit: A wild plant of darjeelinghimalaya. Int. J. Pharma Bio Sci. 2013, 4, P671–P684.
  51. Parihar, G.; Balekar, N. Calotropis procera: A phytochemical and pharmacological review. Thai J. Pharm. Sci. 2016, 40, 115–131.
  52. Dangi, K.S.; Mishra, S.N. Antihyperglycemic, antioxidant and hypolipidemic effect of Capparis aphyllastem extract in streptozotocin induced diabetic rats. Biol. Med. 2010, 2, 35–44.
  53. Goyal, M. Traditional plants used for the treatment of diabetes mellitus in sursagar constituency, jodhpur, rajasthan—An ethnomedicinal survey. J. Ethnopharmacol. 2015, 174, 364–368.
  54. Selvamani, P.; Latha, S.; Elayaraja, K.; Babu, P.; Gupta, J.; Pal, T.; Ghosh, L.; Sen, D. Antidiabetic activity of the ethanol extract of Capparis sepiariaL. leaves. Indian J. Pharm. Sci. 2008, 70, 378–380.
  55. Sher, H.; Alyemeni, M.N. Ethnobotanical and pharmaceutical evaluation of Capparis spinosa L., validity of local folk and unani system of medicine. J. Med. Plant Res. 2010, 4, 1751–1756.
  56. Adnan, M.; Jan, S.; Mussarat, S.; Tariq, A.; Begum, S.; Afroz, A.; Shinwari, Z.K. A review on ethnobotany, phytochemistry and pharmacology of plant genus CarallumaR. Br. J. Pharm. Pharmacol. 2014, 66, 1351–1368.
  57. Bellamakondi, P.K.; Godavarthi, A.; Ibrahim, M. Anti-hyperglycemic activity of Carallumaumbellatahaw. BioImpacts2014, 4, 113–116.
  58. Singh,      A.;       Uppal, G.K.    A review on carissa carandas-phytochemistry, ethno-pharmacology, and micropropagation as conservation strategy. Asian J. Pharm. Clin. Res. 2015, 8, 26–30.
  59. Ayyanar, M.; Ignacimuthu, S. Pharmacological actions of Cassia auriculata L. And Cissus quadrangularis wall: A short review. J. Pharmacol. Toxicol. 2008, 3, 213–221.
  60. Thakur, M.; Asrani, R.K.; Thakur, S.; Sharma, P.K.; Patil, R.D.; Lal, B.; Parkash, O. Observations on traditional usage of ethnomedicinal plants in humans and animals of kangra and chamba districts of himachalpradesh in north-western himalaya, india. J. Ethnopharmacol. 2016, 191, 280–300.
  61. Boaduo, N.K.K.; Katerere, D.; Eloff, J.N.; Naidoo, V. Evaluation of six plant species used traditionally in the treatment and control of diabetes mellitus in south africa using in vitro methods. Pharm. Biol. 2014, 52, 756–761.
  62. Tarak, D.; Namsa, N.D.; Tangjang, S.; Arya, S.C.; Rajbonshi, B.; Samal, P.K.; Mandal, M. An inventory of the ethnobotanicals used as anti-diabetic by a rural community of Dhemaji district of Assam, Northeast India.Ethnopharmacol. 2011, 138, 345–350.
  63. Kar, A.; Choudhary, B.K.; Bandyopadhyay, N.G. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J. Ethnopharmacol. 2003, 84, 105–108.
  64. Shihabudeen, H.M.S.; Priscilla, D.H.; Thirumurugan, K. Cinnamon extract inhibits ?-glucosidase activity and dampens postprandial glucose excursion in diabetic rats. Nutr. Metab. 2011, 8, 46.
  65. Shakthi Deve, A.; Sathish kumar, T.; Kumaresan, K.; Rapheal, V.S. Extraction process optimization of polyphenols from indianCitrus sinensis—As novel antiglycative agents in the management of diabetes mellitus. J. Diabetes Metab. Disord. 2014, 13, 11.
  66. Jadeja, R.N.; Thounaojam, M.C.; Ramani, U.V.; Devkar, R.V.; Ramachandran, A.V. Anti-obesity potential of clerodendronglandulosum.Coleb leaf aqueous extract. J. Ethnopharmacol. 2011, 135, 338–343.
  67. Barman, T.K.; Kalita, P.; Pal, T.K. Comparative evaluation of total flavonoid content and antioxidant activity of methanolic root extract of Clerodendrum infortunatumand methanolic whole plant extract of biophytumsensitivum. Int. J. Pharm. Sci. Rev. Res. 2013, 22, 62–6
  68. Mohan Maruga Raja, M.K.; Mishra, S.H. Comprehensive review of Clerodendrum phlomidis: A traditionally used bitter. J. Chin. Integr. Med. 2010, 8, 510–524.
  69. Kuriyan, R.; Rajendran, R.; Bantwal, G.; Kurpad, A.V. E_ect of supplementation of Coccinia cordifolia extract on newly detected diabetic patients. Diabetes Care 2008, 31, 216–220.
  70. Waisundara, V.Y.; Watawana, M.I. Evaluation of the antioxidant activity and additive e_ects of traditional medicinal herbs from sri lanka. Aust. J. Herb. Med. 2014, 26, 22–28
  71. Attanayake, A.P.; Jayatilaka, K.A.P.W.; Pathirana, C.; Mudduwa, L.K.B. Antihyperglycemic activity of Coccinia grandis (L.) voigt in streptozotocin induced diabetic rats. Indian J. Trad. Knowl. 2015, 14, 376–381.
  72. Pulbutr, P.; Saweeram, N.; Ittisan, T.; Intrama, H.; Jaruchotikamol, A.; Cushnie, B. In vitro ? -amylase and ?-glucosidase inhibitory activities of Coccinia grandis aqueous leaf and stem extracts. J. Biol. Sci. 2017, 17, 61–68.
  73. Krishnan, K.; Mathew, L.E.; Vijayalakshmi, N.R.; Helen, A. Anti-inflammatory potential of _-amyrin, a triterpenoid isolated from costus igneus. Inflammopharmacology 2014, 22, 373–385.
  74. Rege, A.; Ambaye, R.; Chowdhary, A. E_ect of Costus pictus D. Don on carbohydrate hydrolyzing enzymes. Int. J. Pharmcy Pharm. Sci. 2014, 6, 278–280.
  75. Govindarajan, R.; Vijayakumar, M.; Rao, C.V.; Pushpangadan, P.; Asare-Anane, H.; Persaud, S.; Jones, P.; Houghton, P.J. Antidiabetic activity of croton klozchianus in rats and direct stimulation of insulin secretion in-vitro. J. Pharm. Pharmacol. 2008, 60, 371–376.
  76. Okokon, J.E.; Bassey, A.L.; Obot, J. Antidiabetic activity of ethanolic leaf extract of croton zambesicus muell. (thunder plant) in alloxan diabetic rats. Afr. J. Trad. Complement. Altern. Med. 2006, 3, 21–26
  77. Panwar, N.S.; Pradheep, K.; Bhatt, K.C.; Deswal, R.P.S. Ethnobotany of a threatened medicinal plant “indravan” (Cucumis callosus) from central india. Med. Plants 2014, 6, 307–309.
  78. Thakur, M.; Chauhan, N.S.; Sharma, V.; Dixit, V.K.; Bhargava, S. E_ect of curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. Int. J. Impot. Res. 2012, 24, 31–37.
  79. Sushma, S.M.; Sharath, R.; Sujan Ganapathy, P.S.; Sivakamisundari, P.; Preetham, J. Pharmacognostic and phytochemical evaluation of Curcuma angustifolia roxb. (rhizome) indigenous ethno-medicinal plant used by tribal soliga community of biligirirangana hills. Int. J. Pharmacogn. Phytochem. Res. 2015, 7, 820–824.
  80. Mishra, R.; Shuaib, M.; Shravan; Mishra, P.S. A review on herbal antidiabetic drugs. J. Appl. Pharm. Sci. 2011, 1, 235–237.
  81. Rafe, M.R. A review of five traditionally used anti-diabetic plants of Bangladesh and their pharmacological activities. Asian Pac. J. Trop. Med. 2017, 10, 933–939.
  82. Gao, J.M.; Li, R.; Zhang, L.; Jia, L.L.; Ying, X.X.; Dou, D.Q.; Li, J.C.; Li, H.B. Cuscuta chinensis seeds water extraction protecting murine osteoblastic mc3t3-e1 cells against tertiary butyl hydroperoxide induced injury. J. Ethnopharmacol. 2013, 148, 587–595.
  83. Lans, C.A. Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus. J. Ethnobiol. Ethnomedicine 2006, 2, 45.
  84. Sudipta, B.; Kumar, D.S.; Goutam, P.; Monalisha, D. Evaluation of antidiabetic activity and histological study of cyperus kyllinga endl. Roots. Ind. J. Nat. Prod. Resour. 2012, 3, 343–346.
  85. Elshamy, A.I.; El-Shazly, M.; Yassine, Y.M.; El-Bana, M.A.; Farrag, A.R.; Nassar, M.I.; Singab, A.N.; Noji, M.; Umeyama, A. Phenolic constituents, anti-inflammatory and antidiabetic activities of Cyperus laevigatus L. Pharm. J. 2014, 9, 828–833.
  86. Pirzada, A.M.; Ali, H.H.; Naeem, M.; Latif, M.; Bukhari, A.H.; Tanveer, A. Cyperus rotundus L.: Traditional uses, phytochemistry, and pharmacological activities. J. Ethnopharmacol. 2015, 174, 540–560.
  87. Nithya Devi, M.; Brindha, P. Herbal nutraceuticals in the management of cancer and chronic diseases—A select study. Int. J. Pharmcy Pharm. Sci. 2014, 6, 104–106.
  88. Rastogi, S.; Pandey, M.M.; Rawat, A.K.S. An ethnomedicinal, phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. And Desmodium adscendens (Sw.) DC. J. Ethnopharmacol. 2011, 136, 283–296.
  89. Pi, W.X.; Feng, X.P.; Ye, L.H.; Cai, B.C. Combination of morroniside and diosgenin prevents high glucose-induced cardiomyocytes apoptosis. Molecules 2017, 22, 163.
  90. Kiran Kumar, A.N.D.E.; Gowrishankar, N.L.; Manju Bhargavi, V.; Nagarjuna, M.; Rajani, G.; Swetha, Y.; Vinay Reddy, P. Evaluation of anti ulcer activity of ethanol extract of Diospyros melanoxylon (roxb). Bark. Int. J. Pharmcy Pharm. Sci. 2012, 4, 537–539.
  91. Dewanjee, S.; Maiti, A.; Sahu, R.; Dua, T.K.; Mandal, V. E_ective control of type 2 diabetes through antioxidant defense by edible fruits of diospyros peregrina. Evid.-Based Complement. Altern. Med. 2011, 2011.
  92. Das, M.; Bandyopadhyay, A. Promising phytomedicines from Elephantopus scaber L: A review. Res. J. Pharm. Biol. Chem. Sci. 2015, 6, 1508–1518.
  93. Ooi, K.L.; Muhammad, T.S.T.; Tan, M.L.; Sulaiman, S.F. Cytotoxic, apoptotic and anti-_-glucosidase activities of 3,4-di-o-ca_eoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of elephantopus mollis kunth. J. Ethnopharmacol. 2011, 135, 685–695.
  94. Miura, T.; Kato, A. Hypoglycémie action ofembelia madagascariensis in normal and diabetic mice. Am. J. Chin. Med. 1997, 25, 169–173.
  95. Bhandari, U.; Jain, N.; Ansari, M.N.; Pillai, K.K. Beneficial e_ect of embelia ribes ethanolic extract on blood pressure and glycosylated hemoglobin in streptozotocin-induced diabetes in rats. Fitoterapia 2008, 79, 351–355.
  96. Ratnasooriya, W.D.; Somarathna, K.I.W.K.; Premakumara, G.A.S.; Ediriweera, E.R.H.S.S. Lack of antiglycation activity of fresh juice of whole plant of Enicostema axillare (lam.) raynal. J. Pharm. Negat. Results 2011, 2, 55–57.
  97. Tripathi, A.K.; Bhoyar, P.K.; Baheti, J.R.; Biyani, D.M.; Khalique, M.; Kothmire, M.S.; Amgaonkar, Y.M.; Bhanarkar, A.B. Herbal antidiabetics: A review. Int. J. Res. Pharm. Sci. 2011, 2, 30–37.
  98. Vadivel, V.; Biesalski, H.K. Phenolic content in traditionally processed Erythrina indica L. Seeds: Antioxidant potential and type ii diabetes related functionality. Curr. Nutr. Food Sci. 2011, 7, 200–208.
  99. Kumar, P.; Mehta, M.; Satija, S.; Garg, M. Enzymatic in vitro anti-diabetic activity of few traditional Indian medicinal plants. J. Biol. Sci. 2013, 13, 540–544.
  100. Jerang, G.; Swamy, B.M.V.; Kotagiri, S.; Dey, T.; Fariyaz, S.M. Indian medicinal plants with antidiabetic and related beneficial e_ects: A review. Res. J. Pharm. Biol. Chem. Sci. 2015, 6, 31–38.
  101. Lelono, R.A.A.; Tachibana, S. Preliminary studies of indonesian eugenia polyantha leaf extracts as inhibitors of key enzymes for type 2 diabetes. J. Med. Sci. 2013, 13, 103–110.
  102. Goyal, M.; Sasmal, D.; Nagori, B.P. Review on medicinal plants used by local community of Jodhpur district of Thar desert. Int. J. Pharmacol. 2011, 7, 333–339.
  103. Cristians, S.; Osuna-Fernández, H.R.; Ramírez-Ávila, G.; Muñóz-Ocotero, V.; Laguna-Hernández, G.; Brechú-Franco, A.E. Euphorbia dioeca kunth as a novel source for _-glucosidase inhibitors. Bol. Lat. Y Del Caribe De Plant. Med. Y Aromat. 2015, 14, 483–490.
  104. Gulati, V.; Harding, I.H.; Palombo, E.A. Enzyme inhibitory and antioxidant activities of traditional medicinal plants: Potential application in the management of hyperglycemia. BMC Complement. Altern. Med. 2012, 12, 77
  105. Bhatia, H.; Sharma, Y.P.; Manhas, R.K.; Kumar, K. Ethnomedicinal plants used by the villagers of district Udhampur, J&K, India. J. Ethnopharmacol. 2014, 151, 1005–1018.
  106. Hossan, M.S.; Hanif, A.; Khan, M.; Bari, S.; Jahan, R.; Rahmatullah, M. Ethnobotanical survey of the Tripura tribe of Bangladesh. Am. Eurasian J. Sustain. Agric. 2009, 3, 253–261.
  107. Kunwar, R.M.; Shrestha, K.P.; Bussmann, R.W. Traditional herbal medicine in Far-west Nepal: A pharmacological appraisal. J. Ethnobiol. Ethnomedicine 2010, 6, 35
  108. Sharma, V. Microscopic studies and preliminary pharmacognostical evaluation of Euphorbia neriifolia L. Leaves. Ind. J. Nat. Prod. Resour. 2013, 4, 348–357.
  109. Alarcon-Aguilara, F.J.; Roman-Ramos, R.; Perez-Gutierrez, S.; Aguilar-Contreras, A.; Contreras-Weber, C.C.; Flores-Saenz, J.L. Study of the anti-hyperglycemic e_ect of plants used as antidiabetics. J. Ethnopharmacol. 1998, 61, 101–110.
  110. Kareparamban, J.A.; Nikam, P.H.; Jadhav, A.P.; Kadam, V.J. Ferula foetida “hing”: A review. Res. J. Pharm. Biol. Chem. Sci. 2012, 3, 775–786.
  111. Zare, A.R.; Omidi, M.; Fallah Hoseini, H.; Yazdani, D.; Sh, R.; Irvani, N.; Oladzad, A. A review on pharmacological e_ects of Ferula assa-foetida L.: A systematic review. J. Med. Plants 2011, 10, 17–25.
  112. Arunachalam, K.; Parimelazhagan, T. Antidiabetic activity of ficus amplissima smith. Bark extract in streptozotocin induced diabetic rats. J. Ethnopharmacol. 2013, 147, 302–310.
  113. Lelono, R.A.A.; Tachibana, S. Preliminary studies of indonesian eugenia polyantha leaf extracts as inhibitors of key enzymes for type 2 diabetes. J. Med. Sci. 2013, 13, 103–110
  114. Joseph, B.; Justin Raj, S. Phytopharmacological and phytochemical properties of three ficus species—An overview. Int. J. Pharma Bio Sci. 2010, 1, 246–253.
  115. Joseph, B.; Justin Raj, S. Pharmacognostic and phytochemical properties of Ficus carica linn—An overview. Int. J. Pharm. Res. 2011, 3, 8–12.
  116. Badgujar, S.B.; Patel, V.V.; Bandivdekar, A.H.; Mahajan, R.T. Traditional uses, phytochemistry and pharmacology of ficus carica: A review. Pharm. Biol. 2014, 52, 1487–1503.
  117. Marwat, S.K.; Fazal Ur, R.; Khan, E.A.; Khakwani, A.A.; Ullah, I.; Khan, K.U.; Khan, I.U. Useful ethnophytomedicinal recipes of angiosperms used against diabetes in south east asian countries (india, pakistan & sri lanka). Pak. J. Pharma. Sci. 2014, 27, 1333–1358.
  118. Vaishnav, R.; Agrawal, R.D.; Sandeep, S. Medicinal value and future perspective of some therapeutically important plants from indian western region. Int. J. Pharm. Sci. Rev. Res. 2015, 34, 88–93.
  119. Singh, D.; Mukhija, M.; Singh, S.; Aggarwal, A.; Sundriyal, A. Anti-diabetic e_ect of hydroalcoholic extract of Ficus palmata forsk leaves in streptozotocin-induced diabetic rats. Int. J. Green Pharm. 2014, 8, 276–282.
  120. Trinh, B.T.D.; Staerk, D.; Jäger, A.K. Screening for potential _-glucosidase and _-amylase inhibitory constituents from selected Vietnamese plants used to treat type 2 diabetes. J. Ethnopharmacol. 2016, 186, 189–195.
  121. Shah, S.K.; Garg, G.; Jhade, D.; Pandey, H. Ficus racemosa linn: Its potentials food security and rural medicinal management. J. Pharm. Sci. Res. 2016, 8, 317–322.
  122. Babu, K.; Gokul Shankar, S.; Rai, S. Comparative pharmacognostic studies on the barks of four ficus species. Turk. J. Bot. 2010, 34, 215–224.
  123. Pandit, S.; Ponnusankar, S.; Bandyopadhyay, A.; Ota, S.; Mukherjee, P.K. Exploring the possible metabolism mediated interaction of glycyrrhiza glabra extract with cyp3a4 and cyp2d6. Phytother. Res. 2011, 25, 1429–1434
  124. Lee, M.; Son, M.; Ryu, E.; Shin, Y.S.; Kim, J.G.; Kang, B.W.; Cho, H.; Kang, H. Quercetin-induced apoptosis prevents ebv infection. Oncotarget 2015, 6, 12603–12624.
  125. Shukla, R.; Sharma, D.C.; Baig, M.H.; Bano, S.; Roy, S.; Provazník, I.; Kamal, M.A. Antioxidant, antimicrobial activity and medicinal properties of Grewia asiatica L. Med. Chem. 2016, 12, 211–216.
  126. Natarajan, A.; Sugumar, S.; Bitragunta, S.; Balasubramanyan, N. Molecular docking studies of (4z,12z)-cyclopentadeca-4, 12-dienone from grewia hirsuta with some targets related to type 2 diabetes. BMC Complement. Altern. Med. 2015, 15, 73.
  127. Meena, S.N.; Ghadi, S.C.; Janarthanam, M.K. Evaluation of medicinal properties of Grewia nervosa (lour.) panigrahi. Int. J. Pharma Bio Sci. 2013, 4, P821–P828.
