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Abstract

Ayurveda offers a holistic approach to the management of jaundice by combining herbal remedies, detoxification therapies, and lifestyle regulation. Key medicinal plants such as Kutki, Kalmegha, Bhumyamalaki, and Triphala are valued for their hepatoprotective and antioxidant properties, helping to restore liver function and reduce oxidative stress. Classical Panchakarma therapy, particularly Virechana or therapeutic purgation, is emphasized for cleansing the liver and improving metabolic balance. Alongside these treatments, patients are advised to avoid alcohol and fatty foods while following a light, easily digestible diet to reduce strain on the liver. Modern scientific studies increasingly validate these traditional practices, highlighting their antioxidant and hepatoprotective mechanisms.

Keywords

Ayurveda, Jaundice, Kamala roga, Liver disorders, Pitta dosha, Hepatoprotective Herbs, Bhumiamalaki, Guduchi, Aloe vera, Kutki, Sugarcane Juice, Traditional medicine.

Introduction

Jaundice is the yellow color of the skin, sclera and mucous membrane due to increased production or impaired hepatic clearance of bilirubin. Yellow skin color may also be seen in carotenoderma with quinacrine use and with phenol excess exposure. The clinical presentations of jaundice include abdominal pain, nausea, and weakness.

Some of the clinical presentations are also addressed in Kamala’s case. Thus, on the basis of common features and pathology, Kamala (Jaundice) can be associated with jaundice. Jaundice or hyperbilirubinemia refers to yellowing of body tissue due to the deposition of an excess of bilirubin . Presence scenario industrialization introduces a lot of Change to our lifestyle and particularly to our food habit Spicy and fast-food day by day also there is rising Prevalence of hepatitis due to growing population Residing in overpopulated area, poor sanitation, contaminated Water, and intake of unhygienic food.

The majority of Time patient just visit with “sick & tired” later it got Diagnosed as Kamala (Jaundice) According to Acharya Charak as Pittaja Nanatmaja Vyadhi and Rakta pradoshaja vyadhi . for this research arises due to the growing enthusiasm for Ayurveda’s classical herbal medicines for managing jaundice and liver disorders. Thus, it becomes important to scientifically assess the efficacy of Ayurvedic treatments.

Figure no.01: Pathophysiology of Jaundice

  1. CAUSES

Pre-Hepatic : Excessive RBC breakdown, as in malaria or sickle cell anemia

Intra-Hepatic: Liver injury itself like hepatitis, alcoholic liver disease, liver cancer

Post-Hepatic: Obstruction to bile ducts - Gallstones, Pancreatic or Bile duct cancer

Pathology:

  • RBCs breakdown → Heme → Biliverdin → Bilirubin
  • When bilirubin level >3 mg/dl, it accumulates in blood → causes yellow discoloration.

Symptoms:

  • Yellowing of skin, eyes, and mucous membranes
  • Dark urine pale stool
  • Fatigue, nausea, itching, and loss of appetite
  1. TYPES OF JAUNDICE

On the basis of causes Jaundice can be classified into three types.

  • Pre-hepatic Jaundice
  • Hepatic Jaundice
  • Post hepatic Jaundice

Figure No. 02: Types of jaundice according to its pathophysiology

  1. Pre-hepatic Jaundice

Pre hepatic jaundice -is such type of jaundice which is Caused due to hemolysis therefore it is also known as Hemolytic jaundice. The major cause of enhanced Hemolysis is defective plasma membrane of red blood Cells. This fragile cell membrane cannot with stand the Shear stress, and hence ruptures, producing hemolysis. Thus, causing increased serum bilirubin level.7-8

Etiology

The pre hepatic jaundice is mainly due to Hemolysis. The causes of pre-hepatic/ haemolytic jaundice9  Are divided into two groups:

Table no: 1

Congenital causes

Acquired causes

Spherocytosis

Resorption of extensive hematomas

Elliptocytosis

Auto immune hemolysis

Congenital LCAT

Deficiency

Transfusion reactions

Thalassemia

Trauma

Sickle cell anemia.

