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Abstract

Ayurvedic traditional medicine frequently employs the medicinal herb Tinospora cordifolia. Having a multiple therapeutical activity which is used in treatment of various disorders. It’s another names are Amrita and Guduchi. Amrita means the drink of god that bestows immortality. So the giloy is also known as Nector of god. The family of giloy is Menispermaceae. In traditional indian medicinal system it is imperative plant. Giloy contains chemical constituents that are Alkaloid, Terpenoids, Lignans, Steroids, which shows pharmacological activity. The element of giloy used in Siddha, Unani, Ayurvedic medicinal system. This review article is on the therapeutical properties, collection, cultivation, harvesting, chemical constituents of giloy which analysed for future research

Keywords

Giloy, Guduchi, Ayurveda, Nector

Reference

  1. Shuddhi Ayruveda, “Giloy-a review”, International Journal of current Research,  Vol.13, Issue 01, January2021, Page no.15779-15785.
  2. Dr.Dattu D. Karande, “Giloy (Tinospora cordifolia)-a review for its hepatoprotetive effects, safety profile and terms and conditions for medicinal use”, Journal of Emerging technologies and Innovative research, Vol.8 , Issue 10, October-2021, Page no.b271-b276.
  3. Priyanka sharma, Bharat P. Dwivedee, Dheeraj Bisht, Ashutosh K. Dash, Deepak kumar, “The chemical constituents and diverse pharmacological importance of tinospora crdifolia”, Heliyon, Vol.5, Issue 9, September -2019.
  4. Technial Dossier on Guduchi (Tinospora Cordifolia), Ministry of  ayush, Government of India, New Delhi, 2022.
  5. Tinospora Cordifolia (Giloy) for socioeconomicempowerment NMPB Ministry of AYUSH Sponsered , Govt. College of pharmacy, Amravati-Maharashtra India, 2020.
  6. Manoj kumar Sarangi, Shasank Soni, “ A Review on Giloy- The Magic Herb”, Inventi Rapid:Planta activa, Vol.2013, Issue 2, March-2013,  Page no.1-4.
  7. Ratnesh Singh, “A Review Artical on Phyochemistry and pharmacological Activity of Tinospora Cordifolia”, International Journal of Pharmacy And Pharmaceutical Research  Human Journal, Vol.19, Issue 1,  August-2020, Page no.253-274.
  8. Kavya B, Kavya N, Ramarao V and Venkateshwarlu G, “ Tinospora cordifolia (Willd.) Miers: Nutritional Ethnomedical and Therapeutic utility, International Journal of Research  Ayurveda Phrama, Vol.6, Issue 2, March-April-2015, Page no.195-198.
  9. C. Bharathi, A. Harinatha Reddy, G. Nageswari, B. Sri Lakshmi, M. Soumya, D.S.Vanisri, B. Venkatappa, “A Review on Medicinal Properties of Tinospora Cordifolia”, International Journal Of Scientific Research and Review,  Vol.7, Issue 12, 2018, Page no.585. 
  10. Rakesh Maurya and Sukhdev S handa, “Phytochemistry”, Vol.49, Issue 1343, 1998.
  11. Amandeep Singh, Nisha A Bhatt, Abhineskar Sagar, Amartya Kumar, Abhay Goswami, “Medicinal Uses of Giloy: A  Review”, European Journal of Molecular and Clinical Medicine, Vol.08, Issue 04, 2021.
  12. Tiwari M, Dwivedi UN, Kakkar P., “Tinospora cordifolia Extract Modulates COX-2, iNOS, ICAM-1, Pro-inflammatory cytokines and redox status in murine model of asthma”, J Ethnopharmacol, Vol.153,  Issue 2, 2014, Page no.326-337.
  13. Charu Saxena, Geeta Rawat, “ Tinospora Cordifoia (Giloy)- Therapeutic uses and Impartance:A review”, Current Research in Pharmaceutical Sciences, Vol.09, Issue 03, 2019,  Page no.42-45.
  14. Patel Nidhi, Ptel Swati, Krishnakumurti R, “Indian Tinospora Species: Ntural Immunomodulator and therapeutic agents”, Internatinal gournal of pharmaceutical biological and chemical sciences, Vol.2, Issue 2, April-Jun 2013, Page no.1-9.
