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  • Erectile Disfunction: A Comprehensive Review on Recent Advancement
  • 1Department of Pharmaceutical Quality Assurance, PRES College of Pharmacy (Women’s), Chincholi, Nashik422102
    2Department of Pharmaceutical Chemistry, PRES College of Pharmacy (Women’s), Chincholi, Nashik-422102

Abstract

In the world today, erectile dysfunction (ED) is a serious health problem that significantly lowers both the quality of life and the level of happiness of both the affected person and his spouse. The male sexual health treatment paradigm for ED has recently evolved from a psychosexual model to a new model that includes oral and intracavernosal injection pharmacotherapy, vacuum constriction devices, and penile prostheses. This evolution has been made possible by recent advances in basic sciences. This development has occurred at the same time that our awareness of male sexual health issues has grown. Epidemiological evidence demonstrates the pervasiveness of these issues and identifies the significant morbidity they cause, both for individuals and relationships. In this study, we looked into the most recent ED studies and revised treatments.

Keywords

Erectile Dysfunction, Phosphodiesterase Type 5 Inhibitor, Psychosexual Therapy

Reference

  1. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. The Journal of urology. 1994;151(1):54-61. Epub 1994/01/01.
  2. Montague DK, Jarow JP, Broderick GA, Dmochowski RR, Heaton JP, Lue TF, et al. Chapter 1: The management of erectile dysfunction: an AUA update. The Journal of urology. 2005;174(1):230-9. Epub 2005/06/11.
  3. Mazzilli, R.; Zamponi, V.; Olana, S.; Mikovic, N.; Cimadomo, D.; Defeudis, G.; Faggiano, A. Erectile dysfunction as a marker of endocrine and glycemic disorders. J. Endocrinol. Investig. 2022, 45, 1527–1534.
  4. Mazzilli, R.; Angeletti, G.; Olana, S.; Delfino, M.; Zamponi, V.; Rapinesi, C.; Del Casale, A.; Kotzalidis, G.D.; Elia, J.; Callovini, G.; et al. Erectile dysfunction in patients taking psychotropic drugs and treated with phosphodiesterase-5 inhibitors. Arch. Ital. Urol. Androl. 2018, 90, 44–48.
  5. Gandaglia, G.; Briganti, A.; Jackson, G.; Kloner, R.A.; Montorsi, F.; Montorsi, P.; Vlachopoulos, C. A systematic review of the association between erectile dysfunction and cardiovascular disease. Eur. Urol. 2014, 65, 968–978.
  6. Fedele, D.; Coscelli, C.; Santeusanio, F.; Bortolotti, A.; Chatenoud, L.; Colli, E.; Landoni, M.; Parazzini, F. Erectile dysfunction in diabetic subjects in Italy. Gruppo Italiano Studio Deficit Erettile nei Diabetici. Diabetes Care 1998, 21, 1973–1977.
  7. Rastrelli, G.; Corona, G.; Mannucci, E.; Maggi, M. Vascular and Chronological Age in Men with Erectile Dysfunction: A Longitudinal Study. J. Sex. Med. 2016, 13, 200–208.
  8. V.; Mazzilli, R.; Bitterman, O.; Olana, S.; Iorio, C.; Festa, C.; Giuliani, C.; Mazzilli, F.; Napoli, A. Association between type 1 diabetes and female sexual dysfunction. BMC Women’s Health 2020, 20, 73.
  9. La Vignera, S.; Condorelli, R.A.; Cannarella, R.; Giacone, F.; Mongioi’, L.M.; Cimino, L.; DeFeudis, G.; Mazzilli, R.; Calogero, A.E. Urogenital infections in patients with diabetes mellitus: Beyond the conventional aspects. Int. J. Immunopathol. Pharmacol. 2019, 33, 2058738419866582
  10. Rosen, R.C.; Riley, A.; Wagner, G.; Osterloh, I.H.; Kirkpatrick, J.; Mishra, A. The international index of erectile function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology 1997, 49, 822–830.
  11. Frank, E.; Anderson, C.; Rubinstein, D. Frequency of sexual dysfunction in “normal” couples. N. Engl. J. Med. 1978, 299, 111–115
  12. Shah J. Erectile dysfunction through the ages. BJU international. 2002;90(4):433-41. Epub 2002/08/15.
  13. McMahon C. Efficacy and safety of daily tadalafil in men with erectile dysfunction previously unresponsive to on-demand tadalafil. The journal of sexual medicine. 2004;1(3):292-300. Epub 2006/01/21.
  14. Cheng JY, Ng EM, Chen RY, Ko JS. Prevalence of erectile dysfunction in Asian populations: a meta-analysis. International journal of impotence research. 2007;19(3):229-44. Epub 2006/08/25.
  15. Chew KK. Prevalence of erectile dysfunction in communitybased studies. International journal of impotence research. 2004;16(2):201-2. Epub 2004/04/10.
  16.  Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. The New England journal of medicine. 1989;320(16):1025-30. Epub 1989/04/20.
  17. Kirby M, Jackson G, Betteridge J, Friedli K. Is erectile dysfunction a marker for cardiovascular disease? International journal of clinical practice. 2001;55(9):614-8. Epub 2002/01/05.
  18. 13. Hannan JL, Maio MT, Komolova M, Adams MA. Beneficial impact of exercise and obesity interventions on erectile function and its risk factors. The journal of sexual medicine. 2009;6 Suppl 3:254-61. Epub 2009/01/28.