Microangiopathy

Stomatocytosis

Hemolytic uremic syndrome

  1. Hepatic Jaundice:-

Hepatic jaundice is a kind of jaundice wherein the basic the defect lies within the liver, mainly in the hepatocytes. Liver captures bilirubin from plasma proteins mainly Albumin, then after conjugation, excretes in the bile via Biliary system. Any pathology of the liver leading to Defect in capture, conjugation & excretion can cause Hepatic jaundice. Main enzyme of conjugation is UDP - Glucronyl tyransferase .10-11

Etiology

Hepatic jaundice is caused due to the defect in capture, Conjugation and excretion of bilirubin by liver. Hepatic causes of jaundice include the following, which can be classified into two types.

Table No.2

Congenital causes

Acquired causes

Wilson's Disease

Viral hepatitis

Rotor's Syndrome

Alcoholic Hepatitis

Haemochromatosis

Autoimmune Hepatitis

CriglerNajar syndrome

Drug-induced Hepatitis (for example NSAIDs)

Gilbert's syndrome

Sepsis

Dubin-Johnson's syndrome

Pregnancy

  1. Post hepatic Jaundice:

Post hepatic jaundice is such type of a jaundice in which the cause of this lies in the biliary portion of hepatobiliary System. The major cause of post hepatic jaundice is extra-Hepatic biliary obstruction. Therefore, it is also called Obstructive jaundice13

Etiology

The major cause of post hepatic jaundice is extra-hepatic Biliary obstruction. (39) The causes of obstruction may be Classified into two types

Table No.3

Congenital causes

Acquired causes

Biliary Atresia.

Portalbiliopathy

Cystic Fibrosis

Cholecystitis

Idiopathic dilation of common bile duct

Trauma

Pancreatic biliary

Pancreatitis

malfunction Choledochal

Strictures

Cyst

Choledocholithiasis

Clinical manifestations of obstructive jaundice are Dark urine, pale-colored stools, and generalized pruritus. History Of fever biliary colic, weight loss, abdominal pain, and abdominal mass are also representatives of Obstructive jaundice.14 Obstructive Jaundice can lead to Various complications including cholangitis, pancreatitis, renal and hepatic failure.

Table No.01: Ayurvedic Roots and their therapeutic Roles in the treatment of jaundice

Sr. No

Ayurvedic Name (Root)

Biological Source (Botanical Name)

Synonyms

Family

Therapeutic Role/Effect

1

Bhumiamalaki

Phyllanthus niruri Linn.

Bhui Amla, Stonebreaker

Phyllanthaceae

Protects liver cells, promotes bole secretion, antiviral against hepatitis, detoxified liver.

2

Guduchi

Tinospora cordifolia (wild) Miers

Amrita., Giloy

Menispermaceae

Hepatoprotective, antioxidant, improves liver function, boots immunity, and reduces bilirubin level

3

Aloe vera

Aloe

barbadensis Mill.

Kumari

Liliceae

Purifies blood, enhance liver metabolism, and aids in regeneration of liver tissue.

4

Sugarcane

Saccharum officinarum Linn

Ikshu

Poaceae

(Gramineae)

Natural liver coolant, promotes urine and bike flow, reduces bilirubin, and helping faster recovery from jaundice

5

Kalmegha

Andrographis paniculata

Kalmegha, Bhunimba

Acanthaceae

Acts as a hepatoprotective and detoxifying herb that support liver health and treats jaundice, Protects liver cell from damage, increases the bile secretion and bilirubin excretion

4. The role of natural remedies for treatment for jaundice:

  1. SUGARCANE:

Figure No. 03: SUGARCANE

Mode of Action

Hepatoprotective: Antioxidants protect and regenerate liver cells.

Choleretic: An agent that increases the flow of bile, thereby facilitating the removal of excess bilirubin.