  128. Varghese, E.; Pappachen, K.L.; Narayanan, S.S. Isolation and evaluation of antimicrobial properties of isolated phytoconstituents of fruits of Helicteres isora linn. Res. J. Pharm., Biol. Chem. Sci. 2012, 3, 959–964.
  129. Sinha, S.; Sharma, A.; Hemalatha Reddy, P.; Rathi, B.; Prasad, N.V.S.R.K.; Vashishtha, A. Evaluation of phytochemical and pharmacological aspects of Holarrhena antidysenterica (wall.): A comprehensive review. J. Pharm. Res. 2013, 6, 488–492.
  130. Balamurugan, R.; Vendan, S.E.; Aravinthan, A.; Kim, J.H. Isolation and structural characterization of 2r, 3r taxifolin 3-o-rhamnoside from ethyl acetate extract of hydnocarpus alpina and its hypoglycemic e_ect by attenuating hepatic key enzymes of glucose metabolism in streptozotocin-induced diabetic rats. Biochimie 2015, 111, 70–81.
  131. Reddy, S.V.; Tiwari, A.K.; Kumar, U.S.; Rao, R.J.; Rao, J.M. Free radical scavenging, enzyme inhibitory constituents from antidiabetic ayurvedic medicinal plant hydnocarpus wightiana blume. Phytother. Res. 2005, 19, 277–281
  132. Hanif, A.; Hossan, M.S.; Mia, M.M.K.; Islam, M.J.; Jahan, R.; Rahmatullah, M. Ethnobotanical survey of the rakhain tribe inhabiting the chittagong hill tracts region of bangladesh. Am. Eurasian J. Sustain. Agric. 2009, 3, 172–180.
  133. Bavarva, J.H.; Narasimhacharya, A.V.R.L. Leucas cephalotes regulates carbohydrate and lipid metabolism and improves antioxidant status in iddm and niddm rats. J. Ethnopharmacol. 2010, 127, 98–102.4
  134. Aderibigbe, A.O.; Emudianughe, T.S.; Lawal, B.A.S. Antihyperglycaemic e_ect of mangifera indica in rat. Phytother. Res. 1999, 13, 504–507.
  135. Ranganathan, R.; Vijayalakshmi, R.; Parameswari, P. Ethnomedicinal survey of jawadhu hills in tamil nadu. Asian J. Pharm. Clin. Res. 2012, 5, 45–49.
  136. Marimuthu, S.; Padmaja, B.; Nair, S. Phytochemical screening studies on melia orientalis by gc-ms analysis. Pharmacogn. Res. 2013, 5, 216–218.
  137. Rao, P.K.; Hasan, S.S.; Bhellum, B.L.; Manhas, R.K. Ethnomedicinal plants of Kathua district, J&K, India. J. Ethnopharmacol. 2015, 171, 12–27.
  138. Ganu, G.P.; Jadhav, S.S.; Deshpande, A.D. Antioxidant and antihyperglycemic potential of methanolic extract of bark of Mimusops elengi L. In mice. Int. J. Phytomed. 2010, 2, 116–123.
  139. Mina, E.C.; Mina, J.F. Ethnobotanical survey of plants commonly used for diabetes in tarlac of central Luzon Philippines. Int. Med. J. Malays. 2017, 16, 21–28.
  140. Tran, M.H.; Hoang, D.M.; Minh, P.T.H.; Ui, J.Y.; Na, M.; Won, K.O.; Byung, S.M.; Bae, K. _-amylase and protein tyrosine phosphatase 1B inhibitory of some Vietnamese medicinal plants used to treat diabetes. Nat. Prod. Sci. 2007, 13, 311–316.
  141. Ocvirk, S.; Kistler, M.; Khan, S.; Talukder, S.H.; Hauner, H. Traditional medicinal plants used for the treatment of diabetes in rural and urban areas of Dhaka, Bangladesh—An ethnobotanical survey. J. Ethnobiol. Ethnomedicine 2013, 9, 43.
  142. Rammal, H.; Bouayed, J.; Desor, F.; Younos, C.; Soulimani, R. A study of the anti-hyperglycaemic e_ects of the medicinal plant, Momordica charantia L.: Validation and contribution. Phytotherapie 2009, 7, 191–196.
  143. Kunyanga, C.N.; Imungi, J.K.; Okoth, M.W.; Biesalski, H.K.; Vadivel, V. Total phenolic content, antioxidant and antidiabetic properties of methanolic extract of raw and traditionally processed Kenyan indigenous food ingredients. LWT Food Sci. Technol. 2012, 45, 269–276
  144. Semenya, S.; Potgieter, M.; Erasmus, L. Ethnobotanical survey of medicinal plants used by Bapedi healers to treat diabetes mellitus in the Limpopo Province, South Africa. J. Ethnopharmacol. 2012, 141, 440–445.
  145. Maiti, R.; Rodriguez, H.G.; Kumari, C.A.; Sarkar, N.C. Macro and micro-nutrient contents of 18 medicinal plants used traditionally to alleviate diabetes in nuevo leon, northeast of mexico. Pak. J. Bot. 2016, 48, 271–276.
  146. Umar, A.N.; Mann, A.; Ajiboso, O.S.O. Ethnodietetics of moringa oleifera leaves amongst the ethnic groups in bida, niger state, nigeria and its hypoglycaemic e_ects in rats. Am. Eurasian J. Sustain. Agric. 2011, 5, 107–114.
  147. Hasani-Ranjbar, S.; Larijani, B.; Abdollah, M. A systematic review of Iranian medicinal plants useful in diabetes mellitus. Arch. Med. Sci. 2008, 4, 285–292.
  148. Chichioco-Hernandez, C.; Wudarski, J.; Gevaert, L.; Verschaeve, L. Evaluation of cytotoxicity and genotoxicity of some Philippine medicinal plants. Pharmacogn. Mag. 2011, 7, 171–175.
  149. Devi, B.; Sharma, N.; Kumar, D.; Jeet, K. Morus alba linn: A phytopharmacological review. Int. J. Pharmcy Pharm. Sci. 2013, 5, 14–18.
  150. Cai, S.; Sun,W.; Fan, Y.; Guo, X.; Xu, G.; Xu, T.; Hou, Y.; Zhao, B.; Feng, X.; Liu, T. E_ect of mulberry leaf (folium mori) on insulin resistance via irs-1/pi3k/glut-4 signalling pathway in type 2 diabetes mellitus rats. Pharm. Biol. 2016, 54, 2685–2691.
  151. Mussarat, S.; Abdel-Salam, N.M.; Tariq, A.; Wazir, S.M.; Ullah, R.; Adnan, M. Use of ethnomedicinal plants by the people living around indus river. Evid.-Based Complement. Altern. Med. 2014, 2014.
  152. Oh, K.S.; Ryu, S.Y.; Lee, S.; Seo,H.W.; Oh, B.K.; Kim,Y.S.; Lee, B.H. Melanin-concentrating hormone-1 receptor antagonism and anti-obesity e_ects of ethanolic extract from morus alba leaves in diet-induced obese mice. J. Ethnopharmacol. 2009, 122, 216–220. [CrossRef]
  153. Lemus, I.; García, R.; Delvillar, E.; Knop, G. Hypoglycaemic activity of four plants used in chilean popular medicine. Phytother. Res. 1999, 13, 91–94.
  154. Adisakwattana, S.; Ruengsamran, T.; Kampa, P.; Sompong, W. In vitro inhibitory e_ects of plant-based foods and their combinations on intestinal _-glucosidase and pancreatic _-amylase. BMC Complement. Altern. Med. 2012, 12, 110.
  155. Yin, N.; Hong, X.; Han, Y.; Duan, Y.; Zhang, Y.; Chen, Z. Cortex mori radicis extract induces neurite outgrowth in pc12 cells activating erk signaling pathway via inhibiting ca2+ influx. Int. J. Clin. Exp. Med.2015, 8, 5022–5032.
  156. Kamat, N.; Pearline, D.; Thiagarajan, P. Murraya koenigii (L.) (curry leaf): A traditional indian plant. Res. J. Pharm. Biol. Chem. Sci. 2015, 6, 691–697.
  157. Egesie, U.G.; Adelaiye, A.B.; Ibu, J.O.; Egesie, O.J. Safety and hypoglycaemic properties of aqueous leaf extract of ocimum gratissimum in streptozotocin induced diabetic rats. Niger. J. Physiol. Sci. 2006, 21, 31–35.
  158. Hong, C.E.; Lyu, S.Y. Evaluation of the mutagenic properties of two lignans from Acanthopanax koreanum Nakai. Toxicol. Res. 2013, 29, 279–283.
  159. Saito, T.; Nishida, M.; Saito, M.; Tanabe, A.; Eitsuka, T.; Yuan, S.H.; Ikekawa, N.; Nishida, H. The fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms improves insulin resistance and hepatic lipid accumulation by modulation of liver adenosine monophosphate–activated protein kinase activity and lipogenic gene expression in high-fat diet–fed obese mice. Nutr. Res. 2016, 36, 1090–1097.
  160. Upadhyay, R.K. Tulsi: A holy plant with high medicinal and therapeutic value. Int. J. Green Pharm. 2017, 11, S1–S12.
  161. Mahajan, N.; Rawal, S.; Verma, M.; Poddar, M.; Alok, S. A phytopharmacological overview on ocimum species with special emphasis on ocimum sanctum. Biomed. Prev. Nutr. 2013, 3, 185–192.
  162. Wang, L.; Jiang, Y.; Han, T.; Zheng, C.; Qin, L. A phytochemical, pharmacological and clinical profile of paederia foetida and p. Scandens. Nat. Pro. Comm. 2014, 9, 879–886.
  163. Madhavan, V.; Nagar, J.C.; Murali, A.; Mythreyi, R.; Yoganarasimhan, S.N. Antihyperglycemic activity of alcohol and aqueous extracts of pandanus fascicularis lam. Roots in alloxan induced diabetic rats. Pharmacologyonline 2008, 3, 529–536.
  164. Englberger, L.; Schierle, J.; Hofmann, P.; Lorens, A.; Albert, K.; Levendusky, A.; Paul, Y.; Lickaneth, E.; Elymore, A.; Maddison, M.; et al. Carotenoid and vitamin content of micronesian atoll foods: Pandanus (Pandanus tectorius) and garlic pear (crataeva speciosa) fruit. J. Food Compos. Anal. 2009, 22, 1–8.
  165. Tokunaga, M.; Matsuda, H.; Iwahashi, H.; Naruto, S.; Tsuruoka, T.; Yagi, H.; Masuko, T.; Kubo, M. Studies on palauan medicinal herbs. Iv. Immunopotentiatory activities of ongael, leaves of phaleria cumingii (meisn.) f. Vill. In diabetic mice. J. Tradit. Med. 2006, 23, 24–26.
  166. Tarafdar, R.G.; Nath, S.; Talukdar, A.D.; Choudhury, M.D. Antidiabetic plants used among the ethnic communities of Unakoti district of Tripura, India. J. Ethnopharmacol. 2015, 160, 219–226.
  167. Baliga, M.S.; Meera, S.; Mathai, B.; Rai, M.P.; Pawar, V.; Palatty, P.L. Scientific validation of the ethnomedicinal properties of the ayurvedic drug triphala: A review. Chin. J. Integr. Med. 2012, 18, 946–954.
  168. Muthulakshmi, S.; Bhavani, K.; Manju, R.; Mohamed Shahila, N.A. Hepatoprotective activity of Phyllanthus gardnerianus (wight) baill. Against d-galactosamine induced hepatotoxicity. Biomedicine 2014, 34, 36–44.
  169. Hashim, A.; Khan, M.S.; Khan, M.S.; Baig, M.H.; Ahmad, S. Antioxidant and _; ylase inhibitory property of Phyllanthus virgatus L.: An in vitro and molecular interaction study. BioMed Res. Int. 2013, 2013, 729393.
  170. Ramasamy, S.; AbdulWahab, N.; Zainal Abidin, N.; Manickam, S. E_ect of extracts from Phyllanthus watsonii airy shaw on cell apoptosis in cultured human breast cancer mcf-7 cells. Exp. Toxicol. Pathol. 2013, 65, 341–349.
  171. Sharma, N.; Bano, A.; Dhaliwal, H.S.; Sharma, V. A pharmacological comprehensive review on ‘rassbhary’ Physalis angulata (L.). Int. J. Pharmcy Pharm. Sci. 2015, 7, 34–38.
  172. Maobe, M.A.G.; Gitu, L.; Gatebe, E.; Rotich, H.; Karanja, P.N.; Votha, D.M.; Nderitu, I.W.; Kungu, W. Antifungal activity of eight selected medicinal herbs used for the treatment of diabetes, malaria and pneumonia in kisii region, southwest kenya. World J. Med. Sci. 2013, 8, 74–78.
  173. Mahabub, A.H.; Hossain, M.; Karim, M.; Khan, M.; Jahan, R.; Rahmatullah, M. An ethnobotanical survey of jessore district in khulna division, bangladesh. Am. Eurasian J. Sustain. Agric. 2009, 3, 238–243.
  174. Srivastava, A.; Karthick, T.; Joshi, B.D.; Mishra, R.; Tandon, P.; Ayala, A.P.; Ellena, J. Spectroscopic (far or terahertz, mid-infrared and Raman) investigation, thermal analysis and biological activity of piplartine. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2017, 184, 368–381.
  175. Manoharan, S.; Silvan, S.; Vasudevan, K.; Balakrishnan, S. Antihyperglycemic and antilipidperoxidative effects of Piper longum (linn.) dried fruits in alloxan induced diabetic rat. J. Biol. Sci. 2007, 7, 161–168.
  176. Ashish, B.; Swapnil, G. Hypoglycemic e_ect of polyherbal formulation in alloxan induced diabetic rats. Pharmacologyonline 2011, 3, 764–773.
  177. Sh Ahmed, A.; Ahmed, Q.U.; Saxena, A.K.; Jamal, P. Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) maton (zingiberaceae), Piper cubeba L. F. (piperaceae), and Plumeria rubra L. (apocynaceae). Pak. J. Pharma. Sci. 2017, 30, 113–126.
  178. Bulle, S.; Reddyvari, H.; Nallanchakravarthula, V.; Vaddi, D.R. Therapeutic potential of Pterocarpus santalinus L.: An update. Pharmacogn. Rev. 2016, 10, 43–49.
  179. Modak, M.; Dixit, P.; Londhe, J.; Ghaskadbi, S.; Devasagayam, T.P.A. Indian herbs and herbal drugs used for the treatment of diabetes. J. Clin. Biochem. Nutr. 2007, 40, 163–173.
  180. Tchamadeu, M.C.; Dzeufiet, P.D.D.; Nana, P.; Kouambou Nouga, C.C.; Ngueguim Tsofack, F.; Allard, J.; Blaes, N.; Siagat, R.; Zapfack, L.; Girolami, J.P.; et al. Acute and sub-chronic oral toxicity studies of an aqueous stem bark extract of Pterocarpus soyauxii taub (papilionaceae) in rodents. J. Ethnopharmacol. 2011, 133, 329–335.
  181. Hephzibah Christabel, P.; Gopalakrishnan, V.K. Enzyme inhibitors from Prunus persica (L.) batsch: An alternate approach to treat diabetes. Intl. J. Pharma Bio Sci. 2013, 4, B1021–B1029.
  182. Arvindekar, A.; More, T.; Payghan, P.V.; Laddha, K.; Ghoshal, N.; Arvindekar, A. Evaluation of anti-diabetic and alpha glucosidase inhibitory action of anthraquinones from Rheum emodi. Food. Funct. 2015, 6, 2693–2700.
  183. McCune, L.M.; Johns, T. Antioxidant activity in medicinal plants associated with the symptoms of diabetes mellitus used by the indigenous peoples of the north american boreal forest. J. Ethnopharmacol. 2002, 82, 197–205.
  184. Gade, D.R.; Sree Kumar Reddy, G.; Akki, S.N.R.; Vamsi Rajasekhar Reddy, P. Hepatoprotective activity of Rhus mysorensis against carbon tetrachloride induced hepatotoxicity in albino rats. Int. J. Pharm. Sci. Rev. Res. 2010, 4, 46–48.
  185. Oda, Y.; Ueda, F.; Kamei, A.; Kakinuma, C.; Abe, K. Biochemical investigation and gene expression analysis of the immunostimulatory functions of an edible salacia extract in rat small intestine. BioFactors 2011, 37, 31–39.
  186. Anitha, S.; Martha Leema Rose, A. Comparative evaluation of antihyperglycaemic e_ect of various parts of Salacia chinensis L. J. Med. Sci. 2013, 13, 493–496.
  187. Singh, A.; Duggal, S. Salacia spp: Hypoglycemic principles and possible role in diabetes management. Integr. Med. 2010, 9, 40–43.
  188. Tanabe, G.; Sakano, M.; Minematsu, T.; Matusda, H.; Yoshikawa, M.; Muraoka, O. Synthesis and elucidation of absolute stereochemistry of salaprinol, another thiosugar sulfonium sulfate from the ayurvedic traditional medicine Salacia prinoides. Tetrahedron 2008, 64, 10080–10086.
  189. Im, R.; Mano, H.; Matsuura, T.; Nakatani, S.; Shimizu, J.; Wada, M. Mechanisms of blood glucose-lowering effect of aqueous extract from stems of kothala himbutu (Salacia reticulata) in the mouse. J. Ethnopharmacol. 2009, 121, 234–240.
  190. Yoshikawa, M.; Murakami, T.; Yashiro, K.; Matsuda, H. Kotalanol, a potent _-glucosidase inhibitor with thiosugar sulfonium sulfate structure, from antidiabetic ayurvedic medicine Salacia reticulata. Chem. Pharm. Bull. 1998, 46, 1339–1340.
  191. Arya, A.; Abdullah, M.A.; Haerian, B.S.; Mohd, M.A. Screening for hypoglycemic activity on the leaf extracts of nine medicinal plants: In-vivo evaluation. E-J. Chem. 2012, 9, 1196–1205.
  192. Mahabub, A.H.; Hossain, M.; Karim, M.; Khan, M.; Jahan, R.; Rahmatullah, M. An ethnobotanical survey of rajshahi district in rajshahi division, bangladesh. Am. Eurasian J. Sustain. Agric. 2009, 3, 143–150.
  193. Ebrahimpoor-Mashhadi, M.R.; Khaksar, Z.; Noorafshan, A.; Mogheisi, B. Stereological study of the effects of orally administrated otostegia persica extract on pancreatic beta cells in male diabetic rats. Comp. Clin. Pathol. 2014, 23, 761–767.
  194. Narendhirakannan, R.T.; Limmy, T.P. Anti-inflammatory and anti-oxidant properties of Sida rhombifolia stems and roots in adjuvant induced arthritic rats. Immunopharmacol. Immunotoxicol. 2012, 34, 326–336.
  195. Ssenyange, C.W.; Namulindwa, A.; Oyik, B.; Ssebuliba, J. Plants used to manage type II diabetes mellitus in selected districts of central Uganda. Afr. Health Sci. 2015, 15, 496–502.
  196. Doss, A.; Palaniswamy, M.; Angayarkanni, J.; Dhanabalan, R. Antidiabetic activity of water extract of Solanum trilobatum (Linn.) in alloxan-induced diabetes in rats. Afr. J. Biotechnol. 2009, 8, 5551–5553.
  197. Perla, V.; Jayanty, S.S. Biguanide related compounds in traditional antidiabetic functional foods. Food Chem. 2013, 138, 1574–1580.
  198. Nag, M.; Mukherjee, P.K.; Chanda, J.; Biswas, R.; Harwansh, R.K.; Al-Dhabi, N.A.; Duraipandiyan, V. Plant developed analytical profile of Stereospermum suaveolens in Indian traditional knowledge. Indian J. Trad. Knowl. 2015, 14, 590–594
  199. Kumar, V.; Van Staden, J. A review of Swertia chirayita (Gentianaceae) as a traditional medicinal plant. Front. Pharmacol. 2016, 6, 308.