  19. Hannan JL, Heaton JP, Adams MA. Recovery of erectile function in aging hypertensive and normotensive rats using exercise and caloric restriction. The journal of sexual medicine. 2007;4(4 Pt 1):886-97. Epub 2007/07/14.
  20. Horasanli K, Boylu U, Kendirci M, Miroglu C. Do lifestyle changes work for improving erectile dysfunction? Asian journal of andrology. 2008;10(1):28-35. Epub 2007/12/19.
  21. Mannino DM, Klevens RM, Flanders WD. Cigarette smoking: an independent risk factor for impotence? American journal of epidemiology. 1994;140(11):1003-8. Epub 1994/12/01.
  22. Guay AT, Perez JB, Heatley GJ. Cessation of smoking rapidly decreases erectile dysfunction. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 1998;4(1):23-6. Epub 2004/07/15.
  23. Lewis RW, Fugl-Meyer KS, Corona G, Hayes RD, Laumann EO, Moreira ED, Jr., et al. Definitions/epidemiology/risk factors for sexual dysfunction. The journal of sexual medicine. 2010;7(4 Pt 2):1598-607. Epub 2010/04/15.
  24. Chew KK, Bremner A, Stuckey B, Earle C, Jamrozik K. Alcohol consumption and male erectile dysfunction: an unfounded reputation for risk? The journal of sexual medicine. 2009;6(5):1386- 94. Epub 2009/01/16.
  25. Corona G, Rastrelli G, Filippi S, Vignozzi L, Mannucci E, Maggi M. Erectile dysfunction and central obesity: an Italian perspective. Asian journal of andrology. 2014;16(4):581-91. Epub 2014/04/10.
  26. Esposito K, Giugliano D. Lifestyle/dietary recommendations for erectile dysfunction and female sexual dysfunction. The Urologic clinics of North America. 2011;38(3):293-301. Epub 2011/07/30.
  27. Esposito K, Giugliano F, Di Palo C, Giugliano G, Marfella R, D'Andrea F, et al. Effect of lifestyle changes on erectile dysfunction in obese men: a randomized controlled trial. Jama. 2004;291(24):2978-84. Epub 2004/06/24.
  28. Maio G, Saraeb S, Marchiori A. Physical activity and PDE5 inhibitors in the treatment of erectile dysfunction: results of a randomized controlled study. The journal of sexual medicine. 2010;7(6):2201-8. Epub 2010/04/07.
  29. Melnik T, Althof S, Atallah AN, Puga ME, Glina S, Riera R. Psychosocial interventions for premature ejaculation. The Cochrane database of systematic reviews. 2011(8):CD008195. Epub 2011/08/13.
  30. Hawton K, Catalan J, Martin P, Fagg J. Long-term outcome of sex therapy. Behaviour research and therapy. 1986;24(6):665-75. Epub 1986/01/01.
  31. Goldstein I, Lue TF, Padma-Nathan H, Rosen RC, Steers WD, Wicker PA. Oral sildenafil in the treatment of erectile dysfunction. Sildenafil Study Group. The New England journal of medicine. 1998;338(20):1397-404. Epub 1998/05/15.
  32. Porst H, Rosen R, Padma-Nathan H, Goldstein I, Giuliano F, Ulbrich E, et al. The efficacy and tolerability of vardenafil, a new, oral, selective phosphodiesterase type 5 inhibitor, in patients with erectile dysfunction: the first at-home clinical trial. International journal of impotence research. 2001;13(4):192-9. Epub 2001/08/09.
  33. Brock GB, McMahon CG, Chen KK, Costigan T, Shen W, Watkins V, et al. Efficacy and safety of tadalafil for the treatment of erectile dysfunction: results of integrated analyses. The Journal of urology. 2002;168(4 Pt 1):1332-6. Epub 2002/09/28.
  34. Porst H, Giuliano F, Glina S, Ralph R, Adolfo R, Casabe AR et al. Evaluation of the efficacy and safety of once-a day dosing of tadalafil 5 mg and 10 mg in the treatment of erectile dysfunction: results of a multicenter, randomized, double-blind, placebo-controlled trial. Eur Urol 2006; 50: 351–9.
  35. Porst H. The rationale for prostaglandin E1 in erectile failure: a survey of worldwide experience. The Journal of urology. 1996;155(3):802-15. Epub 1996/03/01.
  36. McMahon CG. Comparison of the response to the intracavernosal injection of a combination of papaverine and phentolamine, prostaglandin E1 alone and a combination of all three in the management of impotence. Int J Impotence Res 1991; 3: 133– 42.

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Rupali Kalambe
Corresponding author

Department of Pharmaceutical Quality Assurance, PRES College of Pharmacy (Women’s), Chincholi, Nashik422102

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Charushila Bhangale
Co-author

Department of Pharmaceutical Chemistry, PRES College of Pharmacy (Women’s), Chincholi, Nashik-422102

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Kaveri Nannor
Co-author

Department of Pharmaceutical Quality Assurance, PRES College of Pharmacy (Women’s), Chincholi, Nashik422102

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Snehal Ugale
Co-author

Department of Pharmaceutical Quality Assurance, PRES College of Pharmacy (Women’s), Chincholi, Nashik422102

Rupali Kalambe*, Charushila Bhangale, Kaveri Nannor, Snehal Ugale, Monali Khatake, Krutanjali Nikumbh, Erectile Disfunction: A Comprehensive Review on Recent Advancement, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 3, 134-142. https://doi.org/10.5281/zenodo.7752052

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