  15. Raghu R, Sharma D, Ramakrishnan R, Khanam S, Chintalwar GJ, Sainis KB, “Mlecular enventsa in the activation of B-cells and macrphages by a non-microbial TLR4 agonist G1-4A from Tinospora Cordifolia, Immunol Lett, Vol.123, Issue 1, 2009, Page no.60-71.
  16. Sharma P, Parmar J, Sharma P, Verma  P, Goyal Pk, “Radiation Induced testicular injury and its amelioration by Tinospora Cordifolia (An indian medicinal Plant) extract, Evidence based comp altern Meb, 2012,  Page no.643-647.
  17. Md. Moniruzzaman Khan, M. Sa’dul Haque,  Md. Saiful Islam Chowdhury, “Medicinal use of the unique plant Tinospora cordifolia: Evidence from the traditional medicinal and recent research”,  Asian Journal if medical and Biological Research, Vol.2, Issue 4 , 2016, Page no.508-512.
  18. Giby Abraham, “ We want to protecting have used in Ayurveda”, Global J Res. Med. Plants and Indigen. Med. Vol.3, Issue 7, July 2014, Page no.303-311.
  19. Hareram Birla, Surya Pratap Singh, “Neuroprotective role of medicinal herbs (Tinospora Cordifolia) in the parkinson disease”, general of biological engineering research and review, Vol.4,  Jan-June 2017, Page no.31.
  20. Kalikaer, M.V., Thawani, V.R.,Varadpande, U.K., Santakke, S.D., Singh, R..P., Khiyani, R.K., “Immunomodulatory effect of Tinospora Cordifolia Extracts in HIV Positive Patients” , Indian Journal of pharmacology, Vol.40, Page no.107-110.
  21. Amarjeet Singh, Bimlesh Kumar, “Comparative antidiarrheal and antiulcer effect on the aqueous and ethanolic stem bark extract of Tinospora Cordifolia in rats, journal of Advanced  pharamaceutical technology and research, Vol.5, Issue 3, Jun-Sep 2014, Page no.122-126.
  22. Harish Chandra Goyal, Madhubala, Paban K Agrawal, Ruchi Dogra, “Radioprotective Potential of herbal extract of Tinospora Cordifolia, Journal of radiation Research, Vol.45, Issue 57-64, 2004, Page no.122-126.
  23. Sowjanya Kattupali, Spandana Uppuluri, vaishnavi Vesta, “ The multi activity herbaceous vine-Tinospora Cordifolia”, Asian Journal of pharmaceutical and clinical research, Vol.12, Issue 3, 2019, Page no.1-4.
  24. Bhawya D, Anilakumar KR, “In-vitro Anti-oxidant Potency of Tinospora Cordifolia (Gulancha) in Sequential Extract”, International Journal of Pharmaceutical and biological Archives, Vol.1, Issue 5, 2010, Page no.448-456.
  25. Sivakumar V, Rajan MS, “ Antioxidant Effect of Tinospora Cordifolia extract in Alloxan-Induced diabetic rats”, Indian J Pharm Sci, Vol. 72, Issue 6, 2010, Page no.795-800.
  26. Gupta R, Shrama V, “Ameliorative Effect of  Tinospora Cordifolia Root Extract on Histolopathological and Biochemical changes induced by Aflatoxin-b(1) in mice kidney”, Toxicol Int, Vol.18, Issue 2, 2011,  Page no.94-98.  
  27. Neha Upadhyay, Showkat A Ganie,  Rajneesh K Agnihotri, Rajendra Sharma, “Free Radical Scavenging  activity of Tinospora Cordifolia (Willd.) Miers”, Journal of Pharmacognocy and Phytochemistry, Vol.3, Issue 2, 2014, Page no.63-69.
  28. Jayaparkash R, Ramesh V, Sasikala C, “Antioxidant Activity of ethanolic extract of Tinospora Cordifolia on N-nitrosodiethylamine (diethylnitrosamine) induced liver cancer in male winster albino rats” , J. Pharm Bioall Sci, Vol.7, 2015, Page no.40-50.
  29. Shakil NA, Saxena DB, “Isolation and sturcture of Tinospora Cordifolin, a novel insecticidal oxygenated chalcone, from the stem of Tinospora Cordifolia Miers”, Natural Product Communications, Vol.1, 2006, Page no.553-556.