  200. Roy, P.; Abdulsalam, F.I.; Pandey, D.K.; Bhattacharjee, A.; Eruvaram, N.R.; Malik, T. Evaluation of antioxidant, antibacterial, and antidiabetic potential of two traditional medicinal plants of India: Swertia cordata and Swertia chirayita. Pharmacogn. Res. 2015, 7, S57–S62.
  201. Saeidnia, S.; Ara, L.; Hajimehdipoor, H.; Read, R.W.; Arshadi, S.; Nikan, M. Chemical constituents of Swertia longifolia boiss. With _-amylase inhibitory activity. Res. Pharm. Sci. 2016, 11, 23–32.
  202. Muthusamy, K.; Krishnasamy, G. A computational study on role of 6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxan-2-yl]oxyoxane-2,4,5-triol in the regulation of blood glucose level. J. Biomol. Struct. Dyn. 2016, 34, 2599–2618.
  203. Basar, M.H.; Hossain, S.J.; Sadhu, S.K.; Rahman, M.H. A comparative study of antioxidant potential of commonly used antidiabetic plants in bangladesh. Orient. Pharm. Exp. Med. 2013, 13, 21–28. 
  204. Bansode, T.S.; Salalkar, B.K. Phytochemical analysis of some selected indian medicinal plants. Intl. J. Pharma Bio Sci. 2015, 6, P550–P556.
  205. Baliga, M.S.; Fernandes, S.; Thilakchand, K.R.; D’Souza, P.; Rao, S. Scientific validation of the antidiabetic effects of Syzygium jambolanum DC (black plum), a traditional medicinal plant of India. J. Altern. Complement. Med. 2013, 19, 191–197.
  206. Zucchi, O.L.A.D.; Moreira, S.; De Jesus, E.F.O.; Salvio Neto, H.; Salvador, M.J. Characterization of hypoglycemiant plants by total reflection X-ray fluorescence spectrometry. Biol. Trace Elem. Res. 2005, 103, 277–290.
  207. Sathishkumar, T.; Baskar, R. Renoprotective e_ect of Tabernaemontana heyneana Wall. Leaves against paracetamol-induced renotoxicity in rats and detection of polyphenols by high-performance liquid chromatography-diode array detector-mass spectrometry analysis. J. Acute Med. 2014, 4, 57–67.
  208. Raghavan, B.; Kumari, S.K. E_ect of Terminalia arjuna stem bark on antioxidant status in liver and kidney of alloxan diabetic rats. Indian J. Physiol. Pharmacol. 2006, 50, 133–142.
  209. Nguyen, Q.V.; Nguyen, V.B.; Eun, J.B.;Wang, S.L.; Nguyen, D.H.; Tran, T.N.; Nguyen, A.D. Anti-oxidant and antidiabetic e_ect of some medicinal plants belong to Terminalia species collected in Dak Lak Province, Vietnam. Res Chem Intermed 2016, 42, 5859–5871.
  210. Tanaka, M.; Kishimoto, Y.; Saita, E.; Suzuki-Sugihara, N.; Kamiya, T.; Taguchi, C.; Iida, K.; Kondo, K. Terminalia bellirica extract inhibits low-density lipoprotein oxidation and macrophage inflammatory response in vitro. Antioxidants 2016, 5, 20.
  211. Venkatalakshmi, P.; Brindha, P.; Saralla, R.P. Analytical and chemical standardisation studies on Terminalia catappa bark. Int. J. Pharmcy Pharm. Sci. 2014, 6, 4–8.
  212. Jokar, A.; Masoomi, F.; Sadeghpour, O.; Nassiri-Toosi, M.; Hamedi, S. Potential therapeutic applications for Terminalia chebula in Iranian traditional medicine. J. Tradit Chin Med. 2016, 36, 250–254.
  213. Rao, N.K.; Nammi, S. Antidiabetic and renoprotective e_ects of the chloroform extract of Terminalia chebula Retz. Seeds in streptozotocin-induced diabetic rats. BMC Complement. Altern. Med. 2006, 6, 17.
  214. Kumar, N.; Singh, S.; Manvi; Gupta, R. Trichosanthes dioica roxb.: An overview. Pharmacogn. Rev. 2012, 6, 61–67.
  215. Beaulieu, L.P.; Harris, C.S.; Saleem, A.; Cuerrier, A.; Haddad, P.S.; Martineau, L.C.; Bennett, S.A.L.; Arnason, J.T. Inhibitory e_ect of the cree traditional medicine wiishichimanaanh (Vaccinium vitis-idaea) on advanced glycation endproduct formation: Identification of active principles. Phytother. Res. 2010, 24, 741–747.
  216. Mishra, J.; Dash, A.K.; Mishra, S.N.; Gupta, A.K. Withania coagulans in treatmen of diabetics and some other diseases: A review. Res. J. Pharm., Biol. Chem. Sci. 2013, 4, 1251–1258.
  217. Maurya, R.; Akanksha; Jayendra; Singh, A.B.; Srivastava, A.K. Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity. Bioorg. Med. Chem. Lett. 2008, 18, 6534–6537.
  218. Jonathan, G.; Rivka, R.; Avinoam, S.; Lumír, H.; Nirit, B. Hypoglycemic activity of withanolides and elicitated Withania somnifera. Phytochemistry 2015, 116, 283–289.
  219. Mukhija, M.; Lal Dhar, K.; Nath Kalia, A. Bioactive lignans from Zanthoxylum alatum Roxb. Stem bark with cytotoxic potential. J. Ethnopharmacol. 2014, 152, 106–112.
  220. Pamhidzai, D.; Isaac, G. Tlc separation, antibacterial and anti-inflammatory activity of extracts derived from Zanthoxylum humile roots. Intern. J. Res. Ayurveda Pharm. 2013, 4, 482–486.
  221. Ranilla, L.G.; Kwon, Y.I.; Apostolidis, E.; Shetty, K. Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America. Bioresour. Technol. 2010, 101, 4676–4689
  222. Morakinyo, A.O.; Akindele, A.J.; Ahmed, Z. Modulation of antioxidant enzymes and inflammatory cytokines: Possible mechanism of anti-diabetic e_ect of ginger extracts. Afr. J. Biomed. Res. 2011, 14, 195–202.
  223. Modi, A.; Jain, S.; Kumar, V. Zizyphus xylopyrus (Retz.) willd: A review of its folkloric, phytochemical and pharmacological perspectives. Asian Pac. J. Trop. Dis. 2014, 4, S1–S6.
  224. Solanki, A.; Zaveri, M. Pharmacognosy, phytochemistry and pharmacology of Abrus precatorius leaf: A review. Int. J. Pharm. Sci. Rev. Res. 2012, 13, 71–76.
  225. Liu, Y.X.; Si, M.M.; Lu, W.; Zhang, L.X.; Zhou, C.X.; Deng, S.L.; Wu, H.S. E_ects and molecular mechanisms of the antidiabetic fraction of Acorus calamus L. On GLP-1 expression and secretion in vivo and in vitro. J. Ethnopharmacol. 2015, 166, 168–175.
  226. Kumar, D.; Bhat, Z.A.; Singh, P.; Khatanglakar, V.; Bhujbal, S.S. Antiasthmatic and antiallergic potential of methanolic extract of leaves of Ailanthus excelsa. Braz. J. Pharamacogn. 2011, 21, 139–145.
  227. Hepcy Kalarani, D.; Dinakar, A.; Senthilkumar, N. Antidiabetic, analgesic and anti-inflammatory activity of aqueous extracts of stem and leaves of Alangium salvifolium and Pavonia zeylanica. Int. J. Drug. Dev. Res. 2012, 4, 298–306.
  228. Hepcy Kalarani, D.; Dinakar, A.; Senthilkumar, N. Hypoglycemic and antidiabetic activity of Alangium salvifolium wang in alloxan induced diabetic rats. Asian J. Pharm. Clin. Res. 2011, 4, 131–133.
  229. Rao, N.K. Anti-hyperglycemic and renal protective activities of Andrographis paniculata roots chloroform extract. Iran. J. Pharmacol. Ther. 2006, 5, 47–50.
  230. Sani, Y.N.; Haque, M.; Suryati, K.; Mohd, K.W.; Khan, A. Isolation and characterisation of andrographolide from Andrographis paniculata (Burm. F) wall. Ex nees and its total flavonoid e_ects from Kemaman, Malaysia. Int. J. Pharm. Qual. Assur. 2017, 8, 119–124.
  231. Devgan, M.; Bhatia, L.; Kumar, H. Anthocephalus cadamba: A comprehensive review. Res. J. Pharm. Technol. 2012, 5, 1478–1483.
  232. Shaikh, S.; Dubey, R.; Dhande, S.; Joshi, Y.M.; Kadam, V.J. Phytochemical and pharmacological profile of Aphanamixis polystachya: An overview. Res. J. Pharm. Technol. 2012, 5, 1260–1263.
  233. Paulke, A.; Kremer, C.; Wunder, C.; Achenbach, J.; Djahanschiri, B.; Elias, A.; Stefan Schwed, J.; Hübner, H.; Gmeiner, P.; Proschak, E.; et al. Argyreia nervosa (Burm. F.): Receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches. J. Ethnopharmacol. 2013, 148, 492–497.
  234. Gupta, V.; Keshari, B.B.; Tiwari, S.K.; Narasimha Murthy, K.H.H.V.S.S. A review on antidiabetic action of Asanadi gana. Intern. J. Res. Ayurveda Pharm. 2013, 4, 638–646.
  235. Kaur, M.; Singh, G.; Mohan, C. Barringtonia acutangula: A traditional medicinal plant. Int. J. Pharm. Sci. Rev. Res. 2013, 23, 168–171.
  236. Jyothi, K.S.N.; Hemalatha, P.; Challa, S. Evaluation of _-amylase inhibitory potential of three medicinally important traditional wild food plants of India. Int. J. Green Pharm. 2011, 5, 95–99.
  237. Deepika, S.; Rajagopal, S.V. Evaluation of phytochemical and bioactive screening of Blepharis molluginifolia flower extracts. Intl. J. Pharma Bio Sci. 2014, 5, P204–P211.
  238. Savithramma, N.; Linga Rao, M.; Venkateswarlu, P. Histochemical studies of Boswellia ovalifoliolata Bal. & Henry—An endemic, endangered and threatened medicinal plant of Seshachalam Hill range of Eastern Ghats of India. Int. J. Pharmacogn. Phytochem. Res. 2014, 6, 1–6.
  239. Darsini, I.P.; Shamshad, S.; John Paul, M. Canna indica (L.): A plant with potential healing powers: A review. Intl. J. Pharma Bio Sci. 2015, 6, B1–B8.
  240. Kumar, D.; Kumar, S.; Gupta, J.; Arya, R.; Gupta, A. A review on chemical and biological properties of Cayratia trifolia Linn. (Vitaceae). Pharmacogn. Rev. 2011, 5, 184–188. 
  241. Alagawadi Kallangouda, R.; Shah Amol, S. Analgesic and antipyretic e_ects of Ceiba pentandra L. Seed extracts. Intl. J. Pharm. Res. 2012, 4, 46–49.
  242. Oyedemi, S.O.; Oyedemi, B.O.; Ijeh, I.I.; Ohanyerem, P.E.; Coopoosamy, R.M.; Aiyegoro, O.A. Alpha-amylase inhibition and antioxidative capacity of some antidiabetic plants used by the traditional healers in Southeastern Nigeria. Sci. World J. 2017, 2017, 3592491.
  243. Satyaprakash, R.J.; Rajesh, M.S.; Bhanumathy, M.; Harish, M.S.; Shivananda, T.N.; Shivaprasad, H.N.; Sushma, G. Hypoglycemic and antihyperglycemic e_ect of Ceiba pentandra L. Gaertn in normal and streptozotocin-induced diabetic rats. Ghana Med J 2013, 47, 121–127.
  244. Peltzer, K.; Sydara, K.; Pengpid, S. Traditional, complementary and alternative medicine use in a community population in lao pdr. Afr. J. Trad. Complement. Altern. Med. 2016, 13, 95–100.
  245. Fitrianda, E.; Sukandar, E.Y.; Elfahmi; Adnyana, I.K. Antidiabetic activity of extract, fractions, and asiaticoside compound isolated from Centella asiatica Linn. Leaves in alloxan-induced diabetic mice. Asian J. Pharm. Clin. Res. 2017, 10, 268–272.
  246. Maulidiani; Abas, F.; Khatib, A.; Perumal, V.; Suppaiah, V.; Ismail, A.; Hamid, M.; Shaari, K.; Lajis, N.H. Metabolic alteration in obese diabetes rats upon treatment with Centella asiatica extract. J. Ethnopharmacol. 2016, 180, 60–69.
  247. Paydar, M.; Moharam, B.A.; Wong, Y.L.; Looi, C.Y.; Wong, W.F.; Nyamathulla, S.; Pandy, V.; Kamalidehghan, B.; Arya, A. Centratherum anthelminticum (L.) kuntze a potential medicinal plant with pleiotropic pharmacological and biological activities. Int. J. Pharmacol. 2013, 9, 211–226.
  248. Thakur, G.S.; Bag, M.; Sanodiya, B.S.; Debnath, M.; Zacharia, A.; Bhadauriya, P.; Prasad, G.B.K.S.; Bisen, P.S. Chlorophytum borivilianum: A white gold for biopharmaceuticals and neutraceuticals. Curr. Pharm. Biotechnol. 2009, 10, 650–666.
  249. Kosai, P.; Sirisidthi, K.; Jiraungkoorskul, K.; Jiraungkoorskul,W. Review on ethnomedicinal uses of memory Boosting Herb, Butterfly Pea, Clitoria ternatea. J. Nat. Rem. 2015, 15, 71–76.
  250. Kavitha, R. Evaluation of hypoglycemic e_ect of ethanolic extracts of leaf and fruit of T. dioica and leaf of C. ternatea in streptozotocin induced diabetic rats. Intl. J. Pharma Bio Sci. 2014, 5, B1061–B1068.
  251. Ramakrishnan, G.; Kothai, R.; Jaykar, B.; Venkata Rathnakumar, T. In vitro antibacterial activity of different extracts of leaves of Coldenia procumbens. Int. J. Pharm. Res. 2011, 3, 1000–1004.
  252. Shirwaikar, A.; Rajendran, K.; Punitha, I.S.R. Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats. J. Ethnopharmacol. 2005, 97, 369–374.
  253. Rai, R.V.; Rajesh, P.S.; Kim, H.M. Medicinal use of Coscinium fenestratum (Gaertn.) colebr.: An short review. Orient. Pharm. Exp. Med. 2013, 13, 1–9.
  254. Mnif, S.; Aifa, S. Cumin (Cuminum cyminum L.) from traditional uses to potential biomedical applications. Chem. Biodivers. 2015, 12, 733–742.
  255. Sharma, P.; Dubey, G.; Kaushik, S. Chemical and medico-biological profile of Cyamopsis tetragonoloba (L) taub: An overview. J. Appl. Pharm. Sci. 2011, 1, 32–37.
  256. Golla, U.; Gajam, P.K.; Solomon Sunder Raj, B. The e_ect of Desmostachya bipinnata (Linn.) extract on physiologically altered glycemic status in non-diabetic rats. J. Med. Sci. 2013, 13, 221–225.
  257. Hardainiyan, S.; Nandy, B.C.; Kumar, K. Elaeocarpus ganitrus (Rudraksha): A reservoir plant with their pharmacological e_ects. Int. J. Pharm. Sci. Rev. Res. 2015, 34, 55–64.
  258. Kumari, S.J.; Sangeetha, M.; Pavithra, R. A retrospective review on Indian traditional herbs and its biocompounds in diabetes. Int. J. Pharm. Res. 2016, 9, 444–460.
  259. Febrinda, A.E.; Yuliana, N.D.; Ridwan, E.; Wresdiyati, T.; Astawan, M. Hyperglycemic control and diabetes complication preventive activities of bawang dayak (Eleutherine palmifolia L. Merr.) bulbs extracts in alloxan-diabetic rats. Int. Food Res. J. 2014, 21, 1405–1411.
  260. Sarma, U.; Borah, V.V.; Saikia, K.K.R.; Hazarika, N.K. Enhydra fluctuans: A review on its pharmacological importance as a medicinal plant and prevalence and use in North-East India. Int. J. Pharmcy Pharm. Sci. 2014, 6, 48–50.
  261. Samal, P.K.; Dangi, J.S.; Meena, K.P.; Beck, N.R.; Patel, A.; Maheshwari, G. Evaluation of analgesic activity of leaves extracts of Feronia limonia in experimental animal models. Res. J. Pharm. Technol. 2011, 4, 710–714.
  262. Veeraiah, S.; Jaganmohan Reddy, K. Current strategic approaches in ethnomedicinal plants of Tinospora cordifolia and Gloriosa superba—A review. Intl. J. Pharma Bio Sci. 2012, 3, 320–326.
  263. Ramesh Petchi, R.; Vijaya, C. Anti-diabetic and anti-arthritic potential of glycosmis pentaphylla stem bark in FCA induced arthritis and streptozotocin induced diabetic rats. Intl. J. Pharma Bio Sci. 2012, 3, P328–P336.
  264. Kulkarni, Y.; Veeranjaneyulu, A. Toxicological studies on aqueous extract of Gmelina arborea in rodents. Pharm. Biol. 2010, 48, 1413–1420.
  265. Attanayake, A.P.; Jayatilaka, K.A.P.W.; Pathirana, C.; Mudduwa, L.K.B. Gmelina arborea roxb. (family: Verbenaceae) extract upregulates the _-cell regeneration in stz induced diabetic rats. J. Dia. Res 2016, 2016.
  266. Devi, K.; Jain, N. Clinical evaluation of the anti-sweet e_ects of Gymnema sylvestre extract developed into a dispersable oral tablet. J. Herb. Med. 2015, 5, 184–189.
  267. Yadav, M.; Lavania, A.; Tomar, R.; Prasad, G.B.K.S.; Jain, S.; Yadav, H. Complementary and comparative study on hypoglycemic and antihyperglycemic activity of various extracts of Eugenia jambolana seed, Momordica charantia fruits, Gymnema sylvestre, and Trigonella foenum graecum seeds in rats. Appl. Biochem. Biotechnol. 2010, 160, 2388–2400.
  268. Mahalingam, G.; Kannabiran, K. Hemidesmus indicus root extract ameliorates diabetes-mediated metabolic changes in rats. Int. J. Green Pharm. 2009, 3, 314–318.
  269. Patra, J.K.; Thatoi, H. Anticancer activity and chromatography characterization of methanol extract of Heritiera fomes buch. Ham., a mangrove plant from Bhitarkanika, India. Orient. Pharm. Exp. Med. 2013, 13, 133–142.
  270. Kumarappan, C.; Mandal, S.C. Antidiabetic e_ect of polyphenol enriched extract of Ichnocarpus frutescens on key carbohydrate metabolic enzymes. Int. J. Diabetes Dev. Ctries. 2015, 35, 425–431.
  271. Vijay Simha, G.; Kumar, M.A.; Rajesh, S.; Panda, P.; Rao, M.M. Evaluation of physicochemical parameters of Imperata cylindrica (Linn) beauv root used in ayurvedic formulations. Res. J. Pharm. Technol. 2012, 5, 1352–1355.
  272. Prajapati, R.; Kalariya, M.; Parmar, S.; Sheth, N. Phytochemical and pharmacological review of Lagenaria sicereria. J. Ayurveda Integr. Med. 2010, 1, 266–272.
  273. Teugwa, C.M.; Boudjeko, T.; Tchinda, B.T.; Mejiato, P.C.; Zofou, D. Anti-hyperglycaemic globulins from selected Cucurbitaceae seeds used as antidiabetic medicinal plants in africa. BMC Complement. Altern. Med. 2013, 13, 63.
  274. Qazi Majaz, A.; Molvi Khurshid, I. A comprehensive review on meyna Laxiflora robyns (rubiaceae). Int. J. Pharm. Sci. Rev. Res. 2015, 35, 22–25.