Diuretic: Promotes diuresis, facilitating the excretion of bilirubin.

Anti-inflammatory: This helps in reducing the inflammation of the liver and also aids in detoxification.

Ayurvedic view: It acts as Pittahara, hence controls excess of bile and purifies blood. It is useful in jaundice-Kamala.

According to Ayurveda, sugarcane juice is highly beneficial for jaundice patients as it helps restore liver function and provides essential nutrients. It acts as a natural energy source, especially since patients are advised to limit carbohydrate intake. With a low glycemic index and complex sugars, sugarcane juice is a healthier alternative to glucose. Its alkaline nature helps maintain low acidity levels in the body, creating an environment unfavorable for diseases.15

  1. BHUMYAMALAKI

Figure No. 04: BHUMYAMALAKI

Bhumyamalaki (Phyllanthus niruri) in Jaundice Treatment Bhumyamalaki, known as Phyllanthus niruri Linn., is one of the most important medicinal herbs in Ayurveda, traditionally used in treating liver disorders, particularly jaundice and hepatitis. It belongs to the family Euphorbiaceae and is commonly called Stonebreaker or Chanca Piedra in English.

Mode of Action:

Hepatoprotective Effect:-The herb protects liver cells (hepatocytes) against toxic injury, infection, or drug-related damage. Mechanism: Promotes antioxidant activity and stabilizes liver cell membranes.

Antioxidant & Detoxifying Activity:-The flavonoids, lignans, and tannins in Bhumyamalaki reduce oxidative stress and support liver detoxification.

Bhumyamalaki possesses:-

  • Rasa (taste): Tikta (bitter), Kashaya (astringent)
  • Guna (qualities): Laghu (light)
  • Virya (potency): Sheeta (cooling) ;
  • Effect:- Pitta-shamaka – balances Pitta, Yakrit-uttejaka – stimulates liver, Pittashodhaka – purifies bile.16

3. GUDUCHI :

Figure No. 05 GUDUCHI

Guduchi in Treatment of Jaundice (Tinospora cordifolia) Guduchi is regarded as a very valuable herbal medicine in Ayurveda and has a wide range of action on various physiological systems. It is often called Amrita or “nectar of immortality” since it provides rejuvenation and detoxification. Guduchi has classically been indicated in liver disorders, fever, and jaundice because of its hepatoprotective, antioxidant, and immunomodulatory actions.

Mode of Action

Hepatoprotective Effect:- Guduchi exerts a protective effect on liver cells from damage caused by toxins, infections, or oxidative stress. Mechanism: By augmenting antioxidant enzyme activity-such as superoxide dismutase and catalase-it reduces lipid peroxidation.

Enhances Liver Function:-Guduchi increases the secretion of bile, which improves bilirubin excretion and helps recover from jaundice.

Detoxification:-The herb cleanses the blood and aids in metabolism, which is very essential in the treatment of Pittaja Kamala.

Ayurvedic Perspective

In Ayurveda, jaundice is described as Kamala Roga caused by Pitta dosha vitiation and liver dysfunction.

Guduchi has the following properties:-

  • Rasa (taste):- Tikta (bitter), Kashaya (astringent)
  • Guna (qualities):-Laghu (light), Snigdha (unctuous)
  • Virya (potency):- Ushna (hot)
  • Vipaka (post-digestive effect):- Madhura (sweet)
  • Action: Pittashamaka, Rasayana, Yakrituttejaka.

Thus, Guduchi restores the balance of Pitta and strengthens liver function.

  1. ALOE VERA:

Figure No. 06: Aloe vera

Aloe vera, belonging to the family Liliaceae, is a succulent plant commonly used in Ayurvedic and contemporary herbal medicinal practices. The juice (Swarasa) of Aloe vera has been reported to possess hepatoprotective, detoxifying, and antioxidant activities.It is traditionally used in treating liver disorders, digestive problems, and skin diseases, and is considered beneficial for jaundice (Kamala Roga) due to its liver-cleansing and Pitta-pacifying actions.

