View Article

  • Coconut Oil As A Remedial Treatment For Alzheimer’s Disorder
  • Department of Pharmacology Rajgad Dnyanpeeth College of Pharmacy, Bhor, Pune

Abstract

The coconut tree (Cocos nucifera) which is also known as the “Tree of Life” has its own values in each part of the tree and coconut oil painting is more prestigious among them. The unique chemical composition of coconut oil painting amended with medium chain adipose acids (MCFAs) has led to the disquisition of these nutritive and remedial influences. Unlike the long-chain adipose acids (LCFAs), the MCFAs generated from the digestion of medium-chain triglycerides (MCTs) have a specific pathway for the metabolism, as they bypass the lymphatic system and enter the liver directly through the portal tone. Due to similar distinct attributes in immersion and metabolism, MCTs are more readily able to form ketone bodies than other triglycerides. These ketone bodies are a competent energy source for the smarts, especially those having cognitive impairments like Alzheimer’s complaints (announcement). announcement is a neurodegenerative complaint characterized clinically by accelerating faults in memory and behavioral changes. circumstance of Cardiovascular conditions (CVD) with elevated LDL situations, hypertension, Type 2 diabetes, rotundity, and insulin resistance are some crucial threat factors that are responsible for the added frequency and prevalence of announcements. There's sufficient substantiation to prove that MCTs in coconut oil painting are metabolized and absorbed in such a way that retards the inflexibility of these physiological threat factors. either, coconut oil painting is endowed with numerous polyphenolic composites that serve as antioxidants by combating oxidative stress and inflammation, which in turn downregulates the etiology of the announcement. But depending on the different processing conditions applied in the birth ways of coconut oil painting, variations in antioxidant capacity can take place.(1)

Keywords

Alzheimer; coconut oil; Beta-amyloid peptide; ketone body

Reference

  1. Sandupama P, Munasinghe D, Jayasinghe M. Coconut oil as a therapeutic treatment for Alzheimer’s disease: a review. Journal of Future Foods. 2022 Mar 1;2(1):41-52.
  2. Zeinab Breijyeh and Rafik Karaman,  Diego Muñoz-Torrero, Academic Editor and Roman Dembinski, Academic Editor Comprehensive
  3. 3] Oseni NT, Fernando WM, Coorey R, Gold I, Jayasena V. Effect of extraction techniques on the quality of coconut oil. African Journal of Food Science. 2017:58-66.
  4. Dhapola R, Hota SS, Sarma P, Bhattacharyya A, Medhi B, Reddy DH. Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer’s disease. Inflammopharmacology. 2021 Dec:1-3.
  5. Medically reviewed by Heidi Moawad, M.D. — By Rashida Ruwa, RN on October 5, 2023Can Coconut Oil Help in Alzheimer’s Disease
  6. Al-Matrafi TA. Effects of coconut oil on Alzheimer's disease. Intl J Adv and ApplScis. 2021 Jan        31;8(5):1229.
  7. Prince Pal*1, Dikshit Rathva1, Devendra Parmar1, Juhil Patel1, Siddhi Upadhyay*2, Umesh

Upadhyay*3 A Review on Coconut Oil: An Essential Oil for All

  1. A.Deen1,2, R. Visvanathan1 D.Wickramarachchi, N.Marikkar1, S.Nammi1,3,4, B.C. Jayawardana5, R.        Liyanage1,* Corresponding author: * R. Liyanage; Title: Chemical Composition and Health Benefits of Coconut Oil: An Overview
  2. Muaz Belviranli Nilsel Okudan Selçuk University Faculty of Medicine: Selcuk Universitesi Tip Fakultesi Coconut oil ameliorates behavioral alterations in a rat model of Alzheimer’s Disease via attenuating oxidative damage and cholinergic impairment and upregulating synaptic transmission
  3. Rajagopal PL, Rajeev VR. Virgin Coconut oil”–An updated Pharmacological.
  4.  Meng J, Chen T, Zhao Y, Lu S, Yu H, Chang Y, Chen D. Study of the mechanism of anti-ulcer effects of virgin coconut oil on a gastric ulcer-induced rat model. Archives of Medical Science. 2019 Sep 1;15(5):1329-35.
  5. Suryani S, Sariani S, Earnestly F, Marganof M, Rahmawati R, Sevindrajuta S, Mahlia TM, Fudholi A. A comparative study of virgin coconut oil, coconut oil, and palm oil in terms of their active ingredients. Processes. 2020 Mar 30;8(4):402.
  6. Carascal MB. Coconut Oil: Good or Bad for Human Health?(Asian and Philippine Perspective). The Medical City. 2018 Mar:31.
  7. Neelakantan N, Seah JY, van Dam RM. The effect of coconut oil consumption on cardiovascular risk factors: a systematic review and meta-analysis of clinical trials. Circulation. 2020 Mar 10;141(10):803-1.
  8. Mullany, S. (2018)Coconut oil and dementia, News. medical.net/health/Coconut-Oil-and-Dementia.aspxss
  9. Chan SC, Esther GE, Yip HL, Sugathan S, Chin PS. Effect of cold pressed coconut oil on cognition and behavior among patients with Alzheimer’s disease-A pilot intervention study. Natl J Physiol Pharm Pharmacol. 2017 Dec 4;7(12):1432-5.
  10. Demirel G, Sanajou S, Yirün A, Çakir DA, Berkkan A, Baydar T, Erkeko?lu P. Evaluation of possible neuroprotective effects of virgin coconut oil on aluminum-induced neurotoxicity in an in vitro Alzheimer's disease model. Journal of Applied Toxicology. 2023 Nov 21.
  11. Alghamdi BS. Possible prophylactic anti-excitotoxic and anti-oxidant effects of virgin coconut oil on aluminum chloride-induced Alzheimer’s in rat models. Journal of integrative neuroscience. 2018 Jan 1;17(3-4):593-607.
  12. Shijna K, Arun S, Annie S. Coconut oil review of potential applications. Hygeia J. Drugs Med.. 2015; 7:34-41.
  13. Guttmann R, Sims P, Churchill C, Waters C, Berry B, Wells J. Coconut Oil and its Constituents as a Treatment for Alzheimer's Dementia. Journal of Student Research. 2020 Nov 3;9(1).
  14. Kappally S, Shirwaikar A, Shirwaikar A. Coconut oil–a review of potential applications. Hygeia JD Med. 2015 Oct;7(2):34-41.
  15. Varma SR, Sivaprakasam TO, Arumugam I, Dilip N, Raghuraman M, Pavan KB, Rafiq M, Paramesh R. In vitro anti-inflammatory and skin protective properties of Virgin coconut oil. Journal of traditional and complementary medicine. 2019 Jan 1;9(1):5-14.