  275. Petrus, A.J.A. Mukia maderaspatana (Linn.) M. Roemer: A potentially antidiabetic and vasoprotective functional leafy-vegetable. Pharm. J. 2012, 4, 1–12.
  276. Liu, S.; Li, D.; Huang, B.; Chen, Y.; Lu, X.;Wang, Y. Inhibition of pancreatic lipase, _-glucosidase, _-amylase, and hypolipidemic e_ects of the total flavonoids from Nelumbo nucifera leaves. J. Ethnopharmacol. 2013, 149, 263–269.
  277. Sharma, B.R.; Gautam, L.N.S.; Adhikari, D.; Karki, R. A comprehensive review on chemical profiling of Nelumbo nucifera: Potential for drug development. Phytother. Res. 2017, 31, 3–26.
  278. Mani, S.S.; Subramanian, I.P.; Pillai, S.S.; Muthusamy, K. Evaluation of hypoglycemic activity of inorganic constituents in Nelumbo nucifera seeds on streptozotocin-induced diabetes in rats. Biol. Trace Elem. Res. 2010, 138, 226–237.
  279. Amel, B. Traditional treatment of high blood pressure and diabetes in Souk Ahras District. J. Pharmacogn. Phytother. 2013, 5, 12–20.
  280. Malik, A.; Mehmood, M.H.; Akhtar, M.S.; Haider, G.; Gilani, A.H. Studies on antihyperlipidemic and endothelium modulatory activities of polyherbal formulation (POL4) and its ingredients in high fat diet-fed rats. Pak. J. Pharma. Sci. 2017, 30, 295–301.
  281. Desai, S.D.; Saheb, S.H.; Das, K.K.; Haseena, S. Phytochemical analysis of Nigella sativa and it’s antidiabetic effect. J. Pharm. Sci. Res. 2015, 7, 527–532.
  282. Meddah, B.; Ducroc, R.; El Abbes Faouzi, M.; Eto, B.; Mahraoui, L.; Benhaddou-Andaloussi, A.; Martineau, L.C.; Cherrah, Y.; Haddad, P.S. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J. Ethnopharmacol. 2009, 121, 419–424.
  283. Rangika, B.S.; Dayananda, P.D.; Peiris, D.C. Hypoglycemic and hypolipidemic activities of aqueous extract of flowers from Nycantus arbor-tristis L. in male mice. BMC Complement. Altern. Med. 2015, 15, 289.
  284. Ojha, D.; Mukherjee, H.; Mondal, S.; Jena, A.; Dwivedi, V.P.; Mondal, K.C.; Malhotra, B.; Samanta, A.; Chattopadhyay, D. Anti-inflammatory activity of Odina wodier Roxb, an indian folk remedy, through inhibition of toll-like receptor 4 signaling pathway. PLoS ONE 2014, 9, e104939.
  285. Ansarullah; Bharucha, B.; Patel, V.; Ramachandran, A.V. Oreocnide integrifolia (Gaud.) miq leaf water extract improves metabolic alterations in high fructose fed insulin resistant and hypertensive rats. Eur. J. Integr. Med. 2010, 2, 79–87.
  286. Dinda, B.; Silsarma, I.; Dinda, M.; Rudrapaul, P. Oroxylum indicum (L.) kurz, an important asian traditional medicine: From traditional uses to scientific data for its commercial exploitation. J. Ethnopharmacol. 2015, 161, 255–278.
  287. Karthishwaran, K.; Mirunalini, S. Therapeutic potential of Pergularia daemia (Forsk.): The ayurvedic wonder. Int. J. Pharmacol. 2010, 6, 836–843.
  288. Xu, Q.; Hu, Y.F.;Wang, D.L.; Xu, G.B.;Wang, N. Analysis on peucedani radix coumarin by UPLC/Q-TOF MS and study on its preliminary pharmacodynamics. Chin. Trad. Herb. Drugs 2015, 46, 3637–3642.
  289. Alkofahi, A.S.; Abdul-Razzak, K.K.; Alzoubi, K.H.; Khabour, O.F. Screening of the anti-hyperglycemic activity of some medicinal plants of jordan. Pak. J. Pharma. Sci. 2017, 30, 907–912.
  290. Ateeq, A.; Sunil, S.D.; Varun, S.K.; Santosh, M.K. Phoenix dactylifera linn.(pind kharjura): A review. Intern. J. Res. Ayurveda Pharm. 2013, 4, 447–451.
  291. Abdelaziz, D.H.A.; Ali, S.A. The protective e_ect of Phoenix dactylifera L. Seeds against CCL4-induced hepatotoxicity in rats. J. Ethnopharmacol. 2014, 155, 736–743.
  292. Raju, R.; Nambi, S.K.; Gurusamy, M. In vitro propagation of Pisonia grandis R. Br.: An indigenous vegetable and promising medicinal plant. Phytomorphology 2015, 65, 133–138.
  293. Jothy, S.L.; Choong, Y.S.; Saravanan, D.; Deivanai, S.; Latha, L.Y.; Vijayarathna, S.; Sasidharan, S. Polyalthia longifolia sonn: An ancient remedy to explore for novel therapeutic agents. Res. J. Pharm. Biol. Chem. Sci. 2013, 4, 714–730.
  294. 838. Satish Kumar, B.N. Phytochemistry and pharmacological studies of Pongamia pinnata (Linn.) pierre. Int. J. Pharm. Sci. Rev. Res. 2011, 9, 12–19.
  295. Dangi, K.S.; Mishra, S.N. Antihyperglycemic, antioxidant and hypolipidemic e_ect of Capparis aphylla stem extract in streptozotocin induced diabetic rats. Biol. Med. 2010, 2, 35–44.
  296. Lans, C.A. Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus. J. Ethnobiol. Ethnomedicine 2006, 2, 45.
  297. Chowdhary, C.V.; Meruva, A.; Naresh, K.; Elumalai, R.K.A.A review on phytochemical and pharmacological profile of Portulaca oleracea Linn. (purslane). Intern. J. Res. Ayurveda Pharm. 2013, 4, 34–37.
  298. Guenzet, A.; Krouf, D.; Berzou, S. Portulaca oleracea extract increases lecithin:Cholesterol acyltransferase and paraoxonase 1 activities and enhances reverse cholesterol transport in streptozotocin-induced diabetic rat. Pharm. J. 2014, 6, 1–9.
  299. Ramadan, B.K.; Schaalan, M.F.; Tolba, A.M. Hypoglycemic and pancreatic protective e_ects of Portulaca oleracea extract in alloxan induced diabetic rats. BMC Complement. Altern. Med. 2017, 17, 37.
  300. Tayade, P.M.; Chandrasekar, M.J.N.; Borde, S.N.; Joshi, A.S.; Angadi, S.S.; Devdhe, S.J. E_ect of Psoralea corylifolia Linn in sexual erectile dysfunction in diabetic rats. Orient. Pharm. Exp. Med. 2013, 13, 35–40.
  301. Mestry, S.N.; Juvekar, A.R. Aldose reductase inhibitory potential and anti-cataract activity of Punica granatum Linn. Leaves against glucose-induced cataractogenesis in goat eye lens. Orient. Pharm. Exp. Med. 2017, 17, 277–284.
  302. Pirbalouti, A.G.; Shahrzad, A.; Abed, K.; Hamedi, B. Wound healing activity of Malva sylvestris and Punica granatum in alloxan-induced diabetic rats. Acta Pol. Pharm. Drug Res. 2010, 67, 511–516.
  303. Salwe, K.J.; Sachdev, D.O.; Bahurupi, Y.; Kumarappan, M. Evaluation of antidiabetic, hypolipedimic and antioxidant activity of hydroalcoholic extract of leaves and fruit peel of Punica granatum in male wistar albino rats. J. Nat. Sci. Biol. Med. 2015, 6, 56–62.
  304. Sharma, R.; Yadav, D.; Asif, M.; Jayasri, M.A.; Agnihotri, V.K.; Ravikumar, P.C. Antidiabetic and antioxidant activities of Roylea cinerea extracts: A comparative study. Indian J. Exp. Biol. 2017, 55, 611–621.
  305. Devi Priya, M.; Siril, E.A. Traditional and modern use of indian madder (Rubia cordifolia L.): An overview. Int. J. Pharm. Sci. Rev. Res. 2014, 25, 154–164.
  306. Makhija, I.K.; Richard, L.; Kirti, S.P.; Saleemullah, K.; Jessy, M.; Annie, S. Sphaeranthus indicus: A review of its chemical, pharmacological and ethnomedicinal properties. Int. J. Pharmacol. 2011, 7, 171–179.
  307. Salunkhe, V.R.; Bhise, S.B. Stevia rebaudiana: An alternative to synthetic sweeteners. Indian Drugs 2010, 47, 5–13.
  308. Abudula, R.; Jeppesen, P.B.; Rolfsen, S.E.D.; Xiao, J.; Hermansen, K. Rebaudioside a potently stimulates insulin secretion from isolated mouse islets: Studies on the dose-, glucose-, and calcium-dependency. Metab. Clin. Exp. 2004, 53, 1378–1381.
  309. Havinga, R.M.; Hartl, A.; Putscher, J.; Prehsler, S.; Buchmann, C.; Vogl, C.R. Tamarindus indica L. (Fabaceae): Patterns of use in traditional african medicine. J. Ethnopharmacol. 2010, 127, 573–588.
  310. Park, C.H.; Noh, J.S.; Tanaka, T.; Uebaba, K.; Cho, E.J.; Yokozawa, T. The e_ects of corni fructus extract and its fractions against _-glucosidase inhibitory activities in vitro and sucrose tolerance in normal rats. Am. J. Chin. Med. 2011, 39, 367–380.
  311. Palbag, S.; Dey, B.K.; Singh, N.K. Ethnopharmacology, phytochemistry and pharmacology of Tephrosia purpurea. Chin. J. Nat. Med. 2014, 12, 1–7.
  312. Pavana, P.; Manoharan, S.; Renju, G.L.; Sethupathy, S. Antihyperglycemic and antihyperlipidemic effects of Tephrosia purpurea leaf extract in streptozotocin induced diabetic rats. J. Environ. Biol. 2007, 28, 833–837.
  313. Satyanarayana, T.; Sarita, T.; Balaji, M.; Ramesh, A.; Boini, M.K. Antihyperglycemic and hypoglycemic effect of Thespesia populnea fruit in normal and alloxan-induced diabetes in rabbits. Saudi Pharm. J. 2004, 12, 107–111.
  314. Mohamed Farook, S.; Clement Atlee,W. Antidiabetic and hypolipidemic potential of Tragia involucrata Linn. in streptozotocin-nicotinamide induced type II diabetic rats. Int. J. Pharmcy Pharm. Sci. 2011, 3, 103–109.
  315. Balekar, N.; Nakpheng, T.; Srichana, T. Wedelia trilobata L.: A phytochemical and pharmacological review. Chiang Mai J. Sci. 2014, 41, 590–605.
  316. Storme\ gemini
  317. http://www.alibaba.com/productgs/357477619/diabetic_herbal_tea.html (accessed July 11, 2011)
  318. http://www.alibaba.com/producttp/109604143/Herbal_diabetes_product.ht ml (accessed July 11, 2011)
  319. http://www.alibaba.com/productfree/103220828/Stevia_33_Diabetes_Herb al_Medicine.html (accessed July 11, 2011)
  320. http://www.alibaba.com/productfree/252036161/Diab_FIT_Herbal_FIT_fo r_Diabetes.html (accessed July 11, 2011)
  321. http://www.alibaba.com/productfree/11942265/ Herbal_Diabetes_Medicine_Madhumaar_Capsule_.html (accessed July 11, 2011)
  322. http://www.alibaba.com/productfree/111557110/daya_ston_powder_for_di abetes.html (accessed July 12, 2011)
  323. http://www.alibaba.com/productfree/108363205/herbal_medicine.html (accessed July 12, 2011)
  324. http://www.alibaba.com/productfree/109219085/Kumari_Saar.html (accessed July 12, 2011)
  325. http://www.alibaba.com/producttp/112065648/Herbal_Spenai_Antidiabetic_Remedy.html (accessed July 12, 2011)
  326. http://www.alibaba.com/producttp/105645757/Blueberry_Root.html (accessed July 12, 2011)
  327. http://www.alibaba.com/productfree/116570928/episulin_diabetic_medicin e.html (accessed July 12, 2011)

Reference

  1. WHO Expert committee on diabetes mellitus: second report, World Health Organ. Tech. Rep. Ser., 646, pp.1-80 (1980). 
  2. Diabetes Mellitus: Report of a WHO Study Group, World Health Organ. Tech. Rep. Ser. 727, pp. 1-113 (1985).
  3. Central Council for Research in Ayurveda and Siddha, Department of AYUSH, Ministry of Health and Family Welfare, New Delhi: HPTLC-Fingerprint atlas of Ayurvedic Single Plant Drugs mentioned in Ayurvedic Pharmacopoeia Vol-III and IV. Submitted to World Health Organization (WHO), India 2008;1-106.
  4. International Diabetes Federation: IDF diabetes Atlas, FifInternational Diabetes Federation: IDF diabetes Atlas, Fifth Edition 2011.
  5. Madur G. Mandatory rural practice proposed in India. BMJ 1995;311:1186. 
  6. Mehrotra R, Bajaj S, Kumar D. Use of complementary and alternative medicine by patients with diabetes mellitus. Natl Med J India 2004;17:243–5.
  7. Saxena, A.; Kishore V. N.; J. Alternat. Complement. Med. 2004, 10(2), 369. [4] Lee, H-S. J. Agric. Food Chem. 2002, 50, 7013.
  8. Matsuda, H.; Morikawa, T.; Yoshikawa, M. Pure Appl. Ch.
  9. Agrawal DP, Diabetes and traditional medicine: new research. [Online]. (2003). Available: www.infinityfoundation.com/ t es/t es agraw diabetes.html [November 3 2003]
  10. Malviya N, Jain S, Malviya S. Antidiabetic potential of medicinal plants. Acta Pol Pharm 2010; 67(2): 113-118.
  11. Zaloya GP,. Catecholamines in anesthetic and surgical stress.  Int Anesthesiol Clin. 1988;26:187-198.
  12. Nistrup-Madsen S, Engqueist A, Badawi I, Kehlet H, Cyclic AMP, glucose and cortisol in plasma drug during surgery, Horm Metab Res. 1976;69:1010-1018.
  13. Sharifi-Rad, M.; Nazaruk, J.; Polito, L.; Morais-Braga, M.F.B.; Rocha, J.E.; Coutinho, H.D.M.; Salehi, B.; Tabanelli, G.; Montanari, C.; del Mar Contreras, M.; et al. Matricaria genus as a source of antimicrobial agents: From farm to pharmacy and food applications. Microbiol. Res. 2018, 215, 76–88.
  14. Salehi, B.; Kumar, N.V.A.; ¸Sener, B.; Sharifi-Rad, M.; K?l?ç, M.; Mahady, G.B.; Vlaisavljevic, S.; Iriti, M.; Kobarfard, F.; Setzer, W.N. Medicinal plants used in the treatment of human immunodeficiency virus. Int. J. Mol. Sci. 2018, 19, 1459.
  15. Sharifi-Rad, M.; Salehi, B.; Sharifi-Rad, J.; Setzer, W.N.; Iriti, M. Pulicaria vulgaris Gaertn. essential oil: An alternative or complementary treatment for leishmaniasis. Cell. Mol. Biol. 2018, 64, 18–21.
  16. Arumugam, G.; Manjula, P.; Paari, N. A review: Anti diabetic medicinal plants used for diabetes mellitus. J. Acute Dis. 2013, 2, 196–200.
  17. Kooti, W.; Moradi, M.; Akbari, S.; Sharafi-Ahvazi, N.; AsadiSamani, M.; Ashtary-Larky, D. Therapeutic and pharmacological potential of Foeniculum vulgare Mill: A review. J. HerbMed Pharm. 2015, 4, 1–9.
  18. Afrisham, R.; Aberomand, M.; Gha_ari, M.; Siahpoosh, A.; Jamalan, M. Inhibitory e_ect of Heracleum persicum and Ziziphus jujuba on activity of alpha-amylase. J. Bot. 2015, 2015, 824683.
  19. Gupta, P.; De, A. Diabetes mellitus and its herbal treatment. Int. J. Res. Pharm. Biomed. Sci. 2012, 3, 706–721.
  20. Ni Y, Turner D, Yates KM, Tizard I. Isolation and characterization of structural components of Aloe vera L. leaf pulp. Int Immunopharmacol. 2004;4(14):1745–55.
  21. Krentz AJ, Bailey CJ (2005) Oral antidiabetic agents: current role in type 2 diabetes mellitus. Drugs 65:385–411
  22. Rahmatullah, M.; Hossain, M.; Mahmud, A.; Sultana, N.; Rahman, S.M.; Islam, M.R.; Khatoon, M.S.; Jahan, S.; Islam, F. Antihyperglycemic and antinociceptive activity evaluation of ‘khoyer’ prepared from boiling the wood of Acacia catechu in water. Afr. J. Tradit. Complement. Altern. Med. 2013, 10, 1–5.
  23. Jawla, S.; Kumar, Y.; Khan, M.S.Y. Antimicrobial and antihyperglycemic activities of Acacia modesta leaves. Pharmacologyonline 2011, 2, 331–347.
  24. Yasir, M.; Jain, P.; Debajyoti, D.; Kharya, M.D. Hypoglycemic and antihyperglycemic effect of different extracts of Acacia arabica lamk bark in normal and alloxan induced diabetic rats. Int. J. Phytomed. 2010, 2, 133–138.
  25. Zahidin, N.S.; Saidin, S.; Zulkifli, R.M.; Muhamad, I.I.; Ya’akob, H.; Nur, H. A review of Acalypha indica L.(Euphorbiaceae) as traditional medicinal plant and its therapeutic potential. J. Ethnopharmacol. 2017, 207, 146–173.
  26. Latiff, A.A.; Teoh, S.L.; Das, S. Wound healing in diabetes mellitus: Traditional treatment modalities. Clin. Ter. 2010, 161, 359–364.
  27. Rao, P.K.; Hasan, S.S.; Bhellum, B.L.; Manhas, R.K. Ethnomedicinal plants of Kathua district, J&K, India. J. Ethnopharmacol. 2015, 171, 12–27.
  28. Sudha, P.; Zinjarde, S.S.; Bhargava, S.Y.; Kumar, A.R. Potent ?-amylase inhibitory activity of Indian Ayurvedic medicinal plants. BMC Complement. Altern. Med. 2011, 11, 5.
  29. Mootoosamy, A.; Mahomoodally, M.F. Ethnomedicinal application of native remedies used against diabetes and related complications in Mauritius. J. Ethnopharmacol. 2014, 151, 413–444.
  30. Bhaludra, C.S.S.; Bethapudi, R.R.; Murugulla, A.C.; Pullagummi, C.; Latha, T.; Venkatesh, K.; Bheemagani, A.J.; Pudutha, A.; Rani, A.R. Cultivation, phytochemical studies, biological activities and medicinal uses of Aloe ferox, grandfather of aloes an important amazing medicinal plant. Int. J. Pharmacol. 2013, 9, 405–415.
  31. Rashidi, A.A.; Mirhashemi, S.M.; Taghizadeh, M.; Sarkhail, P. Iranian medicinal plants for diabetes mellitus: A systematic review. Pak. J. Biol. Sci. 2013, 16, 401–411.
  32. Kamel, F.O.; Magadmi, R.M.; Hagras, M.M.; Magadmi, B.; AlAhmad, R.A. Knowledge, attitude, and beliefs toward traditional herbal medicine use among diabetics in Jeddah Saudi Arabia. Complement. Ther. Clin. Pract. 2017, 29, 207–212.
  33. Xie, W.; Du, L. Diabetes is an inflammatory disease: Evidence from traditional Chinese medicines. Diabetes Obes. Metab. 2011, 13, 289–301Sharma, P.; Kharkwal, A.C.; Kharkwal, H.; Abdin, M.Z.; Varma, A. A review on pharmacological properties of Aloe vera. Int. J. Pharm. Sci. Rev. Res. 2014, 29, 31–37.