Mode of Action in Jaundice

Hepatoprotective Effect:-Aloe vera contains aloin, barbaloin, and aloe-emodin, which exert protective effects on the hepatocytes against toxic injury and inflammation.The extract improves liver enzyme activity and prevents fat accumulation in liver tissues.

Bile Flow Regulation:-Aloe vera juice stimulates bile secretion and, hence, improves the metabolism of bilirubin, thereby helping in the removal of excess bile pigments from the bloodstream.

Detoxification:-Aloe vera helps to purify the blood, aids in metabolism, and is useful for removing toxins that burden the liver during jaundice.

Ayurvedic Perspective

In Ayurveda, jaundice is described as Kamala Roga, due mainly to the vitiation of Pitta dosha. Aloe vera (known as Kumari) has the following Ayurvedic attributes:-

  • Rasa (taste):-Tikta (bitter), Madhura (sweet)
  • Guna (qualities):-Snigdha (unctuous), Sara (mobile)
  • Virya (potency):- Sheeta (cooling)
  • Karma:- Pittashamaka, Yakrituttejaka, Raktashodhaka

Therefore, Kumari Swarasa (Aloe vera juice) has classically been prescribed for jaundice and other Pitta-related disorders.17

  1. KALMEGH

Figure No. 07: KALMEGH

Mode of action

  1. Hepatoprotective Activity:

The active compound andrographolide has been shown to stabilize liver cell membranes, preventing their destruction by toxins, infections, and free radicals.

  1. Choleretic Effect: Bile Stimulation

Kalmegha increases the production and secretion of bile, which enhances the excretion of bilirubin, thereby reducing yellow discoloration in jaundice.

  1. Antioxidant Action:

Neutralizes toxic free radicals and protects hepatocytes against oxidative stress to assist in liver restoration.

  1. Anti-inflammatory Effect:

Reduces liver inflammation and congestion, thereby restoring normal hepatic function.

  1. Antiviral & Antimicrobial Activity:

Helps fight viral hepatitis and other infections that commonly cause jaundice.

  1. Liver Regeneration:

Stimulates hepatic cell regeneration and supports detoxification enzymes

Kalmegha is referred to as the "King of Bitters." It is a well-recognized herbal plant in Ayurveda, used to maintain liver health and overall well-being. It is really bitter in taste and thus forms an ingredient in herbal tonics, which help in cleaning the body and providing immunity. The herb promotes digestion, supports the health of the liver, and helps detoxify the system by eliminating harmful toxins through respiration and perspiration. Kalmegha is taken mainly during seasonal changes to avoid catching infections and to keep the liver healthy. It is also beneficial for reducing fever, increasing appetite, and enhancing strength and vitality. 18

5. CONCLUSION

From roots to relief, Ayurveda has a holistic and natural approach toward treating jaundice by getting to the very root of it, rather than just the symptoms. Utilizing some of the most potent herbs for liver rejuvenation, including Bhumiamalaki, Kutki, and Guduchi, Ayurvedic treatment creates a balance in food and lifestyle that restores health to the liver, purifies the blood, and rejuvenates overall well-being. By balancing the internal systems in the body and facilitating detoxification, Ayurveda not only offers symptomatic relief in jaundice but also ensures resilience of the body to future ailments-a true reflection of the wisdom:to heal from nature’s roots.

