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Abstract

A Dry Powder Inhaler (DPI) is a device that inhales dry powdered medicine into the lungs. DPIs are frequently used to treat respiratory conditions like COPD, bronchitis, and asthma. In recent years, interest in DPI as an effective and ecologically friendly method of medication delivery to the lung has increased. Only an effective metering mechanism, a well-chosen device, and an appropriate powder composition will allow a dry powder inhaler to achieve these objectives. The three primary categories are nebulizer, pMDI, and DPI. DPIs, which provide medicine to the lungs in the form of a dry powder, are an alternative to pMDI. To ensure that the patient receives the same dosage each time at a varied airflow rate, API particles must be present in the size range of 1 to 10 m. Four different formulation procedures, including carrier-free, drug carrier, drug additive, and drug carrier additive, are used to create DPI. 'Twin Stage Impingner' completes the lung deposition research. The inward breath device, which is primarily divided based on measurements into single-unit and multi-dosage stores, is essential for achieving appropriate delivery of breathed in medication to the lung.

Keywords

Pulmonary route, Dry powder inhaler, Carrier particle, Inhalation Device

Reference

  1. Challenges and goals for next generation therapies, By Hak-Kim Chan, Paul M. Young, Daniela Traini, MatthewCoates. [www.pharmtech.findpharma.com/pharmtech/Do sage+Forms/Dry-powder-inhalers-challenges-andgoals-for-Articlestandard/Article/detail/418244, Dry powder inhalers] 
  2. Dry Powder Inhaler. http://en.wikipedia.org/wiki/Dry_Powder_Inhal er ] 
  3. Daniher D.I, Zhu J.Review Dry powder Platform for pulmonary drug delivery. Particuology., 2008, 6: 225- 238. 
  4. A Review by Prof. Naushad Khan Ghilzai, Midwestern University. [ILwww.drugdel.com/Pulm_review.pdf, Pulmonary Drug Delivery] 
  5. Dr. Morton D, Prof. Stanlforth J. Systemic Pulmonary Delivery: Success through Integrated Formulation and Device Development; ON drug Delivery, Pulmonary delivery: innovative technologies breathing new life into inhalable therapeutics,2008, 12-13. 
  6. Shaikh S, Nazim S, Khan T, Shaikh A, Zameeruddin M, Quazi A. Recent Advances In Pulmonary Drug Delivery System: A Review; International Journal of Applied Pharmaceutics 2010, 2(4): 27-31. 
  7. Prime D, Atkins P. J, Slater A, Sunby B. Review of Dry Powder inhalers; Advance Drug Delivery Reviews., 1997, 26: 51-58. 
  8. Respirable Microparticles Of Aminoglycoside Antibiotics For Pulmonary Administration by Chiara Parlati.
  9. Factors to Consider in Developing a Dry Powder Inhaler by David L. Gardner. [http://nanoparticles.org/pdf/Gardner.pdf ] 
  10. Telko M. J, Embleton J. K. Dry Powdr Inhaler Formulation; Respiratory Care.,2005, 50(9):1209- 1227. 
  11. Malcolmson R. J, Embleton J. K. Dry powder formulations for pulmonary delivery; Reviews research focus, December 1998, 1(9): 394-398. 
  12. Dry powder inhalers. [www.lactose.com] 
  13. Keller M, Walz R. M. Dry Powder For Inhalation, United State Patent Application Publication, Publication No.- US2011/0114092 A1, Publication Date- May 19, 2011. 
  14. Ashurst I, Malton A, Prime D, SumbyB. Latest advances in the development of dry powder inhalers, reviews-research focus., 2000, 3(7): 246- 256. 
  15. Alagusundaram M, Deepthi N, Angalaparameswari S. R. S, Mohamed Saleem T. S, Gnanaprakash K, Thiruvengadarajan V. S, Madhusudhana C. Dry Powder Inhalers - An Overview; International Journal Research Pharmaceutical Science., 2010, 1(1): 34-42. 
  16. Dry Powder Inhaler Formulation By John Staniforth ,Mike Tobyn, Robert Price, 6th February 2001. 
  17. Information Broucher Copley Scientific, Quality Solutions for Inhaler Testing. [www.copleyscientific.com]
  18. Indian Pharmacopoeia, The Indian Pharmacopoeia Commission Ghaziabad, 2010, 2( 3); 20-34: 1187- 1188. 
  19. Shah nutan, shah vishal. Dry Powder Inhalation: A Review, International Journal of Research & Review in Pharmacy & Applied Science., 2010, 2(3): 458-472.
  20. Frijlink H W, De Boer AH. Review Dry Powder Inhalers for Pulmonary Delivery; Expert Opinion, Ashley Publication., 2004, 1(1): 67-86. 
  21. Newman S. P, Busse W. W. Review Evolution of dry powder inhaler design, formulation, and performance; Respiratory Medicine., 2002, 96: 293-304. 
  22. Nazrul Islam, Ellen Gldaki. Mini Review Dry Powder Inhalers (DPIs)- A review of device reliability and innovation; International Journal of Pharmaceutics., 2008, 360: 1-11. 
  23. Kapileshwar Swain, Mahesh Giri, RN Gupta, VK Arora. Dry powder inhaler a Review; Research journal of pharmaceutical, biological and chemical science,2012, 3(3): 1346-1356. 
  24. Cochrane MG, Bala MV, Downs KE, et al. Inhaled corticosteroids for asthma therapy. Patient compliance, devices and inhalation technique.,2000, 117: 542–50.
  25. Bissera Pilicheva, Plamen Katsarov, Margarita Kassarova. Flowability Evaluation of Dry Powder Inhalation Formulations Intended for Nasal Delivery of Betahistine Dihydrochloride.SMU medical journal.,2015, 2: 77-90. 
  26. Taneja ruche, sachdeva vishal, etal.recent trend in dpi technology. International research journal of pharmacy.,2012, 3(11),27-34 
  27. Niti Yadav, Alka Lohani. Dry Powder Inhalers: A Review. Indo Global Journal of Pharmaceutical Sciences, 2013, 3(2): 142-155. 
  28. Roberto W, Dal Negro. Dry powder inhalers and the right things to remember: a concept review. Dal Negro Multidisciplinary Respiratory Medicine. ,2015, 10(13): 2-4. 
  29. SP. Sahane, AK. Nikhar, S. Bhaskarana, DR. 
  30. Mundhada. Dry Powder Inhaler: An Advance 
  31. Technique for Pulmonary Drug Delivery System. 
  32. International journal of pharmaceutical and chemical sciences.,2012,1(3): 1027-1034.

Photo
Trupti Bhalekar
Corresponding author

Department of Quality Assurance, PRES College of Pharmacy (Women’s), Chincholi, Nashik-422102

Photo
Kalpana Sable
Co-author

Department of Quality Assurance, PRES College of Pharmacy (Women’s), Chincholi, Nashik-422102

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Jaya Mehetre
Co-author

Department of Quality Assurance, PRES College of Pharmacy (Women’s), Chincholi, Nashik-422102

Photo
Kiran Dhamak
Co-author

Department of Quality Assurance, PRES College of Pharmacy (Women’s), Chincholi, Nashik-422102

Trupti Bhalekar*, Kalpana Sable, Jaya Mehetre, Kiran Dhamak, Dry Powder Inhalers: A Critical Evaluation Of Their Effectiveness And Accessibility, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 7, 288-301. https://doi.org/10.5281/zenodo.8173889

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