  34. Tripathi, P.; Swain, S.N. In-vitro antioxidant and free radical scavenging activity of Alpinia calcaratain Andaman Islands. Plant Arch. 2016, 16, 685–694.
  35. Arawwawala, L.D.A.M.; Arambewela, L.S.R.; Ratnasooriya, W.D. Alpinia calcarata Roscoe: A rich source of phytopharmaceuticals in Sri Lanka. Nat. Prod. J. 2012, 2, 263–269.
  36. Ayyanar, M.; Ignacimuthu, S. Ethnobotanical survey of medicinal plants commonly used by Kani tribals in Tirunelveli hills of Western Ghats, India. J. Ethnopharmacol. 2011, 134, 851–864.
  37. Ahuja, J.; Suresh, J.; Paramakrishnan, N.; Mruthunjaya, K.; Naganandhini, M.N. An ethnomedical, phytochemical and pharmacological profile of Artemisia parviflora roxb. J. Essent. Oil Bear. Plant. 2011, 14, 647–657.
  38. Mahomoodally, M.F.; Ramalingum, N. An investigation into the consumption patterns, attitude, and perception of Mauritians towards common medicinal food plants. J. Herb. Med. 2015, 5, 99–112.
  39. Chandrika, U.G.; Wedage, W.S.; Wickramasinghe, S.M.D.N.; Fernando, W.S. Hypoglycaemic action of the flavonoid fraction of Artocarpus heterophyllus leaf. Afr. J. Trad. Complement. Altern. Med. 2006, 3, 42–50.
  40. Kotowaroo, M.I.; Mahomoodally, M.F.; Gurib-Fakim, A.; Subratty, A.H. Screening of traditional antidiabetic medicinal plants of mauritius for possible ?-amylase inhibitory effects in vitro. Phytother. Res. 2006, 20, 228–231.
  41. Khan, I.; Najeebullah, S.; Ali, M.; Shinwari, Z. Phytopharmacological and ethnomedicinal uses of the genus Berberis (berberidaceae): A review. Trop. J. Pharm. Res. 2016, 15, 2047–2057.
  42. Maithani, A.; Parcha, V.; Kumar, D. Quantitative estimation of berberine content of berberis asiatica from different altitude of garhwalhimalaya. Asian J. Pharm. Clin. Res. 2014, 7, 165–167.
  43. Grover, J.K.; Yadav, S.; Vats, V. Medicinal plants of India with anti-diabetic potential. J. Ethnopharmacol. 2002, 81, 81–100.
  44. Roman-Ramos, R.; Flores-Saenz, J.L.; Alarcon-Aguilar, F.J. Anti-hyperglycemic effect of some edible plants. J. Ethnopharmacol. 1995, 48, 25–32.
  45. Cui, G.; Qin, X.; Zhang, Y.; Gong, Z.; Ge, B.; Zang, Y.Q. Berberine differentially modulates the activities of erk, p38 mapk, and jnk to suppress th17 and th1 t cell differentiation in type 1 diabetic mice. J. Biol. Chem. 2009, 284, 28420–28429.
  46. Namsa, N.D.; Mandal, M.; Tangjang, S.; Mandal, S.C. Ethnobotany of the monpa ethnic group at arunachalpradesh, india. J. Ethnobiol. Ethnomed. 2011, 7, 31.
  47. Kumar, M.; Malik, J. Pharmacognostical studies and evaluation of quality parameters of butea frondosa leaves. Int. J. Pharmcy Pharm. Sci. 2012, 4, 610–614.
  48. Bhutkar, M.A.; Bhise, S.B. In vitro assay of alpha amylase inhibitory activity of some indigenous plants.Int. J. Chem. Sci. 2012, 10, 457–462.
  49. Tag, H.; Kalita, P.; Dwivedi, P.; Das, A.K.; Namsa, N.D. Herbal medicines used in the treatment of diabetes mellitus in Arunachal Himalaya, Northeast, India. J. Ethnopharmacol. 2012, 141, 786–795.
  50. Ghosal, M.; Mandal, P. In-vitro antidiabetic and antioxidant activity of Calamus erectus roxb. Fruit: A wild plant of darjeelinghimalaya. Int. J. Pharma Bio Sci. 2013, 4, P671–P684.
  51. Parihar, G.; Balekar, N. Calotropis procera: A phytochemical and pharmacological review. Thai J. Pharm. Sci. 2016, 40, 115–131.
  52. Dangi, K.S.; Mishra, S.N. Antihyperglycemic, antioxidant and hypolipidemic effect of Capparis aphyllastem extract in streptozotocin induced diabetic rats. Biol. Med. 2010, 2, 35–44.
  53. Goyal, M. Traditional plants used for the treatment of diabetes mellitus in sursagar constituency, jodhpur, rajasthan—An ethnomedicinal survey. J. Ethnopharmacol. 2015, 174, 364–368.
  54. Selvamani, P.; Latha, S.; Elayaraja, K.; Babu, P.; Gupta, J.; Pal, T.; Ghosh, L.; Sen, D. Antidiabetic activity of the ethanol extract of Capparis sepiariaL. leaves. Indian J. Pharm. Sci. 2008, 70, 378–380.
  55. Sher, H.; Alyemeni, M.N. Ethnobotanical and pharmaceutical evaluation of Capparis spinosa L., validity of local folk and unani system of medicine. J. Med. Plant Res. 2010, 4, 1751–1756.
  56. Adnan, M.; Jan, S.; Mussarat, S.; Tariq, A.; Begum, S.; Afroz, A.; Shinwari, Z.K. A review on ethnobotany, phytochemistry and pharmacology of plant genus CarallumaR. Br. J. Pharm. Pharmacol. 2014, 66, 1351–1368.
  57. Bellamakondi, P.K.; Godavarthi, A.; Ibrahim, M. Anti-hyperglycemic activity of Carallumaumbellatahaw. BioImpacts2014, 4, 113–116.
  58. Singh,      A.;       Uppal, G.K.    A review on carissa carandas-phytochemistry, ethno-pharmacology, and micropropagation as conservation strategy. Asian J. Pharm. Clin. Res. 2015, 8, 26–30.
  59. Ayyanar, M.; Ignacimuthu, S. Pharmacological actions of Cassia auriculata L. And Cissus quadrangularis wall: A short review. J. Pharmacol. Toxicol. 2008, 3, 213–221.
  60. Thakur, M.; Asrani, R.K.; Thakur, S.; Sharma, P.K.; Patil, R.D.; Lal, B.; Parkash, O. Observations on traditional usage of ethnomedicinal plants in humans and animals of kangra and chamba districts of himachalpradesh in north-western himalaya, india. J. Ethnopharmacol. 2016, 191, 280–300.
  61. Boaduo, N.K.K.; Katerere, D.; Eloff, J.N.; Naidoo, V. Evaluation of six plant species used traditionally in the treatment and control of diabetes mellitus in south africa using in vitro methods. Pharm. Biol. 2014, 52, 756–761.
  62. Tarak, D.; Namsa, N.D.; Tangjang, S.; Arya, S.C.; Rajbonshi, B.; Samal, P.K.; Mandal, M. An inventory of the ethnobotanicals used as anti-diabetic by a rural community of Dhemaji district of Assam, Northeast India.Ethnopharmacol. 2011, 138, 345–350.
  63. Kar, A.; Choudhary, B.K.; Bandyopadhyay, N.G. Comparative evaluation of hypoglycaemic activity of some Indian medicinal plants in alloxan diabetic rats. J. Ethnopharmacol. 2003, 84, 105–108.
  64. Shihabudeen, H.M.S.; Priscilla, D.H.; Thirumurugan, K. Cinnamon extract inhibits ?-glucosidase activity and dampens postprandial glucose excursion in diabetic rats. Nutr. Metab. 2011, 8, 46.
  65. Shakthi Deve, A.; Sathish kumar, T.; Kumaresan, K.; Rapheal, V.S. Extraction process optimization of polyphenols from indianCitrus sinensis—As novel antiglycative agents in the management of diabetes mellitus. J. Diabetes Metab. Disord. 2014, 13, 11.
  66. Jadeja, R.N.; Thounaojam, M.C.; Ramani, U.V.; Devkar, R.V.; Ramachandran, A.V. Anti-obesity potential of clerodendronglandulosum.Coleb leaf aqueous extract. J. Ethnopharmacol. 2011, 135, 338–343.
  67. Barman, T.K.; Kalita, P.; Pal, T.K. Comparative evaluation of total flavonoid content and antioxidant activity of methanolic root extract of Clerodendrum infortunatumand methanolic whole plant extract of biophytumsensitivum. Int. J. Pharm. Sci. Rev. Res. 2013, 22, 62–6
  68. Mohan Maruga Raja, M.K.; Mishra, S.H. Comprehensive review of Clerodendrum phlomidis: A traditionally used bitter. J. Chin. Integr. Med. 2010, 8, 510–524.
  69. Kuriyan, R.; Rajendran, R.; Bantwal, G.; Kurpad, A.V. E_ect of supplementation of Coccinia cordifolia extract on newly detected diabetic patients. Diabetes Care 2008, 31, 216–220.
  70. Waisundara, V.Y.; Watawana, M.I. Evaluation of the antioxidant activity and additive e_ects of traditional medicinal herbs from sri lanka. Aust. J. Herb. Med. 2014, 26, 22–28
  71. Attanayake, A.P.; Jayatilaka, K.A.P.W.; Pathirana, C.; Mudduwa, L.K.B. Antihyperglycemic activity of Coccinia grandis (L.) voigt in streptozotocin induced diabetic rats. Indian J. Trad. Knowl. 2015, 14, 376–381.
  72. Pulbutr, P.; Saweeram, N.; Ittisan, T.; Intrama, H.; Jaruchotikamol, A.; Cushnie, B. In vitro ? -amylase and ?-glucosidase inhibitory activities of Coccinia grandis aqueous leaf and stem extracts. J. Biol. Sci. 2017, 17, 61–68.
  73. Krishnan, K.; Mathew, L.E.; Vijayalakshmi, N.R.; Helen, A. Anti-inflammatory potential of _-amyrin, a triterpenoid isolated from costus igneus. Inflammopharmacology 2014, 22, 373–385.
  74. Rege, A.; Ambaye, R.; Chowdhary, A. E_ect of Costus pictus D. Don on carbohydrate hydrolyzing enzymes. Int. J. Pharmcy Pharm. Sci. 2014, 6, 278–280.
  75. Govindarajan, R.; Vijayakumar, M.; Rao, C.V.; Pushpangadan, P.; Asare-Anane, H.; Persaud, S.; Jones, P.; Houghton, P.J. Antidiabetic activity of croton klozchianus in rats and direct stimulation of insulin secretion in-vitro. J. Pharm. Pharmacol. 2008, 60, 371–376.
  76. Okokon, J.E.; Bassey, A.L.; Obot, J. Antidiabetic activity of ethanolic leaf extract of croton zambesicus muell. (thunder plant) in alloxan diabetic rats. Afr. J. Trad. Complement. Altern. Med. 2006, 3, 21–26
  77. Panwar, N.S.; Pradheep, K.; Bhatt, K.C.; Deswal, R.P.S. Ethnobotany of a threatened medicinal plant “indravan” (Cucumis callosus) from central india. Med. Plants 2014, 6, 307–309.
  78. Thakur, M.; Chauhan, N.S.; Sharma, V.; Dixit, V.K.; Bhargava, S. E_ect of curculigo orchioides on hyperglycemia-induced oligospermia and sexual dysfunction in male rats. Int. J. Impot. Res. 2012, 24, 31–37.
  79. Sushma, S.M.; Sharath, R.; Sujan Ganapathy, P.S.; Sivakamisundari, P.; Preetham, J. Pharmacognostic and phytochemical evaluation of Curcuma angustifolia roxb. (rhizome) indigenous ethno-medicinal plant used by tribal soliga community of biligirirangana hills. Int. J. Pharmacogn. Phytochem. Res. 2015, 7, 820–824.
  80. Mishra, R.; Shuaib, M.; Shravan; Mishra, P.S. A review on herbal antidiabetic drugs. J. Appl. Pharm. Sci. 2011, 1, 235–237.
  81. Rafe, M.R. A review of five traditionally used anti-diabetic plants of Bangladesh and their pharmacological activities. Asian Pac. J. Trop. Med. 2017, 10, 933–939.
  82. Gao, J.M.; Li, R.; Zhang, L.; Jia, L.L.; Ying, X.X.; Dou, D.Q.; Li, J.C.; Li, H.B. Cuscuta chinensis seeds water extraction protecting murine osteoblastic mc3t3-e1 cells against tertiary butyl hydroperoxide induced injury. J. Ethnopharmacol. 2013, 148, 587–595.
  83. Lans, C.A. Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus. J. Ethnobiol. Ethnomedicine 2006, 2, 45.
  84. Sudipta, B.; Kumar, D.S.; Goutam, P.; Monalisha, D. Evaluation of antidiabetic activity and histological study of cyperus kyllinga endl. Roots. Ind. J. Nat. Prod. Resour. 2012, 3, 343–346.
  85. Elshamy, A.I.; El-Shazly, M.; Yassine, Y.M.; El-Bana, M.A.; Farrag, A.R.; Nassar, M.I.; Singab, A.N.; Noji, M.; Umeyama, A. Phenolic constituents, anti-inflammatory and antidiabetic activities of Cyperus laevigatus L. Pharm. J. 2014, 9, 828–833.
  86. Pirzada, A.M.; Ali, H.H.; Naeem, M.; Latif, M.; Bukhari, A.H.; Tanveer, A. Cyperus rotundus L.: Traditional uses, phytochemistry, and pharmacological activities. J. Ethnopharmacol. 2015, 174, 540–560.
  87. Nithya Devi, M.; Brindha, P. Herbal nutraceuticals in the management of cancer and chronic diseases—A select study. Int. J. Pharmcy Pharm. Sci. 2014, 6, 104–106.
  88. Rastogi, S.; Pandey, M.M.; Rawat, A.K.S. An ethnomedicinal, phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. And Desmodium adscendens (Sw.) DC. J. Ethnopharmacol. 2011, 136, 283–296.
  89. Pi, W.X.; Feng, X.P.; Ye, L.H.; Cai, B.C. Combination of morroniside and diosgenin prevents high glucose-induced cardiomyocytes apoptosis. Molecules 2017, 22, 163.
  90. Kiran Kumar, A.N.D.E.; Gowrishankar, N.L.; Manju Bhargavi, V.; Nagarjuna, M.; Rajani, G.; Swetha, Y.; Vinay Reddy, P. Evaluation of anti ulcer activity of ethanol extract of Diospyros melanoxylon (roxb). Bark. Int. J. Pharmcy Pharm. Sci. 2012, 4, 537–539.
  91. Dewanjee, S.; Maiti, A.; Sahu, R.; Dua, T.K.; Mandal, V. E_ective control of type 2 diabetes through antioxidant defense by edible fruits of diospyros peregrina. Evid.-Based Complement. Altern. Med. 2011, 2011.
  92. Das, M.; Bandyopadhyay, A. Promising phytomedicines from Elephantopus scaber L: A review. Res. J. Pharm. Biol. Chem. Sci. 2015, 6, 1508–1518.
  93. Ooi, K.L.; Muhammad, T.S.T.; Tan, M.L.; Sulaiman, S.F. Cytotoxic, apoptotic and anti-_-glucosidase activities of 3,4-di-o-ca_eoyl quinic acid, an antioxidant isolated from the polyphenolic-rich extract of elephantopus mollis kunth. J. Ethnopharmacol. 2011, 135, 685–695.
  94. Miura, T.; Kato, A. Hypoglycémie action ofembelia madagascariensis in normal and diabetic mice. Am. J. Chin. Med. 1997, 25, 169–173.
  95. Bhandari, U.; Jain, N.; Ansari, M.N.; Pillai, K.K. Beneficial e_ect of embelia ribes ethanolic extract on blood pressure and glycosylated hemoglobin in streptozotocin-induced diabetes in rats. Fitoterapia 2008, 79, 351–355.
  96. Ratnasooriya, W.D.; Somarathna, K.I.W.K.; Premakumara, G.A.S.; Ediriweera, E.R.H.S.S. Lack of antiglycation activity of fresh juice of whole plant of Enicostema axillare (lam.) raynal. J. Pharm. Negat. Results 2011, 2, 55–57.
  97. Tripathi, A.K.; Bhoyar, P.K.; Baheti, J.R.; Biyani, D.M.; Khalique, M.; Kothmire, M.S.; Amgaonkar, Y.M.; Bhanarkar, A.B. Herbal antidiabetics: A review. Int. J. Res. Pharm. Sci. 2011, 2, 30–37.
  98. Vadivel, V.; Biesalski, H.K. Phenolic content in traditionally processed Erythrina indica L. Seeds: Antioxidant potential and type ii diabetes related functionality. Curr. Nutr. Food Sci. 2011, 7, 200–208.
  99. Kumar, P.; Mehta, M.; Satija, S.; Garg, M. Enzymatic in vitro anti-diabetic activity of few traditional Indian medicinal plants. J. Biol. Sci. 2013, 13, 540–544.
  100. Jerang, G.; Swamy, B.M.V.; Kotagiri, S.; Dey, T.; Fariyaz, S.M. Indian medicinal plants with antidiabetic and related beneficial e_ects: A review. Res. J. Pharm. Biol. Chem. Sci. 2015, 6, 31–38.
  101. Lelono, R.A.A.; Tachibana, S. Preliminary studies of indonesian eugenia polyantha leaf extracts as inhibitors of key enzymes for type 2 diabetes. J. Med. Sci. 2013, 13, 103–110.
  102. Goyal, M.; Sasmal, D.; Nagori, B.P. Review on medicinal plants used by local community of Jodhpur district of Thar desert. Int. J. Pharmacol. 2011, 7, 333–339.
  103. Cristians, S.; Osuna-Fernández, H.R.; Ramírez-Ávila, G.; Muñóz-Ocotero, V.; Laguna-Hernández, G.; Brechú-Franco, A.E. Euphorbia dioeca kunth as a novel source for _-glucosidase inhibitors. Bol. Lat. Y Del Caribe De Plant. Med. Y Aromat. 2015, 14, 483–490.
  104. Gulati, V.; Harding, I.H.; Palombo, E.A. Enzyme inhibitory and antioxidant activities of traditional medicinal plants: Potential application in the management of hyperglycemia. BMC Complement. Altern. Med. 2012, 12, 77
  105. Bhatia, H.; Sharma, Y.P.; Manhas, R.K.; Kumar, K. Ethnomedicinal plants used by the villagers of district Udhampur, J&K, India. J. Ethnopharmacol. 2014, 151, 1005–1018.
  106. Hossan, M.S.; Hanif, A.; Khan, M.; Bari, S.; Jahan, R.; Rahmatullah, M. Ethnobotanical survey of the Tripura tribe of Bangladesh. Am. Eurasian J. Sustain. Agric. 2009, 3, 253–261.
  107. Kunwar, R.M.; Shrestha, K.P.; Bussmann, R.W. Traditional herbal medicine in Far-west Nepal: A pharmacological appraisal. J. Ethnobiol. Ethnomedicine 2010, 6, 35
  108. Sharma, V. Microscopic studies and preliminary pharmacognostical evaluation of Euphorbia neriifolia L. Leaves. Ind. J. Nat. Prod. Resour. 2013, 4, 348–357.
  109. Alarcon-Aguilara, F.J.; Roman-Ramos, R.; Perez-Gutierrez, S.; Aguilar-Contreras, A.; Contreras-Weber, C.C.; Flores-Saenz, J.L. Study of the anti-hyperglycemic e_ect of plants used as antidiabetics. J. Ethnopharmacol. 1998, 61, 101–110.
  110. Kareparamban, J.A.; Nikam, P.H.; Jadhav, A.P.; Kadam, V.J. Ferula foetida “hing”: A review. Res. J. Pharm. Biol. Chem. Sci. 2012, 3, 775–786.