REFERENCES

  1. Davidson. Davidson’s Principles and Practice of Medicine. 19th ed. Edited by Davidson. London: Churchill Livingstone.
  2. Schwarzenbach HR. Ikterus und pathologische Leberwerte [Jaundice and pathological liver values]. Praxis (Bern 1994). 2013;102(12):727-729.
  3. Pandey KN, Chaturvedi GN. Charak Samhita of Agnivesh Elaborated With Commentary, Part 1, Sutra Sthan; Mahrogadhyay, Chapter 20, Verse 14. 19th ed. Varanasi: Choukhambha Bharti Academy; 2021:351.
  4. Penman I, Ralston S, eds. Davidson’s Principles and Practice of Medicine. 24th ed. London: Elsevier; 2022:870-872.
  5. Shukla VD, Tripathi RD. Charak Samhita of Agnivesh Elaborated With Commentary, Part 2, Chikitsa Sthan; Pandu Rog Chikitshitam, Chapter 16, Verse 34. Varanasi: Choukhambha Sanskrit Pratishthan; 2007:399.
  6. Shukla VD, Tripathi RD. Charak Samhita of Agnivesh Elaborated With Commentary, Part 2, Chikitsa Sthan; Pandu Rog Chikitshitam, Chapter 16, Verse 34. Varanasi: Choukhambha Sanskrit Pratishthan; 2007:399.
  7. Wickramasinghe SN, Wood WG. Advances in the understanding of the congenital dyserythropoietic anaemias. Br J Haematol. 2005;131(4):431-446.
  8. Jacques G. Types of jaundices. Visual Understanding Environment (VUE), Enigma. 2009; 18:55
  9. Galanello R, Piras S, Barella S, Leoni GB, Cipollina MD, Perseu L. Cholelithiasis and Gilbert’s syndrome in homozygous β-thalassaemia. Br J Haematol. 2001;115(4):926-928.
  10. Bekta? M, Dökmeci A, Cinar K, Halici I, Oztas E, Karayalcin S. Endoscopic management of biliary parasitic diseases. Dig Dis Sci. 2010;55(5):1472-1478.
  11. Raijmakers MT, Jansen PL, Steegers EA, Peters WH. Association of human liver bilirubin UDP- glucuronyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene. J Hepatol. 2000;33(3):348-351.
  12. Malhi H, Gores GJ. Review article: The modern diagnosis and therapy of cholangiocarcinoma. Aliment Pharmacol Ther. 2006;23(9):1287-1296
  13. Barkun JS, Chaudhury P, Barkun AN. Approach to the jaundiced patient. In: ACS Surgery: Principles and Practice. 2006
  14. Yusuf TE, Bhutani MS. Role of endoscopic ultrasonography in diseases of the extrahepatic biliary system. J Gastroenterol Hepatol. 2004;19(3):243-250.
  15. Gurusamy KS, Samraj K. Primary closure versus T-tube drainage after laparoscopic common bile duct stone exploration. Cochrane Database Syst Rev. 2007;(1):CD005641.
  16. Tai CK, Tang CN, Ha JP, Chau CH, Siu WT, Li MK. Laparoscopic exploration of common bile duct in difficult choledocholithiasis. Surg Endosc. 2004;18(6):910-914.
  17. Wamsteker EJ. Updates in biliary endoscopy 2006. Curr Opin Gastroenterol. 2007;23(3):324- 328.
  18. Sahu, J. K., Nichat, A. R., Chauhan, J., Singh, B., Shivakumar, P., Supriya Devi, R., Kumar, S., & Hossain, E. (2025). Herbal remedies for jaundice: An exploration of traditional knowledge of India. Annual Research & Review in Biology, 40(8), 1–8.

