1Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.
2,3,4,5Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.
6,7Department of Pharmaceutics, JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA.
8JIUU’s Ali – Allana College of Pharmacy and Research Center, Akkalkuwa, District – Nandurbar, Maharashtra – 425415, INDIA
The goal of the current study was to formulate and evaluate vildagliptin sustained release tablets. It is thought to be a good medicine for the development of sustained release tablets because of its short biological half-life (1.5 h), which will allow it to continue to have a therapeutic effect for longer. Vildagliptin is a novel dipeptidyl peptidase-4 inhibitor family of oral antihyperglycemic medication. Materials and Method: Sustain Release tablets were developed using a direct compression Method using various ratios of natural polymers (Gum). The preparations were examined for their compressibility index, Hausner's ratio, bulk density, and tapped density. statistical analysis The Fourier-transform infrared spectra of vildagliptin and Vildagliptin + polymers mixture, both separately and in combination, demonstrate the drug's compatibility with excipients. Results: The tablets physicochemical characteristics were confirmed to be within acceptable limits. The weight variation, thickness, hardness, friability, drug content, and in vitro release of the produced tablets were all evaluated. In vitro - dissolution studies were carried out using USP paddle apparatus ?, at 370C ± 0.50C in 0.1 N HCL (1.2 pH) for 12 hours. the optimized formulation F - 6 Shows the Maximum drug release 99.70 ± 0.5 in 12 hours of dissolution.
Mayur Gokul Jayswal*, Vasudev Sharma, Adnan Siddiqui, Raza Khan, Shaikh Aaqueeb Ahmed, Afsar Shaikh, Qazi Majaz Ahamad Aejazuddin, G. J. Khan, Formulation and Evaluation of Sustained Release Tablet of an Anti-Diabetic Drug Vildagliptin Using Natural Polymer, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 9, 457-468. https://doi.org/10.5281/zenodo.8394231
10.5281/zenodo.8394231