Photo
Garad P. Swapnil
Corresponding author

Department of Pharmacology Rajgad Dnyanpeeth College of Pharmacy, Bhor, Pune

Garad P. Swapnil, Coconut Oil As A Remedial Treatment For Alzheimer’s Disorder, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 29-40. https://doi.org/10.5281/zenodo.10603216

More related articles
Bipolar Disorder ...
Avishkar Gharbudve , Shweta Agrawal, Dr.Rajendra Kawade, ...
A Review Article On The Artificial Intelligence [A...
Padala Ramesh, Patnala Vaishnavi Gayathri, Mamindla Chandrika, Da...
Unravelling Acne Vulgaris: A Comprehensive Review ...
Piyush Lekhraj Yadav, Prajakta Dattatraya Gawade, Manasi Vishwas ...
Review On Bryophyllum Pinnatum ...
Mahendra Siddheshwar Shendkar , Snehal Kothavale , Lahoo Palave, Leena Parkhi, Lalit Ambhore, Snehal...
Advancing HIV Prevention: A Comprehensive Analysis Of PrEP's Efficacy, Adherence...
Manav Kumar, Kajal Kumari , Nahida Khatun, Sapna Kumari, Laxman Kumar Mahto, Divya Roshni Panna, Bin...
Related Articles
A Review Article On Transforming Parkinson’s Disease Care :Innovative Treatmen...
Siddhant M. Sawant, Prashant J. Burange, Maithili P. Amale, Pankaj Chaudhary , ...
Drug Interaction Study of Gastric Irritant Drugs (Nsaids, Iron Supplements and A...
Deepak Venkataraman N., Charumathi P., Bharathwaj J., Lakshminarasimman S., Purushothaman K., Sudhar...
To Study The Preparation Formulation And Evaluation Of Medicated Lollipop...
Khandagale Sandip suresh, Madane Somnath Jotiram, Patil Onkar Ganpat, Dabhade Sakshi kailasrao, Salv...
Bipolar Disorder ...
Avishkar Gharbudve , Shweta Agrawal, Dr.Rajendra Kawade, ...
More related articles
Bipolar Disorder ...
Avishkar Gharbudve , Shweta Agrawal, Dr.Rajendra Kawade, ...
A Review Article On The Artificial Intelligence [Ai] In Tumour Detection [Oncolo...
Padala Ramesh, Patnala Vaishnavi Gayathri, Mamindla Chandrika, Daravath Pawan Kalyan, ...
Unravelling Acne Vulgaris: A Comprehensive Review of Epidemiology, Pathogenesis,...
Piyush Lekhraj Yadav, Prajakta Dattatraya Gawade, Manasi Vishwas Shelke , Rahul Rakesh Vishwakarma, ...
Bipolar Disorder ...
Avishkar Gharbudve , Shweta Agrawal, Dr.Rajendra Kawade, ...
A Review Article On The Artificial Intelligence [Ai] In Tumour Detection [Oncolo...
Padala Ramesh, Patnala Vaishnavi Gayathri, Mamindla Chandrika, Daravath Pawan Kalyan, ...
Unravelling Acne Vulgaris: A Comprehensive Review of Epidemiology, Pathogenesis,...
Piyush Lekhraj Yadav, Prajakta Dattatraya Gawade, Manasi Vishwas Shelke , Rahul Rakesh Vishwakarma, ...