  111. Zare, A.R.; Omidi, M.; Fallah Hoseini, H.; Yazdani, D.; Sh, R.; Irvani, N.; Oladzad, A. A review on pharmacological e_ects of Ferula assa-foetida L.: A systematic review. J. Med. Plants 2011, 10, 17–25.
  112. Arunachalam, K.; Parimelazhagan, T. Antidiabetic activity of ficus amplissima smith. Bark extract in streptozotocin induced diabetic rats. J. Ethnopharmacol. 2013, 147, 302–310.
  113. Lelono, R.A.A.; Tachibana, S. Preliminary studies of indonesian eugenia polyantha leaf extracts as inhibitors of key enzymes for type 2 diabetes. J. Med. Sci. 2013, 13, 103–110
  114. Joseph, B.; Justin Raj, S. Phytopharmacological and phytochemical properties of three ficus species—An overview. Int. J. Pharma Bio Sci. 2010, 1, 246–253.
  115. Joseph, B.; Justin Raj, S. Pharmacognostic and phytochemical properties of Ficus carica linn—An overview. Int. J. Pharm. Res. 2011, 3, 8–12.
  116. Badgujar, S.B.; Patel, V.V.; Bandivdekar, A.H.; Mahajan, R.T. Traditional uses, phytochemistry and pharmacology of ficus carica: A review. Pharm. Biol. 2014, 52, 1487–1503.
  117. Marwat, S.K.; Fazal Ur, R.; Khan, E.A.; Khakwani, A.A.; Ullah, I.; Khan, K.U.; Khan, I.U. Useful ethnophytomedicinal recipes of angiosperms used against diabetes in south east asian countries (india, pakistan & sri lanka). Pak. J. Pharma. Sci. 2014, 27, 1333–1358.
  118. Vaishnav, R.; Agrawal, R.D.; Sandeep, S. Medicinal value and future perspective of some therapeutically important plants from indian western region. Int. J. Pharm. Sci. Rev. Res. 2015, 34, 88–93.
  119. Singh, D.; Mukhija, M.; Singh, S.; Aggarwal, A.; Sundriyal, A. Anti-diabetic e_ect of hydroalcoholic extract of Ficus palmata forsk leaves in streptozotocin-induced diabetic rats. Int. J. Green Pharm. 2014, 8, 276–282.
  120. Trinh, B.T.D.; Staerk, D.; Jäger, A.K. Screening for potential _-glucosidase and _-amylase inhibitory constituents from selected Vietnamese plants used to treat type 2 diabetes. J. Ethnopharmacol. 2016, 186, 189–195.
  121. Shah, S.K.; Garg, G.; Jhade, D.; Pandey, H. Ficus racemosa linn: Its potentials food security and rural medicinal management. J. Pharm. Sci. Res. 2016, 8, 317–322.
  122. Babu, K.; Gokul Shankar, S.; Rai, S. Comparative pharmacognostic studies on the barks of four ficus species. Turk. J. Bot. 2010, 34, 215–224.
  123. Pandit, S.; Ponnusankar, S.; Bandyopadhyay, A.; Ota, S.; Mukherjee, P.K. Exploring the possible metabolism mediated interaction of glycyrrhiza glabra extract with cyp3a4 and cyp2d6. Phytother. Res. 2011, 25, 1429–1434
  124. Lee, M.; Son, M.; Ryu, E.; Shin, Y.S.; Kim, J.G.; Kang, B.W.; Cho, H.; Kang, H. Quercetin-induced apoptosis prevents ebv infection. Oncotarget 2015, 6, 12603–12624.
  125. Shukla, R.; Sharma, D.C.; Baig, M.H.; Bano, S.; Roy, S.; Provazník, I.; Kamal, M.A. Antioxidant, antimicrobial activity and medicinal properties of Grewia asiatica L. Med. Chem. 2016, 12, 211–216.
  126. Natarajan, A.; Sugumar, S.; Bitragunta, S.; Balasubramanyan, N. Molecular docking studies of (4z,12z)-cyclopentadeca-4, 12-dienone from grewia hirsuta with some targets related to type 2 diabetes. BMC Complement. Altern. Med. 2015, 15, 73.
  127. Meena, S.N.; Ghadi, S.C.; Janarthanam, M.K. Evaluation of medicinal properties of Grewia nervosa (lour.) panigrahi. Int. J. Pharma Bio Sci. 2013, 4, P821–P828.
  128. Varghese, E.; Pappachen, K.L.; Narayanan, S.S. Isolation and evaluation of antimicrobial properties of isolated phytoconstituents of fruits of Helicteres isora linn. Res. J. Pharm., Biol. Chem. Sci. 2012, 3, 959–964.
  129. Sinha, S.; Sharma, A.; Hemalatha Reddy, P.; Rathi, B.; Prasad, N.V.S.R.K.; Vashishtha, A. Evaluation of phytochemical and pharmacological aspects of Holarrhena antidysenterica (wall.): A comprehensive review. J. Pharm. Res. 2013, 6, 488–492.
  130. Balamurugan, R.; Vendan, S.E.; Aravinthan, A.; Kim, J.H. Isolation and structural characterization of 2r, 3r taxifolin 3-o-rhamnoside from ethyl acetate extract of hydnocarpus alpina and its hypoglycemic e_ect by attenuating hepatic key enzymes of glucose metabolism in streptozotocin-induced diabetic rats. Biochimie 2015, 111, 70–81.
  131. Reddy, S.V.; Tiwari, A.K.; Kumar, U.S.; Rao, R.J.; Rao, J.M. Free radical scavenging, enzyme inhibitory constituents from antidiabetic ayurvedic medicinal plant hydnocarpus wightiana blume. Phytother. Res. 2005, 19, 277–281
  132. Hanif, A.; Hossan, M.S.; Mia, M.M.K.; Islam, M.J.; Jahan, R.; Rahmatullah, M. Ethnobotanical survey of the rakhain tribe inhabiting the chittagong hill tracts region of bangladesh. Am. Eurasian J. Sustain. Agric. 2009, 3, 172–180.
  133. Bavarva, J.H.; Narasimhacharya, A.V.R.L. Leucas cephalotes regulates carbohydrate and lipid metabolism and improves antioxidant status in iddm and niddm rats. J. Ethnopharmacol. 2010, 127, 98–102.4
  134. Aderibigbe, A.O.; Emudianughe, T.S.; Lawal, B.A.S. Antihyperglycaemic e_ect of mangifera indica in rat. Phytother. Res. 1999, 13, 504–507.
  135. Ranganathan, R.; Vijayalakshmi, R.; Parameswari, P. Ethnomedicinal survey of jawadhu hills in tamil nadu. Asian J. Pharm. Clin. Res. 2012, 5, 45–49.
  136. Marimuthu, S.; Padmaja, B.; Nair, S. Phytochemical screening studies on melia orientalis by gc-ms analysis. Pharmacogn. Res. 2013, 5, 216–218.
  137. Rao, P.K.; Hasan, S.S.; Bhellum, B.L.; Manhas, R.K. Ethnomedicinal plants of Kathua district, J&K, India. J. Ethnopharmacol. 2015, 171, 12–27.
  138. Ganu, G.P.; Jadhav, S.S.; Deshpande, A.D. Antioxidant and antihyperglycemic potential of methanolic extract of bark of Mimusops elengi L. In mice. Int. J. Phytomed. 2010, 2, 116–123.
  139. Mina, E.C.; Mina, J.F. Ethnobotanical survey of plants commonly used for diabetes in tarlac of central Luzon Philippines. Int. Med. J. Malays. 2017, 16, 21–28.
  140. Tran, M.H.; Hoang, D.M.; Minh, P.T.H.; Ui, J.Y.; Na, M.; Won, K.O.; Byung, S.M.; Bae, K. _-amylase and protein tyrosine phosphatase 1B inhibitory of some Vietnamese medicinal plants used to treat diabetes. Nat. Prod. Sci. 2007, 13, 311–316.
  141. Ocvirk, S.; Kistler, M.; Khan, S.; Talukder, S.H.; Hauner, H. Traditional medicinal plants used for the treatment of diabetes in rural and urban areas of Dhaka, Bangladesh—An ethnobotanical survey. J. Ethnobiol. Ethnomedicine 2013, 9, 43.
  142. Rammal, H.; Bouayed, J.; Desor, F.; Younos, C.; Soulimani, R. A study of the anti-hyperglycaemic e_ects of the medicinal plant, Momordica charantia L.: Validation and contribution. Phytotherapie 2009, 7, 191–196.
  143. Kunyanga, C.N.; Imungi, J.K.; Okoth, M.W.; Biesalski, H.K.; Vadivel, V. Total phenolic content, antioxidant and antidiabetic properties of methanolic extract of raw and traditionally processed Kenyan indigenous food ingredients. LWT Food Sci. Technol. 2012, 45, 269–276
  144. Semenya, S.; Potgieter, M.; Erasmus, L. Ethnobotanical survey of medicinal plants used by Bapedi healers to treat diabetes mellitus in the Limpopo Province, South Africa. J. Ethnopharmacol. 2012, 141, 440–445.
  145. Maiti, R.; Rodriguez, H.G.; Kumari, C.A.; Sarkar, N.C. Macro and micro-nutrient contents of 18 medicinal plants used traditionally to alleviate diabetes in nuevo leon, northeast of mexico. Pak. J. Bot. 2016, 48, 271–276.
  146. Umar, A.N.; Mann, A.; Ajiboso, O.S.O. Ethnodietetics of moringa oleifera leaves amongst the ethnic groups in bida, niger state, nigeria and its hypoglycaemic e_ects in rats. Am. Eurasian J. Sustain. Agric. 2011, 5, 107–114.
  147. Hasani-Ranjbar, S.; Larijani, B.; Abdollah, M. A systematic review of Iranian medicinal plants useful in diabetes mellitus. Arch. Med. Sci. 2008, 4, 285–292.
  148. Chichioco-Hernandez, C.; Wudarski, J.; Gevaert, L.; Verschaeve, L. Evaluation of cytotoxicity and genotoxicity of some Philippine medicinal plants. Pharmacogn. Mag. 2011, 7, 171–175.
  149. Devi, B.; Sharma, N.; Kumar, D.; Jeet, K. Morus alba linn: A phytopharmacological review. Int. J. Pharmcy Pharm. Sci. 2013, 5, 14–18.
  150. Cai, S.; Sun,W.; Fan, Y.; Guo, X.; Xu, G.; Xu, T.; Hou, Y.; Zhao, B.; Feng, X.; Liu, T. E_ect of mulberry leaf (folium mori) on insulin resistance via irs-1/pi3k/glut-4 signalling pathway in type 2 diabetes mellitus rats. Pharm. Biol. 2016, 54, 2685–2691.
  151. Mussarat, S.; Abdel-Salam, N.M.; Tariq, A.; Wazir, S.M.; Ullah, R.; Adnan, M. Use of ethnomedicinal plants by the people living around indus river. Evid.-Based Complement. Altern. Med. 2014, 2014.
  152. Oh, K.S.; Ryu, S.Y.; Lee, S.; Seo,H.W.; Oh, B.K.; Kim,Y.S.; Lee, B.H. Melanin-concentrating hormone-1 receptor antagonism and anti-obesity e_ects of ethanolic extract from morus alba leaves in diet-induced obese mice. J. Ethnopharmacol. 2009, 122, 216–220. [CrossRef]
  153. Lemus, I.; García, R.; Delvillar, E.; Knop, G. Hypoglycaemic activity of four plants used in chilean popular medicine. Phytother. Res. 1999, 13, 91–94.
  154. Adisakwattana, S.; Ruengsamran, T.; Kampa, P.; Sompong, W. In vitro inhibitory e_ects of plant-based foods and their combinations on intestinal _-glucosidase and pancreatic _-amylase. BMC Complement. Altern. Med. 2012, 12, 110.
  155. Yin, N.; Hong, X.; Han, Y.; Duan, Y.; Zhang, Y.; Chen, Z. Cortex mori radicis extract induces neurite outgrowth in pc12 cells activating erk signaling pathway via inhibiting ca2+ influx. Int. J. Clin. Exp. Med.2015, 8, 5022–5032.
  156. Kamat, N.; Pearline, D.; Thiagarajan, P. Murraya koenigii (L.) (curry leaf): A traditional indian plant. Res. J. Pharm. Biol. Chem. Sci. 2015, 6, 691–697.
  157. Egesie, U.G.; Adelaiye, A.B.; Ibu, J.O.; Egesie, O.J. Safety and hypoglycaemic properties of aqueous leaf extract of ocimum gratissimum in streptozotocin induced diabetic rats. Niger. J. Physiol. Sci. 2006, 21, 31–35.
  158. Hong, C.E.; Lyu, S.Y. Evaluation of the mutagenic properties of two lignans from Acanthopanax koreanum Nakai. Toxicol. Res. 2013, 29, 279–283.
  159. Saito, T.; Nishida, M.; Saito, M.; Tanabe, A.; Eitsuka, T.; Yuan, S.H.; Ikekawa, N.; Nishida, H. The fruit of Acanthopanax senticosus (Rupr. et Maxim.) Harms improves insulin resistance and hepatic lipid accumulation by modulation of liver adenosine monophosphate–activated protein kinase activity and lipogenic gene expression in high-fat diet–fed obese mice. Nutr. Res. 2016, 36, 1090–1097.
  160. Upadhyay, R.K. Tulsi: A holy plant with high medicinal and therapeutic value. Int. J. Green Pharm. 2017, 11, S1–S12.
  161. Mahajan, N.; Rawal, S.; Verma, M.; Poddar, M.; Alok, S. A phytopharmacological overview on ocimum species with special emphasis on ocimum sanctum. Biomed. Prev. Nutr. 2013, 3, 185–192.
  162. Wang, L.; Jiang, Y.; Han, T.; Zheng, C.; Qin, L. A phytochemical, pharmacological and clinical profile of paederia foetida and p. Scandens. Nat. Pro. Comm. 2014, 9, 879–886.
  163. Madhavan, V.; Nagar, J.C.; Murali, A.; Mythreyi, R.; Yoganarasimhan, S.N. Antihyperglycemic activity of alcohol and aqueous extracts of pandanus fascicularis lam. Roots in alloxan induced diabetic rats. Pharmacologyonline 2008, 3, 529–536.
  164. Englberger, L.; Schierle, J.; Hofmann, P.; Lorens, A.; Albert, K.; Levendusky, A.; Paul, Y.; Lickaneth, E.; Elymore, A.; Maddison, M.; et al. Carotenoid and vitamin content of micronesian atoll foods: Pandanus (Pandanus tectorius) and garlic pear (crataeva speciosa) fruit. J. Food Compos. Anal. 2009, 22, 1–8.
  165. Tokunaga, M.; Matsuda, H.; Iwahashi, H.; Naruto, S.; Tsuruoka, T.; Yagi, H.; Masuko, T.; Kubo, M. Studies on palauan medicinal herbs. Iv. Immunopotentiatory activities of ongael, leaves of phaleria cumingii (meisn.) f. Vill. In diabetic mice. J. Tradit. Med. 2006, 23, 24–26.
  166. Tarafdar, R.G.; Nath, S.; Talukdar, A.D.; Choudhury, M.D. Antidiabetic plants used among the ethnic communities of Unakoti district of Tripura, India. J. Ethnopharmacol. 2015, 160, 219–226.
  167. Baliga, M.S.; Meera, S.; Mathai, B.; Rai, M.P.; Pawar, V.; Palatty, P.L. Scientific validation of the ethnomedicinal properties of the ayurvedic drug triphala: A review. Chin. J. Integr. Med. 2012, 18, 946–954.
  168. Muthulakshmi, S.; Bhavani, K.; Manju, R.; Mohamed Shahila, N.A. Hepatoprotective activity of Phyllanthus gardnerianus (wight) baill. Against d-galactosamine induced hepatotoxicity. Biomedicine 2014, 34, 36–44.
  169. Hashim, A.; Khan, M.S.; Khan, M.S.; Baig, M.H.; Ahmad, S. Antioxidant and _; ylase inhibitory property of Phyllanthus virgatus L.: An in vitro and molecular interaction study. BioMed Res. Int. 2013, 2013, 729393.
  170. Ramasamy, S.; AbdulWahab, N.; Zainal Abidin, N.; Manickam, S. E_ect of extracts from Phyllanthus watsonii airy shaw on cell apoptosis in cultured human breast cancer mcf-7 cells. Exp. Toxicol. Pathol. 2013, 65, 341–349.
  171. Sharma, N.; Bano, A.; Dhaliwal, H.S.; Sharma, V. A pharmacological comprehensive review on ‘rassbhary’ Physalis angulata (L.). Int. J. Pharmcy Pharm. Sci. 2015, 7, 34–38.
  172. Maobe, M.A.G.; Gitu, L.; Gatebe, E.; Rotich, H.; Karanja, P.N.; Votha, D.M.; Nderitu, I.W.; Kungu, W. Antifungal activity of eight selected medicinal herbs used for the treatment of diabetes, malaria and pneumonia in kisii region, southwest kenya. World J. Med. Sci. 2013, 8, 74–78.
  173. Mahabub, A.H.; Hossain, M.; Karim, M.; Khan, M.; Jahan, R.; Rahmatullah, M. An ethnobotanical survey of jessore district in khulna division, bangladesh. Am. Eurasian J. Sustain. Agric. 2009, 3, 238–243.
  174. Srivastava, A.; Karthick, T.; Joshi, B.D.; Mishra, R.; Tandon, P.; Ayala, A.P.; Ellena, J. Spectroscopic (far or terahertz, mid-infrared and Raman) investigation, thermal analysis and biological activity of piplartine. Spectrochim. Acta Part A Mol. Biomol. Spectrosc. 2017, 184, 368–381.
  175. Manoharan, S.; Silvan, S.; Vasudevan, K.; Balakrishnan, S. Antihyperglycemic and antilipidperoxidative effects of Piper longum (linn.) dried fruits in alloxan induced diabetic rat. J. Biol. Sci. 2007, 7, 161–168.
  176. Ashish, B.; Swapnil, G. Hypoglycemic e_ect of polyherbal formulation in alloxan induced diabetic rats. Pharmacologyonline 2011, 3, 764–773.
  177. Sh Ahmed, A.; Ahmed, Q.U.; Saxena, A.K.; Jamal, P. Evaluation of in vitro antidiabetic and antioxidant characterizations of Elettaria cardamomum (L.) maton (zingiberaceae), Piper cubeba L. F. (piperaceae), and Plumeria rubra L. (apocynaceae). Pak. J. Pharma. Sci. 2017, 30, 113–126.
  178. Bulle, S.; Reddyvari, H.; Nallanchakravarthula, V.; Vaddi, D.R. Therapeutic potential of Pterocarpus santalinus L.: An update. Pharmacogn. Rev. 2016, 10, 43–49.
  179. Modak, M.; Dixit, P.; Londhe, J.; Ghaskadbi, S.; Devasagayam, T.P.A. Indian herbs and herbal drugs used for the treatment of diabetes. J. Clin. Biochem. Nutr. 2007, 40, 163–173.
  180. Tchamadeu, M.C.; Dzeufiet, P.D.D.; Nana, P.; Kouambou Nouga, C.C.; Ngueguim Tsofack, F.; Allard, J.; Blaes, N.; Siagat, R.; Zapfack, L.; Girolami, J.P.; et al. Acute and sub-chronic oral toxicity studies of an aqueous stem bark extract of Pterocarpus soyauxii taub (papilionaceae) in rodents. J. Ethnopharmacol. 2011, 133, 329–335.
  181. Hephzibah Christabel, P.; Gopalakrishnan, V.K. Enzyme inhibitors from Prunus persica (L.) batsch: An alternate approach to treat diabetes. Intl. J. Pharma Bio Sci. 2013, 4, B1021–B1029.
  182. Arvindekar, A.; More, T.; Payghan, P.V.; Laddha, K.; Ghoshal, N.; Arvindekar, A. Evaluation of anti-diabetic and alpha glucosidase inhibitory action of anthraquinones from Rheum emodi. Food. Funct. 2015, 6, 2693–2700.
