View Article

Abstract

Suppositories are pharmaceutical dosage forms that hold a crucial place in the realm of drug delivery. Suppositories are the dosage form inserted into body cavity, mainly rectum and vagina to deliver the drug into the systemic circulation. Suppositories can be taken by patients who are unable to take medicine orally due to nausea and vomiting, and neurological disorder. Suppositories are used over other dosage form because it comes in different shapes and sizes. Suppositories are one of the very feasible modes of administration for medication. It can be prepared by using various bases like cocoa butter, PEG, and fatty base as main ingredients. It can be prepared by using hand rolling, compression molding, fusion molding, and automatic Mold method. Evaluation tests like Uniformity of weight, Content Uniformity test, Melting point determination test, General appearance test, Assay of active contents, Liquefaction time, Breaking test, Disintegration test, Dissolution test.

Keywords

Suppositories; Suppository Bases; Preparation methods; Characteristics

Reference

  1. https://www.researchgate.net/publication/374708622_Modern_Aspects_of_Suppositories_A_Review
  2. https://gsconlinepress.com/journals/gscbps/sites/default/files/GSCBPS-2023-0429.pdf
  3. https://unacademy.com/content/nta-ugc/study-material/pharmaceutical-analysis/an-overview-of suppositories/
  4. https://pharmlabs.unc.edu/labexercises/compounding/suppositories/
  5. Vijay D. Havaldar, Adhikrao V. Yadav, Remeth J. Dias, Kailas K. Mali, Vishwajeet S. Ghorpade, Nitin H. Salunkhe. Rectal suppository as an effective alternative for oral administration. Research J. Pharm. and Tech. 2015; 8(6): 759-766.
  6. Pushkar Baviskar, Anjali Bedse, Sayyed Sadique, Vikas Kunde, Shivkumar Jaiswal. Drug delivery on rectal absorption: Suppositories. Int. J. Pharm. Sci. Rev. Res. 2003; 22(1): 70-76.
  7. Lachman Leon, Lieberman H., The Theory and practise of industrial pharmacy, CBS Publisher and distributor, New Delhi, Fourth edition, 2013, 744-769.
  8. Christine Edwards. Physiology of the colorectal barrier. Adv. Drug Delivery Reviews. 1997; 2: 173-190.
  9. Lo YL, Lin Y, Lin HR. Evaluation of epirubicin in thermogelling and bioadhesive liquid and solid suppository formulations for rectal administration. Int. J. of Molecular Sci. 2014; 15: 342-360.
  10. Jawahar N, Jayaprakash S, Maria GRNS, Nagarajan M, Dhachina Moorthi D, Jubie S, Manivannan R. Design and evaluation of sustained release suppositories of nimesulide. Indian J. of Pharm. Sci. 2005; 67(5): 558-61.
  11. Susan Hua. Physiological and pharmaceutical considerations for rectal drug formulations. Frontiers in Pharmacology. 2019; 10: 1196.
  12. Akl, M. A., Ismael, H. R., Abd Allah, F. I., Kassem, A. A., and Samy, A. M. Tolmetin sodium-loaded thermosensitive mucoadhesive liquid suppositories for rectal delivery; strategy to overcome oral delivery drawbacks. Drug Dev. Ind. Pharm. 2019; 45 (2): 252–264.
  13. Purohit, T. J., Hanning, S. M., and Wu, Z. (2018). Advances in rectal drug delivery systems. Pharm. Dev. Technol. 2018; 23 (10): 942–952.
  14. Lieberman H, Rieger M, Banker GS, editors Pharmaceutical Dosage Forms: disperse systems. 2nd ed. CRC Press; 2019.
  15. Aulton ME, Taylor K, editors. Aulton's pharmaceutics: the design and manufacture of medicines. Elsevier Health Sciences; 2013.
  16. De Boer AG, Moolenaar F, De Leede LG, Breimer DD. Rectal drug administration: clinical pharmacokinetic considerations. Clinical pharmacokinetics. 1982 Aug;7:285-311.
  17. Gunn C, Cooper JW, Carter SJ. Cooper and Gunn's dispensing for Pharmaceutical Students. Pitman; 1965.
  18. Singh B, Kumar R, Ahuja N. Optimizing drug delivery systems using systematic" design of experiments." Part I: fundamental aspects. Critical Reviews™ in Therapeutic Drug Carrier Systems. 2005;22(1).

Photo
N Deekshitha Reddy
Corresponding author

Sri Venkateswara University College of pharmaceutical sciences

Photo
K. Muniraja Lakshmi
Co-author

Sri Venkateswara University College of pharmaceutical sciences

K. Muniraja Lakshmi, N. Deekshitha Reddy, A Review On Suppositories, Int. J. of Pharm. Sci., 2024, Vol 2, Issue 2, 668-675. https://doi.org/10.5281/zenodo.10701894

More related articles
Formulation And Evaluation Of Herbal Mosquito Repe...
Saddam Hussain , Neelam Painuly , ...
Artificial Intelligence in Cancer Biomedicine: A C...
Brijesh Yadav , Vanshika , Vinay Pal Chaudhary , Ashu Kumar, Mant...
The Alzheimer's Dieases...
Siddhant Sawatkar, Shivanee Tupkar, Dr. Gajanan Sanap, ...
Formulation and Evaluation Herbal Face Pack Powder For Glowing Skin ...
Ravindra Kalyan Narwade, Deepak Sudhakar Surase, Prachi Murkute, ...
Varenicline Tartrate: A New Hope for Those Seeking to Quit Smoking ...
Raj Chauhan, Khushbu Patel, Dr. Khushbu Patel, Dr. C. N. Patel, Sweety Oza, ...
A Review On Application And Scopes For Dosage Forms Of Cissus Quadrangularis Ext...
Rohit R. Eklare, Mahesh M. Biradar, Anita S. Chavan, Vaishnavi K. Chavhan, Anjali G. Chopade, ...
Related Articles
Pharmacognostic Standardization, Phytochemical Profiling, and Pharmacological Ev...
Ishika Kumari, Anurag Singh, Dr. Arvind Kumar Srivastava, Sailesh Patak, Ayushi Rai, ...
Design and Assessment of Mucoadhesive Insitu Gel Forming Spray for Oral Delivery...
Pranay Sawant, Tejas Sutar, Sayali Sawant, Susmita Holmukhe, ...
Review on Recent Advances in Transdermal Drug Delivery Systems...
Sakshi Kulkarni , Prof. Madhuri Shirsath, Prof .Zahid Anwer Ansari Shahid Ahmed, Prof Tufail Dana , ...
A Review On Male Breast Cancer...
Akhila S. P., Dr. Sree Lekshmi.R.S, Sneha P. S., Ancy T. S., Prasobh G. R. , ...
More related articles
Artificial Intelligence in Cancer Biomedicine: A Comprehensive Survey of Diagnos...
Brijesh Yadav , Vanshika , Vinay Pal Chaudhary , Ashu Kumar, Mantasha Rani, ...
The Alzheimer's Dieases...
Siddhant Sawatkar, Shivanee Tupkar, Dr. Gajanan Sanap, ...
Artificial Intelligence in Cancer Biomedicine: A Comprehensive Survey of Diagnos...
Brijesh Yadav , Vanshika , Vinay Pal Chaudhary , Ashu Kumar, Mantasha Rani, ...
The Alzheimer's Dieases...
Siddhant Sawatkar, Shivanee Tupkar, Dr. Gajanan Sanap, ...