  30. Deepika Singh, Prabir Ke chaudhari, “Chemistry and pharmacology of tinospora cordifolia” Natural Product  communication, Vol.12, 2001, Page no.299-308.
  31. RS Gupta, Rakhi Sharma, “A Review on medicinal plants exhibiting antifertility activity in males”, Natural Product radiance, Vol.5, Issue 5, 2006, Page no.389-410.
  32. Vikram Singh, H. S. Banyal, “Antimalarial effect of Tinospora Cordifolia (Willd.) Hook. F. and THOMS and Cissampelos pareira L. On Plasmodium Berghei”, Current Science, Vol.101, Issue 10, Nov 2011, Page no.1356-1358.
  33. S.K. Dwivedi, Enespa, “Hillsborough Cordifolia with reference to biological and microbial properties” , International Journal of Current Microbiology and Applied Sciences, Vol.5, 2016, Page no.446-465.
  34. Patel MB, Mishra S, “Hypoglycemic activity of alkaloidal fraction of Tinospora Cordifolia”, Phytomedicine, Vol.18, Issue 12,  2011, Page no.1045-1052.
  35. Shivananjappa MM, “Abrogation Of maternal and fetal oxidative stress in the streptozotocin-induced diabetic rat by dietary supplements of tinospora corddifolia”, Nutrition, Vol.28, Issue 5, 2012, Page no.581587.
  36. Stanely P, Prince M, Menon VP, “Hypoglycemic and other related  actions of Tinospora cordifolia roots in alloxan-induced diabetic rats”, J Ethnopharmacol, Vol.70, Issue 1, 2000, Page no.9-15.
  37. Sangeetha MK, Raghavendran HR, Gayathri V, Vasanthi HR, “ Tinospora Cordifolia attenuates oxidative stress and distorted carbohydrate metabolism in experimentally induced type 2 diabeties in rats” , J Nat Med, Vol.65, Issue 3-4, 2011,  Page no.544-550.
  38. Syed Ismail Jabiullah, Jainendra Kumar battineni, Vasudha Bakshi, Narender Boggula, “Tinospora Cordifolia a medicinal plant: A Review”,  Journal of Medicinal Plants Studies, Vol.6, Issue 6, 2018,  Page no.226-230.
  39. Yoggeta, Deepika Bhatia, Sheetal Rani, “Tinospora Cordifolia: A Literature Review on therapeutic uses and pharmacological actions”, Journal of Pharmaceutical Research International, Vol.33, Issue 57A, 2021, Page no.330-343.
  40. Kohno H, maeda M, Tanino M, Tsukio Y, Ueda N, Wada K, Mori H, Tanaka T, “A Bitter diterpenoid furanolactonecolumbin from calumbae radix inhibits azoxymethane-induced rat colon carcinogenesis”, Cancer Letters, Vol.183, 2002,  Page no.131-139.
  41. Thippeswamy  G,  Sheela ML, Salimath BP, “Octacosanol isolated from Tinospora Cordifolia Downregulates VEGF gene expression by inhibiting nuclear translocation of NF-B and its DNA binding activity”, Eur J  Pharmacol, Vol.588, Issue 2, 2008, Page no.141-150.
  42. Deepika Singh, Prabir K Chaudhari, “Chemistry and pharmacology of Tinospora cordifolia”, Natural Product Communications, Vol.12, 2017, Page no.299-308.
  43. Pal Neha, Maya Datt Joshi, Yashwant Singh, Narendra Paratap Singh, “Review article of tinospora cordifolia” , World general of Pharmaceutical Research, Vol.9, Issue 2, Page no. 604-620.
  44. Vijaya Nirmala R., Abhinaya R., “Any effect of cardioprotective activity in various medicinal plants: A  Review”,  International Journal of current pharmaceutical  research, Vol.11, Issue 2, 2019, Page no.2-3.
  45. Pritika Devi, “Role of Tinospora Cordifolia in metabolic health disorders: An uodated review”, Himalayan Journal of Health Science, Vol.6, Issue 1, 2021, Page no.6-14.
  46. Madhav Mutalik, Mutalik Maitreyee, “Tinospora Cordifolia: role in depression, cognition and memory” , Australian journal of medicinal herbalism, Vol.23, Issue 4, 2011, Page no.168-171.
  47. Yanshi Rahal, Anshu Rahal, “Giloy (Tinospora Cordifolia): A medicinal herb for livestock and poultry” , International Journal of current Advanced Research, Vol.8, Issue 04, April-2019, Page no.18523-18526.