  183. McCune, L.M.; Johns, T. Antioxidant activity in medicinal plants associated with the symptoms of diabetes mellitus used by the indigenous peoples of the north american boreal forest. J. Ethnopharmacol. 2002, 82, 197–205.
  184. Gade, D.R.; Sree Kumar Reddy, G.; Akki, S.N.R.; Vamsi Rajasekhar Reddy, P. Hepatoprotective activity of Rhus mysorensis against carbon tetrachloride induced hepatotoxicity in albino rats. Int. J. Pharm. Sci. Rev. Res. 2010, 4, 46–48.
  185. Oda, Y.; Ueda, F.; Kamei, A.; Kakinuma, C.; Abe, K. Biochemical investigation and gene expression analysis of the immunostimulatory functions of an edible salacia extract in rat small intestine. BioFactors 2011, 37, 31–39.
  186. Anitha, S.; Martha Leema Rose, A. Comparative evaluation of antihyperglycaemic e_ect of various parts of Salacia chinensis L. J. Med. Sci. 2013, 13, 493–496.
  187. Singh, A.; Duggal, S. Salacia spp: Hypoglycemic principles and possible role in diabetes management. Integr. Med. 2010, 9, 40–43.
  188. Tanabe, G.; Sakano, M.; Minematsu, T.; Matusda, H.; Yoshikawa, M.; Muraoka, O. Synthesis and elucidation of absolute stereochemistry of salaprinol, another thiosugar sulfonium sulfate from the ayurvedic traditional medicine Salacia prinoides. Tetrahedron 2008, 64, 10080–10086.
  189. Im, R.; Mano, H.; Matsuura, T.; Nakatani, S.; Shimizu, J.; Wada, M. Mechanisms of blood glucose-lowering effect of aqueous extract from stems of kothala himbutu (Salacia reticulata) in the mouse. J. Ethnopharmacol. 2009, 121, 234–240.
  190. Yoshikawa, M.; Murakami, T.; Yashiro, K.; Matsuda, H. Kotalanol, a potent _-glucosidase inhibitor with thiosugar sulfonium sulfate structure, from antidiabetic ayurvedic medicine Salacia reticulata. Chem. Pharm. Bull. 1998, 46, 1339–1340.
  191. Arya, A.; Abdullah, M.A.; Haerian, B.S.; Mohd, M.A. Screening for hypoglycemic activity on the leaf extracts of nine medicinal plants: In-vivo evaluation. E-J. Chem. 2012, 9, 1196–1205.
  192. Mahabub, A.H.; Hossain, M.; Karim, M.; Khan, M.; Jahan, R.; Rahmatullah, M. An ethnobotanical survey of rajshahi district in rajshahi division, bangladesh. Am. Eurasian J. Sustain. Agric. 2009, 3, 143–150.
  193. Ebrahimpoor-Mashhadi, M.R.; Khaksar, Z.; Noorafshan, A.; Mogheisi, B. Stereological study of the effects of orally administrated otostegia persica extract on pancreatic beta cells in male diabetic rats. Comp. Clin. Pathol. 2014, 23, 761–767.
  194. Narendhirakannan, R.T.; Limmy, T.P. Anti-inflammatory and anti-oxidant properties of Sida rhombifolia stems and roots in adjuvant induced arthritic rats. Immunopharmacol. Immunotoxicol. 2012, 34, 326–336.
  195. Ssenyange, C.W.; Namulindwa, A.; Oyik, B.; Ssebuliba, J. Plants used to manage type II diabetes mellitus in selected districts of central Uganda. Afr. Health Sci. 2015, 15, 496–502.
  196. Doss, A.; Palaniswamy, M.; Angayarkanni, J.; Dhanabalan, R. Antidiabetic activity of water extract of Solanum trilobatum (Linn.) in alloxan-induced diabetes in rats. Afr. J. Biotechnol. 2009, 8, 5551–5553.
  197. Perla, V.; Jayanty, S.S. Biguanide related compounds in traditional antidiabetic functional foods. Food Chem. 2013, 138, 1574–1580.
  198. Nag, M.; Mukherjee, P.K.; Chanda, J.; Biswas, R.; Harwansh, R.K.; Al-Dhabi, N.A.; Duraipandiyan, V. Plant developed analytical profile of Stereospermum suaveolens in Indian traditional knowledge. Indian J. Trad. Knowl. 2015, 14, 590–594
  199. Kumar, V.; Van Staden, J. A review of Swertia chirayita (Gentianaceae) as a traditional medicinal plant. Front. Pharmacol. 2016, 6, 308.
  200. Roy, P.; Abdulsalam, F.I.; Pandey, D.K.; Bhattacharjee, A.; Eruvaram, N.R.; Malik, T. Evaluation of antioxidant, antibacterial, and antidiabetic potential of two traditional medicinal plants of India: Swertia cordata and Swertia chirayita. Pharmacogn. Res. 2015, 7, S57–S62.
  201. Saeidnia, S.; Ara, L.; Hajimehdipoor, H.; Read, R.W.; Arshadi, S.; Nikan, M. Chemical constituents of Swertia longifolia boiss. With _-amylase inhibitory activity. Res. Pharm. Sci. 2016, 11, 23–32.
  202. Muthusamy, K.; Krishnasamy, G. A computational study on role of 6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxan-2-yl]oxyoxane-2,4,5-triol in the regulation of blood glucose level. J. Biomol. Struct. Dyn. 2016, 34, 2599–2618.
  203. Basar, M.H.; Hossain, S.J.; Sadhu, S.K.; Rahman, M.H. A comparative study of antioxidant potential of commonly used antidiabetic plants in bangladesh. Orient. Pharm. Exp. Med. 2013, 13, 21–28. 
  204. Bansode, T.S.; Salalkar, B.K. Phytochemical analysis of some selected indian medicinal plants. Intl. J. Pharma Bio Sci. 2015, 6, P550–P556.
  205. Baliga, M.S.; Fernandes, S.; Thilakchand, K.R.; D’Souza, P.; Rao, S. Scientific validation of the antidiabetic effects of Syzygium jambolanum DC (black plum), a traditional medicinal plant of India. J. Altern. Complement. Med. 2013, 19, 191–197.
  206. Zucchi, O.L.A.D.; Moreira, S.; De Jesus, E.F.O.; Salvio Neto, H.; Salvador, M.J. Characterization of hypoglycemiant plants by total reflection X-ray fluorescence spectrometry. Biol. Trace Elem. Res. 2005, 103, 277–290.
  207. Sathishkumar, T.; Baskar, R. Renoprotective e_ect of Tabernaemontana heyneana Wall. Leaves against paracetamol-induced renotoxicity in rats and detection of polyphenols by high-performance liquid chromatography-diode array detector-mass spectrometry analysis. J. Acute Med. 2014, 4, 57–67.
  208. Raghavan, B.; Kumari, S.K. E_ect of Terminalia arjuna stem bark on antioxidant status in liver and kidney of alloxan diabetic rats. Indian J. Physiol. Pharmacol. 2006, 50, 133–142.
  209. Nguyen, Q.V.; Nguyen, V.B.; Eun, J.B.;Wang, S.L.; Nguyen, D.H.; Tran, T.N.; Nguyen, A.D. Anti-oxidant and antidiabetic e_ect of some medicinal plants belong to Terminalia species collected in Dak Lak Province, Vietnam. Res Chem Intermed 2016, 42, 5859–5871.
  210. Tanaka, M.; Kishimoto, Y.; Saita, E.; Suzuki-Sugihara, N.; Kamiya, T.; Taguchi, C.; Iida, K.; Kondo, K. Terminalia bellirica extract inhibits low-density lipoprotein oxidation and macrophage inflammatory response in vitro. Antioxidants 2016, 5, 20.
  211. Venkatalakshmi, P.; Brindha, P.; Saralla, R.P. Analytical and chemical standardisation studies on Terminalia catappa bark. Int. J. Pharmcy Pharm. Sci. 2014, 6, 4–8.
  212. Jokar, A.; Masoomi, F.; Sadeghpour, O.; Nassiri-Toosi, M.; Hamedi, S. Potential therapeutic applications for Terminalia chebula in Iranian traditional medicine. J. Tradit Chin Med. 2016, 36, 250–254.
  213. Rao, N.K.; Nammi, S. Antidiabetic and renoprotective e_ects of the chloroform extract of Terminalia chebula Retz. Seeds in streptozotocin-induced diabetic rats. BMC Complement. Altern. Med. 2006, 6, 17.
  214. Kumar, N.; Singh, S.; Manvi; Gupta, R. Trichosanthes dioica roxb.: An overview. Pharmacogn. Rev. 2012, 6, 61–67.
  215. Beaulieu, L.P.; Harris, C.S.; Saleem, A.; Cuerrier, A.; Haddad, P.S.; Martineau, L.C.; Bennett, S.A.L.; Arnason, J.T. Inhibitory e_ect of the cree traditional medicine wiishichimanaanh (Vaccinium vitis-idaea) on advanced glycation endproduct formation: Identification of active principles. Phytother. Res. 2010, 24, 741–747.
  216. Mishra, J.; Dash, A.K.; Mishra, S.N.; Gupta, A.K. Withania coagulans in treatmen of diabetics and some other diseases: A review. Res. J. Pharm., Biol. Chem. Sci. 2013, 4, 1251–1258.
  217. Maurya, R.; Akanksha; Jayendra; Singh, A.B.; Srivastava, A.K. Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity. Bioorg. Med. Chem. Lett. 2008, 18, 6534–6537.
  218. Jonathan, G.; Rivka, R.; Avinoam, S.; Lumír, H.; Nirit, B. Hypoglycemic activity of withanolides and elicitated Withania somnifera. Phytochemistry 2015, 116, 283–289.
  219. Mukhija, M.; Lal Dhar, K.; Nath Kalia, A. Bioactive lignans from Zanthoxylum alatum Roxb. Stem bark with cytotoxic potential. J. Ethnopharmacol. 2014, 152, 106–112.
  220. Pamhidzai, D.; Isaac, G. Tlc separation, antibacterial and anti-inflammatory activity of extracts derived from Zanthoxylum humile roots. Intern. J. Res. Ayurveda Pharm. 2013, 4, 482–486.
  221. Ranilla, L.G.; Kwon, Y.I.; Apostolidis, E.; Shetty, K. Phenolic compounds, antioxidant activity and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal plants, herbs and spices in Latin America. Bioresour. Technol. 2010, 101, 4676–4689
  222. Morakinyo, A.O.; Akindele, A.J.; Ahmed, Z. Modulation of antioxidant enzymes and inflammatory cytokines: Possible mechanism of anti-diabetic e_ect of ginger extracts. Afr. J. Biomed. Res. 2011, 14, 195–202.
  223. Modi, A.; Jain, S.; Kumar, V. Zizyphus xylopyrus (Retz.) willd: A review of its folkloric, phytochemical and pharmacological perspectives. Asian Pac. J. Trop. Dis. 2014, 4, S1–S6.
  224. Solanki, A.; Zaveri, M. Pharmacognosy, phytochemistry and pharmacology of Abrus precatorius leaf: A review. Int. J. Pharm. Sci. Rev. Res. 2012, 13, 71–76.
  225. Liu, Y.X.; Si, M.M.; Lu, W.; Zhang, L.X.; Zhou, C.X.; Deng, S.L.; Wu, H.S. E_ects and molecular mechanisms of the antidiabetic fraction of Acorus calamus L. On GLP-1 expression and secretion in vivo and in vitro. J. Ethnopharmacol. 2015, 166, 168–175.
  226. Kumar, D.; Bhat, Z.A.; Singh, P.; Khatanglakar, V.; Bhujbal, S.S. Antiasthmatic and antiallergic potential of methanolic extract of leaves of Ailanthus excelsa. Braz. J. Pharamacogn. 2011, 21, 139–145.
  227. Hepcy Kalarani, D.; Dinakar, A.; Senthilkumar, N. Antidiabetic, analgesic and anti-inflammatory activity of aqueous extracts of stem and leaves of Alangium salvifolium and Pavonia zeylanica. Int. J. Drug. Dev. Res. 2012, 4, 298–306.
  228. Hepcy Kalarani, D.; Dinakar, A.; Senthilkumar, N. Hypoglycemic and antidiabetic activity of Alangium salvifolium wang in alloxan induced diabetic rats. Asian J. Pharm. Clin. Res. 2011, 4, 131–133.
  229. Rao, N.K. Anti-hyperglycemic and renal protective activities of Andrographis paniculata roots chloroform extract. Iran. J. Pharmacol. Ther. 2006, 5, 47–50.
  230. Sani, Y.N.; Haque, M.; Suryati, K.; Mohd, K.W.; Khan, A. Isolation and characterisation of andrographolide from Andrographis paniculata (Burm. F) wall. Ex nees and its total flavonoid e_ects from Kemaman, Malaysia. Int. J. Pharm. Qual. Assur. 2017, 8, 119–124.
  231. Devgan, M.; Bhatia, L.; Kumar, H. Anthocephalus cadamba: A comprehensive review. Res. J. Pharm. Technol. 2012, 5, 1478–1483.
  232. Shaikh, S.; Dubey, R.; Dhande, S.; Joshi, Y.M.; Kadam, V.J. Phytochemical and pharmacological profile of Aphanamixis polystachya: An overview. Res. J. Pharm. Technol. 2012, 5, 1260–1263.
  233. Paulke, A.; Kremer, C.; Wunder, C.; Achenbach, J.; Djahanschiri, B.; Elias, A.; Stefan Schwed, J.; Hübner, H.; Gmeiner, P.; Proschak, E.; et al. Argyreia nervosa (Burm. F.): Receptor profiling of lysergic acid amide and other potential psychedelic LSD-like compounds by computational and binding assay approaches. J. Ethnopharmacol. 2013, 148, 492–497.
  234. Gupta, V.; Keshari, B.B.; Tiwari, S.K.; Narasimha Murthy, K.H.H.V.S.S. A review on antidiabetic action of Asanadi gana. Intern. J. Res. Ayurveda Pharm. 2013, 4, 638–646.
  235. Kaur, M.; Singh, G.; Mohan, C. Barringtonia acutangula: A traditional medicinal plant. Int. J. Pharm. Sci. Rev. Res. 2013, 23, 168–171.
  236. Jyothi, K.S.N.; Hemalatha, P.; Challa, S. Evaluation of _-amylase inhibitory potential of three medicinally important traditional wild food plants of India. Int. J. Green Pharm. 2011, 5, 95–99.
  237. Deepika, S.; Rajagopal, S.V. Evaluation of phytochemical and bioactive screening of Blepharis molluginifolia flower extracts. Intl. J. Pharma Bio Sci. 2014, 5, P204–P211.
  238. Savithramma, N.; Linga Rao, M.; Venkateswarlu, P. Histochemical studies of Boswellia ovalifoliolata Bal. & Henry—An endemic, endangered and threatened medicinal plant of Seshachalam Hill range of Eastern Ghats of India. Int. J. Pharmacogn. Phytochem. Res. 2014, 6, 1–6.
  239. Darsini, I.P.; Shamshad, S.; John Paul, M. Canna indica (L.): A plant with potential healing powers: A review. Intl. J. Pharma Bio Sci. 2015, 6, B1–B8.
  240. Kumar, D.; Kumar, S.; Gupta, J.; Arya, R.; Gupta, A. A review on chemical and biological properties of Cayratia trifolia Linn. (Vitaceae). Pharmacogn. Rev. 2011, 5, 184–188. 
  241. Alagawadi Kallangouda, R.; Shah Amol, S. Analgesic and antipyretic e_ects of Ceiba pentandra L. Seed extracts. Intl. J. Pharm. Res. 2012, 4, 46–49.
  242. Oyedemi, S.O.; Oyedemi, B.O.; Ijeh, I.I.; Ohanyerem, P.E.; Coopoosamy, R.M.; Aiyegoro, O.A. Alpha-amylase inhibition and antioxidative capacity of some antidiabetic plants used by the traditional healers in Southeastern Nigeria. Sci. World J. 2017, 2017, 3592491.
  243. Satyaprakash, R.J.; Rajesh, M.S.; Bhanumathy, M.; Harish, M.S.; Shivananda, T.N.; Shivaprasad, H.N.; Sushma, G. Hypoglycemic and antihyperglycemic e_ect of Ceiba pentandra L. Gaertn in normal and streptozotocin-induced diabetic rats. Ghana Med J 2013, 47, 121–127.
  244. Peltzer, K.; Sydara, K.; Pengpid, S. Traditional, complementary and alternative medicine use in a community population in lao pdr. Afr. J. Trad. Complement. Altern. Med. 2016, 13, 95–100.
  245. Fitrianda, E.; Sukandar, E.Y.; Elfahmi; Adnyana, I.K. Antidiabetic activity of extract, fractions, and asiaticoside compound isolated from Centella asiatica Linn. Leaves in alloxan-induced diabetic mice. Asian J. Pharm. Clin. Res. 2017, 10, 268–272.
  246. Maulidiani; Abas, F.; Khatib, A.; Perumal, V.; Suppaiah, V.; Ismail, A.; Hamid, M.; Shaari, K.; Lajis, N.H. Metabolic alteration in obese diabetes rats upon treatment with Centella asiatica extract. J. Ethnopharmacol. 2016, 180, 60–69.
  247. Paydar, M.; Moharam, B.A.; Wong, Y.L.; Looi, C.Y.; Wong, W.F.; Nyamathulla, S.; Pandy, V.; Kamalidehghan, B.; Arya, A. Centratherum anthelminticum (L.) kuntze a potential medicinal plant with pleiotropic pharmacological and biological activities. Int. J. Pharmacol. 2013, 9, 211–226.
  248. Thakur, G.S.; Bag, M.; Sanodiya, B.S.; Debnath, M.; Zacharia, A.; Bhadauriya, P.; Prasad, G.B.K.S.; Bisen, P.S. Chlorophytum borivilianum: A white gold for biopharmaceuticals and neutraceuticals. Curr. Pharm. Biotechnol. 2009, 10, 650–666.
  249. Kosai, P.; Sirisidthi, K.; Jiraungkoorskul, K.; Jiraungkoorskul,W. Review on ethnomedicinal uses of memory Boosting Herb, Butterfly Pea, Clitoria ternatea. J. Nat. Rem. 2015, 15, 71–76.
  250. Kavitha, R. Evaluation of hypoglycemic e_ect of ethanolic extracts of leaf and fruit of T. dioica and leaf of C. ternatea in streptozotocin induced diabetic rats. Intl. J. Pharma Bio Sci. 2014, 5, B1061–B1068.
  251. Ramakrishnan, G.; Kothai, R.; Jaykar, B.; Venkata Rathnakumar, T. In vitro antibacterial activity of different extracts of leaves of Coldenia procumbens. Int. J. Pharm. Res. 2011, 3, 1000–1004.
  252. Shirwaikar, A.; Rajendran, K.; Punitha, I.S.R. Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats. J. Ethnopharmacol. 2005, 97, 369–374.
  253. Rai, R.V.; Rajesh, P.S.; Kim, H.M. Medicinal use of Coscinium fenestratum (Gaertn.) colebr.: An short review. Orient. Pharm. Exp. Med. 2013, 13, 1–9.
  254. Mnif, S.; Aifa, S. Cumin (Cuminum cyminum L.) from traditional uses to potential biomedical applications. Chem. Biodivers. 2015, 12, 733–742.
  255. Sharma, P.; Dubey, G.; Kaushik, S. Chemical and medico-biological profile of Cyamopsis tetragonoloba (L) taub: An overview. J. Appl. Pharm. Sci. 2011, 1, 32–37.
  256. Golla, U.; Gajam, P.K.; Solomon Sunder Raj, B. The e_ect of Desmostachya bipinnata (Linn.) extract on physiologically altered glycemic status in non-diabetic rats. J. Med. Sci. 2013, 13, 221–225.
