View Article

Abstract

Suppositories are pharmaceutical dosage forms that hold a crucial place in the realm of drug delivery. Suppositories are the dosage form inserted into body cavity, mainly rectum and vagina to deliver the drug into the systemic circulation. Suppositories can be taken by patients who are unable to take medicine orally due to nausea and vomiting, and neurological disorder. Suppositories are used over other dosage form because it comes in different shapes and sizes. Suppositories are one of the very feasible modes of administration for medication. It can be prepared by using various bases like cocoa butter, PEG, and fatty base as main ingredients. It can be prepared by using hand rolling, compression molding, fusion molding, and automatic Mold method. Evaluation tests like Uniformity of weight, Content Uniformity test, Melting point determination test, General appearance test, Assay of active contents, Liquefaction time, Breaking test, Disintegration test, Dissolution test.

Keywords

Suppositories; Suppository Bases; Preparation methods; Characteristics

Reference

  1. https://www.researchgate.net/publication/374708622_Modern_Aspects_of_Suppositories_A_Review
  2. https://gsconlinepress.com/journals/gscbps/sites/default/files/GSCBPS-2023-0429.pdf
  3. https://unacademy.com/content/nta-ugc/study-material/pharmaceutical-analysis/an-overview-of suppositories/
  4. https://pharmlabs.unc.edu/labexercises/compounding/suppositories/
  5. Vijay D. Havaldar, Adhikrao V. Yadav, Remeth J. Dias, Kailas K. Mali, Vishwajeet S. Ghorpade, Nitin H. Salunkhe. Rectal suppository as an effective alternative for oral administration. Research J. Pharm. and Tech. 2015; 8(6): 759-766.
  6. Pushkar Baviskar, Anjali Bedse, Sayyed Sadique, Vikas Kunde, Shivkumar Jaiswal. Drug delivery on rectal absorption: Suppositories. Int. J. Pharm. Sci. Rev. Res. 2003; 22(1): 70-76.
  7. Lachman Leon, Lieberman H., The Theory and practise of industrial pharmacy, CBS Publisher and distributor, New Delhi, Fourth edition, 2013, 744-769.
  8. Christine Edwards. Physiology of the colorectal barrier. Adv. Drug Delivery Reviews. 1997; 2: 173-190.
  9. Lo YL, Lin Y, Lin HR. Evaluation of epirubicin in thermogelling and bioadhesive liquid and solid suppository formulations for rectal administration. Int. J. of Molecular Sci. 2014; 15: 342-360.
  10. Jawahar N, Jayaprakash S, Maria GRNS, Nagarajan M, Dhachina Moorthi D, Jubie S, Manivannan R. Design and evaluation of sustained release suppositories of nimesulide. Indian J. of Pharm. Sci. 2005; 67(5): 558-61.
  11. Susan Hua. Physiological and pharmaceutical considerations for rectal drug formulations. Frontiers in Pharmacology. 2019; 10: 1196.
  12. Akl, M. A., Ismael, H. R., Abd Allah, F. I., Kassem, A. A., and Samy, A. M. Tolmetin sodium-loaded thermosensitive mucoadhesive liquid suppositories for rectal delivery; strategy to overcome oral delivery drawbacks. Drug Dev. Ind. Pharm. 2019; 45 (2): 252–264.
  13. Purohit, T. J., Hanning, S. M., and Wu, Z. (2018). Advances in rectal drug delivery systems. Pharm. Dev. Technol. 2018; 23 (10): 942–952.
  14. Lieberman H, Rieger M, Banker GS, editors Pharmaceutical Dosage Forms: disperse systems. 2nd ed. CRC Press; 2019.
  15. Aulton ME, Taylor K, editors. Aulton's pharmaceutics: the design and manufacture of medicines. Elsevier Health Sciences; 2013.
  16. De Boer AG, Moolenaar F, De Leede LG, Breimer DD. Rectal drug administration: clinical pharmacokinetic considerations. Clinical pharmacokinetics. 1982 Aug;7:285-311.
  17. Gunn C, Cooper JW, Carter SJ. Cooper and Gunn's dispensing for Pharmaceutical Students. Pitman; 1965.
  18. Singh B, Kumar R, Ahuja N. Optimizing drug delivery systems using systematic" design of experiments." Part I: fundamental aspects. Critical Reviews™ in Therapeutic Drug Carrier Systems. 2005;22(1).

Photo
N Deekshitha Reddy
Corresponding author

Sri Venkateswara University College of pharmaceutical sciences

Photo
K. Muniraja Lakshmi
Co-author

Sri Venkateswara University College of pharmaceutical sciences

K. Muniraja Lakshmi, N. Deekshitha Reddy, A Review On Suppositories, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 668-675. https://doi.org/10.5281/zenodo.10701894

More related articles
Diabetes And Hepatic Dysfunction: Exploring the Co...
Vikas Gupta, Sayyed Mateen, Amit Sharma , Aafreen Qureshi , ...
A Comparative Overview of Medical Device Registrat...
Gunjan Ginoya, Hitesh Raval, Tejal Gandhi, ...
Mechanisms, Clinical Manifestations, And Management of Doxorubicin-Induced Cardi...
Ankit Verma, Priyanshi Sharma, Anupama Patel , Aviraj Kumar Gaurav, ...
HPTLC Method Development and Validation: An Overview...
Divya Bhondve , Rasika Kamthe, Samruddhi Zagade, Biradar S. M., ...
A Case Report on Coagulopathy Induced Pharyngeal and Laryngeal Hematoma...
Grace Raju, Arya Mohan, Sanil Anil S., Shaiju Dharan, ...
Related Articles
Introduction of Asthma, Which is Treated by Bronchodilator...
Pratiksha Shejul, Tarrnum Shaikh, Shrikant Madhekar, Sanchidanand Angdi, ...
Formulation and Optimization of Natural Anti-Inflammatory Cream Using Herbal Ext...
Kute Swamini Bhaskar, Harsh Yogesh Meher , Swapnil Kale, ...
Formulation And Evaluation of Effervescent Granules Containing Clitoria Ternatea...
Ekbote Eshaan M., Gadiya Kashish M., Gaikwad Divya D., Gorde Sakshi S., ...