  48. Suman PS khanuja, “Tinospora Cordifolia (Guduchi): A reservoir plant for the therapeutical application: A Review article” , Indian Journal of traditional knowledge, Vol.3, Issue 3, August 2004, Page no.251-267.
  49. Pendse VK, Dadhich AP, Mathur PN, Bal MS, Madam BR, “Anti-inflammatory, immunosuppressive and some related Pharmacological actions of the water extract of neem giloy (Tinspora cordifolia)- A preliminary  report” , Indian  J  Pharm, Vol.9, 1977, Page no.221-224.
  50. Siddalingappa C M, Rajesh T, Kudagi B L, krishnakanth K, Sujit T R, “Evaluation of Analgesic and Antiinflammmatory activities of tinospora cordifolia” , International Journal of Basic medical Science, Vol.3, Issue 5, 2012.
  51. Muhammad Saeed, Muhammad Naveed, Ihsanullah kakar, Ifayat Ullah, Fawwad Ahmad, Muhammad
  52. Sharif, Asif Javaid, Mubasher Rauf, Moamed E., Abd El-Hack, Mervat A., Abdel-Latif, YY ,Sun Chao, “Using Guduchi (Tinospora cordifolia) as an eco-friendly feed supplement in human and poultry nutrition” , Poultry Science, 2020, Page no.801-809.
  53. Sumit Sharma, “Unproven/Alternative methods for treating allergic rhinitis”, Global general of  otolaryngology, Vol.3, Issue 1, Jan-2017, Page no.08-09.
  54. Hamsa T P, Kuttan G, “Tinospora cordifolia ameliorates urotoxic effect of cyclophosphamide by ,odulating GSH and Cytokine levels” , Exp Toxicol pathol, Vol.64, Issue 4, 2012, page no.307-314.
  55. Sharma V,  Pandey D, “Protective role of tinospora cordifolia against lead-induced hepatotoxicity”, Toxicol International, Vol.17, Issue 1, 2010,  Page no.12.
  56. Shanish Antony A, Partha Deb Roy, Vadivelan R, Jaysankar K, Vikram M, Nandini S, Sundeep M, Elango
  57. K, Suresh B, “Amelioration of  CNS toxicities of L-Dopa in experimental models of parkinson’s disease by concurrent treatment with tinospora cordifolia” , Hygeia J D Med, Vol.2, Issue 1, 2010, Page no.28-37.
  58. Singh K, Panghal M, Kadyan S, Chaudhary U, Yadav JP, “Antibacterial activity of synthesized silver nanoparticles from Tinospora Cordifolia against multidrug resistant strains of Pseudomonas aeruginosa isolated from burn patients” , J Nanomed  Nanotechnol, Vol.5, Issue 2, 2014, Page no.1-6.
  59. Jayachandran R, Xavier TF, Anand SP, “Antibacterial activity of stem extracts of Tinospora cordifolia (Willd.) Hook. F and Thomson” , Ancient Sci Life, Vol.23, Issue 1, 2003, Page no.40-43.
  60. Duraipandiyan V, Ignacimuthu S, Balakrishna K, AL-Harbi NA, “Antimicrobial activity of Tinospora cordifolia: an ethno medicinal plant”, Asian J Tradit Med., Vol.7, Issue 2, 2012, Page no.59-65.
  61. Purandare H, Supe A, “Immunomoduatory role of tinospora cordifolia  as an adjuvant in surgical treatment of diabetic foot ulcers: A prospective randomized controlled study”, Indian J Med Sci., Vol.61, Issue 6, 2007, Page no.347-355.
  62. Shanthi V, Nelson R, “Antibacterial activity of tinospora cordifolia (Willd) Hook F Thoms on urinary tract pathogens”, Int J Curr Microbial app Sci., Vol.2, Issue 6, 2013, Page no.190-400.
  63. Bonvicini F, Mandrone M, Antognonii F, Poli F, Angela Gentilomi G, “Ethanolic extracts of Tinospora Cordifolia and Alstonia scholaris show antimicrobial activity towards clinical isoaltes of methicillin-resistant and carbapenemase producing bacteria” , Nat  Prod Res., Vol.28, Issue 18, 2014, Page no.1438-1445.
  64. Narayanan A, Raja S, Ponmurugan K,  Kandekar S, Natarajaseenivasan K, Maripandi A, et al , “Antibacterial activity of selected medicinal plants against multiple antibiotic resistant uropathogens: a study from kolli hills, Tamil nadu” , Indian Benef Microbes, Vol.2, Issue 3, 2011, Page no.235-243.