Reference

  1. Davidson. Davidson’s Principles and Practice of Medicine. 19th ed. Edited by Davidson. London: Churchill Livingstone.
  2. Schwarzenbach HR. Ikterus und pathologische Leberwerte [Jaundice and pathological liver values]. Praxis (Bern 1994). 2013;102(12):727-729.
  3. Pandey KN, Chaturvedi GN. Charak Samhita of Agnivesh Elaborated With Commentary, Part 1, Sutra Sthan; Mahrogadhyay, Chapter 20, Verse 14. 19th ed. Varanasi: Choukhambha Bharti Academy; 2021:351.
  4. Penman I, Ralston S, eds. Davidson’s Principles and Practice of Medicine. 24th ed. London: Elsevier; 2022:870-872.
  5. Shukla VD, Tripathi RD. Charak Samhita of Agnivesh Elaborated With Commentary, Part 2, Chikitsa Sthan; Pandu Rog Chikitshitam, Chapter 16, Verse 34. Varanasi: Choukhambha Sanskrit Pratishthan; 2007:399.
  6. Shukla VD, Tripathi RD. Charak Samhita of Agnivesh Elaborated With Commentary, Part 2, Chikitsa Sthan; Pandu Rog Chikitshitam, Chapter 16, Verse 34. Varanasi: Choukhambha Sanskrit Pratishthan; 2007:399.
  7. Wickramasinghe SN, Wood WG. Advances in the understanding of the congenital dyserythropoietic anaemias. Br J Haematol. 2005;131(4):431-446.
  8. Jacques G. Types of jaundices. Visual Understanding Environment (VUE), Enigma. 2009; 18:55
  9. Galanello R, Piras S, Barella S, Leoni GB, Cipollina MD, Perseu L. Cholelithiasis and Gilbert’s syndrome in homozygous β-thalassaemia. Br J Haematol. 2001;115(4):926-928.
  10. Bekta? M, Dökmeci A, Cinar K, Halici I, Oztas E, Karayalcin S. Endoscopic management of biliary parasitic diseases. Dig Dis Sci. 2010;55(5):1472-1478.
  11. Raijmakers MT, Jansen PL, Steegers EA, Peters WH. Association of human liver bilirubin UDP- glucuronyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene. J Hepatol. 2000;33(3):348-351.
  12. Malhi H, Gores GJ. Review article: The modern diagnosis and therapy of cholangiocarcinoma. Aliment Pharmacol Ther. 2006;23(9):1287-1296
  13. Barkun JS, Chaudhury P, Barkun AN. Approach to the jaundiced patient. In: ACS Surgery: Principles and Practice. 2006
  14. Yusuf TE, Bhutani MS. Role of endoscopic ultrasonography in diseases of the extrahepatic biliary system. J Gastroenterol Hepatol. 2004;19(3):243-250.
  15. Gurusamy KS, Samraj K. Primary closure versus T-tube drainage after laparoscopic common bile duct stone exploration. Cochrane Database Syst Rev. 2007;(1):CD005641.
  16. Tai CK, Tang CN, Ha JP, Chau CH, Siu WT, Li MK. Laparoscopic exploration of common bile duct in difficult choledocholithiasis. Surg Endosc. 2004;18(6):910-914.
  17. Wamsteker EJ. Updates in biliary endoscopy 2006. Curr Opin Gastroenterol. 2007;23(3):324- 328.
  18. Sahu, J. K., Nichat, A. R., Chauhan, J., Singh, B., Shivakumar, P., Supriya Devi, R., Kumar, S., & Hossain, E. (2025). Herbal remedies for jaundice: An exploration of traditional knowledge of India. Annual Research & Review in Biology, 40(8), 1–8.

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Sakshi Jaju
Corresponding author

Dr. Babasaheb Ambedkar Technological University, Raigad, Lonere

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Bharti Dighule
Co-author

Dr. Babasaheb Ambedkar Technological University, Raigad, Lonere

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Dr. Sunil Jaybhaye
Co-author

Dr. Babasaheb Ambedkar Technological University, Raigad, Lonere

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Prachi Pawar
Co-author

Dr. Babasaheb Ambedkar Technological University, Raigad, Lonere

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Neha Chavan
Co-author

Dr. Babasaheb Ambedkar Technological University, Raigad, Lonere

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Jitendra Mundada
Co-author

Dr. Babasaheb Ambedkar Technological University, Raigad, Lonere

Bharti Dighule, Sakshi Jaju*, Dr. Sunil Jaybhaye, Prachi Pawar, Neha Chavan, Jitendra Mundada, From Roots to Relief- Ayurvedic Secrets for Treating Jaundice, Int. J. of Pharm. Sci., 2025, Vol 3, Issue 12, 1869-1877. https://doi.org/10.5281/zenodo.17883070

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