  257. Hardainiyan, S.; Nandy, B.C.; Kumar, K. Elaeocarpus ganitrus (Rudraksha): A reservoir plant with their pharmacological e_ects. Int. J. Pharm. Sci. Rev. Res. 2015, 34, 55–64.
  258. Kumari, S.J.; Sangeetha, M.; Pavithra, R. A retrospective review on Indian traditional herbs and its biocompounds in diabetes. Int. J. Pharm. Res. 2016, 9, 444–460.
  259. Febrinda, A.E.; Yuliana, N.D.; Ridwan, E.; Wresdiyati, T.; Astawan, M. Hyperglycemic control and diabetes complication preventive activities of bawang dayak (Eleutherine palmifolia L. Merr.) bulbs extracts in alloxan-diabetic rats. Int. Food Res. J. 2014, 21, 1405–1411.
  260. Sarma, U.; Borah, V.V.; Saikia, K.K.R.; Hazarika, N.K. Enhydra fluctuans: A review on its pharmacological importance as a medicinal plant and prevalence and use in North-East India. Int. J. Pharmcy Pharm. Sci. 2014, 6, 48–50.
  261. Samal, P.K.; Dangi, J.S.; Meena, K.P.; Beck, N.R.; Patel, A.; Maheshwari, G. Evaluation of analgesic activity of leaves extracts of Feronia limonia in experimental animal models. Res. J. Pharm. Technol. 2011, 4, 710–714.
  262. Veeraiah, S.; Jaganmohan Reddy, K. Current strategic approaches in ethnomedicinal plants of Tinospora cordifolia and Gloriosa superba—A review. Intl. J. Pharma Bio Sci. 2012, 3, 320–326.
  263. Ramesh Petchi, R.; Vijaya, C. Anti-diabetic and anti-arthritic potential of glycosmis pentaphylla stem bark in FCA induced arthritis and streptozotocin induced diabetic rats. Intl. J. Pharma Bio Sci. 2012, 3, P328–P336.
  264. Kulkarni, Y.; Veeranjaneyulu, A. Toxicological studies on aqueous extract of Gmelina arborea in rodents. Pharm. Biol. 2010, 48, 1413–1420.
  265. Attanayake, A.P.; Jayatilaka, K.A.P.W.; Pathirana, C.; Mudduwa, L.K.B. Gmelina arborea roxb. (family: Verbenaceae) extract upregulates the _-cell regeneration in stz induced diabetic rats. J. Dia. Res 2016, 2016.
  266. Devi, K.; Jain, N. Clinical evaluation of the anti-sweet e_ects of Gymnema sylvestre extract developed into a dispersable oral tablet. J. Herb. Med. 2015, 5, 184–189.
  267. Yadav, M.; Lavania, A.; Tomar, R.; Prasad, G.B.K.S.; Jain, S.; Yadav, H. Complementary and comparative study on hypoglycemic and antihyperglycemic activity of various extracts of Eugenia jambolana seed, Momordica charantia fruits, Gymnema sylvestre, and Trigonella foenum graecum seeds in rats. Appl. Biochem. Biotechnol. 2010, 160, 2388–2400.
  268. Mahalingam, G.; Kannabiran, K. Hemidesmus indicus root extract ameliorates diabetes-mediated metabolic changes in rats. Int. J. Green Pharm. 2009, 3, 314–318.
  269. Patra, J.K.; Thatoi, H. Anticancer activity and chromatography characterization of methanol extract of Heritiera fomes buch. Ham., a mangrove plant from Bhitarkanika, India. Orient. Pharm. Exp. Med. 2013, 13, 133–142.
  270. Kumarappan, C.; Mandal, S.C. Antidiabetic e_ect of polyphenol enriched extract of Ichnocarpus frutescens on key carbohydrate metabolic enzymes. Int. J. Diabetes Dev. Ctries. 2015, 35, 425–431.
  271. Vijay Simha, G.; Kumar, M.A.; Rajesh, S.; Panda, P.; Rao, M.M. Evaluation of physicochemical parameters of Imperata cylindrica (Linn) beauv root used in ayurvedic formulations. Res. J. Pharm. Technol. 2012, 5, 1352–1355.
  272. Prajapati, R.; Kalariya, M.; Parmar, S.; Sheth, N. Phytochemical and pharmacological review of Lagenaria sicereria. J. Ayurveda Integr. Med. 2010, 1, 266–272.
  273. Teugwa, C.M.; Boudjeko, T.; Tchinda, B.T.; Mejiato, P.C.; Zofou, D. Anti-hyperglycaemic globulins from selected Cucurbitaceae seeds used as antidiabetic medicinal plants in africa. BMC Complement. Altern. Med. 2013, 13, 63.
  274. Qazi Majaz, A.; Molvi Khurshid, I. A comprehensive review on meyna Laxiflora robyns (rubiaceae). Int. J. Pharm. Sci. Rev. Res. 2015, 35, 22–25.
  275. Petrus, A.J.A. Mukia maderaspatana (Linn.) M. Roemer: A potentially antidiabetic and vasoprotective functional leafy-vegetable. Pharm. J. 2012, 4, 1–12.
  276. Liu, S.; Li, D.; Huang, B.; Chen, Y.; Lu, X.;Wang, Y. Inhibition of pancreatic lipase, _-glucosidase, _-amylase, and hypolipidemic e_ects of the total flavonoids from Nelumbo nucifera leaves. J. Ethnopharmacol. 2013, 149, 263–269.
  277. Sharma, B.R.; Gautam, L.N.S.; Adhikari, D.; Karki, R. A comprehensive review on chemical profiling of Nelumbo nucifera: Potential for drug development. Phytother. Res. 2017, 31, 3–26.
  278. Mani, S.S.; Subramanian, I.P.; Pillai, S.S.; Muthusamy, K. Evaluation of hypoglycemic activity of inorganic constituents in Nelumbo nucifera seeds on streptozotocin-induced diabetes in rats. Biol. Trace Elem. Res. 2010, 138, 226–237.
  279. Amel, B. Traditional treatment of high blood pressure and diabetes in Souk Ahras District. J. Pharmacogn. Phytother. 2013, 5, 12–20.
  280. Malik, A.; Mehmood, M.H.; Akhtar, M.S.; Haider, G.; Gilani, A.H. Studies on antihyperlipidemic and endothelium modulatory activities of polyherbal formulation (POL4) and its ingredients in high fat diet-fed rats. Pak. J. Pharma. Sci. 2017, 30, 295–301.
  281. Desai, S.D.; Saheb, S.H.; Das, K.K.; Haseena, S. Phytochemical analysis of Nigella sativa and it’s antidiabetic effect. J. Pharm. Sci. Res. 2015, 7, 527–532.
  282. Meddah, B.; Ducroc, R.; El Abbes Faouzi, M.; Eto, B.; Mahraoui, L.; Benhaddou-Andaloussi, A.; Martineau, L.C.; Cherrah, Y.; Haddad, P.S. Nigella sativa inhibits intestinal glucose absorption and improves glucose tolerance in rats. J. Ethnopharmacol. 2009, 121, 419–424.
  283. Rangika, B.S.; Dayananda, P.D.; Peiris, D.C. Hypoglycemic and hypolipidemic activities of aqueous extract of flowers from Nycantus arbor-tristis L. in male mice. BMC Complement. Altern. Med. 2015, 15, 289.
  284. Ojha, D.; Mukherjee, H.; Mondal, S.; Jena, A.; Dwivedi, V.P.; Mondal, K.C.; Malhotra, B.; Samanta, A.; Chattopadhyay, D. Anti-inflammatory activity of Odina wodier Roxb, an indian folk remedy, through inhibition of toll-like receptor 4 signaling pathway. PLoS ONE 2014, 9, e104939.
  285. Ansarullah; Bharucha, B.; Patel, V.; Ramachandran, A.V. Oreocnide integrifolia (Gaud.) miq leaf water extract improves metabolic alterations in high fructose fed insulin resistant and hypertensive rats. Eur. J. Integr. Med. 2010, 2, 79–87.
  286. Dinda, B.; Silsarma, I.; Dinda, M.; Rudrapaul, P. Oroxylum indicum (L.) kurz, an important asian traditional medicine: From traditional uses to scientific data for its commercial exploitation. J. Ethnopharmacol. 2015, 161, 255–278.
  287. Karthishwaran, K.; Mirunalini, S. Therapeutic potential of Pergularia daemia (Forsk.): The ayurvedic wonder. Int. J. Pharmacol. 2010, 6, 836–843.
  288. Xu, Q.; Hu, Y.F.;Wang, D.L.; Xu, G.B.;Wang, N. Analysis on peucedani radix coumarin by UPLC/Q-TOF MS and study on its preliminary pharmacodynamics. Chin. Trad. Herb. Drugs 2015, 46, 3637–3642.
  289. Alkofahi, A.S.; Abdul-Razzak, K.K.; Alzoubi, K.H.; Khabour, O.F. Screening of the anti-hyperglycemic activity of some medicinal plants of jordan. Pak. J. Pharma. Sci. 2017, 30, 907–912.
  290. Ateeq, A.; Sunil, S.D.; Varun, S.K.; Santosh, M.K. Phoenix dactylifera linn.(pind kharjura): A review. Intern. J. Res. Ayurveda Pharm. 2013, 4, 447–451.
  291. Abdelaziz, D.H.A.; Ali, S.A. The protective e_ect of Phoenix dactylifera L. Seeds against CCL4-induced hepatotoxicity in rats. J. Ethnopharmacol. 2014, 155, 736–743.
  292. Raju, R.; Nambi, S.K.; Gurusamy, M. In vitro propagation of Pisonia grandis R. Br.: An indigenous vegetable and promising medicinal plant. Phytomorphology 2015, 65, 133–138.
  293. Jothy, S.L.; Choong, Y.S.; Saravanan, D.; Deivanai, S.; Latha, L.Y.; Vijayarathna, S.; Sasidharan, S. Polyalthia longifolia sonn: An ancient remedy to explore for novel therapeutic agents. Res. J. Pharm. Biol. Chem. Sci. 2013, 4, 714–730.
  294. 838. Satish Kumar, B.N. Phytochemistry and pharmacological studies of Pongamia pinnata (Linn.) pierre. Int. J. Pharm. Sci. Rev. Res. 2011, 9, 12–19.
  295. Dangi, K.S.; Mishra, S.N. Antihyperglycemic, antioxidant and hypolipidemic e_ect of Capparis aphylla stem extract in streptozotocin induced diabetic rats. Biol. Med. 2010, 2, 35–44.
  296. Lans, C.A. Ethnomedicines used in Trinidad and Tobago for urinary problems and diabetes mellitus. J. Ethnobiol. Ethnomedicine 2006, 2, 45.
  297. Chowdhary, C.V.; Meruva, A.; Naresh, K.; Elumalai, R.K.A.A review on phytochemical and pharmacological profile of Portulaca oleracea Linn. (purslane). Intern. J. Res. Ayurveda Pharm. 2013, 4, 34–37.
  298. Guenzet, A.; Krouf, D.; Berzou, S. Portulaca oleracea extract increases lecithin:Cholesterol acyltransferase and paraoxonase 1 activities and enhances reverse cholesterol transport in streptozotocin-induced diabetic rat. Pharm. J. 2014, 6, 1–9.
  299. Ramadan, B.K.; Schaalan, M.F.; Tolba, A.M. Hypoglycemic and pancreatic protective e_ects of Portulaca oleracea extract in alloxan induced diabetic rats. BMC Complement. Altern. Med. 2017, 17, 37.
  300. Tayade, P.M.; Chandrasekar, M.J.N.; Borde, S.N.; Joshi, A.S.; Angadi, S.S.; Devdhe, S.J. E_ect of Psoralea corylifolia Linn in sexual erectile dysfunction in diabetic rats. Orient. Pharm. Exp. Med. 2013, 13, 35–40.
  301. Mestry, S.N.; Juvekar, A.R. Aldose reductase inhibitory potential and anti-cataract activity of Punica granatum Linn. Leaves against glucose-induced cataractogenesis in goat eye lens. Orient. Pharm. Exp. Med. 2017, 17, 277–284.
  302. Pirbalouti, A.G.; Shahrzad, A.; Abed, K.; Hamedi, B. Wound healing activity of Malva sylvestris and Punica granatum in alloxan-induced diabetic rats. Acta Pol. Pharm. Drug Res. 2010, 67, 511–516.
  303. Salwe, K.J.; Sachdev, D.O.; Bahurupi, Y.; Kumarappan, M. Evaluation of antidiabetic, hypolipedimic and antioxidant activity of hydroalcoholic extract of leaves and fruit peel of Punica granatum in male wistar albino rats. J. Nat. Sci. Biol. Med. 2015, 6, 56–62.
  304. Sharma, R.; Yadav, D.; Asif, M.; Jayasri, M.A.; Agnihotri, V.K.; Ravikumar, P.C. Antidiabetic and antioxidant activities of Roylea cinerea extracts: A comparative study. Indian J. Exp. Biol. 2017, 55, 611–621.
  305. Devi Priya, M.; Siril, E.A. Traditional and modern use of indian madder (Rubia cordifolia L.): An overview. Int. J. Pharm. Sci. Rev. Res. 2014, 25, 154–164.
  306. Makhija, I.K.; Richard, L.; Kirti, S.P.; Saleemullah, K.; Jessy, M.; Annie, S. Sphaeranthus indicus: A review of its chemical, pharmacological and ethnomedicinal properties. Int. J. Pharmacol. 2011, 7, 171–179.
  307. Salunkhe, V.R.; Bhise, S.B. Stevia rebaudiana: An alternative to synthetic sweeteners. Indian Drugs 2010, 47, 5–13.
  308. Abudula, R.; Jeppesen, P.B.; Rolfsen, S.E.D.; Xiao, J.; Hermansen, K. Rebaudioside a potently stimulates insulin secretion from isolated mouse islets: Studies on the dose-, glucose-, and calcium-dependency. Metab. Clin. Exp. 2004, 53, 1378–1381.
  309. Havinga, R.M.; Hartl, A.; Putscher, J.; Prehsler, S.; Buchmann, C.; Vogl, C.R. Tamarindus indica L. (Fabaceae): Patterns of use in traditional african medicine. J. Ethnopharmacol. 2010, 127, 573–588.
  310. Park, C.H.; Noh, J.S.; Tanaka, T.; Uebaba, K.; Cho, E.J.; Yokozawa, T. The e_ects of corni fructus extract and its fractions against _-glucosidase inhibitory activities in vitro and sucrose tolerance in normal rats. Am. J. Chin. Med. 2011, 39, 367–380.
  311. Palbag, S.; Dey, B.K.; Singh, N.K. Ethnopharmacology, phytochemistry and pharmacology of Tephrosia purpurea. Chin. J. Nat. Med. 2014, 12, 1–7.
  312. Pavana, P.; Manoharan, S.; Renju, G.L.; Sethupathy, S. Antihyperglycemic and antihyperlipidemic effects of Tephrosia purpurea leaf extract in streptozotocin induced diabetic rats. J. Environ. Biol. 2007, 28, 833–837.
  313. Satyanarayana, T.; Sarita, T.; Balaji, M.; Ramesh, A.; Boini, M.K. Antihyperglycemic and hypoglycemic effect of Thespesia populnea fruit in normal and alloxan-induced diabetes in rabbits. Saudi Pharm. J. 2004, 12, 107–111.
  314. Mohamed Farook, S.; Clement Atlee,W. Antidiabetic and hypolipidemic potential of Tragia involucrata Linn. in streptozotocin-nicotinamide induced type II diabetic rats. Int. J. Pharmcy Pharm. Sci. 2011, 3, 103–109.
  315. Balekar, N.; Nakpheng, T.; Srichana, T. Wedelia trilobata L.: A phytochemical and pharmacological review. Chiang Mai J. Sci. 2014, 41, 590–605.
  316. Storme\ gemini
  317. http://www.alibaba.com/productgs/357477619/diabetic_herbal_tea.html (accessed July 11, 2011)
  318. http://www.alibaba.com/producttp/109604143/Herbal_diabetes_product.ht ml (accessed July 11, 2011)
  319. http://www.alibaba.com/productfree/103220828/Stevia_33_Diabetes_Herb al_Medicine.html (accessed July 11, 2011)
  320. http://www.alibaba.com/productfree/252036161/Diab_FIT_Herbal_FIT_fo r_Diabetes.html (accessed July 11, 2011)
  321. http://www.alibaba.com/productfree/11942265/ Herbal_Diabetes_Medicine_Madhumaar_Capsule_.html (accessed July 11, 2011)
  322. http://www.alibaba.com/productfree/111557110/daya_ston_powder_for_di abetes.html (accessed July 12, 2011)
  323. http://www.alibaba.com/productfree/108363205/herbal_medicine.html (accessed July 12, 2011)
  324. http://www.alibaba.com/productfree/109219085/Kumari_Saar.html (accessed July 12, 2011)
  325. http://www.alibaba.com/producttp/112065648/Herbal_Spenai_Antidiabetic_Remedy.html (accessed July 12, 2011)
  326. http://www.alibaba.com/producttp/105645757/Blueberry_Root.html (accessed July 12, 2011)
  327. http://www.alibaba.com/productfree/116570928/episulin_diabetic_medicin e.html (accessed July 12, 2011)

Photo
Abhishek V. Desai
Corresponding author

Ashokrao Mane institute of pharmacy,Ambap

Photo
Sammed Babaso Sangale
Co-author

Ashokrao Mane institute of pharmacy Ambap

Photo
Dr. N. B. Chougule
Co-author

Ashokrao Mane institute of pharmacy Ambap

Sammed Sangale*, Abhishek Desai, Dr. Nilesh Chougule, Harnessing Nature’s Power: Antidiabetic Medicinal Plants, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 11, 1008-1042. https://doi.org/10.5281/zenodo.14209619

More related articles
Diabetes and Gender: Exploring the Disparity, Risk...
Bharathi DR, Chandana G., Mohammad Ali, ...
Phyto-Fabrication, Characterization and Anti-Diabe...
Shivani Kumari, Akshay Sharma, Dheeraj Kumar Vishwakarma, ...
Preparation And Evaluation Oral Buccal Patches Of ...
Nikita Nagnath Bagal, Radhika S. Subhedar, Nilesh Chougale, ...
Formulation And Evaluation Of An Osmotic Drug Delivery System For An Antidiabeti...
Vishal R. Rasve, Vidya D. Waghmode, Akash S. Malthankar, Supriya S. Darandale, Rajiya A. Khan, Swati...
A Review On To Expose The Effect Of Plant Ghee And Animal Ghee On Biochemical Pa...
Shubham Kshirsagar, Nikhil Bondhare, Ankita Shinde, Jagruti Shinde, ...
Antimicrobial Activity Of Morus Alba Leaf Extract Against Potent Oral Pathogens ...
Indranil Chatterjee, Bishan Sarkar, Pritam Ghosh, Suchetan Sarkar, ...
Related Articles
A Systemic Review on Neuroprotective Activity of Various Herbal Plants...
Pallavi N, Iyswarya G M, Kavya P Reddy, Karthik S, Kiran G M, ...
Formulation And Evaluation Of An Osmotic Drug Delivery System For An Antidiabeti...
Vishal R. Rasve, Vidya D. Waghmode, Akash S. Malthankar, Supriya S. Darandale, Rajiya A. Khan, Swati...
Drug Resistance In Various Disorders...
T. V. Sowjanya, B. Akhila, N. Ahalya, T. Sai Ram, T. Maneesha, V. Pavithra, ...
Plant Derived Antioxidant: Significance In Skin Health and Ageing Process ...
Yashsavi Murarkar, Aditya Chaudhari , Aishwarya Mande, Smita Mankar, ...
More related articles
Phyto-Fabrication, Characterization and Anti-Diabetic Activity of Silver Nanopar...
Shivani Kumari, Akshay Sharma, Dheeraj Kumar Vishwakarma, ...
Preparation And Evaluation Oral Buccal Patches Of Sitagliptin Phosphate As Antid...
Nikita Nagnath Bagal, Radhika S. Subhedar, Nilesh Chougale, ...