  65. Abiramasundari G, Sumalatha KR, Sreepriya M, “Effects of Tinospora cordifolia (Menispermaceae) on the proliferation, osteogenic differentiation and mineralization of osteoblast model systems in vitro” , J Ethnopharmacol, Vol.141, Issue 1, 2012, Page no.474-480.
  66. Kapur P, Wuttke W, Jarry H, Seidlova-Wuttke D, “Beneficial effects of Beta-Ecdysone on the joint epiphyseal cartilage tissue and trabecular bone in ovariectomizd rats”,  Phytomedicine, Vol.17, Issue 5, 2010, Page no.350-500.
  67. J. A. Wani, R. N. Achur, R. K. Nema, “Phytochemical Screening and aphordisiac activity of asparagus racemosus”, International Journal of Pharmaceutical Science and Drug Research, Vol.3, 2011, Page no.112115.
  68. P. P. M. Stanely, V. P. Menon, G. Gunasekharam, “Hypolipidaemic action of tinospora cordifolia roots in alloxan induced diabetic rats” , J. Ethnopharmacol, Vol.64, 1999, Page no.53-57.
  69. Priyanka Sharma, Jyoti Parmar, Priyanka Sharma, Preeti Verma, P K Goyal, “Radiation-induced Testicular injury and its amelioration by Tinospora cordifolia  (An Indian Medicinal Plant) Extract evidence based complementary and alternative medicine”, Vol.2011, 2011, Page no.1-9.
  70. D N K Sarma, R L Khosa, J P N Chansauria, M Sahai, “Antiulcer activity of Tinospora cordifolia Miers and centella asiatica linn extracts”, Phytotherapy Research, Vol.9, Issue 8, 1995, Page no.589-590.
  71. Herbal Remedies for Dengue, Planet ayurveda – Holistic healing through herbs.
  72. Avnish K Upadhyay, Kaushal Kumar, Arvind Kumar, Hari S Mishra, “Tinospora cordifolia (Willd.) Hook. F. and Thoms  (Guduchi)- validation of the ayurvedic pharmacology through experimental and clinical studies” , Int J Ayurveda Res., Vol.1, Issue 2, Apr-Jun 2010, Page no.112-121.
  73. Birla H Rai, S. N. Singh, S. S. Zahra, W. Rawat, A. Tiwari, N. Singh, R. K. ,Pathak A., Singh S. P., “Tinospora Cordifolia suppresses Neuroinflammation in Parkinsonian Mouse Model” , Neuromolecular  Medicine, Vol.21, 2019, Page no.42-53.
  74. Baghel P, “Plant of versatile Propertis of Tinospora cordifolia (Guduchi)” , International Journal of Agriculture Innovations and Research, Vol.5, 2017, Page no.751-753.

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Shital Devkar
Corresponding author

Ashokrao Mane Institute Of Pharmacy, Ambap Kolhapur 416112, Maharashtra, India

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Suvarna Deshmukh
Co-author

Ashokrao Mane Institute Of Pharmacy, Ambap Kolhapur 416112, Maharashtra, India

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Sourabh Patil
Co-author

Ashokrao Mane Institute Of Pharmacy, Ambap Kolhapur 416112, Maharashtra, India

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Shreyash Koli
Co-author

Ashokrao Mane Institute Of Pharmacy, Ambap Kolhapur 416112, Maharashtra, India

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Prachi L. Khochage
Co-author

Ashokrao Mane Institute Of Pharmacy, Ambap Kolhapur 416112, Maharashtra, India

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Nilesh B. Chougule
Co-author

Ashokrao Mane Institute Of Pharmacy, Ambap Kolhapur 416112, Maharashtra, India

Shital Devkar*, Suvarna Deshmukh, Sourabh Patil, Shreeyash Koli, Prachi Khochage, Nilesh Chougule, Allounder Of Ayurveda-Tinospora Cordifolia, Int. J. in Pharm. Sci., 2023, Vol 1, Issue 12, 580-598. https://doi.org/ 10.5281/zenodo.10423831

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